Characterization of curcumin-loaded nano thermo-sensitive hydrogel by Ikhsanudin Azis, Saifullah S Teuku Nanda, Zai Khadijah, Ari S Bambang

“…Breast cancer is one of the most common cancers affecting women. Breast cancer therapy is one of the targets of the Sustainable Development Goals (SDGs), namely reducing death rates and ensuring that people receive safe and quality medicines. …”
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Cardiovascular Risk Assessment: A Comparison of the Framingham, PROCAM, and DAD Equations in HIV-Infected Persons by Max Weyler Nery, Celina Maria Turchi Martelli, Erika Aparecida Silveira, Clarissa Alencar de Sousa, Marianne de Oliveira Falco, Aline de Cássia Oliveira de Castro, Jorge Tannus Esper, Luis Carlos Silva e Souza, Marília Dalva Turchi

“…The participants' mean age was 36.8 years (SD = 10.3), 76.9% were men, and 66.3% were on antiretroviral therapy. 47.8% of the participants had abdominal obesity, 23.1% were current smokers, 20.0% had hypertension, and 2.0% had diabetes. …”
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The skin manifestations in end-stage renal disease patients in Jordan, single-center experience by Mohammad Hassan Al-thnaibat, Heba M. Urabi, Hadeel S. Alkofahi, Ola Mohannad Alshriedeh, Raneem Alshraideh, Hanan Esmadi, Ahmed Sheyyab, Bakri Roumi Jamal, Hanan Khaled Hasan

“…Abstract Introduction Patients with end-stage renal disease usually undergo hemodialysis as a way of renal function replacement therapy which comes with a wide array of systemic and cutaneous complications. …”
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Evaluation of post-earthquake fractures according to anatomical body parts: A retrospective study by Muhammed Furkan Arpaci, Ferhat Tas, Gokce Bagci Uzun, Mehmet Akcicek, Feyza Inceoglu, Mine Argali Deniz, Emre Demirel, Hidir Pekmez

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A multicenter study investigating the genetic analysis of childhood steroid-resistant nephrotic syndrome: Variants in COL4A5 may not be coincidental. by Sheng Li, Miaoyue Hu, Chao He, Yu Sun, Weifang Huang, Fengying Lei, Yunguang Liu, Zengpo Huang, Yongqiu Meng, Wenjing Liu, Xianqiang Lei, Yanfang Dong, Zihui Lin, Chunlin Huang, Rihong Zhao, Yuanhan Qin

“…The identified variant group demonstrated a significant association with positive family history, steroid resistant-style, and response to immune therapy (P<0.001). Patients with the identified genetic variant were approximately ten times more likely to develop CKD (P<0.001) than those in the unidentified group at the last follow-up. …”
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Human Liver Cells Expressing Albumin and Mesenchymal Characteristics Give Rise to Insulin-Producing Cells by Irit Meivar-Levy, Tamar Sapir, Dana Berneman, Tal Weissbach, Sylvie Polak-Charcon, Philippe Ravassard, Andreas G. Tzakis, Eytan Mor, Camillo Ricordi, Sarah Ferber

“…Activation of the pancreatic lineage in the liver has been suggested as a potential autologous cell replacement therapy for diabetic patients. Transcription factors-induced liver-to-pancreas reprogramming has been demonstrated in numerous species both in vivo and in vitro. …”
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Functional Brain Correlates of Upper Limb Spasticity and Its Mitigation following Rehabilitation in Chronic Stroke Survivors by Svetlana Pundik, Adam D. Falchook, Jessica McCabe, Krisanne Litinas, Janis J. Daly

“…Methods. 23 stroke survivors (>6 months) were treated with an arm motor learning and spasticity therapy (5 d/wk for 12 weeks). Outcome measures included Modified Ashworth scale, sensory tests, and functional magnetic resonance imaging (fMRI) for wrist and hand movement. …”
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Selection of specific nanobodies against peanut allergen through unbiased immunization strategy and the developed immuno-assay by Yaozhong Hu, Chuan Zhang, Jing Lin, Yi Wang, Sihao Wu, Ying Sun, Bowei Zhang, Huan Lv, Xuemeng Ji, Yang Lu, Shuo Wang

“…To date, no effective curative approach has been applied for the therapy of the anaphylaxis resulting from the peanut allergens. …”
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Association of intraprocedural near admission-level blood pressure with functional outcome in stroke patients treated with mechanical thrombectomy by Min Chen, Lukas Daniel Sauer, Mika Herwig, Jessica Jesser, Meinhard Kieser, Arne Potreck, Markus Möhlenbruch, Peter Arthur Ringleb, Silvia Schönenberger

“…Methods We conducted a retrospective observational study at a single center at a university hospital, which included patients from August 2018 to September 2020 suffering from acute ischemic stroke with anterior circulation vessel occlusion and treated with endovascular therapy. Time and proportion of procedure time where systolic blood pressure (SBP) was near the baseline SBP on admission (bSBP) were used as exposure variables. …”
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High-Flow Nasal Cannula in Hypercapnic Respiratory Failure: A Systematic Review and Meta-Analysis by Yongkang Huang, Wei Lei, Wenyu Zhang, Jian-an Huang

“…Due to a physiological friendly interface and variation, HFNC showed a significant advantage over NIV in patients’ comfort and complication of therapy. Conclusion. Despite the limitations noted, HFNC may be an effective and safe alternative to prevent endotracheal intubation and mortality when NIV is unsuitable in mild-to-moderate hypercapnia. …”
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High-Flow Nasal Cannula versus Noninvasive Ventilation in AECOPD Patients with Respiratory Acidosis: A Retrospective Propensity Score-Matched Study by Meng Wang, Feifan Zhao, Lina Sun, Ying Liang, Wei Yan, Xiaoyan Sun, Qingtao Zhou, Bei He

“…Compared with NIV, HFNC followed by NIV as rescue therapy may be a viable initial ventilation support strategy for AECOPD patients with respiratory acidosis. …”
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Adverse effects of GLP – 1 Receptor Agonists by Anna Kasprzak, Monika Kułaga, Monika Grzybek, Diana Mazur-Lesińska, Barbara Szostak, Sylwia Wielgosz-Biała, Krzysztof Tyszkiewicz, Borys Łozowski, Małgorzata Kasprzak, Barbara Wilczyńska

“…The aim of this article is to review the side effects associated with GLP – 1 RAs therapy. …”
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Increased Peripheral Proinflammatory T Helper Subsets Contribute to Cardiovascular Complications in Diabetic Patients by Ru-xing Zhao, Wen-juan Li, Yi-ran Lu, Jun Qin, Chuan-long Wu, Meng Tian, Tian-yi He, Shou-nan Yi, Dong-qi Tang, Lei Sun, Li Chen

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Impact of gingival pigmentation on laypersons’ perception of smile aesthetics: an observational study by Preethi Raj, Shweta Nagesh, Ramanarayana Boyapati

“…While gingival depigmentation is not mandatory, it may be recommended for individuals seeking cosmetic smile enhancements post-orthodontic therapy to improve the overall patient satisfaction.…”
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PD-L1 Immunohistochemistry Comparability and Their Correlation with Clinical Characteristics in NSCLC by Chiao-En Wu, Ching-Fu Chang, Liao Kou-Sheng, Ju Chiang, Shih-Wei Lee, Yu-Chi Chiu

“…PD-L1 expression is an important predictive factor of response to therapy with immune checkpoint inhibitors (ICIs). …”
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Protocol for the impact of CBT for insomnia on pain symptoms and central sensitisation in fibromyalgia: a randomised controlled trial by Michael Robinson, Chokkalingam Siva, Christina S McCrae, Ashley F Curtis, Jason Craggs, Chelsea Deroche, Pradeep Sahota, Roland Staud

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Metabolic and Hepatic Effects of Energy-Reduced Anti-Inflammatory Diet in Younger Adults with Obesity by Gordana Kenđel Jovanović, Ines Mrakovcic-Sutic, Sandra Pavičić Žeželj, Indira Benjak Horvat, Lucia Šuša, Dario Rahelić, Sanja Klobučar Majanović

“…Associated with epidemics of obesity, nonalcoholic fatty liver disease (NAFLD) is becoming the most prevalent liver disease worldwide. The cornerstone of therapy for NAFLD is lifestyle intervention, mainly focused on weight loss. …”
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Comparative Outcomes of Standard Perioperative Eye Drops, Intravitreal Triamcinolone Acetonide-Moxifloxacin, and Intracameral Dexamethasone-Moxifloxacin-Ketorolac in Cataract Surge... by Robin K. Kuriakose, Soungmin Cho, Saman Nassiri, Frank S. Hwang

“…Throughout the postoperative time points, there were no significant differences in corneal edema between intravitreal triamcinolone acetonide-moxifloxacin versus the standard eye drop therapy (OR [95% CI]: 1.09 [0.82, 1.45], P=0.54) and intracameral dexamethasone-moxifloxacin-ketorolac versus the standard eye drop treatment (OR [95% CI]: 1.22 [0.89, 1.67], P=0.22). …”
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Improving Individualized Salbutamol Treatment: A Population Pharmacokinetic Model for Oral Salbutamol in Virtual Patients by Lara Marques, Nuno Vale

“…This study further highlights the potential of popPK modeling in personalized therapy through a fully in silico approach.…”
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Rare Site of an Inflammatory Myofibroblastic Tumor at the Epididymis: A Case Report by Lange A, Dominiak N, Petros FG

“…Literature reports some lesions have demonstrated metastatic tendencies and therefore complete excision of the mass is the recommended therapy of choice. This case highlights the increasing need to include IMT in differential diagnoses for patients presenting with painless lumps even in unlikely locations. …”
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