Systematic Review and Meta-Analysis of Remineralizing Agents: Outcomes on White Spot Lesions by Ana Josefina Monjarás-Ávila, Louis Hardan, Carlos Enrique Cuevas-Suárez, Norma Verónica Zavala Alonso, Miguel Ángel Fernández-Barrera, Carol Moussa, Jamal Jabr, Rim Bourgi, Youssef Haikel

“…White spot lesions, the earliest stage of caries, compromise enamel’s esthetics and integrity. Remineralization therapies, both fluoride and non-fluoride based, aim to restore enamel, but limited comparative data exist on their effects on lesion depth and microhardness. …”
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Dialysate White Blood Cell Change after Initial Antibiotic Treatment Represented the Patterns of Response in Peritoneal Dialysis-Related Peritonitis by Pichaya Tantiyavarong, Opas Traitanon, Piyatida Chuengsaman, Jayanton Patumanond, Adis Tasanarong

“…Clinicians should focus on the delayed response and failure patterns in order to make a decision whether to continue medical therapies or to aggressively remove the peritoneal catheter.…”
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Novel Therapeutic Approaches to the Treatment of Chronic Abdominal Visceral Pain by Franca Patrizi, Steven D. Freedman, Alvaro Pascual-Leone, Felipe Fregni

“…This paper will present an overview of the pathophysiology and the available therapies for CAVP, focusing on the recent advances in the treatment of this pathology.…”
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Canadian Helicobacter pylori Consensus Conference Update: Infections in Adults by RH Hunt, CA Fallone, ABR Thomson, Canadian Helicobacter Study Group

“…Key changes included the following: the recommendation for testing and treating H pylori infection in patients with known peptic ulcer disease was extended to testing and treating patients with ulcer-like dyspepsia; it was decided that the urea breath test (not serology) should be used for routine diagnosis of H pylori infection unless endoscopy is indicated for another reason; and recommended therapies were a twice daily, seven-day regimen of a proton pump inhibitor (omeprazole 20 mg, lansoprazole 30 mg, pantoprazole 40 mg) or ranitidine bismuth citrate 400 mg, plus clarithromycin 500 mg and amoxicillin 1000 mg, or plus clarithromycin 500 or 250 mg and metronidazole 500 mg. …”
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Differential expression of CD175 and CA19-9 in pancreatic adenocarcinoma by Jane J. Cheng, Yasuyuki Matsumoto, Gabrielle E. Dombek, Kathryn A. Stackhouse, Ana Sofia Ore, Jonathan N. Glickman, Jamie Heimburg-Molinaro, Richard D. Cummings

“…These data provide avenues for novel therapeutic approaches that could combine CD175- and CA19-9-targeting therapies for PDAC patients.…”
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Physicochemical properties and drug likeness of hydroxycinnamic acids and their molecular docking with caffeine and amoxicillin: Potential anticancer drugs by Umer Sherefedin, Abebe Belay, Kusse Gudishe, Alemu Kebede, Alemayehu Getahun Kumela, Tesfaye Feyisa, Jebel Haji Mahamud, Shallo Fekadu

“…Cancer is a major global health challenge, with traditional therapies often yielding limited success and significant side effects. …”
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Evaluation of Health-related Quality of Life in Regular Hemodialysis Patients Using the KDQOL-SFTM Questionnaire by Eliseo Capote Leyva, Raydel Argudín Selier, Salvador Roberto Mora González, Lázaro Capote Pereira, Idrissa Leonard Rupalé, Yosvany Moret Hernández

“…<strong>Background:</strong> in end-stage chronic renal failure, treatments like hemodialysis induce substantial changes in lifestyle. Such therapies aim to achieve functional improvement by reducing symptoms and/or slowing disease progression. …”
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Perspectives in Molecular Imaging Using Staging Biomarkers and Immunotherapies in Alzheimer’s Disease by Benoît Leclerc, Abedelnasser Abulrob

“…Early diagnosis is the challenge task that needs to look first at plausible mechanisms of actions behind therapies, and combining them would allow for the development of efficient AD treatment in a near future.…”
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Anticancer potential of coumarins from the Ferulago genus by Mansour Mofasseri, Elham Eini, Saber Mofasseri, Bahram Hanifehpour, Fatemeh Zanbili, Ahmad Poursattar Marjani

“…Accordingly, continued investigations into their pharmacological properties and therapeutic applications will be crucial in developing novel anticancer therapies, ultimately contributing to improved patient quality of life.…”
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Lipid metabolic reprogramming and associated ferroptosis in osteosarcoma: From molecular mechanisms to potential targets by Zhiyang Yin, Guanlu Shen, Minjie Fan, Pengfei Zheng

“…A comprehensive understanding of the interplay between dysregulation of lipid metabolism and ferroptosis is essential for the development of innovative and effective therapies for OS, with the ultimate goal of improving patient outcomes.…”
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Clonal Heterogeneity in the Neuronal and Glial Differentiation of Dental Pulp Stem/Progenitor Cells by Fraser I. Young, Vsevolod Telezhkin, Sarah J. Youde, Martin S. Langley, Maria Stack, Paul J. Kemp, Rachel J. Waddington, Alastair J. Sloan, Bing Song

“…Cellular heterogeneity presents an important challenge to the development of cell-based therapies where there is a fundamental requirement for predictable and reproducible outcomes. …”
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Involvement of the TGF-β pathway in epithelialmesenchymal transition promoted by the pulmonary microenvironment in Mycoplasma pneumoniae pneumonia by Fan Lu, Wang Huixia, Xu Nuo, Guo Yun, Li Ling

“…This may represent a crucial mechanism contributing to pulmonary fibrosis, underscoring the need to focus on the pulmonary microenvironment and TGF-β-targeted therapies for the prevention and management of pulmonary fibrosis in these patients.…”
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Calcium Phosphate Nanoparticles Functionalized with a Cardio-Specific Peptide by Federica Mancini, Lorenzo Degli Esposti, Alessio Adamiano, Jessica Modica, Daniele Catalucci, Dora Mehn, Otmar Geiss, Michele Iafisco

“…Cardiovascular diseases (CVDs) remain the leading cause of mortality worldwide, highliting the urgent need for new therapeutic strategies. Peptide-based therapies have demonstrated significant potential for treating CVDs; however, their clinical application is hindered by their limited stability in physiological fluids. …”
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Practical Recommendations of Scientific Society for the Study of Human Microbiome and the Russian Gastroenterological Association on Use of Probiotics, Prebiotics, Synbiotics and F... by V. T. Ivashkin, I. V. Maev, D. I. Abdulganieva, S. A. Alekseenko, A. V. Gorelov, I. N. Zakharova, O. Yu. Zolnikova, N. Yu. Ivashkina, N. V. Korochanskaya, S. N. Mammayev, E. A. Poluektova, A. S. Trukhmanov, D. V. Usenko, Yu. P. Uspensky, V. V. Tsukanov, O. S. Shifrin, I. V. Berezhnaya, K. V. Ivashkin, T. L. Lapina, R. V. Maslennikov, S. V. Nikolaeva, N. G. Sugyan, A. I. Ulyanin

“…The practical guidelines are intended for primary care physicians, general practitioners, paediatricians, gastroenterologists and general internists to advance the treatment and prevention of gastroenterological diseases in adults and children in therapies with probiotics, prebiotics, synbiotics and their enriched functional foods.Key points. …”
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Comparative analysis of diabetes risk in patients with obstructive sleep apnea undergoing different treatment approaches by Nai-Chen Shih, James Cheng-Chung Wei

“…The study findings suggest that both therapies offer protection against diabetes, with upper airway surgery demonstrating better preventive efficacy than CPAP. …”
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A Review on Expression, Pathological Roles, and Inhibition of TMPRSS2, the Serine Protease Responsible for SARS-CoV-2 Spike Protein Activation by Jyotirmoy Sarker, Pritha Das, Sabarni Sarker, Apurba Kumar Roy, A. Z. M. Ruhul Momen

“…Complete understanding of the biological roles of TMPRSS2 is necessary before such therapies are applied.…”
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About Marie Skłodowska-Curie on the occasion of her 150th anniversary of the birth by Alicja Rafalska-Łasocha

“…The scientific achievements of Maria Skłodowska-Curie were a breakthrough in the history of exact sciences and the basis for the application of new methods in oncological therapies. For modern scientists she is a timeless source of inspiration and is admired not only for her scientific achievements but also for her courage in breaking barriers and helping to redefine the role of women in society and science. …”
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Nuclear Magnetic Resonance Fingerprinting and Principal Component Analysis Strategies Lead to Anti-Tuberculosis Natural Product Discovery from Actinomycetes by Jianying Han, Xueting Liu, Lixin Zhang, Ronald J. Quinn, Miaomiao Liu

“…Conclusions: These findings emphasize the value of microbial metabolites as a reservoir of bioactive compounds and provide new avenues for developing next-generation anti-TB therapies.…”
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Electroconvulsive shock and transcranial magnetic stimulation do not alter the survival or spine density of adult-born striatal neurons. by Tara Gaertner, Tian Rui Zhang, Baran Askari, Fidel Vila-Rodriguez, Jason S Snyder

“…Since striatal dysfunction occurs in Parkinson's disease, which is amenable to neurostimulation therapies, we investigated whether electroconvulsive shock (ECS) or transcranial magnetic stimulation (rTMS) modulate neuroplasticity of adult-born striatal neurons. …”
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Characterization of the ZDSD Rat: A Translational Model for the Study of Metabolic Syndrome and Type 2 Diabetes by Richard G. Peterson, Charles V. Jackson, Karen Zimmerman, Willem de Winter, Norman Huebert, Michael K. Hansen

“…ZDSD rats will provide a novel, translational animal model for the study of human metabolic diseases and for the development of new therapies.…”
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