Megestrol acetate for appetite stimulation and weight gain in older adults with unintentional weight loss: a systematic review and meta-analysis by Larissa de Freitas do Lago-Abreu, Raphael Lopes Olegário, Luciana Lilian Louzada Martini, Einstein Francisco Camargos

“…Although the studies selected for the systematic review suggest that patients with the anorexia-cachexia syndrome secondary to cancer may benefit from MA therapy, a meta-analysis of 8 selected studies (total n = 592) did not confirm this effect (p = 0.104). …”
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Functional Properties of Human-Derived Mesenchymal Stem Cell Spheroids: A Meta-Analysis and Systematic Review by Sarah Ezquerra, Amparo Zuleta, Rodrigo Arancibia, José Estay, Francisco Aulestia, Flavio Carrion

“…They show great potential for cell therapy-based treatments, which is why they are being used in numerous clinical trials for a wide range of diseases. …”
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Frotteuristic disorder - a specific paraphilia by Krystian Wdowiak, Agnieszka Maciocha, Julia Wąż, Aleksandra Witas, Weronika Chachaj, Aleksandra Winsyk, Ewa Gardocka

“…Cognitive-behavioral therapy has shown significant therapeutic success, while pharmacological treatments typically involve antiandrogenic medications and drugs that lower sexual drive. …”
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Role of the hospital pharmacists during COVID-19 pandemic in the RN Macedonia by Zorica Naumovska, Biljana Lazarova, Maja Kovaceva, Aleksandra Kapedanovska Nestorovska, Maja Simonoska Crcarevska, Evgenija Mihajloska, Aleksandar Dimkovski

“…Only 22.7% were not consulted for therapy advice for hospitalized COVID-19 patients. …”
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Nomogram for predicting mild cognitive impairment in Chinese elder CSVD patients based on Boruta algorithm by Yanzi Huang, Wendie Huang, Xiaoming Ma, Guoyin Zhao, Jingwen Kang, Huajie Li, Jingwei Li, Jingwei Li, Jingwei Li, Jingwei Li, Jingwei Li, Jingwei Li, Shiying Sheng, Fengjuan Qian

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Patterns of prescription opioid use in Swiss emergency department patients and its association with outcome: a retrospective analysis by Aristomenis K Exadaktylos, Gregor Lindner, Georg-Christian Funk, Bertram K Woitok, Petra Büttiker, Svenja Ravioli

“…Hospitalisation rate (78.3 vs 49%, p<0.0001), 72 hours ED reconsultation rate (0.8 vs 0.3%, p=0.004), 30-day rehospitalisation rate (6.2 vs 1.5%, p<0.0001) and in-hospital mortality (6.3 vs 1.6%, p<0.0001) were significantly higher in patients with opioid therapy than other patients. In 25 cases (1.3%), admission to the ED was due to opioid intoxication.Conclusions Daily prescription opioid use is common in patients presenting to the ED. …”
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Poor radiological outcomes and associated factors among tibial shaft fracture patients treated with intramedullary nail fixation at Addis Ababa Burn, Emergency and Trauma Hospital,... by Yohannes Shugie, Samuel Kebede, Fanna Adugna, Dereje Bayissa Demissie, Tilahun Desta

“…For both open and closed injuries, intramedullary fixation has become the standard of therapy. At Addis Ababa Burn, Emergency, and Trauma (AaBET) Hospital, the rates of poor radiological outcomes for tibial shaft fractures treated with intramedullary fixation are unknown.MethodsA retrospective health facility-based cross-sectional study design was conducted among patients with tibial shaft fractures treated with intramedullary nails at AaBET Hospital. …”
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Characteristics of NAFLD Based on Hypopituitarism by Kazuhisa Kodama, Atsuhiro Ichihara, Yasufumi Seki, Yuichi Ikarashi, Takaomi Sagawa, Tomomi Kogiso, Maiko Taniai, Katsutoshi Tokushige

“…The causes of hypopituitarism were surgical in eight cases (six with craniopharyngioma and two with prolactinoma) and nonsurgical in seven cases, including unexplained hypopituitarism in five cases, Sheehan syndrome in one case, and one case that occurred after the radiation therapy. Serum adiponectin, soluble tumor necrosis factor receptor-2 (TNFR-2), and leptin levels were measured. …”
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Research progress in the treatment and nursing of ulcerative colitis with Traditional Chinese Medicine and western medicine (溃疡性结肠炎中西医治疗及护理研究进展) by Li Dongqing (李东青), FAN Dongying (范东英), JIANG Xiaofang (蒋小芳)

“…There is an urgent need of developing effective combination of Traditional Chinese Medicine and western medicine therapy, as well as integrative nursing interventions, for the treatment of ulcerative colitis. …”
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Severe Diabetic Ketoacidosis in Children with Type 1 Diabetes: Ongoing Challenges in Care by Simone Foti Randazzese, Mariarosaria La Rocca, Bruno Bombaci, Alessandra Di Pisa, Elèna Giliberto, Teresa Inturri, Daniel Militi, Fortunato Lombardo, Eloisa Gitto, Giuseppina Salzano, Stefano Passanisi

“…Several prevention strategies, including awareness campaigns, early diagnosis of diabetes, regular monitoring and management, effective insulin therapy, education, access to healthcare and technological assistance, may contribute to reduce the risk of severe diabetic ketoacidosis episodes in children and adolescents.…”
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Reduction of Ascaridia galli Pathology by Salmonella typhimurium in Broiler Chicken by Eric Igor Sop Foka, Cedric Yamssi, Ben Enyetornye, Christelle Noumedem Anangmo, Mpoame Mbida, Theodore B. Mayaka

“…In this study, S. typhimurium and Ascaridia galli coinfections were analyzed, and the consequences on therapy were proposed. In a first experiment where the effect of the bacteria on the nematode was evaluated, thirty 42-day-old broiler chickens were divided into 3 groups and coinfected with both parasites. …”
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Killer-Cell Immunoglobulin-Like Receptors (KIR) in HIV-Exposed Infants in Cameroon by Kagoué Simeni Luc-Aimé, Yindom Louis-Marie, Loni Ekali Gabriel, Clauvis Kunkeng Yengo, F. Esemu Livo, Nguedia Jules Clement Assob

“…The biological reason(s) behind persistent mother-to-child transmission (MTCT) of HIV (albeit at reduced rate compared to the preantiretroviral therapy era) in spite of the successful implementation of advanced control measures in many African countries remains a priority concern to many HIV/AIDS control programs. …”
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The Synergistic Effects of Celastrol in combination with Tamoxifen on Apoptosis and Autophagy in MCF-7 Cells by Lijun Wang, Luqun Tang, Chengyun Yao, Chunyan Liu, Yongqian Shu

“…Considering the urgent need for novel therapeutic strategies in anticancer therapy, this combinatorial approach is worthy of further investigation.…”
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Tele-rehabilitation for children with physical disabilities: qualitative exploration of challenges in Iran by Mahta Alsadat Aarabi, Kianoush Abdi, Farin Soleimani

“…The 10 categories are as follows: unorganized internet infrastructure, lack of a developed program, inefficient technology, disregard for ethical principles, lack of therapist information, visual and auditory limitations, cultural misconceptions, weakness of empathy and therapeutic alliance, Lack of familiarity with telerehabilitation, and the other online therapy problems. Conclusion Finally, by identifying these challenges, it is possible to provide services with higher qualities to people of this group by reducing barriers. …”
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6-thioguanine inhibits EV71 replication by reducing BIRC3-mediated autophagy by Qiao You, Jing Wu, Ruining Lyu, Yurong Cai, Na Jiang, Ye Liu, Fang Zhang, Yating He, Deyan Chen, Zhiwei Wu

“…Our work provided a basis for the further development of 6-TG as a therapy for EV71-associated HFMD.…”
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Association between serum levels of 12 different cytokines and short-term efficacy of chemoradiotherapy in esophageal squamous cell carcinoma by Yaping Zhang, Qiufeng Qi, Ming Zhu, Yun Peng, Yanqing Bao, Jun Liu, Yanzhi Bi, Min Xiao, Shaohua Chi, Yongping Liu

“…Higher levels of IL-5 and IFN-γ levels following therapy were associated with worse outcomes. Conclusions Our findings indicate that IL-8, IL-1β, IL-5, and IFN-γ may serve as potential biomarkers for treatment efficacy and prognosis in ESCC. …”
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The prognostic and immunomodulatory role of the MMR system in patients with stomach adenocarcinoma by Zhihui Tian, Lili Yang, Rong Yang, Wenhui Yang

“…The clinical value of the MMR molecular marker as an immunotherapy for advanced solid tumors has been documented. However, this therapy is not effective in some patients. This study aimed to develop an MMR-related molecular prognostic model for identifying appropriate populations of stomach adenocarcinoma (STAD) for better treatment outcome. …”
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Synergistic Antitumour Properties of viscumTT in Alveolar Rhabdomyosarcoma by Rahel Mascha Stammer, Susann Kleinsimon, Jana Rolff, Sebastian Jäger, Angelika Eggert, Georg Seifert, Catharina I. Delebinski

“…Additionally, viscumTT changed the ratio of apoptosis-associated proteins by downregulation of antiapoptotic proteins such as XIAP and BIRC5, thus shifting the balance towards apoptosis. viscumTT effectively reduced tumour volume in patient-derived xenografts in vivo and may be considered a promising substance for rhabdomyosarcoma therapy.…”
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Tripchlorolide May Improve Spatial Cognition Dysfunction and Synaptic Plasticity after Chronic Cerebral Hypoperfusion by Zhao-Hui Yao, Xiao-li Yao, Shao-feng Zhang, Ji-chang Hu, Yong Zhang

“…Because CCH causes disturbances in brain energy homeostasis, TRC therapy may resolve this instability by correcting a variety of cognitive-related signaling pathways. …”
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Immunomodulation effects of collagen hydrogel encapsulating extracellular vesicles derived from calcium silicate stimulated-adipose mesenchymal stem cells for diabetic healing by Yen-Hong Lin, Yeh Chen, En-Wei Liu, Mei-Chih Chen, Min-Hua Yu, Cheng-Yu Chen, Chia-Che Ho, Tai-Yi Hsu-Jiang, Jian-Jr Lee, Der-Yang Cho, Ming-You Shie

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