A rare case of blast injury of the chest and spine on the background of a congenital malformation in the form of a complete mirror image arrangement of internal organs by E.M. Khoroshun, V.V. Makarov, V.V. Nehoduiko, S.A. Shypilov, S.V. Tertyshnyi, K.S. Slesarenko

“…The injured person was taken to a territorial hospital base for further treatment, where he received painkillers, anti-inflammatory therapy, and prescribed multivitamins. The total bed-day was 7 days. …”
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Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19 by Yongzhi Lu, Qi Yang, Ting Ran, Guihua Zhang, Wenqi Li, Peiqi Zhou, Jielin Tang, Minxian Dai, Jinpeng Zhong, Hua Chen, Pan He, Anqi Zhou, Bao Xue, Jiayi Chen, Jiyun Zhang, Sidi Yang, Kunzhong Wu, Xinyu Wu, Miru Tang, Wei K. Zhang, Deyin Guo, Xinwen Chen, Hongming Chen, Jinsai Shang

“…Our results indicate that PLpro inhibitors represent a promising SARS-CoV-2 therapy.…”
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Characteristics, Incidence, and Management of Immune Checkpoint Inhibitors Related Cardiovascular Adverse Events in Real-World Practice-A Retrospective Study in Chinese Han Populat... by Wang RH, Chen Y, Lou YL, Lu YL, Xu HM

“…Rong-Hua Wang,1 Yin Chen,1 Ya-Ling Lou,1 Yu-Liang Lu,2 Hui-Min Xu3 1Department of Pharmacy, HuZhou Central Hospital (The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University), Huzhou, People’s Republic of China; 2Department of Cardiology, HuZhou Central Hospital (The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University), Huzhou, People’s Republic of China; 3Department of Pharmacy, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of ChinaCorrespondence: Rong-Hua Wang, Department of Pharmacy HuZhou Central Hospital (The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University), No. 1558 Sanhuan North Road, Wuxing District, Huzhou, Zhejiang, 313000, People’s Republic of China, Email legend.blue@163.com Hui-Min Xu, Department of Pharmacy Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88 Jiefang Road, Shangcheng District, Hangzhou, Zhejiang, 310009, People’s Republic of China, Email xuhuimin78@zju.edu.cnPurpose: This study aimed to elaborate on the incidence, clinical features, and management of immune checkpoint inhibitors (ICIs) related cardiovascular adverse events (CVAEs) in real-world practice.Patients and Methods: We performed a retrospective chart review study on patients receiving at least one dose of ICI therapy at a Chinese tertiary hospital from March 2020 to March 2021. …”
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The impact of anticoagulant-related bleeding on quality of life: Development of a novel measure based on perspectives from older adults. by Anna L Parks, Stacey L Slager, Amy M Cizik, Margaret C Fang, Mark A Supiano, Patti P Katz, Daniel M Witt

“…<h4>Background</h4>Venous thromboembolism (VTE) and atrial fibrillation (AF) disproportionately affect older adults, who are at increased risk of bleeding from treatment with anticoagulant therapy. The impact of bleeding on older adults' quality of life (QoL) is poorly understood due to the lack of a validated measure of their experience. …”
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Research Progress on the Brain Effect Mechanism of Tai Chi Chuan Training by WANG Yajun, XU Shurui, LIU Jiao

“…As a traditional exercise rehabilitation therapy in China, Tai Chi Chuan can improve the excitability of the nervous system and the ability to regulate brain functional activities. …”
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Efficacy of onabotulinumtoxinA treatment in episodic migraine by Jasem Al-Hashel, Jasem Al-Hashel, Raed Alroughani, Malak Almojel, Malak Almojel, Samar Farouk Ahmed, Samar Farouk Ahmed

“…Fifty-four patients (14.4%) experienced mild and short-lasting AEs.ConclusionBoNT-A is an effective and well tolerated therapy in the prophylaxis of EM. It improved MSQ and WPAI.…”
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LncRNA SNHG17 Contributes to Proliferation, Migration, and Poor Prognosis of Hepatocellular Carcinoma by Yue Luo, Junhao Lin, Jiakang Zhang, Zhenghui Song, Dayong Zheng, Fengsheng Chen, Xuefen Zhuang, Aimin Li, Xinhui Liu

“…Broadly, our findings illustrate that SNHG17 acts as a noncoding oncogene in HCC progression, suggesting its potential value as a novel target for HCC therapy.…”
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Integration of Umbilical Cord Mesenchymal Stem Cell Application in Hydroxyapatite-Based Scaffolds in the Treatment of Vertebral Bone Defect due to Spondylitis Tuberculosis: A Trans... by Ahmad Jabir Rahyussalim, Ahmad Nugroho, Muhammad Luqman Labib Zufar, Irfan Fathurrahman, Tri Kurniawati

“…Umbilical cord mesenchymal stem cells combined with hydroxyapatite-based scaffold utilization represent a prospective alternative therapy for bone formation and regeneration of vertebral bone defect due to spondylitis tuberculosis. …”
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Update on the Medical Management of Gastrointestinal Behçet’s Disease by Giuseppe Lopalco, Donato Rigante, Vincenzo Venerito, Claudia Fabiani, Rossella Franceschini, Michele Barone, Giovanni Lapadula, Mauro Galeazzi, Bruno Frediani, Florenzo Iannone, Luca Cantarini

“…To date, there are no standardized medical treatments for GIBD; therefore therapy should be tailored to the single patient and based on the severity of the clinical features and their complications. …”
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Factors Associated with Mortality in Severe Acute Cholangitis in a Moroccan Intensive Care Unit: A Retrospective Analysis of 140 Cases by Soumaya Touzani, Abderrahim El Bouazzaoui, Fatima Bouyarmane, Kaoutar Faraj, Nawfal Houari, Brahim Boukatta, Nabil Kanjaa

“…Statistically significant factors for mortality (p<0.05) were history of taking anticoagulant treatment, use of catecholamines and mechanical ventilation during ICU stay, and delay in consultation and administration of antibiotic therapy. Conclusions. Early recognition, antibiotics, resuscitation, and minimally invasive biliary drainage have improved patient outcomes although there is still progress to be made. …”
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Long-Term Clinical Outcomes of Invasive Giant Prolactinomas after a Mean Ten-Year Followup by Ze Rui Wu, Yong Zhang, Lin Cai, Shao Jian Lin, Zhi Peng Su, Yong Xu Wei, Han Bing Shang, Wen Lei Yang, Wei Guo Zhao, Zhe Bao Wu

“…DAs are a first-line therapy for IGPs because they can effectively achieve long-term control in both shrinking tumor volume and normalizing the PRL level, and majority of patients need low-dose DA maintenance. …”
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“I think we're on a cusp of some change:” coping and support for mental wellness among Black American women by Terika McCall, Terika McCall, Terika McCall, Meagan Foster, Holly Tomlin, Holly Tomlin, Bolatito Adepoju, Mckenzie Bolton-Johnson, Chyrell D. Bellamy

“…Descriptive qualitative content analysis of the focus group transcripts was conducted.ResultsResults consistently showed that intersectional identities of being both Black and a woman resulted in feelings of both hypervisibility and invisibility, representation matters when it comes to mental health providers, an increased openness to therapy across age groups, and a willingness to try digital health tools (e.g., smartphone app) for mental health needs. …”
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Evaluation of maSSS/maSES-PEG2-RM26 for their potential therapeutic use after labeling with Re-188. Could their [99mTc]Tc-labeled counterparts be used to estimate dosimetry? by Panagiotis Kanellopoulos, Quanyi Yu, Abouzayed Abouzayed, Ekaterina Bezverkhniaia, Vladimir Tolmachev, Anna Orlova

“…Abstract Background Gastrin releasing peptide receptor (GRPR)-directed radiopharmaceuticals for targeted radionuclide therapy may be a very promising addition in prostate and breast cancer patient management. …”
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Detection of Dengue Virus-Specific IgM and IgG Antibodies through Peptide Sequences of Envelope and NS1 Proteins for Serological Identification by Pradeep Kumar Nagar, Deepali Savargaonkar, Anupkumar R. Anvikar

“…Thus, precise diagnosis of dengue at the early stage is very essential for disease control and effective therapy in order to treat or prevent severe complications. …”
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Management of Hypertension in the Elderly Patient at Abidjan Cardiology Institute (Ivory Coast) by K. E. Kramoh, E. Aké-Traboulsi, C. Konin, Y. N'goran, I. Coulibaly, A. Adoubi, J. Koffi, J. B. Anzouan-Kacou, M. Guikahue

“…According to the European Guidelines stratification of the cardiovascular risk-excess attributable to high blood pressure, 82.1% of the sample had a very high added risk. The pharmacological therapy was prescribed in 93.5%. More than 66% of patients were receiving ≥2 antihypertensive drugs including fixed-dose combination drugs. …”
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Bufalin targets the SRC-3/c-Myc pathway in chemoresistant cells to regulate metastasis induced by chemoresistance in colorectal cancer by Jinbao Chen, Chenqi Wu, Kun Yu, Jinpei Liu, Jiahua Yang, Wei Li, Xiaoxia Tang, Yihai Shi, Ke Xu, Yi Chen, Xiaoyu Qin

“…Conclusion Bufalin can target the SRC-3/c-Myc signaling pathway to affect the prometastatic effect of chemoresistant cells, suggesting that bufalin may be used as a new adjuvant antimetastatic therapy for colorectal cancer.…”
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Small Bowel Bacterial Overgrowth Syndrome in Patients with Bronchial Asthma by N. D. Potskhverashvili, O. Yu. Zolnikova, N. I. Kokina, N. L. Dzhakhaya, A. V. Sedova, E. L. Bueverova, A. S. Trukhmanov

“…Patients received conventional basal therapy with combined drugs (long-acting β2-adrenomimetics, and inhaled glucocorticoids). …”
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Utilizing bioinformatics and machine learning to identify CXCR4 gene-related therapeutic targets in diabetic foot ulcers by Hengyan Zhang, Ye Zhou, Heguo Yan, Changxing Huang, Licong Yang, Yangwen Liu

“…Identifying key molecular targets associated with DFUs could help develop targeted therapies to promote wound healing and prevent further complications. …”
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Assessment of the Impact of Different Types and Intensities of Physical Exercise on the Quality of Life of Patients with Alzheimer’s Disease: A Literature Review by Katarzyna Barabasz, Paulina Więcławek, Piotr Juda, Patrycja Kłaptocz, Katarzyna Łukoś-Karcz, Dominik Bańkowski, Gabriela Pabian, Karol Musiał, Kamil Bielak

“…Conclusions Moderate aerobic and combined exercises are effective in preventing and supporting AD therapy. Further research is needed to standardize exercise protocols and evaluate their long-term effects. …”
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Robot-Assisted Partial Splenectomy for Splenic Epidermoid Cyst by Mubarak Ali kirih, Xiao Liang, Yangyan Xie, Jingwei Cai, Junhao Zheng, Feng Xu, Shilin He, Liye Tao, Faisa Ali Abdi

“…Postoperative pathology revealed epidermoid cyst. The therapy strategy of the splenic cyst is ambiguous. …”
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