Extracecellulr vesicles (EVs) microRNAs (miRNAs) derived from mesenchymal stem cells (MSCs) in osteoarthritis (OA); detailed role in pathogenesis and possible therapeutics by Seyede Sara Pakdaman Kolour, Saeide Nematollahi, Masoud Dehbozorgi, Farnaz Fattahi, Fatemeh Movahed, Neda Esfandiari, Mohammad Saeed Kahrizi, Nima Ghavamikia, Bahareh Salmanian Hajiagha

“…Further, attractive candidates for cell-free therapy for OA are MSC-derived extracecellulr vesicles (EVs) that convey bioactive molecules of the original cells, such as microRNAs. …”
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Impacts of surface wear of attachments on maxillary canine distalization with clear aligners: a three-dimensional finite element study by Qiuying Li, Bowen Xu, Dongyu Fang, Kai Yang

“…ObjectivesThis study established three-dimensional finite element models to explore the impacts of surface wear of attachments on maxillary canine distalization with clear aligners, thereby guiding the clinical application of attachments and enhancing the efficiency of clear aligner therapy.Materials and methodsFinite element models of maxillary canine distalization, including the maxilla, dentition, periodontal ligament, attachments (in both initial and worn states), and clear aligners, were established. …”
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Episcleral spread of ciliochoroidal melanoma following surgeries: a case report by E.E. Grishina, I.D. Kim, E.N. Izotova

“…The disrupted eye globe integrity caused by the glaucoma surgery and cataract extraction contributed to the extrascleral tumor growth. The inadequate therapy and delayed anti-tumor treatment of uveal melanoma necessitated to increase the scope of the surgical excision — the left orbital exenteration and, potentially, could deteriorate the survival prognosis. …”
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Alteration of Differentiation Potentials by Modulating GATA Transcription Factors in Murine Embryonic Stem Cells by Callinice D. Capo-chichi, Jennifer L. Smedberg, Malgorzata Rula, Emmanuelle Nicolas, Anthony T. Yeung, Richard F. Adamo, Andrey Frolov, Andrew K. Godwin, Xiang-Xi Xu

“…The finding offers a potential approach to produce desirable cell types from ES cells, useful for regenerative cell therapy.…”
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The Relevance of CD117-Immunocytochemistry Staining Patterns to Mutational Exon-11 in c-kit Detected by PCR from Fine-Needle Aspirated Canine Mast Cell Tumor Cells by A. Sailasuta, D. Ketpun, P. Piyaviriyakul, S. Theerawatanasirikul, P. Theewasutrakul, A. Rungsipipat

“…Almost MCT dogs usually require a rapid diagnosis and therapy. However, MCT diagnosis and prognosis are still dependent on histopathology which is rather inconvenient, time-consuming, painful, and harmful for some cases. …”
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Exploring Quality of Life in Adults Living With Late-onset Pompe Disease: A Combined Quantitative and Qualitative Analysis of Patient Perceptions from Australia, France, Italy, and... by Holly Lumgair, Lisa Bashorum, Alasdair MacCulloch, Elizabeth Minas, George Timmins, Drago Bratkovic, Richard Perry, Medi Stone, Vasileios Blazos, Elisabetta Conti, Raymond Saich

“…Physical functioning scores were generally stable in respondents who had been receiving enzyme replacement therapy (ERT) for 1-15 years, but those who had received ERT for >15 years had lower scores. …”
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Breast cancer patterns by age groups in Brazil: insights from population-based registries data by Jessé Lopes da Silva, Luiz Claudio Santos Thuler, Andréia Cristina de Melo

“…The ≥ 70 years group experienced a longer delay exceeding 60 days from diagnosis to treatment onset (54%, p < 0.001), while exhibiting a higher proportion of endocrine therapy utilization (45.3%, p < 0.01). Mortality rates increased across all subgroups, with the < 40 years group showing the most pronounced increase (AAPC + 1.8%; 95% CI: 1.6 to 2.1; p < 0.001). …”
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Acylated Ghrelin Renders Chemosensitive Ovarian Cancer Cells Resistant to Cisplatin Chemotherapy via Activation of the PI3K/Akt/mTOR Survival Pathway by Attalla Farag El-kott, Ali A. Shati, Mohammed Ali Al-kahtani, Sultan Alqahtani

“…In conclusion, the findings of this study show that AG promotes cell survival of the OC cells and renders them resistat to Cis therapy, an effect that is mediated by the activation of PI3K/Akt/mTOR and activation of NF-κB, and requires GHS-R1a.…”
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Association of Psychological Characteristics and Functional Dyspepsia Treatment Outcome: A Case-Control Study by Yiping Chen, Caihua Wang, Jinyu Wang, Leilei Zheng, Weibo Liu, Huichun Li, Shaohua Yu, Bin Pan, Hualiang Yu, Risheng Yu

“…The LDQ scores change after therapy, and the degraded rate of LDQ was used to assess the prognosis of patients. …”
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Using β-Elemene to reduce stemness and drug resistance in osteosarcoma: A focus on the AKT/FOXO1 signaling pathway and immune modulation by Shaochun Zhang, Zhijie Xing, Jing Ke

“…These findings suggest β-elemene as a potential adjunct therapy for osteosarcoma, providing novel therapeutic strategies to overcome chemotherapy resistance and improve patient outcomes.…”
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One Earth-One Health (OE-OH): Antibacterial Effects of Plant Flavonoids in Combination with Clinical Antibiotics with Various Mechanisms by Ganjun Yuan, Fengxian Lian, Yu Yan, Yu Wang, Li Zhang, Jianping Zhu, Aiman Fatima, Yuxing Qian

“…<b>Background/Objectives:</b> Antimicrobial resistance (AMR) poses a significant threat to human health, and combination therapy has proven effective in combating it. It has been reported that some plant flavonoids can enhance the antibacterial effects of antibiotics and even reverse AMR. …”
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Interleukin-2/Anti-Interleukin-2 Immune Complex Expands Regulatory T Cells and Reduces Angiotensin II-Induced Aortic Stiffening by Beenish Majeed, Supannikar Tawinwung, Lance S. Eberson, Timothy W. Secomb, Nicolas Larmonier, Douglas F. Larson

“…This study provides data that support the protective roles of Tregs in vascular stiffening and highlights the use of the IL-2/mAbCD25 complex as a new potential therapy in angiotensin II-related vascular diseases.…”
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Cost-effectiveness of Chloride-liberal versus Chloriderestrictive Intravenous Fluids among Patients Hospitalized in the United States by Louise Perrault, Dilip Makhija, Idal Beer, Suzanne Laplante, Sergio Iannazzo, Karthik Raghunathan

“…**Background:** Patients developing acute kidney injury (AKI) during critical illness or major surgery are at risk for renal sequelae such as costly and invasive acute renal replacement therapy (RRT) and chronic dialysis (CD). Rates of renal injury may be reduced with use of chloride-restrictive intravenous (IV) resuscitation fluids instead of chloride-liberal fluids. …”
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The Prognostic Value of Total Blood Count Parameter Ratios in Acute Pulmonary Embolism by Aynur Yurtseven, Kerem Ensarioğlu

“…Exclusion criteria included recent infection, autoimmune diseases, or immunosuppressive therapy. Laboratory data, clinical parameters, and outcomes (e.g., hospitalization duration, complications, and mortality) were analyzed. …”
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Prulifloxacin Effectiveness in Moderate-to-Severe Acute Exacerbations of Chronic Bronchitis: Α Noninterventional, Multicentre, Prospective Study in Real-Life Clinical Practice—The... by Konstantinos Gourgoulianis, Alessandro Ruggieri, Alessandra del Vecchio, Fabrizio Calisti, Alessandro Comandini, Giovanna Esposito, Giorgio Di Loreto, Nikolaos Tzanakis

“…Data were collected at prulifloxacin onset (baseline), 7–10 days after baseline, and at least 28 days after therapy completion. Between 23 November 2015 and 27 January 2018, 305 patients (males: 76.4%; mean (standard deviation) (SD) age: 69.7 (9.8) years; Anthonisen type I/II: 94.8%; chronic bronchitis duration >10 years: 24.9%) were consecutively enrolled. …”
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Do maternal haemodynamics have a causal influence on treatment for gestational diabetes? by Abigail R. Anness, Michael Foster, Mohammed W. Osman, David Webb, Thompson Robinson, Asma Khalil, Neil Walkinshaw, Hatem A. Mousa

“…Maternal booking BMI was identified as having a causative influence on treatment requirement, with each unit increase in BMI increasing the odds of needing metformin and/or insulin therapy by 12% [OR 1.12 (1.02 − 1.22)]. The raw values of maternal heart rate (87.6 ± 11.7 vs. 92.9 ± 11.90 bpm, p = 0.014) and PWV (7.8 ± 1.04 vs. 8.4 ± 1.61 m/s, p = 0.029) were both significantly higher amongst the women requiring pharmacological management, though these relationships did not remain significant in causal logistic regression.Conclusions Maternal BMI at booking has a causal, rather than simply associational, relationship on the need for pharmacological treatment of GDM. …”
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Effects of Teriparatide on Bone Mineral Density and Prevention of Fragility Fractures in Saudi Arabian Subjects with Osteoporosis: A Two-Year Clinical Study from a Single Center by Mir Sadat-Ali, Abdallah Al-Omran, Khalid AlTabash, Dakheel A. AlDakheel, Salma Elansassy, Tarek Hegazi, Mona Al Muhaish

“…The data gathered before starting medication were age, sex, previous therapy, history of fractures, and other diseases like diabetes mellitus, hypertension, and cardiac disease. …”
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Comparing Balance Performance on Force Platform Measures in Individuals with Parkinson’s Disease and Healthy Adults by Cathy C. Harro, Amanda Kelch, Cora Hargis, Abigail DeWitt

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Platelet-rich fibrin and silver nano-particles loaded chitosan treatment for post- laminectomy epidural scar adhesions: in vivo rats study model by Samah Fouad, Awad Rizk, Esam Mosbah, Mostafa M. Nabeeh, Walaa Awadin, Ayman S. Elmezayyen, Ekramy Elmorsy, Adel Zaghloul

“…Conclusion The use of PRF with Chi/Ag-NPs as nano biomaterials could be considered a combination therapy for the reduction of EF post-laminectomy in a rat model.…”
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Severity and Determinants of Anemia in TB/HIV Coinfected Adults at Mekelle, Ethiopia: Hospital Based Retrospective Study by Kebede Embaye Gezae, Kiflom Hagos, Assefa Ayalew Gebreslassie

“…A hospital based retrospective study was conducted among 305 TB/HIV coinfected adults who enrolled for antiretroviral therapy (ART) from January, 2009 to December, 2016 in two public hospital of Mekelle, Ethiopia, by reviewing ART register. …”
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