TNBC response to paclitaxel phenocopies interferon response which reveals cell cycle-associated resistance mechanisms by Nicholas L. Calistri, Tiera A. Liby, Zhi Hu, Hongmei Zhang, Mark A. Dane, Sean M. Gross, Laura M. Heiser

“…Abstract Paclitaxel is a standard of care neoadjuvant therapy for patients with triple negative breast cancer (TNBC); however, it shows limited benefit for locally advanced or metastatic disease. …”
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Modulation of Tumor Immunity by Soluble and Membrane-Bound Molecules at the Immunological Synapse by Pablo A. González, Leandro J. Carreño, Pablo F. Céspedes, Susan M. Bueno, Claudia A. Riedel, Alexis M. Kalergis

“…Here, we discuss recent literature on the regulation and assembly of IS and the mechanisms evolved by tumors to modulate its function to escape T cell cytotoxicity, as well as novel strategies targeting the IS for therapy.…”
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The Impact of Silymarin on Inflammation and Oxidative Stress: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Mahdi Vajdi, Shaghayegh Adeli, Arash Karimi, Vahid Asghariazar, Arezoo Moini Jazani, Ramin Nasimidoost Azgomi

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Beyond the Ear, the Hidden Threat of Paecilomyces Neuro-Otological Infection: A Case Report by Jing Hern Khoo, Izny Hafiz Zainon, Hafizah Husna Johari, Ida Sadja’ah Sachlin

“…Results: Paecilomyces middle ear infection leading to intracranial involvement of such magnitude is yet to be reported, and we showcase its successful management through a combined surgical neuro-otology approach and oral antifungal therapy. Fungal ear infections can lead to severe extracranial and intracranial complications if inadequately treated. …”
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Barriers to and Facilitators of Implementing Team-Based Extracorporeal Membrane Oxygenation Simulation Study: Exploratory Analysis by Joan Brown, Sophia De-Oliveira, Christopher Mitchell, Rachel Carmen Cesar, Li Ding, Melissa Fix, Daniel Stemen, Krisda Yacharn, Se Fum Wong, Anahat Dhillon

“…Simulation training was offered for 1 hour monthly to the clinical team focused on the collaboration and decision-making needed to evaluate the initiation of ECMO therapy. Electronic surveys were distributed before, after, and 3 months post training. …”
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Real-World Effectiveness and Safety of Isavuconazole Versus Amphotericin B for Patients with Invasive Mucormycosis by Jiayuan Qin, Hongxia Bi, Guangmin Tang, Xinyao Liu, Junyan Qu, Xiaoju Lv, Yanbin Liu

“…The proportion of patients who received salvage therapy was greater in the amphotericin B group than in the isavuconazole group (42% vs. 6%, <i>p</i> < 0.001). …”
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The Binding of BF-227-Like Benzoxazoles to Human α-Synuclein and Amyloid β Peptide Fibrils by Lee Josephson PhD, Nancy Stratman MS, YuTing Liu MS, Fang Qian MS, Steven H. Liang PhD, Neil Vasdev PhD, Shil Patel PhD

“…Development of an α-synuclein (α-Syn) positron emission tomography agent for the diagnosis and evaluation of Parkinson disease therapy is a key goal of neurodegenerative disease research. …”
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The Initial Assessment of Daily Insulin Dose in Chinese Newly Diagnosed Type 2 Diabetes by Jing Ma, Huan Zhou, Hua Xu, Xie Chen, Xiangyu Teng, Qianjing Liu, Wei Liu

“…It has been well accepted that insulin therapy is the ideal treatment for newly diagnosed diabetic patients. …”
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Digital Interventions for the Rehabilitation of First-Episode Psychosis: An Integrated Perspective by Annarita Vignapiano, Francesco Monaco, Ernesta Panarello, Stefania Landi, Benedetta Di Gruttola, Raffaele Malvone, Vassilis Martiadis, Fabiola Raffone, Alessandra Marenna, Maria Pontillo, Valeria Di Stefano, Martina D’Angelo, Luca Steardo, Giulio Corrivetti

“…Digital innovations, including Cognitive Behavioral Therapy for insomnia (CBT-I) and telepsychiatry, demonstrated improvements in recovery and treatment adherence. …”
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An indole alkaloid from a tribal folklore inhibits immediate early event in HSV-2 infected cells with therapeutic efficacy in vaginally infected mice. by Paromita Bag, Durbadal Ojha, Hemanta Mukherjee, Umesh Chandra Halder, Supriya Mondal, Nidhi S Chandra, Suman Nandi, Ashoke Sharon, Mamta Chawla Sarkar, Sekhar Chakrabarti, Debprasad Chattopadhyay

“…Till date no effective vaccine is available, while the existing therapy frequently yielded drug resistance, toxicity and treatment failure. …”
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Putative and pretreatment drug resistance mutations in reverse transcriptase gene among untreated chronic hepatitis B patients at Arifin Achmad Regional District Hospital, Riau, In... by Arfianti Arfianti, Fauzia Andrini Djojosugito, Maisaroh Maisaroh, Hendra Asputra, Dita Kartika Sari, Tubagus Odih Rhomdani Wahid

“…Objective: This study aimed to identify mutations in the RT gene among patients with chronic hepatitis B (CHB) before receiving antiviral therapy and its relationship with the HBV genotypes. …”
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Metabolic Profile in a Cohort of Young Sicilian Patients with Klinefelter’s Syndrome: The Role of Irisin by Stefano Radellini, Valentina Guarnotta, Vincenzo Sciabica, Giuseppe Pizzolanti, Carla Giordano

“…In our study, 25 consecutive Caucasian adult outpatients (age range 21–52 years, mean age 32.9 ± 12.2) with KS in testosterone replacement therapy and 30 healthy men (age range 25–45 years, mean age 32.4 ± 7.62) were studied. …”
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The Oncogenic Human Papillomavirus Involvement as a Risk Factor of Measles, Mumps, and Rubella Vaccine Immunotherapy Failure in Anogenital Warts by Achdiat PA, Ismiranty D, Hindritiani R, Rizqandaru T, Usman HA, Maharani RH

“…Several research on AGW therapy with measles, mumps, and rubella (MMR) vaccine injections have been successful without adverse effects. …”
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Factors associated with low bone mineral density in Turner syndrome: a multicenter prospective observational study by Kento Ikegawa, Eri Koga, Tomoyo Itonaga, Hideya Sakakibara, Masanobu Kawai, Yukihiro Hasegawa

“…In total, 48 patients with TS aged between 5 and 49 years comprising a pre-pubertal group (n = 9), a cyclical menstruation group (n = 6), and a hormone replacement therapy (HRT) group (n = 33) were enrolled. The cyclical menstruation group and the HRT group were referred to collectively as the post-pubertal group. …”
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LRP11 facilitates lipid metabolism and malignancy in hepatocellular carcinoma by stabilizing RACK1 through USP5 regulation by Litao Liang, Wenbo Jia, Jinyi Wang, Yanzhi Feng, Deming Zhu, Wenhu Zhao, Chao Xu, Xiangyu Ling, Qingpeng Lv, Xiaoming Ai, Lianbao Kong, Wenzhou Ding

“…Based on these results, LRP11 emerges as a potential target for further exploration in HCC therapy. Targeting LRP11 or disrupting its interactions with USP5 or RACK1 could offer new avenues for treatment, though additional research is required to validate these therapeutic possibilities.…”
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International perspective on healthcare provider gender bias in musculoskeletal pain management: a scoping review protocol by Katherine Fisher Wilford, Maria Jesus Mena-Iturriaga, Margaret Vugrin, Macarena Wainer, Phillip S Sizer, Gesine Hendrijke Seeber

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Motivasi belajar sejarah kebudayaan islam (MBSKI) scale: mengukur sifat psikometri dengan rasch measurement tool (RMT) by Yasnel Yasnel, Sariah Sariah, Susiba Susiba, Syafi'ah Syafi'ah, M. Fahli Zatrahadi, Darmawati Darmawati, Istiqomah Istiqomah

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The study of interactome in Russian patients with Usher syndrome to select priority approaches in pathogenetically oriented treatment by M.E. Ivanova, D.S. Atarshchikov, A.M. Demchinsky, V.V. Strelnikov, D. Barh, G.V. Poryadin, L.M. Balashova, J.M. Salmasi

“…The most promising treatment strategies including gene therapy are discussed.</i> </p> <p> <i><b>Keywords</b>: USH, USH2A, MYO7A, mutation, Usher syndrome, congenital deaf-blindness, gene therapy, interactome, modeling.…”
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Exploring the association between tissue sodium content, heart failure subtypes, and symptom burden: insights from magnetic resonance imaging by Djawid Hashemi, Djawid Hashemi, Djawid Hashemi, Djawid Hashemi, Karl Jakob Weiß, Karl Jakob Weiß, Karl Jakob Weiß, Patrick Doeblin, Patrick Doeblin, Patrick Doeblin, Moritz Blum, Radu Tanacli, Radu Tanacli, Radu Tanacli, Hana Camdzic, Hana Camdzic, Hans-Dirk Düngen, Hans-Dirk Düngen, Frank Edelmann, Frank Edelmann, Frank Edelmann, Titus Kuehne, Titus Kuehne, Titus Kuehne, Marcus Kelm, Marcus Kelm, Marcus Kelm, Sebastian Kelle, Sebastian Kelle, Sebastian Kelle

“…Similarly, there was a correlation between kidney function and both free (r = −0.64, p = 0.025) and total (r = −0.61, p = 0.035) skin sodium in patients with edema and no prior use of loop diuretics, but no correlation for kidney function and both free and total skin sodium in symptomatic patients with established diuretic therapy or asymptomatic patients with no diuretic therapy.ConclusionOur findings provide exploratory insights into the potential diagnostic value of tissue sodium content in HF, particularly in HFrEF patients. …”
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