Theoretical and Practical Issues That Are Relevant When Scaling Up hMSC Microcarrier Production Processes by Valentin Jossen, Cedric Schirmer, Dolman Mostafa Sindi, Regine Eibl, Matthias Kraume, Ralf Pörtner, Dieter Eibl

“…The potential of human mesenchymal stem cells (hMSCs) for allogeneic cell therapies has created a large amount of interest. However, this presupposes the availability of efficient scale-up procedures. …”
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Effects of radiation and manganese oxide nanoparticles on human glioblastoma cell line U-87 MG glycolysis by N. B. Illarionova, D. V. Petrovski, I. A. Razumov, E. L. Zavyalov

“…This study may be useful for the development of new therapies and diagnosis of gliomas.…”
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Versatile High-Throughput Platform for Focused Ultrasound In Vitro Application by Steffen H. Tretbar, Marc Fournelle, Christian Degel, Franz-Josef Becker, Peter Weber, Sarah Therre-Mohr, Wolfgang Bost, Lisa Landgraf, Andreas Melzer

“…For the more efficient application of ultrasound in future therapies, fundamental research is needed on the mode of action of ultrasound on biological systems using therapeutic frequencies. …”
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Bile cast nephropathy (cholemic nephropathy) associated with hepatitis A-induced acute liver failure and haemolysis in a patient with glucose-6-phosphate dehydrogenase deficiency by Ali Hamdan, Johny Salem, Karam Karam, Maria Ziadeh, Pierre Hani

“…In this case, plasmapheresis effectively reduced bilirubin and inflammatory mediators, while haemodialysis addressed renal dysfunction. Together, these therapies were crucial in stabilising renal function. …”
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A novel 4-(1,3,4-thiadiazole-2-ylthio)pyrimidine derivative inhibits cell proliferation by suppressing the MEK/ERK signaling pathway in colorectal cancer by Li Weiwei, Yang Zhifu, Ding Likun, Wang Ying, Zhao Xian, Chu Jian Jie, Ji Qing, Yao Minna, Wang Jingwen

“…Although molecularly targeted therapies have significantly improved treatment outcomes, most of these target inhibitors are resistant. …”
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Gamified Shoulder Rehabilitation for Mild Stroke Patients Using Virtual Reality by Roy Francis Navea, Vincent Mao Talde, Francisco Luis Armintia, Sarrah Mae Dela Cruz, Gabriel Medina, Alvin Decena

“…The feedback and evaluation results from participants showed that, on average, 75% agreed with the metrics used, underscoring the significance of participant feedback and involvement in effective rehabilitation therapies, while perceptions of effectiveness, which influenced motivation and adherence, highlighted the importance of enhancing user experience in VR rehabilitation for better recovery outcomes which is supported by 69% of participant’s agreement. …”
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Age-Related Changes in Nucleus Pulposus Mesenchymal Stem Cells: An In Vitro Study in Rats by Yachao Zhao, Zhiwei Jia, Shanshan Huang, Yaohong Wu, Longgang Liu, Linghan Lin, Deli Wang, Qing He, Dike Ruan

“…The functions of mesenchymal stem cells (MSCs) appear to decline with age due to cellular senescence, which could reduce the efficacy of MSCs-based therapies. Recently, MSCs have been identified in the nucleus pulposus, which offers great potential for intervertebral disc (IVD) repair. …”
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Management of Oro-Antral Communication: A Systemic Review of Diagnostic and Therapeutic Strategies by Gianna Dipalma, Angelo Michele Inchingolo, Irma Trilli, Laura Ferrante, Angela Di Noia, Elisabetta de Ruvo, Francesco Inchingolo, Antonio Mancini, Stefan Cocis, Andrea Palermo, Alessio Danilo Inchingolo

“…Multidisciplinary collaboration, along with timely surgical intervention and adherence to medical therapies, is essential for successful management. …”
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Distribution, Phytochemical Insights, and Cytotoxic Potential of the <i>Sesbania</i> Genus: A Comprehensive Review of <i>Sesbania grandiflora</i>, <i>Sesbania sesban</i>, and <i>Se... by Fatma Alzahraa Mokhtar, Mariam Ahmed, Aishah Saeed Al Dhanhani, Serag Eldin I. Elbehairi, Mohammad Y. Alfaifi, Ali A. Shati, Amal M. Fakhry

“…While further research is warranted, the <i>Sesbania</i> genus offers a promising basis for the development of innovative anticancer therapies.…”
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Comparative analysis of Proximate and Anti-fungal Activities on Palm Oil Treated Ash Extracts of Musa sapientum and Musa paradisiaca Peels collected from Local Market in Akwa Ibom... by I. D. Uffia, O. E. Udofia, M. E. Bassey, R. O. Esen, E. J. Egong, O. D. Akan

“… Extracts from banana and plantain parts (flowers, bracts, ripe, unripe fruits, leaves, and stems) have bioactive constituents used as therapies for different human ailments. Although similar in growing on large herbs, elongated leaves, and producing edible fruits, they differ in taste and need for processing. …”
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Identification of blood plasma protein ratios for distinguishing Alzheimer's disease from healthy controls using machine learning by Ali Safi, Elisa Giunti, Omar Melikechi, Weiming Xia, Noureddine Melikechi

“…Early detection of Alzheimer's disease is essential for effective treatment and the development of therapies that modify disease progression. Developing sensitive and specific noninvasive diagnostic tools is crucial for improving clinical outcomes and advancing our understanding of this condition. …”
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Cold Plasma Activity Against Biofilm Formation of Prosthetic Joint Infection Pathogens by Christopher Spiegel, Débora C. Coraça-Huber, Michael Nogler, Rohit Arora, David Putzer

“…Although strong efforts have been made to reduce infection rates, conventional therapies like one- or two-stage revisions have failed to lower the infection rates. …”
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Comprehensive Pan-Cancer Analysis and Functional Studies Reveal SLC2A6 as a Ferroptosis Modulator in Hepatocellular carcinoma by Guohong Yan, Hailian Huang, Ziyan Lu, Meifeng Chen, Xiang Wang, Pei Zhong, Chongjiu Qin, Shutian Mo, Chuangye Han, Xiaoling Luo, Xinping Ye

“…In LIHC, it emerges as a potential prognostic biomarker and therapeutic target for the regulation of ferroptosis, offering new insights for targeted cancer therapies.…”
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Study protocol for a randomized controlled trial: Integrating the 'Time-limited Trial' in the emergency department. by Tadayuki Hashimoto, Rachel K Putman, Anthony F Massaro, Youkie Shiozawa, Katherine McGough, Kerry K McCabe, Judith A Linden, Wei Wang, Shan W Liu, Maura Kennedy, Thanh H Neville, Jacqueline M Kruser, Rebecca L Sudore, Mara A Schonberg, James A Tulsky, Kei Ouchi

“…<h4>Introduction</h4>Time-limited trial (TLT) is a structured approach between clinicians and seriously ill patients or their surrogates to discuss patients' values and preferences, prognosis, and shared decision-making to use specific therapies for a prespecified period of time in the face of prognostic uncertainty. …”
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Reprogramming the tumor immune microenvironment using engineered dual-drug loaded Salmonella by Dinh-Huy Nguyen, Sung-Hwan You, Hien Thi-Thu Ngo, Khuynh Van Nguyen, Khang Vuong Tran, Tan-Huy Chu, So-young Kim, Sang-Jun Ha, Yeongjin Hong, Jung-Joon Min

“…Abstract Synergistic combinations of immunotherapeutic agents can improve the performance of anti-cancer therapies but may lead to immune-mediated adverse effects. …”
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High Plasma Glucagon Levels Correlate with Waist-to-Hip Ratio, Suprailiac Skinfold Thickness, and Deep Subcutaneous Abdominal and Intraperitoneal Adipose Tissue Depots in Nonobese... by Shajith Anoop, Anoop Misra, Surya Prakash Bhatt, Seema Gulati, Harsh Mahajan, Gokulraj Prabakaran

“…These observations in Asian Indians may have significance for diabetes therapies which impact glucagon levels.…”
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Expression of VEGF-A, Otx Homeobox and p53 Family Genes in Proliferative Vitreoretinopathy by Claudio Azzolini, Ilaria Stefania Pagani, Cristina Pirrone, Davide Borroni, Simone Donati, Muna Al Oum, Diana Pigni, Anna Maria Chiaravalli, Riccardo Vinciguerra, Francesca Simonelli, Giovanni Porta

“…Individuating the genetic pathways of PVR represents a novel approach to PVR therapies.…”
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Unveiling the omics tapestry of B-acute lymphoblastic leukemia: bridging genomics, metabolomics, and immunomics by Yin Le, Shicong Zhu, Hongling Peng, Zhihua Wang

“…Based on these findings, this study provides novel potential therapeutic targets for the personalized treatment of B-ALL and lays the foundation for further development of PI3K-Akt pathway inhibitors and immunometabolism-targeted therapies.…”
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Transcriptome sequencing reveals regulatory genes associated with neurogenic hearing loss by Fengfeng Jia, Fang Wang, Song Li, Yunhua Cui, Yongmei Yu

“…In conclusion, our study contributes to the understanding of hearing loss pathogenesis and offers potential targets for molecular diagnostics and gene-based therapies. This provides a foundation for further research into personalized approaches to diagnosing and treating hearing loss.…”
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Biogenic silver nanoparticles produced by Trichoderma reesei inhibit SARS-CoV-2 infection, reduce lung viral load and ameliorate acute pulmonary inflammation by Marcus V.M.V. Amaral, Cláudia B. Carraro, Amanda C.C. Antoniêto, Mariana N. Costa, Thais F.C. Fraga-Silva, Ualter G. Cipriano, Rodrigo P.F. Abuná, Tamara S. Rodrigues, Ronaldo B. Martins, Andreia M. Luzenti, Glaucia R. Caruso, Priscyla D. Marcato, Vania L.D. Bonato, Dario S. Zamboni, Bergman M. Ribeiro, Sônia N. Báo, Joao S. da Silva, Flávio P. Veras, Roberto N. Silva

“…The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), posed a significant global health challenge and still demands efforts to develop new therapies. In this study, we investigated the potential of biogenic silver nanoparticles (AgNPs) synthesized by the fungus Trichoderma reesei to combat SARS-CoV-2 infection. …”
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