Hydroxychloroquine Therapy Led to the Diagnosis of Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency in an Elderly Patient with COVID-19 Involvement: A Case Report and Review of the Literature by Razieh Taghizadeh-Sarvestani, Hamid Reihani, Ali Ghanei-Shahmirzadi, Alireza Keshtkar, Parsa Yazdanpanahi

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Effects of Clinicopathological Characteristics on the Survival of Patients Treated with PD-1/PD-L1 Inhibitor Monotherapy or Combination Therapy for Advanced Cancer: A Systemic Review and Meta-Analysis by Yuhan Wei, Yongfu Li, Qi Du, Xinyi Peng, Jiangtao Jin, Hong Guo, Yongyan Li, Qin Li

“…EGFR status for monotherapy and sex and smoking status for combination therapy were important predictors of survival benefits.…”
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Density functional theory and molecular dynamics simulation-based bioprospection of Agathosma betulina essential oil metabolites against protein tyrosine phosphatase 1B for interventive antidiabetic therapy by Oluwaseye Adedirin, Rukayat A. Abdulsalam, Khadeejah O. Nasir-Naeem, Ayenitaju A. Oke, Akolade O. Jubril, Saheed Sabiu

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Is C-reactive protein sufficient to guide antimicrobial therapy for lower respiratory tract infections among children?... by Chris A Rees, Prashant Mahajan, Quique Bassat

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Complete PSA Remission without Adjuvant Therapy after Secondary Lymph Node Surgery in Selected Patients with Biochemical Relapse after Radical Prostatectomy and Pelvic Lymph Node Dissection by Alexander Winter, Jens Uphoff, Rolf-Peter Henke, Friedhelm Wawroschek

“…Materials and Methods. 11 patients with PSA relapse (mean 3.02 ng/mL, range 0.5–9.55 ng/mL) after radical prostatectomy without adjuvant therapy were included. Suspicious LN (1–3) detected on choline PET/CT and nearby LN were openly dissected (09/04–02/11). …”
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Acupuncture Combined with Traditional Chinese Medicine and Drug Therapy for the Treatment of Cerebral Infarction (Phlegm-Blood Stasis Syndrome) and Carotid Atherosclerotic Plaque: A Preliminary Randomized Controlled Study by Wentong Wang, Zhuli Liu, Yongxiong Wu

“…Here, we performed a randomized controlled study to investigate the effectiveness of acupuncture combined with drug therapy (TCM and Western) to treat cerebral infarction (phlegm-blood stasis syndrome) and CAP. …”
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Efficacy and Safety of Chemotherapy or EGFR‐TKIs as First‐Line Therapy in NSCLC Patients Harboring Non‐Ex 20 Ins Uncommon EGFR Mutations: A Retrospective Study in China by Chen Liao, Li Bai, Tingting He, Qingle Liang, Defeng Hu, Shipeng Lei, Yong He, Yubo Wang

“…Patients' clinical characteristics and the efficacy and safety of different first‐line therapies were analyzed and compared. Results Our data reviewed that for first‐line therapy, NSCLC patients harboring non‐ex 20 ins uncommon EGFR mutations benefited more from EGFR‐TKIs compared with chemotherapy. …”
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Application and advantages of auricular acupoint pressing therapy in patients with diseases of the digestive system (耳穴压丸在消化系统疾病中的应用及优势) by JI Zhi (姬陟), KONG Huihua (孔会华), LI Ning (李宁), LI Yueru (李月茹), LI Jing (李静), CAO Hongjing (曹红京)

“…Auricular acupoint pressing therapy has certain advantages in relieving symptoms of digestive disorders such as stomach pain, eructation and constipation. …”
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The impact of neuroscience education therapy, behavioral economics, and digital navigators on patient migraine treatment adherence to a mobile health application: a prospective pilot randomized controlled trial by Mia T. Minen, Erin K. Waire, John Torous, Jessica Fishman, Richard B. Lipton, Scott W. Powers

“…Abstract Mobile health (mHealth) tools can be used to deliver nonpharmacologic therapies to patients with migraine. However, mHealth studies often report poor treatment adherence. …”
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Utilizing Technology-Enabled Intervention to Improve Blood Glucose Self-Management Outcome in Type 2 Diabetic Patients Initiated on Insulin Therapy: A Retrospective Real-World Study by Jian Lin, Xia Li, Shan Jiang, Xiao Ma, Yuxin Yang, Zhiguang Zhou

“…This retrospective study included T2DM patients who were initiated on insulin therapy (mostly premixed insulin) after failure to respond to oral antidiabetic drugs. …”
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An Open‐Label Phase II Trial of Pembrolizumab, an Immune Checkpoint Inhibitor Alone or in Combination With Oral Azacitidine as Second‐Line Therapy for Advanced Head and Neck Squamous Cell Cancers by Vinod K. Ramani, Srimonta Gayen, Radheshyam Naik

“…ABSTRACT Background and Aims Sensitivity to immune checkpoint inhibitor (ICI) therapy depends in part on the genetic and epigenetic makeup of cancer cells, and CD8 T‐lymphocytes that mediate immune responses. …”
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HER-SAFE study design: an open-label, randomised controlled trial to investigate the safety of withdrawal of pharmacological treatment for recovered HER2-targeted therapy-related cardiac dysfunction by Robin Chung, James C Moon, Alexander R Lyon, Charlotte H Manisty, Muhummad Sohaib Nazir, Malcolm Walker, Peter Kellman, Benjamin Dowsing, Daniel Chen, Jessica Artico, Mark Westwood, Hakim-Moulay Dehbi, Rebecca Roylance, Tom Crake, Peter Schmid, Arjun Ghosh, Maria Sol Andres, Joanna Pedra, Orla Worn

“…Introduction A quarter of breast cancers show human epidermal growth factor-2 (HER2) overexpression, where targeted therapy dramatically improves survival. However, cancer therapy-related cardiac dysfunction (CTRCD) occurs in up to 15% of patients. …”
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Feasibility and acceptability for LION, a fully remote, randomized clinical trial within the VA for light therapy to improve sleep in Veterans with and without TBI: An MTBI2 sponsored protocol. by Jonathan E Elliott, Jessica S Brewer, Allison T Keil, Brittany R Ligman, Mohini D Bryant-Ekstrand, Alisha A McBride, Katherine Powers, Savanah J Sicard, Elizabeth W Twamley, Maya E O'Neil, Andrea D Hildebrand, Thuan Nguyen, Benjamin J Morasco, Jessica M Gill, Bradley A Dengler, Miranda M Lim

“…These TBI-related sleep impairments confer significant burden and commonly exacerbate other functional impairments. Therapies to improve sleep following mTBI are limited and studies in Veterans are even more scarce. …”
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Comparison of growth hormone therapy response according to the presence of growth hormone deficiency in children born small for gestational age with short stature in Korea: a retrospective cohort study by Ha Young Jo, Hyun Ji Jang, Chong Kun Cheon, Ju Young Yoon, Sukdong Yoo, Jung Hyun Lee, Jeong Eun Lee, Ye Jin Kim, Sejin Kim, Hyun-Ji Kim, Im Jeong Choi, Min Jung Kwak

“…Nonetheless, if there are any signs of decreased growth velocity or hypopituitarism, the presence of GHD should be assessed before GH therapy, and personalized therapy based on the results is required.…”
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Safety of a co-designed cognitive behavioural therapy intervention for people with type 1 diabetes and eating disorders (STEADY): a feasibility randomised controlled trialResearch in context by Marietta Stadler, Natalie Zaremba, Amy Harrison, Jennie Brown, Divina Pillay, Jacqueline Allan, Rachael Tan, Salma Ayis, Emmanouela Konstantara, Janet Treasure, David Hopkins, Khalida Ismail

Subjects: “…Cognitive behavioural therapy…”
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Research progress of non-drug therapy for post-stroke patients with cognitive impairment (脑卒中后认知障碍患者非药物治疗的研究进展) by SONG Wanchen (宋宛宸), DENG Ying (邓颖), HUANG Shan (黄山), LI Yang (李洋)

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Effectiveness of direct patient outreach with a narrative naloxone and overdose prevention video to patients prescribed long-term opioid therapy in the USA: the Naloxone Navigator randomised clinical trial by Jason M Glanz, Ingrid A Binswanger, Shane R Mueller, Komal J Narwaney, Nicole M Wagner, Stanley Xu, Courtney R Kraus, Kris Wain, Sheila Botts

“…People receiving long-term opioid therapy (LTOT) are at increased risk for overdose, yet naloxone uptake in this population remains low. …”
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Towards a conceptual framework of the working alliance in a blended low-intensity cognitive behavioural therapy intervention for depression in primary mental health care: a qualitative study by Sarah Smith, Caroline Free, Daniel Michelson, Jesus Montero-Marin, Ricardo Araya, Asmae Doukani, Arlinda Cerga-Pashoja, Ritsuko Kakuma

“…Objectives To examine and adapt a conceptual framework of the working alliance (WA) in the context of a low-intensity blended (psychological well-being practitioner (PWP) plus computerised program) cognitive behavioural therapy intervention (b-CBT) for depression.Design Patient involvement was enlisted to collaboratively shape the design of the project from the onset, before data collection. …”
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Safety and efficacy of dual versus triple antithrombotic therapy (DAT vs TAT) in patients with atrial fibrillation following a PCI: a systematic review and network meta-analysis by Abdulaali R Almutairi, Renad M Altoukhi, Reema A Alshouimi, Shahad M Al Rammah, Mohammed Y Alzahrani, Abdulmajeed M Alshehri, Osamah M Alfayez, Majed S Al Yami, Omar A Almohammed

“…Objective Creating an appropriate antithrombotic therapy for patients with atrial fibrillation (AF) who have undergone percutaneous coronary intervention (PCI) remains a dilemma. …”
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Dual antiplatelet therapy with ticagrelor vs clopidogrel in patients with TIA or minor stroke with or without symptomatic carotid artery stenosis: a post hoc analysis of the CHANCE-2 trial by Yongjun Wang, Yilong Wang, Xingquan Zhao, Jing Jing, Hao Li, Xia Meng, Anxin Wang, Yong Jiang, Jinxi Lin, Qin Xu, Xuewei Xie, Pan Chen

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