Leber's Hereditary Optic Neuropathy-Gene Therapy: From Benchtop to Bedside by Rajeshwari D. Koilkonda, John Guy

“…In a population-based study, the mtDNA background of haplogroup J was associated with an inverse relationship of low-ATP generation and increased production of reactive oxygen species (ROS). Effective therapy for LHON has been elusive. In this paper, we describe the findings of pertinent published studies and discuss the controversies of potential strategies to ameliorate the disease.…”
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A Survey of Insulin-Dependent Diabetes—Part I: Therapies and Devices by Daisuke Takahashi, Yang Xiao, Fei Hu, Michael Lewis

“…This paper surveys diabetes therapies from telemedicine viewpoint. In type 1 diabetes therapies, the exogenous insulin replacement is generally considered as a primary treatment. …”
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Real-world experience with TTFields in glioma patients with emphasis on therapy usage by Claudius Jelgersma, Joan Alsolivany, Gülsüm Akkas, David Wasilewski, David Wasilewski, Bastian Gastl, Martin Misch, David Capper, David Capper, David Kaul, David Kaul, Lars Bullinger, Lars Bullinger, Peter Vajkoczy, Julia Onken, Julia Onken, Julia Onken

“…Most of the patients (75.2%) initiated therapy concurrently with first-line treatment, of whom 27.6% started TTFields therapy concomitant to the first cycle of temozolomide. 15.2% started TTFields therapy in the second-line and 9.5% in the third-line setting. …”
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Post-Autologous (ASCT) Stem Cell Transplant Therapy in Multiple Myeloma by Zeina Al-Mansour, Muthalagu Ramanathan

“…Achieving and maintaining “best response” to initial therapy is the ultimate goal of first-line treatment and sustained CR is a powerful surrogate for extended survival especially in high-risk multiple myeloma. …”
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Physical Therapy Adjuvants to Promote Optimization of Walking Recovery after Stroke by Mark G. Bowden, Aaron E. Embry, Chris M. Gregory

“…The majority of scientific inquiries have focused on singular intervention approaches, with recent attention given to task specific therapies. We propose that measurement should indicate the most critical limiting factor(s) to be addressed and that a combination of adjuvant treatments individualized to target accompanying impairment(s) will result in the greatest improvements in locomotor function. …”
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Recanalization Therapies in Acute Ischemic Stroke: Pharmacological Agents, Devices, and Combinations by Vijay K. Sharma, Hock Luen Teoh, Lily Y. H. Wong, Jie Su, Benjamin K. C. Ong, Bernard P. L. Chan

“…Although intra-arterial delivery of the thrombolytic agent seems effective, various logistic constraints limit its routine use and as yet no lytic agent have not received full regulatory approval for intra-arterial therapy. Mechanical devices and approaches can achieve higher rates of recanalization but their safety and efficacy still need to be established in larger clinical trials. …”
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Comparison of Concomitant Mesalamine and Immunomodulator Therapy and Immunomodulator Monotherapy for Crohn’s Disease by Min Seob Kwak, Kyung-Jo Kim, Jae Hee Cheon, Wan Soo Kim, Jeong-Mi Lee, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang

“…Each patient was matched with 3 randomly selected controls who were treated with concomitant therapy during the same period. Results. The cumulative probabilities of steroid use at 5 and 10 years were 24.9% and 75.8% in the 5-ASA + AZA/6-MP group and 31.2% and 87.8% in the AZA/6-MP group, respectively (P=0.187). …”
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How to Translate Basic Knowledge into Clinical Application of Biologic Therapy in Spondyloarthritis by Chung-Tei Chou

“…Therefore, the dramatic clinical and pathologic response of anti-TNFα therapy in SpA is based upon the presence of increased TNFα in synovial tissues and sacroiliac joints, which perpetuates chronic inflammation. …”
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Low-Level Laser Therapy and Calcitonin in Bone Repair: Densitometric Analysis by Tatiana Pinto Ribeiro, Simone Bustamante Nascimento, Claúdia Alessandra Cardoso, Raduan Hage, Janete Dias Almeida, Emilia Angela Loschiavo Arisawa

“…The aim of this work was to evaluate the association of low-level laser therapy (LLLT, 830 nm) and calcitonin in bone repair considering that bone healing remains a challenge to health professionals. …”
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Photosynthetic Bacteria: Light-Responsive Biomaterials for Anti-Tumor Photodynamic Therapy by Jiang Y

“…Yuan Jiang Department of Rehabilitation Medicine, School of Clinical Medicine and The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, People’s Republic of ChinaCorrespondence: Yuan Jiang, Email 85741920@qq.comAbstract: Photodynamic therapy (PDT) is a promising noninvasive tumor treatment modality that relies on generating reactive oxygen species (ROS) and requires an adequate oxygen supply to the target tissue. …”
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Cupping Therapy May be Harmful for Eczema: A PubMed Search by Kam Lun E. Hon, David Chi Kong Luk, Kin Fon Leong, Alexander K. C. Leung

“…As there is no immediate cure, many parents seek alternative therapies that claim unproven therapeutic efficacy. …”
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Effectiveness of Thrombolytic Therapy in Acute Embolic Stroke due to Infective Endocarditis by Siva P. Sontineni, Aryan N. Mooss, Venkata G. Andukuri, Susan Marie Schima, Dennis Esterbrooks

“…To identify the role of thrombolytic therapy in acute embolic stroke due to infective endocarditis. …”
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Optimizing Antipsychotic Therapy in Acute Alcoholic Hallucinosis through Pharmacogenetic Testing by Valentin Skryabin, Anton Masyakin, Sergei Pozdniakov, Igor Shatokhin, Svetlana Sokolova, Valentina Ivanchenko

“…Psychotic disorders triggered by alcohol consumption, such as hallucinations and delusions, require antipsychotic treatment, though standard therapy often results in adverse drug reactions and variable efficacy. …”
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A Pharmacotherapy and ECT resistant OCD patient’s Cognitive Behavioral Therapy by Tacettin KURU, M. Hakan TÜRKÇAPAR

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Stem Cell Therapy: A Compassionate Use Program in Perianal Fistula by M. D. Herreros, D. Garcia-Olmo, H. Guadalajara, T. Georgiev-Hristov, L. Brandariz, M. Garcia-Arranz

“…No adverse effects related to stem cell therapy were reported. Conclusion. Stem cells are safe and useful for treating anal fistulae. …”
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Leveraging mRNA technology for antigen based immuno-oncology therapies by Wei Zheng, Michele Ceccarelli, Charalampos S Floudas, Siranush Sarkizova

“…Journal for ImmunoTherapy of Cancer…”
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Increasing the level of self-esteem in adolescent children through art therapy by T. S. Gordon

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Critical Aspects of Clinical Trial Design for Novel Cell and Gene Therapies by Zinovia Kefalopoulou, Iciar Aviles-Olmos, Thomas Foltynie

“…Neural cell transplantation and gene therapy have attracted considerable interest as promising therapeutic alternatives for patients with Parkinson's disease (PD). …”
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The hidden economic and environmental costs of antimicrobial therapies: a call to action by Mildred Nelson, Sarah B. Green, Sujit Suchindran, Lucy S. Witt

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Application of rapid genotyping of Warfarin individualized pharmacogenetic variants in Warfarin therapy by Defa Huang, Fangfang Xie, Shengpeng Xiao, Minyang Cai, Die Hu, Baodian Ling, Fangsheng Wang, Xuan Lin, Fangli Song, Qi Wang, Tianyu Zhong

“…In summary, the detection and genotyping of four polymorphic SNP sites using a multiplex fluorescent melting curve assay of whole blood direct amplification through nested PCR is highly importance for guiding personalized warfarin anticoagulant therapy.…”
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