SMR-guided molecular subtyping and machine learning model reveals novel prognostic biomarkers and therapeutic targets in non-small cell lung adenocarcinoma by Baozhen Wang, Yichen Yin, Anqi Wang, Weidi Liu, Jing Chen, Tao Li

“…This study offers fresh insights into the molecular subtyping, prognostic prediction, and personalized therapeutic decision-making in LUAD, laying a critical foundation for future clinical applications and targeted therapy research.…”
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Tracheal Resection for Critical Airway Obstruction in Morquio A Syndrome by Claire Frauenfelder, Elizabeth Maughan, Johnny Kenth, Reema Nandi, Simon Jones, Robert Walker, Bill Walsh, Nagarajan Muthialu, Iain Bruce, Richard Hewitt, Colin Butler

“…The relative pathophysiological contributions of an inherent cartilage processing defect versus a mismatch in longitudinal growth between the trachea and the thoracic cage are currently a subject of debate. Enzyme replacement therapy (ERT) and multidisciplinary management continue to improve life expectancy for Morquio A patients by slowing many of the multisystem pathological consequences of the disease but are not as effective at reversing established pathology. …”
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Impact of the Balloon Inflation Time and Pattern on the Coronary Stent Expansion by Jarosław Skowroński, Rafał Wolny, Jan Jastrzębski, Paweł Tyczyński, Karol Szlazak, Jerzy Pręgowski, Gary S. Mintz, Karolina Liżewska, Wojciech Świeszkowski, Zbigniew Chmielak, Adam Witkowski

“…The selection of coronary stent size and its proper deployment is crucial in coronary artery interventions, having an impact on the success of the procedure and further therapy. Methods. Ten pairs of different stents were deployed under nominal pressure using sequential (5, 5, 10, and 10 seconds of repeated inflations, thus 30 seconds of summarized time) and continuous (30 seconds) deployment pattern. …”
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Hypomania, Depression, Euthymia: New Evidence in Parkinson’s Disease by Margherita Canesi, Sara Lavolpe, Viviana Cereda, Alessandra Ranghetti, Roberto Maestri, Gianni Pezzoli, Maria Luisa Rusconi

“…Our results show that mood alterations in PD, considering both depressive symptoms and mood elevation, are related to the advanced stages of the disease as well as the presence of ICDs, and dopaminergic therapy would not always be able to restore a normal mood condition.…”
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A biomechanical comparison of posterior malleolar fracture fixation using screws and locking plates in Trimalleolar fractures: a finite element study by Chih-Wei Chang, Yen-Nien Chen, Guan-Heng Jhong, Kuo-Chih Su, Chun-Ting Li

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Puerarin pretreatment provides protection against myocardial ischemia/reperfusion injury via inhibiting excessive autophagy and apoptosis by modulation of HES1 by Yong Yuan, Songqing Lai, Tie Hu, Fajia Hu, Chenchao Zou, Xiuqi Wang, Ming Fang, Jichun Liu, Huang Huang

“…Abstract The study aimed to elucidate the underlying pharmacological mechanism of the traditional Chinese medicine Pue in ameliorating myocardial ischemia-reperfusion injury (MIRI), a critical clinical challenge exacerbated by reperfusion therapy. In vivo MIRI and in vitro anoxia/reoxygenation (A/R) models were constructed. …”
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Chest wall perforator flap reconstruction in breast conserving surgery: quality of life and limited complications in outpatient treatment by L. J. van Zeelst, R. Straten, R. R. J. P. van Eekeren, D. J. P. van Uden, J. H. W. de Wilt, L. J. A. Strobbe

“…Outcomes were complication incidence and patient satisfaction reported in the Breast-Q Breast Conserving Therapy (BCT) module. Results In the study cohort, the median age was 59.5 (49.8–71.3) years. …”
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Development of Hollow Fiber Membranes Suitable for Outside-In Filtration of Human Blood Plasma by David Ramada, Bente Adema, Mohamed Labib, Odyl ter Beek, Dimitrios Stamatialis

“…In fact, blood flow in the hollow fiber (HF) membrane could trigger inflammatory responses and thrombus formation, leading to reduced filtration efficiency and limiting therapy duration, a consequence of flowing the patients’ blood through the lumen of each fiber while the dialysate passes along the inter-fiber space (IOF, inside-out filtration). …”
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Severe Symptomatic Primary CMV Infection in Inflammatory Bowel Disease Patients with Low Population Seroprevalence by Catherine Rowan, Ciaran Judge, Mary D. Cannon, Garret Cullen, Hugh E. Mulcahy, Elizabeth Ryan, Cillian F. De Gascun, Glen A. Doherty

“…Infection resolved in all cases with withdrawal of immunomodulator and/or antiviral therapy. Seroprevalence of IgG to CMV, indicating prior exposure, in a subgroup of IBD patients (n=80) was 30.5% and increased with age. …”
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RBM47 is a novel immunotherapeutic target and prognostic biomarker in gliomas by Wei Wei, Yongfu Cao, Xin Lu, Long Wang, Jianbin Li, Guojun Deng, Donghai Li, Limin Xiao

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Community-based culturally tailored education programmes for black adults with cardiovascular disease, diabetes, hypertension and stroke: a systematic review protocol of primary em... by Hardeep Singh, Michelle LA Nelson, Joseph IV Fulton, Oya Pakkal, Elizabeth M Uleryk

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PIM2 inhibition promotes MCL1 dependency in plasma cells involving integrated stress response-driven NOXA expression by Marion Haas, Sabrina Cherfa, Léa Nguyen, Maxence Bourgoin, Gersende Caron, Elise Dessauge, Tony Marchand, Laurent Delpy, Patrick Auberger, Jérôme Moreaux, Arnaud Jacquel, Thierry Fest

“…This work elucidates the molecular intricacies of PIM2 inhibition and its implications for cancer therapy, especially in tumors with elevated PIM2 expression.…”
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Nursing management of a patient with oculomotor nerve paralysis caused by systemic lupus erythematosus (1例系统性红斑狼疮致动眼神经麻痹患者护理体会) by LI Yuncui (李运翠), TANG Ling (唐玲), HU Hairong (胡海荣), PENG Dan (彭丹), QI Wenjing (綦文婧)

“…Responsible nurses were involved throughout the process, in which overall evaluation of disease condition, routine nursing management, auricular point needle combined with auricular point pressing therapy were carried out. Targeted nursing plan should be made based on the overall evaluation and Traditional Chinese Medicine syndrome differentiation, in order to improve the rehabilitation of the patient. …”
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Current virtual reality-based rehabilitation interventions in neuro-developmental disorders at developmental ages by Micaela Capobianco, Concetto Puzzo, Concetto Puzzo, Concetto Puzzo, Chiara Di Matteo, Alberto Costa, Alberto Costa, Walter Adriani, Walter Adriani, Walter Adriani

“…We conclude that both immersive and non-immersive VR represents a valuable supplement to traditional therapies, allowing for personalized approaches.…”
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Imbalance of the Gut Microbiota May Be Associated with Missed Abortions: A Perspective Study from a General Hospital of Hunan Province by Bingsi Gao, Xingping Zhao, Xinyi Liu, Xuan Yang, Aiqian Zhang, Huan Huang, Yu-ligh Liou, Dabao Xu

“…To conduct a preliminary investigation that shows the possible correlation between the change of gut microbiota and missed abortions (MAs), which further provides a new potential insight for the prevention and therapy of MAs. Method. One hundred women, including 50 patients with MAs (case group) and 50 normal pregnant women (control group), were enrolled in the study. …”
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An Autopsy Case of a 5-Year-Old Child with Acute Pancreatitis Caused by Eosinophilic Granulomatosis with Polyangiitis-like Necrotizing Vasculitis by Haruna Yagi, Seishiro Takahashi, Tetsuo Kibe, Kenji Shirai, Isao Kosugi, Hideya Kawasaki, Shiori Meguro, Toshihide Iwashita, Hiroshi Ogawa

“…The patient was a 5-year-old Japanese boy who suddenly presented with gastrointestinal (GI) bleeding. Therapy with antiulcer drugs successfully stopped bleeding, but subsequently, high fever, leukocytosis, and hypoxia appeared. …”
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Psychiatric Assessment in Patients with Mild Temporal Lobe Epilepsy by Antonella Bruni, Iolanda Martino, Maria Eugenia Caligiuri, Maria Grazia Vaccaro, Michele Trimboli, Cristina Segura Garcia, Pasquale De Fazio, Antonio Gambardella, Angelo Labate

“…Cluster 1 was characterized by an early onset, more severe anxiety traits, and combined drug therapy (antiepileptic drug and Benzodiazepine/Selective Serotonin Reuptake Inhibitors) compared to Cluster 2. …”
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Misdiagnosis of Leprosy with Severe Reversal Reaction as Psoriatic Arthritis: A Case Report and Literature Review by Gunawan H, Hidayah RMN, Ruchiatan K, Pangastuti M, Usman HA, Amalia F

“…The patient was diagnosed as mid-borderline leprosy with severe reversal reaction, then received multidrug therapy–multibacillary and prednisone. The improvement of skin lesions and fingers edema were found on the 40th day of observation.Conclusion: The varying symptoms of leprosy can lead to misdiagnosis. …”
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Urinary Proteomic Shifts over Time and Their Associations with eGFR Decline in Chronic Kidney Disease by Zhalaliddin Makhammajanov, Kamila Nurlybayeva, Zikrillo Artikov, Pavel Tarlykov, Mohamad Aljofan, Rostislav Bukasov, Duman Turebekov, Syed Hani Abidi, Mehmet Kanbay, Abduzhappar Gaipov

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Factors associated with treatment response in chronic nonbacterial osteomyelitis at a single center: a retrospective cohort study by Katherine D. Nowicki, Nathan D. Rogers, Carson L. Keeter, Nathan J. Donaldson, Jennifer B. Soep, Yongdong Zhao

“…Abstract Background NSAIDs are commonly used as first line therapy in chronic nonbacterial osteomyelitis (CNO) but are not effective for all patients. …”
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