Based on network pharmacology and molecular docking to study the mechanisms of active ingredients of ginseng in the treatment of atopic dermatitis by BU Jialiang, SHEN Lin, MENG Yuan, PIAO Yingshi

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Cross-sectional patient survey of biological medicine users in Finland to investigate the types of guidance needed by patients in order to carry out their treatment successfully by Tuire Prami, Mari Pölkki

“…In general, biosimilar users were more concerned about adverse effects than users of originator products.Conclusion Patients consider information about adverse effects an important part of patient guidance when starting and maintaining self-administered biological therapy. The results highlight the importance of ensuring that up-to-date evidence-based information is readily available to patients from reliable sources.…”
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Signal Factors Secreted by 2D and Spheroid Mesenchymal Stem Cells and by Cocultures of Mesenchymal Stem Cells Derived Microvesicles and Retinal Photoreceptor Neurons by Lili Xie, Mao Mao, Liang Zhou, Lusi Zhang, Bing Jiang

“…Moreover, 3D-MSC-MVs also possessed an enhanced capability to promote signal factors secretion compared to 2D-MSC-MVs and may possess enhanced immunomodulating activities and might be a better regenerative therapy for retinal degenerative diseases.…”
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A Small-Sized Population of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Shows High Stemness Properties and Therapeutic Benefit by Miyeon Kim, Yun Kyung Bae, Soyoun Um, Ji Hye Kwon, Gee-Hye Kim, Soo Jin Choi, Wonil Oh, Hye Jin Jin

“…Therefore, the isolation of this small-sized population of UCB-MSCs could be a simple and effective way to enhance the efficacy of cell therapy.…”
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Factors related to the progression of chronic obstructive pulmonary disease: a retrospective case-control study by Fang Ding, Wenjing Liu, Xiaoying Hu, Chunyan Gao

“…More frequent use of antibiotics, corticosteroids, oxygen therapy, and mechanical ventilation were observed in the progression group than that in the non-progression group (P < 0.05). …”
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Intralesional steroid injection in keloid ear — a prospective observational study by Vinod Bangalore Narayanaswamy, Tejaswini H, Saritha H M, Udayabhanu H N, Nagarathna H K

“…All patients underwent compression therapy. Patients were evaluated at every visit and then at 1 year for symptom relief, keloid regression, and complications if any. …”
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Biological Characteristics and Medical Treatment of Breast Cancer in Young Women—A Featured Population: Results from the NORA Study by P. Pronzato, G. Mustacchi, A. De Matteis, F. Di Costanzo, E. Rulli, I. Floriani, M. E. Cazzaniga

“…Positive nodal status, large tumors, and elevated Ki67 all associated with the choice for chemotherapy followed by endocrine therapy in hormone receptor-positive patients (𝑃<.0001). …”
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Liraglutide Attenuates Hepatic Oxidative Stress, Inflammation, and Apoptosis in Streptozotocin-Induced Diabetic Mice by Modulating the Wnt/β-Catenin Signaling Pathway by Jie Yu, Yuan Zhao, Lingling Xu, Wei Li, Huabing Zhang, Fan Ping, Yuxiu Li

“…Interestingly, liraglutide monotherapy showed better efficacy in ameliorating liver injury in T1DM mice than insulin monotherapy, similar to the combined drug therapy. Furthermore, the expression of Wnt/β-catenin signaling pathway-associated molecules was upregulated in the liver of mice treated with liraglutide or insulin. …”
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Use of Condition-Specific Patient-Reported Outcome Measures in Clinical Trials among Patients with Wrist Osteoarthritis: A Systematic Review by Steven M. McPhail, Karl S. Bagraith, Mandy Schippers, Paula J. Wells, Anna Hatton

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Cangfudaotan Decoction Alleviates Insulin Resistance and Improves Follicular Development in Rats with Polycystic Ovary Syndrome via IGF-1-PI3K/Akt-Bax/Bcl-2 Pathway by Chenye Wang, Caifei Ding, Zhoujia Hua, Chunyue Chen, Jia Yu

“…Pharmacology is a basic option for PCOS therapy; traditional Chinese medicine (TCM), as a significant part of complementary and alternative medicine, has a long history in the clinical management of PCOS. …”
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Pengembangan balok suku kata untuk mengatasi kesulitan membaca di sekolah dasar by Zakiyah Andiny Sihombing, Rina Devianty

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Short-term and long-term prognoses in AChR-Ab positive very-late-onset myasthenia gravis patients by Nairong Xie, Qing Liu, Qi Wen, Yaye Wang, Haoran Liu, Yuting Jiang, Yan Lu, Li Di, Min Wang, Wenjia Zhu, Xinmei Wen, Xuxiang Zhang, Xin-Ming Shen, Yuwei Da

“…Low baseline MG-ADL score and steroid therapy were associated with better short-term prognosis ( p  = 0.007 and p  = 0.002, respectively). …”
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Intrahepatic Cholestasis of Pregnancy Leading to Severe Vitamin K Deficiency and Coagulopathy by Maria Maldonado, Ali Alhousseini, Michael Awadalla, Jay Idler, Robert Welch, Karoline Puder, Manasi Patwardhan, Bernard Gonik

“…Her serum vitamin K level was undetectable (<0.1 nMol/L). Initial therapy consisted of intramuscular replacement of vitamin K and administration of fresh frozen plasma. …”
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Trajectory of the arterial-alveolar oxygen gradient in COPD for a decade. by Kazuma Nagata, Susumu Sato, Kiyoshi Uemasu, Naoya Tanabe, Atsuyasu Sato, Shigeo Muro, Toyohiro Hirai

“…Retrospective tracking from the initiation of long-term oxygen therapy (LTOT) revealed significant increases in A-aDO2 from 5 years prior to LTOT initiation in the CRF group when compared to the non-CRF group.…”
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The Fate of the Tumor in the Hands of Microenvironment: Role of TAMs and mTOR Pathway by Danilo Figueiredo Soave, Marina Pacheco Miguel, Fernanda Dias Tomé, Liliana Borges de Menezes, Patrícia Resende Alo Nagib, Mara Rúbia Nunes Celes

“…We also discuss the recent findings in M1 and M2 polarization as a possible target in the cancer therapy.…”
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A systematic review of the clinical use of a single-layer bovine collagen-elastin acellular dermal matrix by David M. Hill

“…Negative pressure wound therapy was utilized in many of the studies. Study endpoints varied widely and included graft take, several objective scar scales, cutometer/durometer measures, range of motion, patient satisfaction scores, and histology. …”
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The role of simultaneous stereotactic biopsy and radiofrequency ablation in the management of brain neoplasms in countries with limited financial resources by Mohamed Ashraf Mahmoud, Abdelrahman El Gayar, Shafik T El Molla, Hesham Radwan, Tarek H El Serry, Ashraf Al Abyad

“…In resource-limited settings, RF ablation can be a safe and available alternative to LITT (Laser Interstitial Thermocoagulative Therapy) that can deliver heat to intracranial tumors.…”
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Transcriptomic and metabolomic analyses reveal the spatial role of carnitine metabolism in the progression of hepatitis B virus cirrhosis to hepatocellular carcinoma by Pengxiang Gao, Qiuping Liu, Ziye Luo, Wenjun Pu, Wenjun Pu

“…Identifying critical biomarkers and molecular targets is needed for early diagnosis, prognosis, and therapy of these diseases.MethodsIn this study, we explored the gene expression and metabolism in the liver tissues of LC, HCC, and healthy controls, to analyse and identify potential biomarkers of disease progression. …”
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Heart rate reserve effects on brain activation and cognitive-motor performance while doing an instrumented trail walking task in middle-aged to older adults by Alka Bishnoi, Manuel E. Hernandez

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Voice-related quality of life after total laryngectomy: a scoping review of recent evidence by Tatiana Pourliaka, Efcharis Panagopoulou, Vassiliki Siafaka

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