Using Community Engagement to Create a Telecoaching Intervention to Improve Self-Management in Adolescents and Young Adults With Cystic Fibrosis: Qualitative Study by Christina L Duncan, Emily F Muther, Jennifer J Lindwall, Kristine Durkin, Elizabeth Ruvalcaba, Eliza Williamson, Corrine Ahrabi-Nejad, Evelyn Bord, Angela Green, Megan L Harrison, Deepika Polineni

“… BackgroundAdolescents and young adults (AYA) with cystic fibrosis (CF) are at risk for deviating from their daily treatment regimen due to significant time burden, complicated daily therapies, and life stressors. Developing patient-centric, effective, engaging, and practical behavioral interventions is vital to help sustain therapeutically meaningful self-management. …”
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Risk Factors and Pharmacological Interventions Impacting Cerebrovascular Ischemic Events in Giant Cell Arteritis: A Narrative Review by Muhammad Osama Siddiqui, Mohammad Ali Syed, Ayaan Ahmed Qureshi, Mustafa Hussain Imam, Jatin Motwani, Verkha Kumari, Arooba Siddiqui, Noor Ul Ain, Mohammed Hammad Jaber

“…Pharmacological treatments, including glucocorticoids and tocilizumab, are instrumental in managing and potentially preventing CIE in GCA patients, with adjunctive therapies such as aspirin and antiplatelet agents also showing promise. …”
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Inter-rater reliability and prognostic value of baseline Radiographic Assessment of Lung Edema (RALE) scores in observational cohort studies of inpatients with COVID-19 by Andrew I Kim, William Bain, Alison Morris, Barbara Methe, Bryan J McVerry, Georgios D Kitsios, Daniel Kotok, Janet S Lee, Nameer Al-Yousif, Christine E Girard, Jana J Jacobs, Konstantin Golubykh, Hafiz Qurashi, Michael Lu, Saketram Komanduri, Anatoliy Korzhuk, Halimat O Lawal, Nicholas Abourizk, Caitlin Schaefer, Kevin J Mitchell, Catherine M Dietz, Ellen K Hughes, Clara S Brandt, Georgia M Fitzgerald, Robin Joyce, Asmaa S Chaudhry, Jose D Rivera, Shruti Shettigar, Allen Lavina, Samantha R Gillenwater, Anas Hadeh, Faraaz A Shah, Matthew Bittner, Niall Prendergast, John Evankovich, Navitha Ramesh, Cathy Kessinger

“…Objectives To reliably quantify the radiographic severity of COVID-19 pneumonia with the Radiographic Assessment of Lung Edema (RALE) score on clinical chest X-rays among inpatients and examine the prognostic value of baseline RALE scores on COVID-19 clinical outcomes.Setting Hospitalised patients with COVID-19 in dedicated wards and intensive care units from two different hospital systems.Participants 425 patients with COVID-19 in a discovery data set and 415 patients in a validation data set.Primary and secondary outcomes We measured inter-rater reliability for RALE score annotations by different reviewers and examined for associations of consensus RALE scores with the level of respiratory support, demographics, physiologic variables, applied therapies, plasma host–response biomarkers, SARS-CoV-2 RNA load and clinical outcomes.Results Inter-rater agreement for RALE scores improved from fair to excellent following reviewer training and feedback (intraclass correlation coefficient of 0.85 vs 0.93, respectively). …”
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Cuproptosis-Related Signature Predicts the Prognosis, Tumor Microenvironment, and Drug Sensitivity of Hepatocellular Carcinoma by Xiangjun Qi, Jiayun Guo, Guoming Chen, Caishan Fang, Leihao Hu, Jing Li, Chi Zhang

“…HCC patients in the high-risk group are more likely to benefit from conventional anti-HCC agents and immune checkpoint inhibitor therapies. Conclusion. The molecular characterization of CRGs in HCC is presented in this study, and a successful prognostic signature for HCC based on the cuproptosis-related molecular subtype was constructed.…”
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Comparative Evaluation of the Effectiveness of Manual and Electric Toothbrushes in Blind Children: A Randomised Controlled Trial by PS Thanalakshme, R Ramesh

“…For blind children to maintain good oral health, it is advised to follow consistent oral hygiene practices and customise therapies.…”
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Hypokalaemia and outcomes in older patients hospitalized for heart failure by Miroslava Valentova, Samir Patel, Phillip H. Lam, Charles Faselis, Cherinne Arundel, Gregg C. Fonarow, Yan Cheng, Richard M. Allman, Stephan vonHaehling, Stefan D. Anker, Ali Ahmed

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Fusidic Acid and Lidocaine-Loaded Electrospun Nanofibers as a Dressing for Accelerated Healing of Infected Wounds by Alsulami KA, Bakr AA, Sirwi A, Elfaky MA, Shaik RA, Alshehri BY, Aodah AH, Al Fayez N, Alshehri AA, Almughem FA, Halwani AA, Tawfik EA

“…Khulud A Alsulami,1 Abrar A Bakr,1 Alaa Sirwi,2 Mahmoud A Elfaky,2 Rasheed A Shaik,3 Bayan Y Alshehri,1 Alhassan H Aodah,1 Nojoud Al Fayez,1 Abdullah A Alshehri,1 Fahad A Almughem,1 Abdulrahman A Halwani,4,5 Essam A Tawfik1 1Advanced Diagnostics and Therapeutics Institute, Health Sector, King Abdulaziz City for Science and Technology (KACST), Riyadh, 11442, Saudi Arabia; 2Department of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah, 21589, Saudi Arabia; 3Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, 21589, Saudi Arabia; 4Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, 21589, Saudi Arabia; 5Regenerative Medicine Unit, King Fahad Medical Research Center, King Abdulaziz University, Jeddah, 21589, Saudi ArabiaCorrespondence: Essam A Tawfik, Email etawfik@kacst.gov.saIntroduction: Wound treatment is a significant health burden in any healthcare system, which requires proper management to minimize pain and prevent bacterial infections that can complicate the wound healing process.Rationale: There is a need to develop innovative therapies to accelerate wound healing cost-effectively. …”
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Biological Characteristics and Whole-Genome Analysis of a Porcine <i>E. coli</i> Phage by Shenghui Wan, Nana Li, Sajid Habib, Pei Zheng, Yanfang Li, Yan Liang, Yonggang Qu

“…In doing so, we provided a reference for phage therapies that can be used to treat multidrug-resistant strains. (2) Method: Using the multidrug-resistant <i>E. coli</i> isolate sq-1 as the host bacterium, bacteriophages were isolated and purified from fecal samples using a double-layer agar plate method. …”
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Impact of the Mediterranean Diet on Patients With Psoriasis: Protocol for a Randomized Controlled Trial by Javier Perez-Bootello, Emilio Berna-Rico, Carlota Abbad-Jaime de Aragon, Ruth Cova-Martin, Leticia Goni, Asuncion Ballester-Martinez, Pedro Jaen-Olasolo, Nehal Mehta, Joel M Gelfand, Miguel Angel Martinez-Gonzalez, Alvaro Gonzalez-Cantero

“… BackgroundPsoriasis is an inflammatory disease primarily treated through molecular-targeted therapies. However, emerging evidence suggests that dietary interventions may also play a role in managing inflammation associated with this condition. …”
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Effect of Lamotrigine on Refractory Epilepsy: Clinical Outcomes and EEG Changes by Li Z, Wu P, Chen Q, Tong X, Yang Q

“…., Internal Medicine, Shijiazhuang, 050000, People’s Republic of China; 2Department of Neurology, Baoding First Central Hospital, Baoding, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zheng Li, Email lizheng741789@163.comBackground: Refractory epilepsy poses significant challenges in clinical management due to its resistance to standard antiepileptic therapies, necessitating the exploration of more effective treatment regimens. …”
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Completely conserved VP2 residue K140 of KREMEN1-dependent enteroviruses is critical for virus-receptor interactions and viral infection by Zeyu Liu, Xue Li, Xiaohong Li, Xingyu Yan, Yuan Tian, Yue Zhao, Kexin Liu, Pei Hao, Shuye Zhang, Chao Zhang

“…Collectively, our findings underscore the significance of the absolutely conserved K2140 residue in receptor interactions and infection of all KRM1-binding enteroviruses, providing novel insights into the molecular basis of enterovirus infection and informing the development of broad-spectrum therapies against HFMD.IMPORTANCEHand, foot, and mouth disease (HFMD) annually affects millions of children worldwide. …”
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CPEB4 modulates liver cancer progression by translationally regulating hepcidin expression and sensitivity to ferroptosis by M. Eugenia Delgado, Salvador Naranjo-Suarez, Marta Ramírez-Pedraza, Beatriz I. Cárdenas, Carmen Gallardo-Martínez, Alexandra Balvey, Eulalia Belloc, Judit Martín, Mark Boyle, Raúl Méndez, Mercedes Fernandez

“…Impact and implications:: This study addresses the pressing need for improved therapies in liver cancer, particularly given its increasing prevalence linked to obesity and metabolic-associated fatty liver disease. …”
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Neoadjuvant atezolizumab plus bevacizumab prior liver transplantation for hepatocellular carcinoma by Parissa Tabrizian, Rebecca Marino, Sherrie Bhoori, Marcus Zeitlhoefler, Neil Mehta, Vanessa Banz, Salvatore Gruttadauria, Massimo Iavarone, Chiara Mazzarelli, Nicolò Simonotti, Francis Yao, Vincenzo Mazzaferro, Josep M. Llovet

“…Neoadjuvant locoregional therapies along with the administration of atezolizumab plus bevacizumab (median: 5 months; discontinued at least 4 weeks prior to LT) led to an objective response rate of 94% (complete response: 59%), downstaging to within Milan criteria (82%) and a pathological response at explant examination of 88%. …”
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Dynamic Profile of CD4+ T-Cell-Associated Cytokines/Chemokines following Murine Myocardial Infarction/Reperfusion by Dongsheng Yuan, Jinjun Tie, Zhican Xu, Guanya Liu, Xinyu Ge, Zhulin Wang, Xumin Zhang, Shiyu Gong, Gang Liu, Qingshu Meng, Fang Lin, Zhongmin Liu, Huimin Fan, Xiaohui Zhou

“…These results provided important evidence necessary for developing future immunomodulatory therapies after MI/R.…”
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Monocyte STAT1 phosphorylation and treatment response of JAK inhibitors in chronic nonbacterial osteomyelitis by Motoshi Sonoda, Keishiro Kinoshita, Nobutaka Harada, Sungyeon Park, Shunichi Adachi, Yutaro Yada, Katsuhide Eguchi, Toshifumi Fujiwara, Makiko Kido-Nakahara, Noriko Kinjo, Masataka Ishimura, Shouichi Ohga

“…Notably, pSTAT1 levels in CNO monocytes fluctuated with disease activity, decreasing in 5 patients during clinical remission following conventional therapies (p = 0.016). In four intractable cases, pSTAT1 levels remained high despite conventional treatments but significantly decreased after initiating JAK inhibitors (p = 0.036). …”
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Sdd3 regulates the biofilm formation of Candida albicans via the Rho1-PKC-MAPK pathway by Li Mei Pang, Guisheng Zeng, Eve Wai Ling Chow, Xiaoli Xu, Ning Li, Yee Jiun Kok, Shu Chen Chong, Xuezhi Bi, Jiaxin Gao, Chaminda Jayampath Seneviratne, Yue Wang

“…Understanding the molecular mechanisms governing biofilm formation is crucial for developing anti-biofilm therapies. In this study, we conducted a genetic screen to identify novel genes that regulate biofilm formation in C. albicans. …”
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Polygonatum kingianum polysaccharide alleviated intestinal injuries by mediating antioxidant ability and microbiota by Reng Qiu, Chuangye Pan, Yuxi Qin, Qianfei Wei, Yue Yu, Ying Zhang, Xuehan Xie, Jianqin Li, Shouhai Chen, Kun Li, Dalia Fouad, Yi Wu, Qiu Zhong

“…We revealed that Polygonatum kingianum polysaccharide could alleviate intestinal injuries by promoting oxidation resistance, decreasing inflammatory responses, and accommodating the intestinal microbiota of mice.DiscussionOur results suggest the possibility of developing novel therapies for intestinal diseases.…”
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Clinicopathological and molecular characterization of astrocytoma by Xiaoyan Wu, Wenfeng Peng, Xu Zhang, Tao Tang, Ling Deng, Yuxia Xu, Xiaoyun Liu, Fang Wang, Wujian Peng, Jianrong Huang, Xiaoni Zhong

“…Identifying mutant genes can aid in reliable and early diagnosis, as well as provide insights for the development of targeted therapies.MethodsThis study aims to investigate the clinicopathologic and molecular characteristics of astroblastoma. …”
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Efficacy of PD-1 blockade plus chemotherapy in patients with oncogenic-driven non-small-cell lung cancer by Haowei Wang, Lei Cheng, Jian Chen, Peixin Chen, Zhuoran Tang, Qianyi Wang, Ying Ma, Chao Zhao, Xuefei Li, Tao Jiang, Fei Zhou, Xiaoxia Chen, Caicun Zhou

“…These findings suggest that PD-1 blockade plus chemotherapy may be considered as an optional treatment option for patients without available targeted therapies.…”
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Optimization of chemical transfection in airway epithelial cell lines by Tony J. F. Guo, Wan Yi Liang, Gurpreet K. Singhera, Jasmine Memar Vaghri, Janice M. Leung, Del R. Dorscheid

“…Additionally, it has been explored for its potential application in delivering gene therapies. Here, we characterize the transfection efficiency of EX-EGFP-Lv105, an EGFP-expressing plasmid into three cell lines commonly used to model the airway epithelium (1HAEo-, 16HBE14o-, and NCI-H292). …”
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