Highly Sensitive In Vivo Imaging of Bacterial Infections with a Hydrophilicity‐Switching, Self‐Immobilizing, Near‐Infrared Fluorogenic β‐Lactamase Probe Enriched within Bacteria... by Fangfang Chen, Yuyao Li, Yan Peng, Yifan Zhu, Gao He, Zhengwei Zhang, Hexin Xie

“…The discovery of effective therapies against antibiotic‐resistant pathogens has become an urgent need, necessitating innovative approaches to accelerate the identification and development of novel antibacterial agents. …”
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Ketamine-Induced Cystitis: A Comprehensive Review of the Urologic Effects of This Psychoactive Drug by Danyon J. Anderson, Jessica Zhou, David Cao, Matthew McDonald, Maya Guenther, Jamal Hasoon, Omar Viswanath, Alan D. Kaye, Ivan Urits

“…Empirical treatment options for KIC are available and consist of ketamine cessation, noninvasive therapies, and surgery, and should be decided upon based on the time course and severity of the disease. …”
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Laser Ablation for Small Hepatocellular Carcinoma by Claudio Maurizio Pacella, Giampiero Francica, Giovanni Giuseppe Di Costanzo

“…For these cases, curative therapies such as resection, liver transplantation, or percutaneous ablation have been proposed. …”
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Targeting the B-Cell Pathway in Lupus Nephritis: Current Evidence and Future Perspectives by Panagiotis Pateinakis, Athina Pyrpasopoulou

“…In an effort to accurately evaluate the potential of these therapies in lupus nephritis, several issues have been raised mainly in terms of patient selection criteria and trial duration. …”
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Looking outside the box with a pathology aware AI approach for analyzing OCT retinal images in Stargardt disease by Parisa Khateri, Tiana Koottungal, Damon Wong, Rupert W. Strauss, Lucas Janeschitz-Kriegl, Maximilian Pfau, Leopold Schmetterer, Hendrik P. N. Scholl

“…The development of effective therapies faces the challenge of identifying appropriate outcome measures that accurately reflect treatment benefits. …”
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Primary intracranial malignant melanoma in an adolescent: case report and literature review by Nyoman Golden, I Gusti Ketut Agung Surya Kencana, Christopher Lauren, Angky Saputra, Denny Japardi

“…Additionally, the findings underscore the critical role of complete surgical resection in improving outcomes, with adjuvant therapies potentially enhancing long-term management and surveillance. …”
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Otomycosis by Yan Edward, Dolly Irfandy

“…<br />Keywords: Otomycosis, Aspergillus sp,Therapy…”
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AVP-GPT2: A Transformer-Powered Platform for De Novo Generation, Screening, and Explanation of Antiviral Peptides by Huajian Zhao, Gengshen Song

“…Despite extensive research, effective antiviral therapies are still limited. To address this urgent need, we present AVP-GPT2, a deep-learning model that significantly outperforms its predecessor, AVP-GPT, in designing and screening antiviral peptides. …”
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Effect of γ-ethyl-γ-phenyl-butyrolactone (EFBL), anticonvulsant and hypnotic drug, on mouse brain catecholamine levels by Rasgado Lourdes A. Vega, Villanueva Iván, Díaz Fernando Vega

“…The results support the role of DA and NA in regulating seizure activity in the brain and indicate that EFBL offers a potential treatment for refractory epilepsy without complementary drugs and Parkinson’s disease, without the drawbacks of oral therapies.…”
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Expert Opinion on Fixed Dose Combination of Dapagliflozin Plus Sitagliptin for Unmet Cardiovascular Benefits in Type 2 Diabetes Mellitus by Soumitra Ray, J Ezhilan, Rajiv Karnik, Ashish Prasad, Rajashree Dhar

“…Based on CV risk, including HF, the combination of SGLT2i and DPP4i may be preferred over other conventional therapies (those with no CV benefit) in cases of established CV disease and/or HF risk. …”
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Employing the Oncolytic Vesicular Stomatitis Virus in Cancer Virotherapy: Resistance and Clinical Considerations by Alaa A. Abdelmageed, Stephen Dewhurst, Maureen C. Ferran

“…Personalized treatments tailored to tumor molecular profiles, along with identifying biomarkers predictive of resistance to VSV oncolysis, will enhance patient selection and enable more effective, individualized VSV-based therapies.…”
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Physical Exercise as a Diagnostic, Rehabilitation, and Preventive Tool: Influence on Neuroplasticity and Motor Recovery after Stroke by Caroline Pin-Barre, Jérôme Laurin

“…Stroke remains a leading cause of adult motor disabilities in the world and accounts for the greatest number of hospitalizations for neurological disease. Stroke treatments/therapies need to promote neuroplasticity to improve motor function. …”
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Circadian Rhythms and Breast Cancer: The Role of Per2 in Doxorubicin-Induced Cell Death by Megan I. Mitchell, Anna-Mart Engelbrecht

“…Due to the severe dose limiting side effects associated with current chemotherapeutic strategies, including the use of doxorubicin, a need for more effective adjuvant therapies to increase cancer cell susceptibility has arisen. …”
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Growing Concerns on Antimicrobial Resistance – Past, Present, and Future Trends by Deepak Saxena, Richa Gwalani, Aarti Yadav, Ragini Shah

“…The future trends anticipate the trajectories of AMR and discuss innovative approaches to combat resistance, including the exploration of alternative therapies and the implementation of stewardship programs. …”
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Migration, Proliferation, and Differentiation of Cord Blood Mesenchymal Stromal Cells Treated with Histone Deacetylase Inhibitor Valproic Acid by Leah A. Marquez-Curtis, Yuanyuan Qiu, April Xu, Anna Janowska-Wieczorek

“…Mesenchymal stromal cells (MSC) have great potential for cellular therapies as they can be directed to differentiate into certain lineages or to exert paracrine effects at sites of injury. …”
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Flt3 Regulation in the Mononuclear Phagocyte System Promotes Ocular Neovascularization by Yushuo Gao, Yisheng Zhong, Yanji Zhu, Anna M. Demetriades, Yujuan Cai, Jikui Shen, Qing Lu, Xi Shen, Bing Xie

“…Based on the above findings, we concluded that Flt3 inhibition alleviated ocular NV by promoting a Mphi polarization shift towards the M2 phenotype. Therapies targeting Flt3 may provide a new approach for the treatment of ocular NV.…”
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L-theanine modulates tissue cortisol levels in zebrafish after single stress by Vinícius Luís da Silva, Mariana Spanamberg Mayer, Andriele dos Reis Severo, Andressa Leal Zambra, Joanna Moraes De Almeida, Laura Moura Sestari, Mariana Migliorini Parisi, Ana Cristina Vendrametto Varrone Giacomini, Murilo Sander De Abreu, Josiane Woutheres Bortolotto, Gabriela Bonfanti-Azzolin

“…Stress is a situation characterized by the stimulus to cortisol secretion and without specific pharmacological therapies. Thus, this study investigates the effect of L-theanine on the response to acute stress, evaluated by tissue cortisol level, oxidative status markers, and behavioral parameters, in zebrafish. …”
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Mind-Body Exercises for Nurses with Chronic Low Back Pain: An Evidence-Based Review by Pinky Budhrani-Shani, Donna L. Berry, Patricia Arcari, Helene Langevin, Peter M. Wayne

“…The multimodal nature of mind-body exercises has potential to impact physiological and psychological processes associated with chronic pain, affording possible advantages over conventional unimodal therapies. This paper summarizes the prevalence of and risk factors for CLBP among nurses, reviews the effectiveness in treating pain and disability of mind-body exercises (yoga and tai chi) for CLBP among the general and nursing population, and describes implications. …”
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Deep Learning for Predicting Spheroid Viability: Novel Convolutional Neural Network Model for Automating Quality Control for Three-Dimensional Bioprinting by Zyva A. Sheikh, Oliver Clarke, Amatullah Mir, Narutoshi Hibino

“…This deep-learning model offers a non-invasive, efficient, and accurate method to streamline the assessment of spheroid quality, thereby accelerating the development of bioengineered cardiac tissue patches for cardiovascular disease therapies.…”
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Recursive seed amplification detects distinct α-synuclein strains in cerebrospinal fluid of patients with Parkinson’s disease by Stefan Bräuer, Iñaki Schniewind, Elisabeth Dinter, Björn H. Falkenburger

“…Measuring aSyn strains may be relevant for prognosis and for therapies targeting aSyn pathology.…”
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