Identifying common pathways for doxorubicin and carfilzomib-induced cardiotoxicities: transcriptomic and epigenetic profiling by Conagh Kelly, Dylan J. Kiltschewskij, Angeline J.W. Leong, Tatt Jhong Haw, Amanda J. Croft, Lohis Balachandran, Dongqing Chen, Danielle R. Bond, Heather J. Lee, Murray J. Cairns, Aaron L. Sverdlov, Doan T. M. Ngo

“…Abstract Cancer therapy-related cardiovascular toxicity (CTR-CVT) is now recognised as one of the leading causes of long-term morbidity and mortality in cancer patients. …”
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Diagnosis and Management of Acquired Hemophilia A: Case Reports and a Literature Review by Ikhwan Rinaldi, Findy Prasetyawaty, Siti Fazlines, Kevin Winston, Yusuf Aji Samudera Nurrobi, Jessica Leoni, Ilham Hidayat Restu Tulus Maha, Satrio Wicaksono, Abdillah Yasir Wicaksono, Averina Octaxena Aslani, Rizkania Ikhsani

“…Treatment consists of factor VIII transfusion and corticosteroid therapy. Bypassing agents are recommended as an alternative to FVIII transfusion.…”
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Non-HDL-c/TC: A Novel Lipid-Related Marker in the Assessment of Severity of Coronary Artery Lesions and Cardiovascular Outcomes by Anan Huang, Xin Qi, Liping Wei, Mingyin Zhang, Shiqi Zhou

“…The association between non-HDL-c and severity of coronary artery lesions in patients treated with lipid-lowering therapy has been unknown. Hypothesis. We hypothesize a novel marker of non-HDL-c/TC predicts the severity of coronary artery lesions and clinical outcomes in 12 months in the patients treated with statin. …”
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Comparison of Sustained Hemodiafiltration with Acetate-Free Dialysate and Continuous Venovenous Hemodiafiltration for the Treatment of Critically Ill Patients with Acute Kidney Inj... by Masanori Abe, Noriaki Maruyama, Shiro Matsumoto, Kazuyoshi Okada, Takayuki Fujita, Koichi Matsumoto, Masayoshi Soma

“…Fifty critically ill patients with acute kidney injury (AKI) who required renal replacement therapy were treated with either CVVHDF or SHDF. CVVDHF was performed using a conventional dialysate with an effluent rate of 25 mL⋅kg−1⋅h−1, and SHDF was performed using an acetate-free dialysate with a flow rate of 300−500 mL/min. …”
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Chemometric Methods—A Valuable Tool for Investigating the Interactions Between Antifungal Drugs (Including Antifungal Antibiotics) and Food by Agnieszka Wiesner-Kiełczewska, Paweł Zagrodzki, Alicja Gawalska, Paweł Paśko

“…We used the partial least squares (PLS) approach to explore the correlations between various characteristics of oral antifungal drugs (including antifungal antibiotics) and dietary interventions, aiming to identify patterns that could inform the optimization of antifungal therapy. Methods: We analyzed 15 oral antifungal drugs, including azoles (8), antifungal antibiotics (4), antifungal antimetabolites (1), squalene epoxidase inhibitors (1), and glucan synthase inhibitors (1). …”
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Metabolomics approach reveals key plasma biomarkers in multiple myeloma for diagnosis, staging, and prognosis by Xiaoxue Wang, Longhao Cheng, Aijun Liu, Lihong Liu, Lili Gong, Guolin Shen

“…Methods Our study included 33 HC, 38 newly diagnosed MM patients (NDMM) categorized into three RISS grades (grade I: n = 5; grade II: n = 19; grade III: n = 8), and 92 MM patients post-targeted therapy with bortezomib-based regimens. Simultaneously, MM cell lines were employed for validation studies. …”
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Non-Drug and Non-Invasive Therapeutic Options in Alzheimer’s Disease by Alina Simona Șovrea, Adina Bianca Boșca, Eleonora Dronca, Anne-Marie Constantin, Andreea Crintea, Rada Suflețel, Roxana Adelina Ștefan, Paul Andrei Ștefan, Mădălin Mihai Onofrei, Christoph Tschall, Carmen-Bianca Crivii

“…Considering that the vast majority of conventional drug therapies did not lead to the expected results, this review will discuss the newly developing therapies as an alternative in the effort to stop or slow AD. …”
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Multivendor Spectral-Domain Optical Coherence Tomography Dataset, Observer Annotation Performance Evaluation, and Standardized Evaluation Framework for Intraretinal Cystoid Fluid S... by Jing Wu, Ana-Maria Philip, Dominika Podkowinski, Bianca S. Gerendas, Georg Langs, Christian Simader, Sebastian M. Waldstein, Ursula M. Schmidt-Erfurth

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A Rare Case of Digital Ischemia and Gangrene in ANCA-Associated Vasculitis with Review of the Literature by Richard A. Lau, Ramandeep Bains, Duminda Suraweera, Jane Ma, Emil R. Heinze, Andrew L. Wong, Philip J. Clements

“…The patient responded well to therapy including high dose steroids and cyclophosphamide, with improvement of all organs involved and had no further digital ischemia or gangrene on follow-up. …”
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Successful Intravascular Correction of Intratumoral Pseudoaneurysm by Erosion of the Aorta in a Patient with Thoracic Giant Cell Tumor of Bone Responding to Denosumab by Natalia M. P. Fraile, Diego Toloi, Ceci O. Kurimori, Adriana R. B. Matutino, Alberto Codima, Veridiana P. Camargo, Olavo Feher, Rodrigo R. Munhoz

“…Patient had an unremarkable recovery from the procedure and continued benefit from therapy with denosumab and remains on treatment 24 months after the first dose.…”
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Genotyping of HCV RNA Reveals That 3a Is the Most Prevalent Genotype in Mardan, Pakistan by Sajid Ali, Ayaz Ahmad, Raham Sher Khan, Sanaullah Khan, Muhammad Hamayun, Sumera Afzal Khan, Amjad Iqbal, Abid Ali Khan, Abdul Wadood, Taj Ur Rahman, Ali Hydar Baig

“…Identification of the infecting virus genotype is indispensable for the exploration of many aspects of HCV infection, including epidemiology, pathogenesis, and response to antiviral therapy. 1419 individuals were screened for anti-HCV in this study, of which 166 (11.7%) were found reactive by ICT (Immunochromatographic test). …”
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Phase 1 study of novel anti-platelet agent to overcome pharmacogenomic limitations of clopidogrel by Anil Pareek, Nitin Chandurkar, Vivek Raut, Kumar Naidu

“…Aims Clopidogrel is the most commonly prescribed thienopyridine as part of dual anti-platelet therapy for the treatment of cardiovascular diseases. …”
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A novel Mutein of TNFα Containing the Arg-Gly-Asp Sequence Shows Reduced Toxicity in Intestine by H. Shikama, K. Miyata, N. Sakae, K. Kuroda, K. Nishimura, S. Yotsuya, M. Kato

“…These results suggest that the Arg-Gly-Asp sequence introduced into the TNFα molecule abrogates the side effect of this cytokine such as tissue injury or shock, and that F4168 could be useful for systemic therapy.…”
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Efficacy and Adverse Reactions of Arthroscopic Half-Moon Plate Invasive Surgery in Patients with Acute Knee Pain (AKP): Systematic Review and Meta-Analysis by Luping Sun, Zhidan Huang

“…The clinical efficacy of injection therapy AKP is better than that of DEB alone.…”
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A cost-utility analysis of adding SGLT2 inhibitors for the management of type 2 diabetes with chronic kidney disease in Thailand by Natthakan Chitpim, Pattara Leelahavarong, Juthamas Prawjaeng, Sakditat Ittiphisit, Varalak Srinonprasert, Tanawan Kongmalai

“…This study evaluates the cost-utility of adding SGLT2i (dapagliflozin, empagliflozin, and canagliflozin) to standard of care therapy (SoCT) for T2D patients with CKD in Thailand. …”
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Diallyl Disulfide Suppresses Inflammatory and Oxidative Machineries following Carrageenan Injection-Induced Paw Edema in Mice by Hongxing Zhang, Chi Shang, Zhao Tian, Hatem K. Amin, Rami B. Kassab, Ahmed E. Abdel Moneim, Yingang Zhang

“…Our findings suggest that DADS could be used as an alternative therapy used to alleviate the pathophysiological changes associated with the genesis of paw edema through its potent anti-inflammatory and antioxidant impacts.…”
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Quality of Life Philosophy VI. The Concepts by Soren Ventegodt, Niels Jørgen Andersen, Joav Merrick

“…The about a hundred central concepts related to research in the global quality of life can, in a holistic medical frame of interpretation, be organized under ten abstract key concepts: existence, creation of the world, state of being, daily living, talents, relations, sex, health, personal development, and therapy with subthemes as discussed in this paper. …”
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Exhibitionism - a review of research by Krystian Wdowiak, Agnieszka Maciocha, Julia Wąż, Aleksandra Witas, Justyna Drogoń, Weronika Chachaj, Paulina Słomka, Ewa Gardocka

“…Treatment of exhibitionistic disorder primarily involves cognitive behavioral therapy (CBT). Pharmacological approaches are also employed to manage symptoms by modulating serotonergic transmission. …”
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Novel Speech-Based Emotion Climate Recognition in Peers’ Conversations Incorporating Affect Dynamics and Temporal Convolutional Neural Networks by Ghada Alhussein, Mohanad Alkhodari, Ahsan H. Khandoker, Leontios J. Hadjileontiadis

“…., in patients’ group therapy, negotiations, and emotion-aware mobile applications.…”
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Changes in the Structural and Functional Albumin Properties in Patients with Decompensated Liver Cirrhosis by A. A. Turkina, M. V. Maevskaya, M. S. Zharkova, V. T. Ivashkin

“…Our data allow us to raise the question of the need to use the EPR test to determine indications for albumin replacement therapy in patients with cirrhosis and the presence of ascites, even at normal values of its serum concentration.…”
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