Pioglitazone Attenuates Drug-Eluting Stent-Induced Proinflammatory State in Patients by Blocking Ubiquitination of PPAR by Zhongxia Wang, Tao Zhang, Lizhe Sun, Ruifeng Li, Yuanyuan Wei, Xiaojuan Fan, Zuyi Yuan, Junhui Liu, Tao Chen

“…Twenty-eight patients with coronary artery disease and who underwent DES implantations were randomly assigned to pioglitazone (30 mg/d; PIO) or placebo (control; Con) treatment in addition to optimal standard therapy. After 12 weeks of treatment, plasma concentrations of high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and matrix metalloproteinase-9 (MMP-9) were significantly decreased in PIO group compared to the Con group (P=0.035, 0.011, 0.008, and 0.012, resp.). …”
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A novel approach for managing the incisions of tibial plateau fractures with soft tissue swelling by Yang Zhang, Yangyang Zhao, Shuanggong Liu, Zihan Yao, Zikang Jin, Wanli Ma

“…For patients with tibial plateau fractures without congestive blisters, open reduction and internal fixation at the early stage of swelling and wide-spacing interrupted suture and negative pressure wound therapy (NPWT) closure of the wound could help obtain excellent to good functional outcomes with fewer complications. …”
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Barriers and facilitators of loaded self-managed exercises and physical activity in people with patellofemoral pain: understanding the feasibility of delivering a multicentred rand... by Michael Skovdal Rathleff, Phillipa Logan, Marcus Bateman, Benjamin E Smith, Fiona Moffatt, Paul Hendrick, James Selfe, Toby O Smith

“…Objectives There is an emergent body of evidence supporting exercise therapy and physical activity in the management of musculoskeletal pain. …”
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Efficacy of acupuncture for primary osteoporosis: a systematic review and meta-analysis of randomized controlled trials by Tianyi Ma, Tiantian Zhang, Le Zhang, Haoming Zhao, Ke Liu, Jianjun Kuang, Liang Ou

“…Acupuncture, a traditional Chinese therapy, has been used to treat osteoporosis for over 2000 years. …”
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Decitabine Compared with Low-Dose Cytarabine for the Treatment of Older Patients with Newly Diagnosed Acute Myeloid Leukemia: A Pilot Study of Safety, Efficacy, and Cost-Effectiven... by Linu A. Jacob, S. Aparna, K. C. Lakshmaiah, D. Lokanatha, Govind Babu, Suresh Babu, Sandhya Appachu

“…The secondary objective was to compare adverse events and cost-effectiveness of therapy in the two study groups. Results. In this study, 15 patients received decitabine and 15 patients received cytarabine. …”
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Economic evaluation of encorafenib with cetuximab in patients with BRAF V600E-mutant metastatic colorectal cancer in France: a cost-effectiveness analysis using data from the BEACO... by David Malka, Philippe Laramée, Mondher Toumi, Jean-Baptiste Trouiller, Bérengère Macabeo, Andrew Poll, Dan Howard, Andy Buckland, Marine Sivignon, Emilie Clay, Emmanuelle Samalin

“…We aimed to evaluate the cost-effectiveness of encorafenib with cetuximab in adult patients with BRAF-mutant mCRC after prior systemic therapy, from the perspective of the French healthcare system.Design A partitioned survival analysis model was developed to assess the cost-effectiveness of encorafenib with cetuximab using data from BEACON CRC (encorafenib with cetuximab and cetuximab with FOLFIRI or irinotecan). …”
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Dual Functions of Androgen Receptor Overexpression in Triple-Negative Breast Cancer: A Complex Prognostic Marker by Umay Kiraz, Emma Rewcastle, Silja K. Fykse, Ingrid Lundal, Einar G. Gudlaugsson, Ivar Skaland, Håvard Søiland, Jan P. A. Baak, Emiel A. M. Janssen

“…In high AR-DIA patients with unfavorable characteristics, ACT did not improve survival, and patients may benefit from AR-targeted therapy. Overall, the DIA method provides reproducibility, high AR-DIA (≥10%) shows opposing survival effects in different TNBC subgroups, and AR evaluation is crucial for prognosis and AR-targeted therapies.…”
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Continuous Glucose Monitoring Among Patients With Type 1 Diabetes in Rwanda (CAPT1D) Phase I: Prospective Observational Feasibility Study by Jason Baker, Giacomo Cappon, Jean Claude Habineza, Corey H Basch, Steven Mey, Diana L Malkin-Washeim, Christian Schuetz, Niyonsenga Simon Pierre, Etienne Uwingabire, Alvera Mukamazimpaka, Paul Mbonyi, Sandhya Narayanan

“…Participants were at least 21 years old, undergoing multiple daily insulin therapy, and not currently pregnant. Phase I of the study was conducted over 12 months, using the Dexcom G6 CGM. …”
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Relationship between psychological empowerment, physical activity enjoyment, and response to a HIIT Program in physically inactive young women: a prospective multicentre study by Irene Ferrando-Terradez, Rodrigo Núñez-Cortés, Laura López-Bueno, Enrique Alcántara, Joaquín Calatayud, José Casaña, Ivana Parčina, Lirios Dueñas

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Intestinal obstruction caused by disseminated mycobacterium avium complex disease following solid organ transplantation: a case report by Akane Mita, Sho Nakakubo, Yusuke Nishimura, Hideki Shima, Masaaki Watanabe, Tsuyoshi Shimamura, Satoshi Konno

“…Despite ongoing antimicrobial therapy, the patient’s intestinal lesions persisted, and she required prolonged hospitalization and interventions for bile drainage and enteral nutrition. …”
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Antenatal Steroids and the IUGR Fetus: Are Exposure and Physiological Effects on the Lung and Cardiovascular System the Same as in Normally Grown Fetuses? by Janna L. Morrison, Kimberley J. Botting, Poh Seng Soo, Erin V. McGillick, Jennifer Hiscock, Song Zhang, I. Caroline McMillen, Sandra Orgeig

“…Hence, antenatal glucocorticoid therapy in the IUGR fetus may compromise regulation of cardiovascular development. …”
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Achieving chronic hepatitis B functional cure: Factors and potential mechanisms by Jiarui Zheng, Zilong Wang, Linxiang Huang, Zixuan Qiu, Yandi Xie, Suzhen Jiang, Bo Feng

“…Factors related to CHB functional cure with antiviral therapy are complex, including host factors, viral factors, environmental factors, etc. …”
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Is There a Mild Form of Pediatric Appendicitis? An Eight-Year Single-Center Retrospective Review by Eric Scheier, Khaled Khalilia, Pavel Peslin, Stav Amir, Luba Pasherstnik Bizer

“…While pediatric appendicitis should not be ruled out in the presence of a normal laboratory evaluation, cases that present without gastrointestinal symptoms, without severe pain, and with an appendiceal diameter and inflammatory markers below a certain threshold may warrant continued observation and serial ultrasound to evaluate for progression prior to initiating therapy.…”
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RNA-binding protein HuR reprograms immune T cells and promotes oral squamous cell carcinoma by Mrinmoyee Majumder, Harinarayanan Janakiraman, Paramita Chakraborty, Anitha Vijayakumar, Sari Mayhue, Hong Yu, Toros Dincman, Romeo Martin, Elizabeth O'Quinn, Shikhar Mehrotra, Viswanathan Palanisamy

“…Thus, HuR-dependent oral neoplasia relies on immunological dysfunction, suggesting that decreasing HuR may boost antitumor potential and offer a novel HNSCC therapy.…”
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Local electrical stimulation: introduction to the problem by Lev G. Agasarov, Maxim Yu. Yakovlev, Tatyana V. Konchugova, Larisa A. Marchenkova, Victor A. Drobyshev, Tatyana V. Apkhanova, Tatyana E. Belousova, Tatyana V. Marfina, Nadezhda V. Gushchina, Valeria A. Vasileva, Anastasia A. Mukhina, Irina A. Grishechkina, Tatyana K. Chernyavskaya, Elena P. Ivanova

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Dynamic ultrasound-based modeling predictive of response to neoadjuvant chemotherapy in patients with early breast cancer by Xinyi Wang, Yuting Zhang, Mengting Yang, Nan Wu, Shan Wang, Hong Chen, Tianyang Zhou, Ying Zhang, Xiaolan Wang, Zining Jin, Ang Zheng, Fan Yao, Dianlong Zhang, Feng Jin, Pan Qin, Jia Wang

“…Such models may offer a means of accurately predicting NACT responses in this setting, helping to individualize patient therapy. Our study may provide additional insights into the US-based response prediction by focusing on the dynamic changes of the tumor in the early and full NACT cycle.…”
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Heteronemin Suppresses Lymphangiogenesis Through ARF-1 and MMP-9/VE-Cadherin/Vimentin by Hsien-Lin Chen, Yu-Chieh Su, Huang-Chi Chen, Jui-Hsin Su, Chang-Yi Wu, Shih-Wei Wang, In-Pin Lin, Chung-Yi Chen, Chien-Hsing Lee

“…Therefore, regulation of lymphangiogenesis has become a promising strategy for cancer therapy. In this study, we aimed to investigate the anti-lymphangiogenic effect of heteronemin (SP-1) isolated from the sponge <i>Hyrtios</i> sp. in vitro and in vivo. …”
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Towards Elimination of Mother-to-Child Transmission of HIV: The Impact of a Rapid Results Initiative in Nyanza Province, Kenya by Lisa L. Dillabaugh, Jayne Lewis Kulzer, Kevin Owuor, Valerie Ndege, Arbogast Oyanga, Evelyne Ngugi, Starley B. Shade, Elizabeth Bukusi, Craig R. Cohen

“…A Rapid Results Initiative (RRI) approach was utilized to address key challenges in delivery of prevention of MTCT (PMTCT) services including highly active antiretroviral therapy (HAART) uptake for women and infants. The RRI was conducted between April and June 2011 at 119 health facilities in five districts in Nyanza Province, Kenya. …”
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Effect of PCSK9 inhibitor on early neurological deterioration in acute ischemic stroke patients with a history of coronary heart disease: a study protocol for a randomized controll... by Xing Gong, Xinting Yu, Lanlan Pu, Yang Jiao, Lin Liu, Hua Cao, Xiaofei Ji

“…The PI group will receive a combination therapy consisting of evolocumab and rosuvastatin calcium tablets, while the AT group will receive only oral rosuvastatin calcium tablets. …”
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The Efficacy of Single-Application NPWTi-d for the Salvage of Infected Breast Prostheses: A Multi-Center Study by Jason C. Llaneras, MD, Robert Craig Clark, MD, Lauren Antognoli, MD, Emily Finkelstein, MD, Luci Hulsman, BS, Luther Holton, MD, Devinder Singh, MD, R. Jason VonderHaar, MD, Risal Djohan, MD, Aladdin H. Hassanein, MD, Chris M. Reid, MD

“…Single-application negative pressure wound therapy with instillation and dwell (NPWTi-d) has shown promise for salvaging infected implants, though prior studies have been small and heterogeneous. …”
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