CCR5-ligand decorated rilpivirine lipid-based nanoparticles for sustained antiretroviral responses by Milankumar Patel, Sudipta Panja, Lubaba A. Zaman, Pravin Yeapuri, Shaurav Bhattarai, Santhi Gorantla, Linda Chang, Alonso Heredia, Piotr Walczak, Brandon Hanson, Samuel M. Cohen, Bhavesh D. Kevadiya, Howard E. Gendelman

“…Abstract Antiretroviral therapy (ART) improves the quality of life for those living with the human immunodeficiency virus type one (HIV-1). …”
Get full text

A Case Series of Gastrointestinal Tuberculosis in Renal Transplant Patients by Pedro Azevedo, Cristina Freitas, Hugo Silva, Pedro Aguiar, Pedro Farrajota, Manuela Almeida, Sofia Pedroso, La Salete Martins, Leonídio Dias, José Ramón Vizcaíno, António Castro Henriques, António Cabrita

“…Therapeutic options may be a problem in the context of an immunosuppressed patient, requiring adjustment of maintenance therapy. The authors report two cases of isolated gastro-intestinal tuberculosis in renal transplant recipients that illustrates the difficulty of making this diagnosis and a brief review of the literature on its clinical presentation, diagnosis, and therapeutic approach.…”
Get full text

The Angiotensin-Melatonin Axis by Luciana A. Campos, Jose Cipolla-Neto, Fernanda G. Amaral, Lisete C. Michelini, Michael Bader, Ovidiu C. Baltatu

“…On the other hand, since melatonin is capable of ameliorating metabolic abnormalities in DM and insulin resistance, the beneficial effects of RAS blockade could be improved through combined RAS blocker and melatonin therapy. Contemporary research is evidencing the existence of specific clock genes forming central and peripheral clocks governing circadian rhythms. …”
Get full text

Exploring Anti-Breast Cancer Effects of Live Pediococcus acidilactici and Its Cell-Free Supernatant Isolated from Human Breast Milk by Naa N. Adumuah, Jude T. Quarshie, Harry Danwonno, Anastasia R. Aikins, Elmer N. Ametefe

“…These findings serve as a foundation to further investigate the usefulness of P. acidilactici as a potential therapeutic agent in breast cancer therapy.…”
Get full text

Navigating Recent Changes in Dosing Information: Dynamics of FDA‐Approved Monoclonal Antibodies in Post‐Marketing Realities by Nai Lee, Su‐jin Rhee, Seong Min Koo, So Won Kim, Gyo Eun Lee, Yoon A Yie, Yun Kim

“…These insights underscore the importance of ongoing monitoring and data integration in the post‐marketing phase, providing a foundation for future precision medicine approaches in mAb therapy.…”
Get full text

Synthesis and Characterization of PEGylated Liposomes and Nanostructured Lipid Carriers with Entrapped Bioactive Triterpenoids: Comparative Fingerprints and Quantification by UHPLC... by Carmen Socaciu, Florinela Fetea, Mihai Adrian Socaciu

Get full text

Continuous wave transscleral cyclophotocoagulation versus MicroPulse (MP-TLT) in patients with blind and painful eyes with absolute glaucoma by Yang Ling, Juan Carlos Medina Perdomo, Sun Li Hua, Zhu Xin Ping, Han Chao

“…Materials and Methods: A retrospective comparative study was carried out in patients with absolute glaucoma of any etiology with the aim of comparing the effectiveness and safety of MicroPulse transscleral laser therapy (MP-TLT) versus continuous wave transscleral cyclophotocoagulation in eyes of patients with absolute glaucoma. …”
Get full text

Prevalence of Erosive-ulcerative Lesions of the Stomach and Helicobacter Pylori Infection in Patients with Ulcerative Colitis by N. A. Ponkratova, P. V. Pavlov, O. S. Shifrin

“…No effect of previous steroid therapy, as well as the high activity of ulcerative colitis on the frequency of the stomach erosive lesions (respectively, p = 0.433; p = 0.158) was detected. …”
Get full text

Pretreatment Fatigue in Breast Cancer Patients: Comparison With Healthy Controls and Associations With Biopsychosocial Variables by Patricia Blickle, Martina E. Schmidt, Karen Steindorf

“…However, investigation of pretreatment fatigue is crucial to identify causal or risk factors other than cancer therapy and to enable timely fatigue management. Methods Two hundred and thirty‐two breast cancer patients (mean age = 55.6) and 41 healthy participants (mean age = 49.3) were recruited via the National Center for Tumor Diseases (NCT) Heidelberg. …”
Get full text

Healthcare assessment tools—a valid source of data for pre-hospital care? Usability for ensuring medical care in the event of a disaster by Robert Konrad, Robert Konrad, Denise Schuster, HJ Heppner, HJ Heppner

“…Without adaptation they cannot be used at all or only after concerted efforts to interpret the needs for the care of vulnerable groups in a non-clinical context.DiscussionAn improved use of individual medical data in disaster and civil protection offers many advantages in prevention, diagnostics, therapy and care in the context of disaster medicine, and not only from an ethical point of view. …”
Get full text

A Safe Framework for Quantitative In Vivo Human Evaluation of Image Guidance by Piper C. Cannon, James M. Ferguson, E. Bryn Pitt, Jason A. Shrand, Shaan A. Setia, Naren Nimmagadda, Eric J. Barth, Nicholas L. Kavoussi, Robert L. Galloway, S. Duke Herrell, Robert J. Webster

“…This isolates the evaluation from the therapy, so that in-development image guidance systems can be tested without risk of negatively impacting the standard of care. …”
Get full text

Evaluasi kinerja pengurus cabang persatuan bolabasket seluruh indonesia dengan teknik CIPP daerah x by M Iqbal, Anton Komaini, Bafirman Bafirman, Ronni Yenes, Yovhandra Ockta

Get full text

Bridging the gap: From petri dish to patient - Advancements in translational drug discovery by Mohamed El-Tanani, Syed Arman Rabbani, Yahia El-Tanani, Ismail I. Matalka, Ikramy A. Khalil

“…Furthermore, it discusses the role of biomarker discovery in preparation of more targeted and personalized therapy approaches and covers the impact of regulatory changes designed to facilitate drug approvals. …”
Get full text

Pneumatosis Cystoides Intestinalis in Patients with Systemic Sclerosis: A Case Report and Review of 39 Japanese Cases by Manabu Kaneko, Shin Sasaki, Shuzo Teruya, Kosuke Ozaki, Kazuhiro Ishimaru, Emi Terai, Hiroshi Nakayama, Toshiyuki Watanabe

“…PCI in patients with SSc is usually benign and requires only conservative therapy. However, two patients (5.1%) with signs of peritoneal irritation required surgery. …”
Get full text

Primary pulmonary diffuse large B cell lymphoma presenting with features of organizing pneumonia: a case report by Sunjie Li, Yige Huang, Linlin Wang, Jintao Zhou

“…Initial empiric antibiotic therapy for suspected lung infection was ineffective. …”
Get full text

Expression of TGF-β in malignant transformation of oral lichen planus - A systematic review by Harinisubasri M, Priyadharsini Nataraj, Dineshkumar Thayalan, Divya Bose, Rameshkumar Annasamy, Rajkumar K

“…So thereby it helps in developing novel targeted therapy to shield the lesion from its carcinomatous transformation.…”
Get full text

Pure Neuritic Leprosy In Children With Grade 2 Disability On Hands And Feet: A Rare Case And Literature Review by Gunawan H, Ruchiatan K, Puspitosari D, Hindritiani R, Usman HA, Widjaja S

“…The patient was treated with multidrug therapy for multibacillary leprosy and consulted with the Department of Physical Medicine and Rehabilitation and the Department of Orthopaedics and Traumatology for contracture management. …”
Get full text

Association between alkaline phosphatase levels and mortality in Chinese patients with colorectal cancer with liver metastases: a retrospective cohort study by ZhaoXi Liu, ZiQing Zhang, GuoFang Yu, MingJiang Mo, ChuanYu Xie, DangHan Xu, JieTao Lin, YuChen Zhang, Li Deng, YiChang Luo, YingFeng Huang, Cui Shao

“…Covariates included the number of liver metastases, T stage, N stage, chemotherapy, tumour location, primary surgery, topical treatment, apolipoprotein A1, targeted therapy, tumour type, CA-199 levels, metastatic surgery, sex, Karnofsky Performance Status and age. …”
Get full text

Gout Flare Burden in the United States: A Multiyear Cross‐Sectional Survey Study by Jasvinder A. Singh, Amy Morlock, Robert Morlock

“…Characteristics of those who were less likely to report gout flares included being younger, being less educated, having a lower Charlson Comorbidity Index score, not being diagnosed with gout by their doctor, and not taking a urate‐lowering therapy. Conclusion This study confirmed that gout flares are common in US adults with gout and found that gout flares are underreported. …”
Get full text

Protective effect of compound K against podocyte injury in chronic kidney disease by maintaining mitochondrial homeostasis by Fugang Huang, Shuo Huang, Ke Sun, Yanhao Chen, Guanqun Xie, Jie Bao, Yongsheng Fan

“…Compound K (CK), a bioactive metabolite derived from ginsenoside, has emerged as a compelling candidate for nephroprotective therapy. Here, we unveil the profound therapeutic potential of CK in a folic acid (FA)-induced CKD mouse model, demonstrating its ability to restore renal function and mitigate podocyte injury. …”
Get full text