An atypical presentation of autoimmune hepatitis with delayed menarche in a Nigerian adolescent: a case report by Promise Udoka Asogwa, Bruno Basil, Winifred Njideka Adiri, Nelson Ugwu, Gideon Ekene Anigbo, Evaristus Offia, Casmir Orjioke

“…Early intervention with immunosuppressive therapy is essential, even in the absence of classic liver-related symptoms, to prevent progression to advanced liver disease.…”
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Tumor necrosis serves as an important pathological characteristic of stage I–II colon cancer by Shuhui Dong, Jin Xu, Mingshan Li, Guangyi Xiong, Ruilin Wang

“…This pathological criterion promises to help in identifying high-risk subgroup from early-stage colon cancer patients, who may benefit from strict follow-up and adjuvant therapy.…”
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Medroxyprogesterone Acetate Plus Metformin to Prevent Persistent Endometrial Hyperplasia by Vakkas Korkmaz, Enis Özkaya, Tuncay Küçüközkan, Fadıl Kara, Yasemin Çekmez, Hilal Korkmaz

“…CONCLUSION: Medroxyprogesterone acetate and metformin may be used as an adjunctive therapy for persistent endometrial hyperplasias especially in women with high body mass index. …”
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Developing a taxonomy to describe offspring outcomes in studies involving pregnant mammals' exposure to non-tobacco nicotine: A systematic scoping review. by Lucy Phillips, Ross Thomson, Tom Coleman-Haynes, Sue Cooper, Felix Naughton, Lisa Mcdaid, Joanne Emery, Tim Coleman

“…<h4>Introduction</h4>Many countries recommend Nicotine Replacement Therapy (NRT) for smoking cessation in pregnancy. …”
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General views on treatment technologies for patients with incisional ventral hernia by E. E. Lukoyanychev, S. G. Izmajlov, V. A. Emelyanov, O. S. Kolchina, A. I. Rotkov, M. N. Kiselyov

“…More and more laparoscopy is being introduced in the treatment of IVH as an assistance and in therapy. The introduction of new methods of hernia repair based on the uncontrolled separation of the anatomical structures of the abdominal wall imposes special requirements on surgical technology: plastic material, instrumental and technical support, wound closure and pharmacological support, especially in conditions of increased intra-abdominal pressure and tissue tension. …”
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Identification and analysis of prognostic ion homeostasis characteristics in kidney renal clear cell carcinoma by Xiangmin Zhang, Xiongxian Qian, Yong Zhao, Maofei Ye, Liyang Li, Jian Chu

“…It has been shown that ion channels are important targets for anti-tumor therapy. In this study, we screened 70 selected KIRC related ion homeostasis genes with significant differential expression. …”
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Role of the IL-6 Gene in the Etiopathogenesis of Idiopathic Scoliosis by Svetla Nikolova, Milka Dikova, Dobrin Dikov, Assen Djerov, Gyulnas Dzhebir, Ventseslav Atanasov, Alexey Savov, Ivo Kremensky

“…That would facilitate the therapy decisions and early stage treatment of the patient with the least invasive procedures.…”
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Evaluation of Vitrectomy with Planned Foveal Detachment as Surgical Treatment for Refractory Diabetic Macular Edema with or without Vitreomacular Interface Abnormality by Ahmed M. Abdel Hadi

“…A prospective, interventional noncomparative case series in which cases had refractory DME with a central macular thickness (CMT) ≥ 300 μm, despite previous anti-VEGF therapy (ranibizumab or bevacizumab with shifting to aflibercept). …”
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Addressing Stem Cell Therapeutic Approaches in Pathobiology of Diabetes and Its Complications by Bou-Yue Peng, Navneet Kumar Dubey, Viraj Krishna Mishra, Feng-Chou Tsai, Rajni Dubey, Win-Ping Deng, Hong-Jian Wei

“…Pancreatic transplantation seemed a viable alternative; however, it is limited due to lack of donors. Cell-based therapy such as stem cells is considered as a promising therapeutic agent against DM and diabetic complications owing to their multilineage differentiation and regeneration potential. …”
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The Effects of Exenatide Once Weekly (EXQW) and Exenatide Twice a Day (EXBID) on Beta-Cell Function in Type 2 Diabetes: A Systematic Review and Network Meta-Analysis by Jie Wang, Xinye Jin, Ping An, Songyan Yu, Yiming Mu

“…In patients with type 2 diabetes mellitus (T2DM) and poor glycemic control receiving metformin (MET), glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are recommended as the adjunctive therapy. However, there are only a few studies involving the comparative effects of exenatide twice a day (EXBID) and exenatide once weekly (EXQW) on HOMA-β. …”
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Enamel Matrix Derivative Enhances the Odontoblastic Differentiation of Dental Pulp Stem Cells via Activating MAPK Signaling Pathways by Beidi Zhang, Min Xiao, Xiaogang Cheng, Yu Bai, Hanze Chen, Qing Yu, Lihong Qiu

“…The findings provide a new insight into the mechanism by which EMD affects DPSCs differentiation and proposes EMD as a promising candidate for future stem cell therapy in endodontics.…”
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Mixed Large Cell Neuroendocrine Carcinoma and Adenocarcinoma with Spindle Cell and Clear Cell Features in the Extrahepatic Bile Duct by John Wysocki, Rishi Agarwal, Laura Bratton, Jeremy Nguyen, Mandy Crause Weidenhaft, Nathan Shores, Hillary Z. Kimbrell

“…The patient’s poor performance status precluded adjuvant therapy and he died with recurrent and metastatic disease 5 months after surgery. …”
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Cancer in ANCA-Associated Glomerulonephritis: A Registry-Based Cohort Study by Sanjeevan Sriskandarajah, Leif Bostad, Tor Åge Myklebust, Bjørn Møller, Steinar Skrede, Rune Bjørneklett

“…Background. Immunosuppressive therapy for antineutrophil cytoplasmic antibody-associated vasculitis has been associated with increased malignancy risk. …”
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RTEL1 is upregulated in gastric cancer and promotes tumor growth by Chunyu Yang, Suzeng Wang, Ge Gao, Peiwen Xu, Mengyuan Qian, Yuan Yin, Surui Yao, Zhaohui Huang, Zehua Bian

“…These findings suggest that RTEL1 plays a critical role in GC tumorigenesis and could be a promising target for the therapy and prognosis of GC.…”
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Single High Intensity Focused Ultrasound Session as a Whole Gland Primary Treatment for Clinically Localized Prostate Cancer: 10-Year Outcomes by Ksenija Limani, Fouad Aoun, Serge Holz, Marianne Paesmans, Alexandre Peltier, Roland van Velthoven

“…Single session HIFU can be alternative therapy for patients with low risk PCa. Patients with intermediate risk should be informed about the need of multiple sessions of HIFU and/or adjuvant treatments and HIFU performed very poorly in high risk patients.…”
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Tailoring the Ablative Strategy for Atrial Fibrillation: A State-of-the-Art Review by Zefferino Palamà, Martina Nesti, Antonio Gianluca Robles, Antonio Scarà, Silvio Romano, Elena Cavarretta, Maria Penco, Pietro Delise, Mariano Rillo, Leonardo Calò, Luigi Sciarra

“…In any case, the superiority of ablation over pharmacological therapy in terms of effectiveness, reduction of hospitalizations, and improvement has been well demonstrated in recent randomized trials. …”
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Neutrophil-to-lymphocyte ratio as a prognostic factor in patients with castration-resistant prostate cancer treated with docetaxel-based chemotherapy: a meta-analysis by Ying Zhang, Xiao Zhou, Ran Xu, Guangcheng Luo, Xinjun Wang

“…The combined results showed that elevated NLR was significantly associated with worse OS (HR = 1.86, 95% CI: 1.55–2.23, P < 0.00001) and PFS (HR = 1.96 (95% CI: 1.52–2.53), P < 0.00001) in patients with mCRPC treated with docetaxel-based therapy. For subgroup analysis of high NLR, studies performed in Asia and cutoff value > 3 were associated with poorer OS, while cutoff values > 3 were associated with poorer PFS. …”
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The Effects of Pitavastatin on Nuclear Factor-Kappa B and ICAM-1 in Human Saphenous Vein Graft Endothelial Culture by Bulent Demir, Burak Onal, Sibel Ozyazgan, Esra Demir, Vedat Bakuy, Ahmet Gokhan Akkan

“…Low-dose (0.1 μM/L) and high-dose (1μM/L) pitavastatin calcium were administered as a frontline therapy in human saphenous endothelial cell culture, followed by induction of inflammation by TNF-α and determination of mRNA level alterations of ICAM-1 and NF-κB genes of endothelial cells using the qRT-PCR method. …”
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PDK1/mTOR Signaling in Myeloid Cells Differentially Regulates the Early and Late Stages of Sepsis by Juan Du, Guoli Li, Mingxi Hua, Junyan Han, Yu Hao, Hui Zeng, Ang Li, Yaxian Kong

“…The present study will provide a theoretical prospect for the therapy of the septic shock in different stages.…”
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Personality Changes after Deep Brain Stimulation in Parkinson’s Disease by Uyen Pham, Anne-Kristin Solbakk, Inger-Marie Skogseid, Mathias Toft, Are Hugo Pripp, Ane Eidahl Konglund, Stein Andersson, Ira Ronit Haraldsen, Dag Aarsland, Espen Dietrichs, Ulrik Fredrik Malt

“…Deep brain stimulation of the subthalamic nucleus (STN-DBS) is a recognized therapy that improves motor symptoms in advanced Parkinson’s disease (PD). …”
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