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17041
Efficacy of transcranial magnetic stimulation in anorexia nervosa: a systematic review and meta-analysis
Published 2025-01-01“…Conclusion TMS represents an effective therapy for patients with AN, leading to improvements in both BMI and core symptoms of AN, with minor and transient side effects. …”
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17042
The Influence of Physical Activity on Inflammatory Markers, Intestinal Microbiota Composition and Disease Activity in Inflammatory Bowel Disease
Published 2025-01-01“…Future research should focus on longitudinal studies, advanced omics technologies, and combined approaches with dietary and pharmacological therapies. …”
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17043
Novel thiazolyl-pyrimidine derivatives as potential anticancer agents: Synthesis, biological evaluation, and molecular docking studies
Published 2025-01-01“…We synthesized and spectroscopically confirmed a series of 1,3-thiazolyl-pyrimidine derivatives to investigate their potential role in cancer therapy. These were created by reacting 2-(1-(6-methyl-2-oxo-4-phenyl- 1,2,3,4-tetrahydropyrimidin-5-yl)ethylidene)hydrazine-1-carbothioamide with hydrazonoyl halides and α-halo compounds, with structures confirmed by spectroscopy. …”
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17044
Phenazine biosynthesis-like domain-containing protein (PBLD) and Cedrelone promote antiviral immune response by activating NF-ĸB
Published 2025-01-01“…Consequently, our findings provide a potential combination model that targets PBLD for Cedrelone antiviral drug therapy, potentially paving the way for the development of broad-spectrum antiviral agents.…”
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17045
Redefining diagnostic parameters: the role of overvaluation of shape and weight in binge-eating disorder: a systematic review
Published 2025-01-01“…It was not clear whether overvaluation predicted dropout from Cognitive Behavior Therapy interventions. Discussion It is suggested to consider including overvaluation of shape and weight as a criterion for the diagnosis of binge-eating disorder. …”
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17046
Network-wide effects of pallidal deep brain stimulation normalised abnormal cerebellar cortical activity in the dystonic animal model
Published 2025-02-01“…Background: Deep brain stimulation (DBS) targeting globus pallidus internus (GPi) is a recognised therapy for drug-refractory dystonia. However, the mechanisms underlying this effect are not fully understood. …”
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17047
Protective effects of wogonin in the treatment of central nervous system and degenerative diseases
Published 2025-02-01“…For patients with hemorrhagic stroke and traumatic brain injury, it accelerates hematoma regression, mitigates secondary brain damage, and promotes neurogenesis, making it an entirely new treatment option for patients with limited access to this type of therapy. Its anticonvulsant and anxiolytic effects are mediated through GABA-A receptor modulation. …”
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17048
Assessment of Confidence Levels of Undergraduate Senior Dental Students and Interns’ During Endodontic Treatment Procedures in a Sample From Saudi Arabia
Published 2025-02-01“…The dental interns demonstrated a notable degree of self-assurance in executing root canal therapy, primarily attributable to their extensive engagement in clinical practice.Keywords: confidence, endodontics, education, dental students, self-assessment…”
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17049
Classification of Nanomaterial Drug Delivery Systems for Inflammatory Bowel Disease
Published 2025-02-01“…Lifelong maintenance therapy may thus be needed to manage these symptoms; however, traditional IBD drugs, such as 5-aminosalicylic acid, glucocorticoids, immunosuppressants, and biological agents, are often associated with problems including poor solubility, instability, and ineffective targeting, as well as causing serious side effects in non-target tissues. …”
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17050
Novel findings regarding treatment obesity and weight-related comorbidities – the systemic literature review
Published 2025-01-01“…However, other drugs show promising results in improving glycemic control, cardiovascular health (semaglutide and tirzepatide), lipid levels, the regression of fibrosis (survodutide), or alleviating OBS symptoms (tirzepatide). Tailored therapy combining both medication’s weight-reducing capacity and the patient’s comorbidities provides the most beneficial effects. …”
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17051
Analysis of clinical characteristics of hemorrhagic fever with renal syndrome with acute pancreatitis: a retrospective study
Published 2025-12-01“…LASSO-Logistic regression was used to screen risk factors and develop a nomogram model.Results After PSM, HFRS patients with AP had higher rates of Continuous Renal Replacement Therapy (CRRT) and/or mechanical ventilation use, , ICU admission, and 30-day mortalitycompared with those without AP (p < 0.05). …”
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17052
Early Effects of Hyperbaric Oxygen on Inducible Nitric Oxide Synthase Activity/Expression in Lymphocytes of Type 1 Diabetes Patients: A Prospective Pilot Study
Published 2019-01-01“…This study aimed at examining the early effects of hyperbaric oxygen therapy (HBOT) on inducible nitric oxide synthase (iNOS) activity/expression in lymphocytes of type 1 diabetes mellitus (T1DM) patients. …”
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17053
Association between the triglyceride–glucose index and the risk of acute kidney injury in critically ill patients with acute pancreatitis: a retrospective study
Published 2025-02-01“…The secondary endpoint was in-hospital mortality and the rate of renal replacement therapy(RRT) use. Cox regression analysis and restricted cubic spline were used to analyze TyG index association with AKI risk. …”
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17054
Eculizumab treatment for Chinese patients with hemolytic paroxysmal nocturnal hemoglobinuria (PNH): efficacy and safety – a single-center study
Published 2025-12-01“…Changes in clinical and laboratory indicators after 1, 3, and 6 months of eculizumab therapy and at the end of follow-up were documented. …”
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17055
Recent advances in the anti-tumor activities of saponins through cholesterol regulation
Published 2025-01-01“…Abnormal cholesterol metabolism has become a popular therapeutic target in cancer therapy. In recent years there has been a surge in interest in the anti-tumor activities of saponins, particularly their ability to disrupt cholesterol homeostasis in tumor cells. …”
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17056
Methods for assessing manifestations of respiratory failure in patients with laryngeal and tracheal compression syndrome caused by thyroid diseases and cicatricial tracheal stenosi...
Published 2024-12-01“…This makes a comprehensive approach to the treatment of such patients obvious. Therapy should be aimed not only at restoring airway patency, but also at supporting the entire body. …”
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17057
Suicidality and Illness Course Worsening in a Male Patient with Bipolar Disorder during Tamoxifen Treatment for ER+/HER2+ Breast Cancer
Published 2021-01-01“…The onset or worsening of depressive symptoms or suicidality should be carefully addressed and promptly treated, and clinicians should be encouraged to consider the possibility of discontinue or reduce Tamoxifen therapy after a multidisciplinary evaluation.…”
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17058
Preliminary analysis of patient assessment within a study on the impact of hydrokinetotherapy on body composition and metabolic disease risk in an adult population segment
Published 2025-12-01“…A personalized approach and careful management of hydrokineto-therapy exercises are necessary. Weight loss through diet and physical exercise is proven to be the most effective treatment strategy for obese and overweight elderly subjects, facilitating the maintenance of muscle mass and promoting functional recovery…”
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17059
Repression of PFKFB3 sensitizes ovarian cancer to PARP inhibitors by impairing homologous recombination repair
Published 2025-01-01“…The in vivo efficacy of PARPi and PFK158 combination therapy was evaluated in OC xenograft models. Results PFKFB3 activity was significantly elevated in OC tissues and associated with PARPi resistance. …”
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17060
Long-Term Prospective Study of the Influence of Estrone Levels on Events in Postmenopausal Women with or at High Risk for Coronary Artery Disease
Published 2012-01-01“…Methods. 251 postmenopausal women age 50–90 years not on estrogen therapy. Fasting blood for estrone and heart disease risk factors were collected at baseline. …”
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