Optimization of Storage Temperature for Cultured ARPE-19 Cells by Lara Pasovic, Tor Paaske Utheim, Rima Maria, Torstein Lyberg, Edward B. Messelt, Peder Aabel, Dong Feng Chen, Xiangjun Chen, Jon Roger Eidet

“…The establishment of future retinal pigment epithelium (RPE) replacement therapy is partly dependent on the availability of tissue-engineered RPE cells, which may be enhanced by the development of suitable storage methods for RPE. …”
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Clinical characteristics and usage of statins in patients with stable ischemic heart disease referred for angiography or coronary artery bypass grafting by I.V. Shklianka, O.J. Zharinov, К.O. Mikhaliev, O.A. Epanchintseva

“…At the same time, groups of patients who had been and had not been prescribed statins, did not differ by vast majority of demographic, clinical and instrumental characteristics, concomitant diseases and risk factors. No statin therapy was associated with higher levels of total cholesterol and interleukin-6 compared with the group of patients taking statins (total cholesterol, respectively, 4.8 versus 4.2 mmol/l (p = 0.016) and interleukin-6, respectively, 4.4 versus. 3.1 p/ml (p = 0.022)). …”
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Effects of Acute Endurance Exercise on Plasma Protein Profiles of Endurance-Trained and Untrained Individuals over Time by Marius Schild, Gerrit Eichner, Thomas Beiter, Martina Zügel, Ilke Krumholz-Wagner, Jens Hudemann, Christian Pilat, Karsten Krüger, Andreas M. Niess, Jürgen M. Steinacker, Frank C. Mooren

“…These findings might be of importance in the development of exercise-based strategies in the prevention and therapy of chronic metabolic and inflammatory diseases and for training monitoring.…”
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Relationship between multiple morbidities and performance on the Timed Up and Go test in elderly patients: a cross-sectional study by Arsalan Tariq, Sayed Alireza Mousavi Zadeh, Muhammad Ammar, Nafisehsadat Mousavizadeh, Arash Hajary, Somayeh Mohamadi

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Temporary spinal cord stimulation combined with lidocaine patch for postherpetic neuralgia in the elderly: a controlled study by Yun Li, Chunhui Hao, Shengtao Wang, Feng Qiu, Xuli Zhao, Tao Sun

“…Patients with PHN duration <60 days benefited more from combination therapy. Adverse events were minimal and similar between groups.ConclusionCombining SCS with lidocaine patches significantly enhances pain relief and sleep quality in elderly PHN patients compared to SCS alone. …”
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Salidroside enhances 5-fluorouracil sensitivity against hepatocellular carcinoma via YIPF5-induced mitophagy by Sumin Sun, Haili Hu, Feiyu Li, Feiyu Li, Sheng Huan, Long Chen, Jiahui Chen, Peihua Sun, Xiaoqing Dong, Xiaoqing Dong

“…Hepatocellular carcinoma (HCC) is a major medical challenge due to its high incidence and poor prognosis. 5-Fluorouracil (5-FU), although extensively studied in the treatment of HCC and other solid tumors, has limited application as a first-line therapy for HCC due to its resistance and significant inter-patient variability. …”
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Effects of Diverting Stoma Creation in Minimally Invasive Surgery for Rectal Cancer by Hirotaka Momose, Makoto Takahashi, Masaya Kawai, Kiichi Sugimoto, Hiromitsu Takahashi, Shunsuke Motegi, Kumpei Honjo, Yu Okazawa, Rina Takahashi, Shun Ishiyama, Yuichi Tomiki, Kazuhiro Sakamoto

“…Results: Of the 143 subjects, 30 (21%) had AL, including asymptomatic AL in 19 cases (13%) and AL requiring conservative therapy in 11 cases (8%). No case of AL required reoperation. …”
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Predictors of response to daclatasvir in addition to sofosbuvir in hepatitis C virus-infected patients with stage 4 and 5 chronic kidney disease and patients on maintenance hemodia... by Rasha Gawish, Eman Elgohary, Mona Tahoun, Mona Elkaraly, Heba Mohsin, Ahmed Kamal

“…Abstract Background The FDA authorized the use of sofosbuvir-based therapy in persons with chronic kidney disease (CKD) stages 4 and 5 and in those on maintenance hemodialysis (HD). …”
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Long-term correction of hemophilia A via integration of a functionally enhanced FVIII gene into the AAVS1 locus by nickase in patient-derived iPSCs by Do-Hun Kim, Sang-Hwi Choi, Jin Jea Sung, Sieun Kim, Hanui Yi, Sanghyun Park, Chan Wook Park, Young Woo Oh, Jungil Lee, Dae-Sung Kim, Jong-Hoon Kim, Chul-Yong Park, Dong-Wook Kim

“…Genome editing in conjunction with patient-derived induced pluripotent stem cells (iPSCs) is a promising cell therapy strategy, as it replaces dysfunctional proteins resulting from genetic mutations with normal proteins. …”
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Conventional magnetic resonance imaging combined with three-dimensional ultrasound for preoperative prediction of immediate ablation rate in high-intensity focused ultrasound treat... by Qiong Hao, Junwei Liu, Ruoying Hou, Wenxia Huang, Juan Liao, Zhenjiang Lin, Tijiang Zhang

“…Objective This study aimed to assess the effectiveness of conventional magnetic resonance imaging (MRI) combined with three-dimensional (3D) ultrasound for the preoperative prediction of nonperfused volume ratio (NPVR) in uterine fibroids after high-intensity focused ultrasound (HIFU) ablation.Materials and methods In total, 178 patients who had undergone HIFU ablation therapy for uterine fibroids between July 2021 and August 2023 were enrolled. …”
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S100P is a ferroptosis suppressor to facilitate hepatocellular carcinoma development by rewiring lipid metabolism by Min Yang, Weiwei Cui, Xiaoting Lv, Gaozhong Xiong, Caiyu Sun, Haocheng Xuan, Wei Ma, Xiuling Cui, Yeping Cheng, Lihui Han, Bo Chu

“…Our work reveals an alternative anti-ferroptosis pathway and suggests S100P as a promising druggable target for ferroptosis-related therapy of HCC.…”
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Similarities and Differences between Clavicular Bacterial Osteomyelitis and Nonbacterial Osteitis: Comparisons of 327 Reported Cases by Nan Jiang, Ping Zhang, Wei-ran Hu, Zi-long Yao, Bin Yu

“…However, no significant differences were identified regarding the serological levels of white blood cell count (P=0.06), erythrocyte sedimentation rate (P=0.27), or C-reactive protein (P=0.33) between BO and NBO patients before therapy. Overall, the BO patients achieved a statistically higher cure rate than that of the NBO patients (P=0.018). …”
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Acute kidney injury in critically ill COVID-19 patients in a tertiary hospital: short and long-term kidney and patient outcomes by Juliana Alves Manhães de Andrade, Gisele Meinerz, Raphael Palma, Eduardo Rech, Marco Antônio Vinciprova Dall’Agnese, Cristiane Bundchen, Fernanda Bordignon Nunes, Gisele Branchini, Elizete Keitel

“…Methods: Prospective single-center cohort of critically ill COVID-19 adult patients with NC-AKI from May 1st, 2020, to April 30th, 2021. Kidney replacement therapy (KRT), recovery of kidney function, and death at 90-day and 1-year follow-up were evaluated. …”
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A qualitative study to understand the facilitators of and barriers to retention in care to the national PMTCT Option B+ programme in Uganda. by Charity Kyomugisha-Nuwagaba, Rachel King, Rose Baryamutuma, Simon Muhumuza, Linda N Kisakye, William Bazeyo, Evelyn Akello

“…Although an increasing number of people living with HIV (PLHIV) in Uganda are benefiting from the rapid scale-up of antiretroviral therapy (ART), retention in HIV care and treatment services remains a major concern. …”
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Ketosis Onset Type 2 Diabetes Had Better Islet β-Cell Function and More Serious Insulin Resistance by Hongyun Lu, Fang Hu, Yingjuan Zeng, Lingling Zou, Shunkui Luo, Ying Sun, Hong Liu, Liao Sun

“…After correction of hyperglycemia and ketosis with insulin therapy, plasma C-peptide concentrations were measured at 0, 0.5, 1, 2, and 3 hours after 75 g glucose oral administration. …”
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Recurrent nocturnal hypoglycemic hemiplegia: a case report and review of the literature by Hanako Toyama, Kazuyuki Takahashi, Tatsunori Shimizu, Izumi Otaka, Sakiko Abe, Shunsuke Kato, Sayaka Ando, Takehiro Sato, Tsukasa Morii, Hiroki Fujita, Hironori Waki

“…A 67-year-old man with type 1 diabetes, Cronkhite-Canada syndrome, and membranous nephropathy who received insulin therapy was admitted to our hospital with right hemiplegia and dysarthria. …”
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The “best practices for farming” successfully contributed to decrease the antibiotic resistance gene abundances within dairy farms by Barbara Salerno, Matteo Cornaggia, Raffaella Sabatino, Andrea Di Cesare, Claudio Mantovani, Lisa Barco, Benedetta Cordioli, Luca Bano, Carmen Losasso

“…This study aimed to evaluate the impact of a guideline on “best practices for farming” aimed at reducing the dissemination of antibiotic resistance.MethodsA guideline focused on prudent antibiotic use, selective therapy, and hygienic and immune-prophylactic practices was developed and provided to the owners of 10 selected dairy farms and their veterinarians. …”
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A Metabolic Gene Signature to Predict Overall Survival in Head and Neck Squamous Cell Carcinoma by Zeng-Hong Wu, Yun Tang, Yue Zhou

“…In this study, we used RNA sequencing (RNA-seq) data from the cancer genome atlas (TCGA), with validation in the GEO dataset to profile the metabolic microenvironment and define potential biomarkers for metabolic therapy. Results. We extracted data for 529 patients and 327 metabolic genes (198 upregulated and 129 downregulated genes) in the TCGA database. …”
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In Acute IgA Nephropathy, Proteinuria and Creatinine Are in the Spot, but Podocyturia Operates in Silence: Any Place for Amiloride? by H. Trimarchi, M. Paulero, R. Canzonieri, A. Schiel, A. Iotti, C. Costales-Collaguazo, A. Stern, M. Forrester, F. Lombi, V. Pomeranz, R. Iriarte, T. Rengel, I. Gonzalez-Hoyos, A. Muryan, E. Zotta

“…The clinical course and the response to therapy are usually assessed with proteinuria and serum creatinine. …”
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Construction of "One Syndrome and One Product” specialized ward in the Department of Spleen and Stomach Disease and it effect on the promotion of patients experience of hospitaliza... by HUANG Yanping (黄砚萍), ZHANG Yuanchun (张元春), LI Jing (李静), TANG Ling (唐玲), LIU Chang (刘唱), TIAN Xiaodong (田小冬), ZHOU Sijia (周思佳), XIE Xiaolei (谢晓磊), LI Mingzhu (李明珠), DONG Shuo (董硕)

“…Methods To carry out the humanistic care service of Traditional Chinese Medicine(TCM) and the characteristic techniques of TCM: shaking-hands nursing shift, the whole process of accompanying inspection service, TCM needle and stone ironing therapy, and so on. Results Through effective TCM nursing service and techniques, patients' satisfaction with nursing service, patients' satisfaction with nursing technology and nurses' satisfaction with nursing plan were improved, and the average hospital stay was reduced. …”
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