Incomplete remyelination via therapeutically enhanced oligodendrogenesis is sufficient to recover visual cortical function by Gustavo Della-Flora Nunes, Lindsay A. Osso, Johana A. Haynes, Lauren Conant, Michael A. Thornton, Michael E. Stockton, Katherine A. Brassell, Amanda Morris, Yessenia I. Mancha Corchado, John A. Gaynes, Anthony R. Chavez, Michaelanne B. Woerner, Deidre A. MacKenna, Aryan Alavi, Anne Danks, Alon Poleg-Polsky, Rohan Gandhi, Jeffrey A. Vivian, Daniel J. Denman, Ethan G. Hughes

“…Because remyelination is often incomplete, better understanding endogenous remyelination and developing remyelination therapies that restore neural function are clinical imperatives. …”
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Glyoxylate, a New Marker Metabolite of Type 2 Diabetes by Victoria J. Nikiforova, Pieter Giesbertz, Jan Wiemer, Bianca Bethan, Ralf Looser, Volker Liebenberg, Patricia Ruiz Noppinger, Hannelore Daniel, Dietrich Rein

“…Glyoxylate in its metabolic network may serve as an early marker in diabetes diagnosis with predictive qualities for associated complications and as potential to guide the development of new antidiabetic therapies.…”
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A Biopsychosocial Overview of Speech Disorders: Neuroanatomical, Genetic, and Environmental Insights by Diya Jaishankar, Tanvi Raghuram, Bhuvanesh Kumar Raju, Divyanka Swarna, Shriya Parekh, Narendra Chirmule, Vikramsingh Gujar

“…Future directions point toward leveraging genetic testing, digital technologies, and personalized therapies, alongside addressing the psychosocial dimensions, to improve outcomes for individuals with speech disorders. …”
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Hepatobiliary organoid research: the progress and applications by Rui-Qi Zou, Rui-Qi Zou, Yu-Shi Dai, Yu-Shi Dai, Fei Liu, Fei Liu, Si-Qi Yang, Si-Qi Yang, Hai-Jie Hu, Hai-Jie Hu, Fu-Yu Li, Fu-Yu Li

“…Consequently, it is widely used in basic and clinical studies, becoming important preclinical models for studying diseases and developing therapies. Here, we introduced the definition and advantages of organoids and described the development and advances in hepatobiliary organoids research. …”
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Difficult to Treat Focal, Stiff Person Syndrome of the Left Upper Extremity by Nathan E. Esplin, John W. Stelzer, Timothy B. Legare, Sayed K. Ali

“…This case represents a case of a rare disease that was refractory to all known therapies. It outlines the need for further understanding of this disorder in order to provide better symptomatic treatment or potentially more definitive care.…”
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Peripheral Blood Derived Mononuclear Cells Enhance the Migration and Chondrogenic Differentiation of Multipotent Mesenchymal Stromal Cells by Niina Hopper, John Wardale, Daniel Howard, Roger Brooks, Neil Rushton, Frances Henson

“…In conclusion, PBMCs increase both MSC migration and differentiation suggesting that they are an ideal candidate for inclusion in regenerative medicine therapies aimed at cartilage repair.…”
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RhoA Regulation of Cardiomyocyte Differentiation by Mari Kaarbø, Denis I. Crane, Wayne G. Murrell

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Guiding the Differentiation Direction of Pancreatic Islet-Derived Stem Cells by Glycated Collagen by Gokhan Duruksu, Aysegul Aciksari

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La prévention anti infectieuse au cours des greffes de cellules souches hématopoïétiques by Mohammed Amine Bekadja

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Necrotizing Epididymo-Orchitis: A Rare Manifestation of COVID-19 by Ali Tavoosian, Sana Ahmadi, Seyed Mohammad Kazem Aghamir

“…During the COVID-19 pandemic, in case of abnormal clinical manifestations of COVID infection and inadequate therapeutic response to the routine therapies, this disease with unusual manifestations should be considered. …”
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The impact of the first wave of the COVID-19 pandemic on hospital admissions and treatment management of ectopic pregnancy by Hande Gurbuz, Gulfem Basol, Mehmet Mustafa Altintas, Betul Kuru

“…Furthermore, surgical treatment methods were used more than conservative therapies during the outbreak.…”
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Advancements of Deep Learning Model-Based Rehabilitation Training System by Xu Chiyu

“…Traditional therapies for rehabilitation training in modern society are difficult to track patients dynamically, so this paper introduces a rehabilitation training evaluation system under deep learning modeling to help assess the effectiveness of rehabilitation training. …”
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Dissolving microneedle patch loaded with adipokines-enriched adipose extract relieves atopic dermatitis in mouse via modulating immune disorders, microbiota imbalance, and skin bar... by Jingyan Guan, Kaiqi Chen, Feng Lu, Yunfan He

“…Atopic dermatitis (AD) is a chronic relapsing dermatosis that demands new therapies. This research group previously developed a physically extracted adipose-derived extracellular matrix named adipose collagen fragments (ACF), which was determined containing massive adipose matrix-bound adipokines and medicable on AD through intradermal injection. …”
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Prognostic Factors and Outcome of Patients with Adult Acute Lymphoblastic Leukemia Treated with the Hyper-CVAD Regimen: A Retrospective Study by Zahra Malakoutikhah, Farzaneh Ashrafi, Ali Derakhshandeh

“…The outcome of the traditional Hyper-CVAD regimen in treating adult ALL was not satisfying. More efficient therapies should be applied for the treatment of adult ALL.…”
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Psoriasis: Unraveling Disease Mechanisms and Advancing Pharmacological and Nanotechnological Treatments by Miao M, Yan J, Sun Y, Liu J, Guo S

“…This review delves into the molecular underpinnings of psoriasis, examining current therapies and promising investigational agents. We highlight the potential of nanotechnology to enhance drug delivery to affected skin areas, with microneedles emerging as a promising platform for psoriasis and other chronic inflammatory skin diseases.Keywords: biodegradable nanoparticles, clinical trials, skin inflammatory diseases, psoriasis, microneedles…”
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La prévention anti infectieuse au cours des greffes de cellules souches hématopoïétiques by Mohammed Amine Bekadja

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Profile of STING agonist and inhibitor research: a bibliometric analysis by Xuemei Wang, Qian Wang, Yidan Gao, Lijuan Jiang, Lingli Tang

“…Its activation has shown great potential in anti-tumor and anti-infective therapies, with STING agonists emerging as a promising approach in cancer immunotherapy in recent years. …”
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Proteomic Analysis of Lung Tissue in a Rat Acute Lung Injury Model: Identification of PRDX1 as a Promoter of Inflammation by Dongdong Liu, Pu Mao, Yongbo Huang, Yiting Liu, Xiaoqing Liu, Xiaoqing Pang, Yimin Li

“…In conclusion, our findings provide a global alteration in the proteome of lung tissues in the ALI rat model and indicate that PRDX1 may play a critical role in the pathogenesis of ARDS by promoting inflammation and represent a novel strategy for the development of new therapies against ALI.…”
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Trypsin-instructed bioactive peptide nanodrugs with cascading transformations to improve chemotherapy against colon cancer by Can Wu, Xiao Wei Zhang, Manman Wang, Jinpan Sun, Jianfei Chen, Yanbin Guan, Xin Pang

“…As the first example of employing trypsin-mediated nanodrugs with cascading transformations to promote chemotherapeutic activity, this work promises a strategy for novel therapies for efficiently combating colon cancer. Graphical Abstract…”
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Characterization of Urine-Derived Stromal/Stem Cells from Healthy Dogs and Dogs Affected by Chronic Kidney Disease (CKD) by Anna Lange-Consiglio, Filippo Tagliasacchi, Fausto Cremonesi, Claudia Gusmara, Claudia Pollera, Paola Scarpa, Giulia Gaspari, Pietro Riccaboni

“…This study confirmed that USCs from healthy and CKD dogs can act as stem cells, with those from sick dogs having greater proliferative ability with the potential for use as autologous therapies.…”
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