O-GlcNAc transferase mediates O-GlcNAcylation of NLRP3 regulates pyroptosis in spinal cord injury by Zhichao Zeng, Xuqiang Liao, Xinjian Zhao

“…Targeting OGT and NLRP3 may be novel therapy method in SCI.…”
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The Influence of Oral Bacteria on Epithelial Cell Migration In Vitro by Alexa M. G. A. Laheij, Johannes J. de Soet, Enno C. I. Veerman, Jan G. M. Bolscher, Cor van Loveren

“…Oral ulcerations often arise as a side effect from chemo- and radiation therapy. In a previous clinical study, Porphyromonas gingivalis was identified as a positive predictor for oral ulcerations after hematopoetic stem cell transplantation, possibly incriminating P. gingivalis in delayed healing of the ulcerations. …”
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Real-World Efficacy and Safety of Tafluprost in Primary Open-Angle Glaucoma Patients with Corneal Disorders: A Taiwan Experience by Ju-Kuo Lin, Fu-Tsung Wei, Yi-Chun Liu, Yung-Chang Yen

“…This was a single-arm, open-label, switching study on adult POAG patients treated with latanoprost 0.005% for more than 3 months, with corneal disorders but no dry eye therapy. All patients were switched to tafluprost 0.0015% and followed up for 3 months. …”
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The Efficacy of Amniotic Membrane Stem Cell (AMSC) Metabolite Product and Vitamin E for Wrinkles, Spots, and Pores in Photoaging by Rahmadewi Rahmadewi, Retha Retha, Dyah Ayu Pitasari, Vidyani Adiningtyas Kusumastanto, Agatha Anindita Ayu Ardhaninggar, Irmadita Citrashanty, Maylita Sari, Menul Ayu Umborowati, Cita Rosita Sigit Prakoeswa

“…This promises an option for photoaging therapy in the future. Materials and Methods. Sixty women with photoaged skins were involved in this experimental study. …”
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Parkinsonism and Sjögren’s Syndrome: A Fortuitous Association or a Shared Immunopathogenesis? by Mariem Kchaou, Nadia Ben Ali, Intissar Hmida, Saloua Fray, Hela Jamoussi, Mohamed Jalleli, Slim Echebbi, Afef Achouri, Samir Belal

“…A 46-year-old woman with a history of progressive Parkinsonism for 6 years and a normal brain magnetic resonance imaging was partially improved with levodopa therapy. The later discovery of a sicca syndrome led to performing of further investigations, which revealed the presence of anti-SSA antibodies and a sialoadenitis of grade 4 according to Chisholm’s classification on labial salivary gland biopsy. …”
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Use of Extracorporeal Membrane Oxygenation in Pneumocystis Pneumonia of an Infant with AIDS by Grégoire Cane, Arnaud De Boislambert, Charlotte Sgro, Pierre Lavedan, Hélène Foulgoc, Nadir Tafer, Alexandre Ouattara

“…We prescribed combined antiretroviral, antibiotic, and steroid therapy aimed at preventing immune reconstitution inflammatory syndrome. …”
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Lnc-DC promotes estrogen independent growth and tamoxifen resistance in breast cancer by Wan-Xin Peng, Pratirodh Koirala, Huaixiang Zhou, Jiahong Jiang, Ziqiang Zhang, Liu Yang, Yin-Yuan Mo

“…However, a major obstacle for such endocrine therapy is estrogen independent growth, leading to resistance, and the underlying mechanism is not fully understood. …”
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Mesenchymal Stromal Cells Mediate Clinically Unpromising but Favourable Immune Responses in Kidney Transplant Patients by Urvashi Kaundal, Raja Ramachandran, Amit Arora, Deepesh B. Kenwar, Ratti Ram Sharma, Ritambhra Nada, Mukut Minz, Vivekanand Jha, Aruna Rakha

“…This study was aimed at investigating safety, feasibility, and immunological effects of autologous MSCs (auto-MSCs) and allogeneic MSCs (allo-MSCs) as a complement to IS drug therapy in KTx patients. Methods. 10 patients undergoing KTx with a living-related donor were analysed along with 5 patients in the control group. …”
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Mastectomy, HER2 Receptor Positivity, NPI, Late Stage and Luminal B-Type Tumor as Poor Prognostic Factors in Geriatric Patients with Breast Cancer by Demet Nak, Mehmet Kivrak

“…Additionally, patients undergoing mastectomy were less likely to receive adjuvant therapies, contributing to inferior outcomes compared to breast-conserving surgery (BCS). …”
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Possible Roles of Micro RNA‑142‑5p and Claudin-1 in Development of Hashimoto’s Thyroiditis in Iraqi Patients by Khaled Nather Taha, Farhan Abood Risan, Abdulameer Jasim Mohammed

“… Background: Micro RNA 142-5p may one day be employed as diagnostic or therapeutic targets in the therapy of autoimmune diseases. The expression of microRNA142-5p in serum from newly diagnosed patients with Hashimoto's thyroiditis has only been studied in a few tissue cases. …”
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Inhibition of GSK3β is synthetic lethal with FHIT loss in lung cancer by blocking homologous recombination repair by Shishi Tao, Yue Pu, Eun Ju Yang, Guowen Ren, Changxiang Shi, Li-Jie Chen, Liang Chen, Joong Sup Shim

“…FHIT loss is frequently observed in lung cancer, making it an important biomarker for the development of targeted therapy for lung cancer. Here, we report that inhibitors of glycogen synthase kinase 3 beta (GSK3β) and the homologous recombination DNA repair (HRR) pathway are synthetic lethal with FHIT loss in lung cancer. …”
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GC–MS analysis and in silico approaches to Stichopus hermanii as anti-inflammatory through PKC-β inhibition by Kurnia Fatwati, Asmawati Amin, Lenni Indriani, Rusdina Bte Ladju, Fuad Husain Akbar, Nurlindah Hamrun

“…Targeting the NF-κB signaling pathway is an interesting approach for anti-inflammatory therapy. Inhibition of the PKC-β pathway has shown to reducing NF-κB activity. …”
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Additive Effects of Glutathione in Improving Antibiotic Efficacy in HIV–<i>M.tb</i> Co-Infection in the Central Nervous System: A Systematic Review by Leena Nabipur, Michael Mouawad, Vishwanath Venketaraman

“…Discussion: GSH shows promise as an adjunct therapy for HIV–<i>M.tb</i> co-infection, particularly for cases involving the CNS, where it may improve immune recovery and reduce inflammation. …”
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Finerenone in the management of diabetes kidney disease by Parijat De, May T Khine, Andrew Frankel, Gabrielle Goldet, Debasish Banerjee, Rosa M Montero, Tahseen A Chowdhury, Damien Fogarty, Janaka Karalliedde, Ritwika Mallik, Dipesh C Patel, Mona Wahba, Peter Winocour, Sagen Zac-Varghese, Stephen Bain, Adnan Sharif, Srikanth Bellary, Indranil Dasgupta

“…Slowing progression of kidney disease and reducing cardiovascular events can be achieved by a number of means including the targeting of blood pressure and the use of specific classes of drugs The use of Renin Angiotensin Aldosterone System (RAAS) blockade is effective in preventing or slowing progression of DKD and reducing cardiovascular events in people with type 2 diabetes, albeit differently according to the stage of DKD. However, emerging therapy such as non-steroidal selective mineralocorticoid antagonists (finerenone) is proven to lower blood pressure and further reduce the risk of progression of DKD and cardiovascular disease in people with type 2 diabetes. …”
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Analisis Proses Suksesi Perusahaan Keluarga (Studi Kasus Pada Sentra Batik Trusmi Cirebon) by Abdurokhim Abdurokhim

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Urinary electrolyte parameters in sepsis-associated acute kidney injury: A prospective observational study by Rajathadri Hosur Ravikumar, Anjan Trikha, Rashmi Ramachandran, Sudip Kumar Datta, Mrudula Prasanna, Vimi Rewari

“…Patients were monitored for 7 days to assess for acute kidney injury (AKI) according to Kidney Disease Improving Global Outcomes (KDIGO) definition criteria, mortality rates, and the need for renal replacement therapy. Mann-Whitney U test and Chi-squared test were used to analyse continuous and categorical variables, respectively. …”
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Comparative study on the bioavailability and bioequivalence of rifapentine capsules in humans by Ying Qi, Pengfei Zhao

“…This study contributes to the body of evidence needed to ensure that patients receive a consistent therapeutic effect when administered either formulation of rifapentine.ConclusionThe bioequivalence demonstrated between the test and reference rifapentine capsules supports their use in clinical settings where rifapentine is indicated for tuberculosis therapy. This study provides a robust foundation for the regulatory approval of generic formulations of rifapentine, ensuring that patients have access to effective and lower-cost medication options.…”
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Protracted Hypocalcemia following 3.5 Parathyroidectomy in a Kidney Pancreas Recipient with a History of Robotic-Assisted Roux-en-Y Gastric Bypass by Hugo Bonatti, Naureen Iqbal, Catherine Kling, Willie Melvin, James Broome

“…She remains in the long term on high-dose medical therapy with normal serum calcium levels and PTH levels around 100 pg/mL. …”
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Analysis of the Serum Bile Acid Composition for Differential Diagnosis in Patients with Liver Disease by Tomonori Sugita, Katsushi Amano, Masanori Nakano, Noriko Masubuchi, Masahiro Sugihara, Tomokazu Matsuura

“…The levels of UDCA and GUDCA were significantly higher in the ALD group, and the levels of DCA and UDCA were significantly lower in the biliary tract diseases group than in viral hepatitis group. In the UDCA therapy (−) subgroup, a significantly lower level of TLCA was observed in the ALD group, with lower levels of CDCA, DCA, and GLCA noted in biliary tract diseases group compared to viral hepatitis group. …”
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Problematic social media use pada anak dengan orangtua yang bekerja by Soeci Izzati Adlya, Nilma Zola, Rima Pratiwi Fadli, Puji Gusri Handayani, Gusni Dian Suri, Salsa Billah Husna, Viona Maisyah Yuliardi

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