Achievement of Therapeutic Goals with Low-Dose Imiglucerase in Gaucher Disease: A Single-Center Experience by Irina Tukan, Irith Hadas-Halpern, Gheona Altarescu, Ayala Abrahamov, Deborah Elstein, Ari Zimran

“…Disease-specific enzyme replacement therapy (ERT) has been shown to reverse or ameliorate disease-specific hepatosplenomegaly and anemia and thrombocytopenia. …”
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Negative Pressure Smart Patch to Sense and Heal the Wound by Xing Liu, Peng Zhao, Xiaozhuo Wu, Yawei Zhao, Feifan Zhou, Ying Luo, Xiaoli Jia, Wen Zhong, Malcolm Xing, Guozhong Lyu

“…Abstract Negative pressure wound therapy (NPWT) offers significant advantages in terms of rate and time for healing through generating sub‐vacuum to draw out inflammatory exudate and promote wound closure. …”
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Necrotizing Liver Granuloma/Abscess and Constrictive Aspergillosis Pericarditis with Central Nervous System Involvement: Different Remarkable Phenotypes in Different Chronic Granul... by Sanem Eren Akarcan, Neslihan Karaca, Guzide Aksu, Halil Bozkaya, Mehmet Fatih Ayik, Yasemin Ozdemir Sahan, Mehmet Arda Kilinc, Zafer Dokumcu, Cenk Eraslan, Emre Divarci, Hudaver Alper, Necil Kutukculer

“…In addition to medical therapy, surgical treatment was necessary for the management of the disease. …”
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Exertional Myopathy in a Juvenile Green Sea Turtle (Chelonia mydas) Entangled in a Large Mesh Gillnet by Brianne E. Phillips, Sarah A. Cannizzo, Matthew H. Godfrey, Brian A. Stacy, Craig A. Harms

“…Treatment with appropriate fluid therapy and supportive care may mitigate the effects of exertional myopathy in some cases.…”
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Clinical utility of tumour mutational burden on efficacy of immune checkpoint inhibitors in malignant solid tumours: protocol for a systematic review and meta-analysis by Xiaoguang Yang, Yunming Li, Xuemei Xiang, Wang Guo, Pengfei Zhou

“…We plan to conduct a subgroup analysis on age, sex, area, number of patients (high/low TMB), cancer type, tumour size, stage, line of therapy, TMB sequencing method, type of immunotherapy and follow-up period.Ethics and dissemination Ethical approval and informed consent are not needed, as the study will be a literature review and will not involve direct contact with patients or alterations to patient care. …”
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Community-Based 4-Level Intervention Targeting Depression and Suicidal Behavior in Europe: Protocol for an Implementation Project by Katharina Schnitzspahn, Kahar Abdulla, Ella Arensman, Chantal Van Audenhove, Rainer Mere, Victor Pérez Sola, Merike Sisask, András Székely, Piotr Toczyski, Ulrich Hegerl

“…Activities comprise the digital iFightDepression tool, a guided self-management tool based on cognitive behavioral therapy. ObjectiveThis study aimed to present the European Union–cofunded EAAD-Best study protocol, aiming at the implementation, dissemination, and evaluation of the 4-level intervention and the iFightDepression tool in several countries across Europe. …”
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Synergistic Approach of High-Precision 3D Printing and Low Cell Adhesion for Enhanced Self-Assembled Spheroid Formation by Chunxiang Lu, Aoxiang Jin, Chuang Gao, Hao Qiao, Huazhen Liu, Yi Zhang, Wenbin Sun, Shih-Mo Yang, Yuanyuan Liu

“…This platform provides an efficient and cost-effective solution for biosensing applications, such as drug screening, disease modeling, and personalized therapy monitoring. Furthermore, the chip shows significant potential for real-time in vitro monitoring of cellular viability, reaction kinetics, and drug sensitivity, offering valuable advancements in biosensor technology for life sciences and medical applications.…”
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The Effects of Anlotinib Combined with Chemotherapy following Progression on Cyclin-Dependent Kinase 4/6 Inhibitor in Hormone Receptor-Positive Metastatic Breast Cancer by Ting Xu, Weili Xiong, Lili Zhang, Yuan Yuan

“…Purpose. Endocrine therapy combined with cyclin-dependent kinase (CDK) 4/6 inhibitors (CDK4/6i) is the preferred treatment for hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2–) metastatic breast cancer (MBC). …”
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Insulinoma in Patients with Diabetes- A Systematic Review of Previously Reported Cases by Subhankar Chatterjee, Rana Bhattacharjee, Ritwik Ghosh, Partha P. Chakraborty, Anirban Sinha, Animesh Maiti

“…Surgical resection was done in 70.9% of cases, while 40% received drug therapy and 12.7% received both, with 20.7% overall mortality. …”
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Downregulation of Gldc attenuates myocardial ischemia reperfusion injury in vitro by modulating Akt and NF-κB signalings by Lian Shuang, Youle Su, Yue Zhang

“…Abstract Myocardial ischemia/reperfusion injury (MIRI) is a serious clinical complication that is caused by reperfusion therapy following myocardial infarction (MI). Mitochondria-related genes (Mito-RGs) play important roles in multiple diseases. …”
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Hepatocellular Carcinoma: Current Management and Future Development—Improved Outcomes with Surgical Resection by Yoji Kishi, Kiyoshi Hasegawa, Yasuhiko Sugawara, Norihiro Kokudo

“…Multimodality approaches combining other local ablation or systemic therapy may help improve the prognosis. On the other hand, minimally invasive, or laparoscopic, hepatectomy has become popular over the last decade. …”
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A study comparing the effectiveness of ondansetron versus ondansetron combined with dexamethasone for preventing postoperative nausea and vomiting in laparoscopic surgeries by Rajan B. Pandya, Deepika Sathe, Ankita Joshi, Vishwas Sathe

“…Thus, the effectiveness of combination therapy surpassed that of ondansetron alone.…”
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Orthostatic Dysregulation during Postural Change on the Dental Chair and Intraoperative Monitoring by Heart Rate Variability Analysis by Yukihiro Momota, Shigemasa Tomioka, Mayuko Furukita, Kenji Fujisawa, Hideyuki Takano, Masayuki Azuma

“…We measured autonomic activity in a patient with OD during dental therapy and assessed the clinical significance of HRV analysis for OD. …”
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The Effects of Alpha Interferon on the Development of Autoimmune Thyroiditis in the NOD H2h4 Mouse by Yael Oppenheim, Grace Kim, Yoshiyuki Ban, Pamela Unger, Erlinda Concepcion, Takao Ando, Yaron Tomer

“…Alpha interferon (αIFN) therapy is known to induce thyroid autoimmunity in up to 40% of patients. …”
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Antifibrotic Effect of Combination of Nilotinib and Stem Cell-Conditioned Media on CCl4-Induced Liver Fibrosis by Gamal Shiha, Ahmed Nabil, Ahmed Lotfy, Reham Soliman, Ayman A. Hassan, Islam S. Ali, Doaa F. Gad, Faten Zahran

“…Nilotinib is a second-generation tyrosine kinase inhibitor, which showed antifibrotic efficacy. Stem cell therapy still has some limitations such as oncogenesis, unexpected differentiation, and ethical consideration. …”
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Identifying the Predictors of Short Term Weight Loss Failure after Roux-En-Y Gastric Bypass by Effat Bahadori, Ali Jafarzadeh Esfehani, Leila Sadat Bahrami, Mohammad Reza Shadmand Foumani Moghadam, Ali Jangjoo, Mohsen Nematy, Afshin Roghani, Reza Rezvani

“…Gastric bypass surgery is a gold standard therapy for severe obesity. This study aimed to evaluate anthropometric predictors for short-term excess weight loss (EWL) after Roux-en-Y gastric bypass surgery (RYGB) in a sample of severely obese patients. …”
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Clinical Scenarios for Discordant Anti-Xa by Jesus Vera-Aguilera, Hindi Yousef, Diego Beltran-Melgarejo, Teng Hugh Teng, Ramos Jan, Mary Mok, Carlos Vera-Aguilera, Eduardo Moreno-Aguilera

“…Anti-Xa test is widely used; however the assay underestimates heparin concentration in the presence of significant AT deficiency, pregnancy, end stage renal disease, and postthrombolysis and in patients with hyperbilirubinemia; limited published data evaluating the safety and effectiveness of anti-Xa assays for managing UH therapy is available. Conclusions and Relevance. To our knowledge this is the first paper that summarizes the most common causes in which this assay can be affected, several “day to day” clinical scenarios can modify the outcomes, and we concur that these rarely recognized scenarios can be affected by negative outcomes in the daily practice.…”
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High Ano1 expression as key driver of resistance to radiation and cisplatin in HPV-negative head and neck squamous cell carcinoma by Solenne Bourdier, Anne-Sophie Fisch, Keziban Merve Alp, Ridhima Das, Philipp Mertins, Ingeborg Tinhofer

“…Copanlisib and afatinib were identified as promising candidates for combination therapy of 11q13-amplified HNSCC tumors. We demonstrated a predominant role for Ano1 in treatment resistance in Cyclin D1highAno1high HNSCC tumors and identified novel potential treatment combinations for this high-risk patient group.…”
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Chronic Endometritis and Antimicrobial Resistance: Towards a Multidrug-Resistant Endometritis? An Expert Opinion by Francesco Di Gennaro, Giacomo Guido, Luisa Frallonardo, Laura Pennazzi, Miriana Bevilacqua, Pietro Locantore, Amerigo Vitagliano, Annalisa Saracino, Ettore Cicinelli

“…Treatment typically involves antibiotic therapy; however, the efficacy of these treatments is increasingly compromised by the rise of antimicrobial resistance (AMR). …”
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Uninvestigated Dyspepsia and Heartburn Overlap Syndrome at Industrial Hub of Eastern Siberia by V. V. Tsukanov, A. V. Vasiutin, J. L. Tonkikh, E. V. Kasparov, O. V. Smirnova

“…Among total patients with the heartburn/uninvestigated dyspepsia overlap syndrome, only 33.3% systemically had proton pump inhibitors, and only 17.4% had a prokinetic therapy.Conclusion. The heartburn/uninvestigated dyspepsia overlap syndrome is an actual issue in the Krasnoyarsk population. …”
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