Risk Factors of Multidrug-Resistant Bacteria in Lower Respiratory Tract Infections: A Systematic Review and Meta-Analysis by Gang Chen, Kailiang Xu, Fangyuan Sun, Yuxia Sun, Ziyuan Kong, Bangjiang Fang

“…The meta-analysis results suggested that prior antibiotic treatment, inappropriate antibiotic therapy, chronic lung disease, chronic liver disease and cerebral disease, prior MDR and PA infection/colonization, recent hospitalization, longer hospitalization stay, endotracheal tracheostomy and mechanical ventilation, tube feeding, nursing home residence, and higher disease severity score were independent risk factors for MDR bacteria. …”
Get full text

Restoration of Innate and Adaptive Immune Responses by HCV Viral Inhibition with an Induction Approach Using Natural Interferon-Beta in Chronic Hepatitis C by Y. Kishida, N. Imaizumi, H. Tanimura, Y. Haruna, S. Kashiwamura, T. Kashiwagi

“…IL-15 was increased at the end of induction therapy in both early virologic responders (EAVRs) and late virologic responders (LAVRs); CXCL-8, CXCL-10, and CCL-4 levels were significantly decreased (𝑃<0.05) in EAVR but not in LAVR during NCT, and IL-12 increased significantly (𝑃<0.05) and CXCL-8 decreased significantly (𝑃<0.05) after the end of NCT in EAVR but not in LAVR. …”
Get full text

Delusions of Glass Under Skin: An Unusual Case of Somatic-Type Delusional Disorder Treated with Olanzapine by Nicholas Comardelle, Amber Edinoff, Juliana Fort

“…Accordingly, clinicians should consider the nature of the delusions along with the unique side effect profile of the pharmacological therapy as any harm might outweigh the potential benefit. …”
Get full text

Popliteal artery aneurysm is a cause that should not be forgotten in acute limb ischemia by Deniz Sarp Beyazpinar, Mehmet Emir Erol

“…Sixty-six (64.7%) patients underwent solely embolectomy, nine (8.7%) patients received combined embolectomy with thrombolytic therapy and twenty-eight patients (27.4%) patients underwent surgical revascularization. …”
Get full text

The Role of PPAR Gamma in Systemic Sclerosis by Andréa Tavares Dantas, Michelly Cristiny Pereira, Moacyr Jesus Barreto de Melo Rego, Laurindo Ferreira da Rocha, Ivan da Rocha Pitta, Cláudia Diniz Lopes Marques, Angela Luzia Branco Pinto Duarte, Maira Galdino da Rocha Pitta

“…SSc has a poor prognosis because no therapy has been shown to reverse or arrest the progression of fibrosis, representing a major unmet medical need. …”
Get full text

Radiofrequency ablation as a method of choice for the treatment of lower extremity varicose veins disease by O. Yu. Atamaniuk, V. D. Skrypko, V. M. Atamaniuk

“…However, in 2 (0.9 %) cases asymptomatic distal DVT and in 1 (0.5 %) EHIT II were diagnosed. Anticoagulant therapy was prescribed. Regression of clinical symptoms with a statistically significant difference in the VCSS score (p < 0.001) was observed 6 months after RFA. …”
Get full text

First Report of Diabetes Phenotype due to a Loss-of-Function ABCC8 Mutation Previously Known to Cause Congenital Hyperinsulinism by Theocharis Koufakis, Amalia Sertedaki, Elizabeth-Barbara Tatsi, Christina-Maria Trakatelli, Spyridon N. Karras, Eleni Manthou, Christina Kanaka-Gantenbein, Kalliopi Kotsa

“…Monogenic Diabetes is relatively rare, representing only 1-2% of total diabetes cases; nevertheless, it is often misdiagnosed primarily as type 1 diabetes, leading to unnecessary insulin therapy and delayed recognition of affected family members. …”
Get full text

Acupuncture for Chronic Prostatitis or Chronic Pelvic Pain Syndrome: An Updated Systematic Review and Meta-Analysis by Juanhong Pan, Song Jin, Quan Xie, Ying Wang, Zhipeng Wu, Jianfeng Sun, Tai Pin Guo, Di Zhang

“…Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a complex male dysfunction, mostly seen in young and middle-aged men with a history of more than 3 months. As a traditional therapy of Traditional Chinese Medicine, acupuncture has been proven an effective method to treat CP/CPPS in recent years. …”
Get full text

The Potential Use of Mesenchymal Stem Cells and Their Derived Exosomes as Immunomodulatory Agents for COVID-19 Patients by Faisal A. Alzahrani, Islam M. Saadeldin, Abrar Ahmad, Dipak Kumar, Esam I. Azhar, Arif Jamal Siddiqui, Bassem Kurdi, Abdulrahim Sajini, Abdulmajeed F. Alrefaei, Sadaf Jahan

“…For example, in acute respiratory distress syndrome (ARDS) and pneumonia patients, MSCs-Exo and MSCs provide similar healing properties and some clinical trials have used cell-based inhalation therapy which show great promise. MSCs and MSCs-Exo have shown potential in clinical trials as a therapeutic tool for severely affected COVID-19 patients when compared to other cell-based therapies, which may face challenges like the cells’ sticking to the respiratory tract epithelia during administration. …”
Get full text

Comparison of three cryotherapy techniques for early post-TKA pain control in terms of efficacy and patient satisfaction: a randomized controlled trial by Keerati Chareancholvanich, Worawut Keesukpunt, Chaturong Pornrattanamaneewong, Rapeepat Narkbunnam, Atthakorn Jarusriwanna

“…Abstract Background Cryotherapy is a non-pharmacological option that complements drug therapy to achieve the most comprehensive multimodal analgesia. …”
Get full text

The Impact of Baseline Risk Factors on the Incidence of Febrile Neutropenia in Breast Cancer Patients Receiving Chemotherapy with Pegfilgrastim Prophylaxis: A Real-World Data Analy... by Edward Li, Bridgette Kanz Schroader, David Campbell, Kim Campbell, Weijia Wang

“…In the first cycle of therapy, patients receiving intermediate-risk regimens were at up to 2 times higher risk for FN across all definitions than those receiving high-risk regimens (_P_<0.01). …”
Get full text

Spectral specific standardized low-resolution brain electromagnetic tomography default mode connectivity network and plasticity alterations in left vertebral artery stent patients by Yan Lv, Xiangying He, Eryi Zhao, Yidong Deng, Yingliu Huang, AC Chen, Shixiong Huang, Qi Qin, Tao Liu, Guoqiang Wen

“…Method: Electroencephalogram default mode network activity, serum brain-derived neurotrophic factor, and basic neuropsychology estimations were obtained from nine male left vertebral artery stenosis patients who underwent left vertebral artery stenting 24 h before and after left vertebral artery stenting therapy. Result: The beta-1 (13–24 Hz) electroencephalogram field power of the pre–left vertebral artery stenting group was significantly higher compared to that of the post–left vertebral artery stenting and control group ( p  < 0.05). …”
Get full text

Prevalence, Risk Factors and Outcomes Associated with Acute Kidney Injury in Patients Hospitalized for COVID-19: A Comparative Study between Diabetic and Nondiabetic Patients by Shayesteh Khalili, Tahereh Sabaghian, Meghdad Sedaghat, Zahra Soroureddin, Elham Askari, Neda Khalili

“…Also, 8 patients (13.8%) required renal replacement therapy (RRT) after developing AKI. Regardless of diabetes status, patients who developed AKI had significantly higher mortality rates compared with patients who did not develop AKI (p=0.02). …”
Get full text

Use of healthcare services during the COVID-19 pandemic in urban Ethiopia: evidence from retrospective health facility survey data by Getnet Alemu, Arjun S Bedi, Zemzem Shuka, Anagaw Mebratie, Matthias Rieger

“…The secondary outcome measures are the use of health services by adults including antiretroviral therapy (ART), tuberculosis (TB) and leprosy and dental servicesResults There is a sharp reduction in the use of both inpatient (20%–27%, p&lt;0.001) and outpatient (27%–34%, p&lt;0.001) care, particularly in Addis Ababa, which has been most acutely affected by the virus. …”
Get full text

Identification of Potential Clusters of Signs and Symptoms to Prioritize Patients’ Eligibility for AADCd Screening by 3-OMD Testing: An Italian Delphi Consensus by Carlotta Spagnoli, Roberta Battini, Filippo Manti, Duccio Maria Cordelli, Andrea Pession, Melissa Bellini, Andrea Bordugo, Gaetano Cantalupo, Antonella Riva, Pasquale Striano, Marco Spada, Francesco Porta, Carlo Fusco

“…AADCd is an ultrarare, underdiagnosed neurometabolic disorder for which a screening test (3-OMD dosing on dried blood spot (DBS)) and targeted gene therapy (authorized in the EU and the UK) are available. …”
Get full text

Intra-rater reliability and validity of navicular drop test for the assessment of medial longitudinal arch in patients having pronated feet with chronic low back pain by Md Farhan Alam, Saima Zaki, Saurabh Sharma, Mohammed Ghareeb, Shibili Nuhmani

Get full text

Inhibitory Effects of iPSC-MSCs and Their Extracellular Vesicles on the Onset of Sialadenitis in a Mouse Model of Sjögren’s Syndrome by Bo Hai, Taeko Shigemoto-Kuroda, Qingguo Zhao, Ryang Hwa Lee, Fei Liu

“…Systemic infusion of allogeneic mesenchymal stem cells (MSCs) isolated from tissues such as bone marrow (BM) alleviated SS in mouse models and a small clinical trial, but further research and application of this MSC therapy were hindered by limited expandability, significant donor variations, and safety concerns of tissue-derived MSCs. …”
Get full text

ALDOA contributes to colorectal tumorigenesis and metastasis by targeting YAP by Liang Sun, Ting Lu, Linhua Jiang, Huihui Yao, Qixuan Xu, Jie Sun, Xiaoqin Yang, Songbing He, Xinguo Zhu

“…The altered metabolic pathways are increasingly being considered as potential targets for cancer therapy. In this view, Aldolase A (ALDOA), a key glycolytic enzyme, has been validated as a candidate oncogene in several cancers. …”
Get full text

NOL-7 serves as a potential prognostic-related biomarker for hepatocellular carcinoma by Qiucheng Lei, Yingchun Huang, Feiwen Deng, Huazhen Zheng, Xitao Hong, Peng Wang, Jin Lv, Huanwei Chen, Zhenling Ji

“…Conclusion NOL7 may serve as a potential biomarker for predicting clinical outcomes and may provide guidance for clinical therapy in patients with HCC.…”
Get full text

Human Brain Organoid: A Versatile Tool for Modeling Neurodegeneration Diseases and for Drug Screening by Cuili Ma, Hwanwook Seong, Xiaowei Li, Xiao Yu, Shunliang Xu, Yujing Li

“…Clinical trials serve as the fundamental prerequisite for clinical therapy of human disease, which is primarily based on biomedical studies in animal models. …”
Get full text