Safety and efficacy of CD33-targeted CAR-NK cell therapy for relapsed/refractory AML: preclinical evaluation and phase I trial by Ruihao Huang, Xiaoqi Wang, Hongju Yan, Xu Tan, Yingying Ma, Maihong Wang, Xiao Han, Jia Liu, Li Gao, Lei Gao, Guangjun Jing, Cheng Zhang, Qin Wen, Xi Zhang

“…Although chimeric antigen receptor (CAR)-T-cell therapy has shown promising effects in acute lymphoblastic leukemia (ALL) and lymphoma, its application in R/R AML is limited by “off-target” effects, which lead to severe bone marrow suppression and limit its clinical application. …”
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Cognitive behavior therapy for academic burnout, procrastination, self-handicapping behavior, and test anxiety among adolescents: a randomized control trial by Khizra Khurshid, Rabia Mushtaq, Umara Rauf, Nida Anwar, Qasir Abbas, Sumayah Aljhani, Zoobia Ramzan, Mafia Shahzadi

“…The present study is designed to investigate the impact of cognitive behavioural therapy (CBT) on procrastination, burnout, self-handicapping behaviour, test anxiety, and school functioning among adolescents facing academic problems. …”
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Results from a UK consensus about the optimal prescribing of medium strength triple therapy in uncontrolled adult asthma patients in the NHS by Richard E. K. Russell, Darush Attar-Zadeh, Natalie Harper, Fiona Mosgrove, Laura Rush, Dave Singh

“…Aims: To define the optimal prescribing of medium-strength ICS/LABA/LAMA triple therapy in adult asthma patients uncontrolled on ICS/LABA. …”
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Stakeholder perspectives on implementation of internet-delivered cognitive behaviour therapy in physical medicine rehabilitation setting using the Consolidated Framework for Implementation Research by Swati Mehta, Ujjoyinee Barua, Marcie Nugent, Kevin Hansen, Luvish Sondhi, Randy Upper, Dalton Wolfe, Eldon Roh, Keith Sequeira, Robert Teasell, Heather D. Hadjistavropoulos

Subjects: “…internet delivered cognitive behaviour therapy…”
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A retrospective study on potential drug‒drug interactions in patients with severe asthma receiving biological therapy: a single-center experience by Mirna Momcilovic, Petra Turcic, Franka Butkovic, Sanja Popovic Grle

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Salvage of Upper Limb following a Severe Crushing Trauma: Immediate Reconstruction with a Free Flap and Subsequent Hyperbaric Oxygen Therapy by M. P. Serra, P. Longhi

“…The authors present a case report where a free latissimus dorsi flap with subsequent hyperbaric oxygen therapy allowed a successful single stage reconstruction of this complex severely contaminated defect.…”
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Comparative Evaluation of Postoperative Incisional Negative Pressure Wound Therapy with Conventional Dressings in Patients of Proximal Tibia Fracture Managed by Dual Plating by Pranav Kothiyal, Kunal Vij, Puneet Gupta

Subjects: “…negative pressure wound therapy…”
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Comparison of outcome and toxicity of postoperative intensity‐modulated radiation therapy with two‐dimensional radiotherapy in patients with soft tissue sarcoma of extremities and trunk by Jianyang Wang, Yongwen Song, Xinfan Liu, Jing Jin, Weihu Wang, Zihao Yu, Yueping Liu, Ning Li, Hui Fang, Hua Ren, Yuan Tang, Yu Tang, Bo Chen, Ningning Lu, Shunan Qi, Shulian Wang, Yexiong Li

Subjects: “…intensity‐modulated radiation therapy…”
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Differences in catheter-related complications to insertion site selection for long peripheral intravenous catheters in antimicrobial therapy: a randomized controlled trial by Linfang Zhao, Xianghong Jin, Xiangyun Li, Chang Liu, Jie Wang, Xiuzhu Cao, Xufen Zeng, Yiyu Zhuang

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Preclinical Evaluation of Oncolytic Δγ134.5 Herpes Simplex Virus Expressing Interleukin-12 for Therapy of Breast Cancer Brain Metastases by James J. Cody, Pietro Scaturro, Alan B. Cantor, G. Yancey Gillespie, Jacqueline N. Parker, James M. Markert

“…Thus, we conclude from this proof-of-principle study that a γ134.5-deleted IL-12 expressing oncolytic HSV may be a potential new therapy for breast cancer brain metastases.…”
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Percutaneous Mitral Valve Repair versus Optimal Medical Therapy in Patients with Functional Mitral Regurgitation: A Systematic Review and Meta-Analysis by Muhammad Uzair Lodhi, Muhammad Shariq Usman, Tariq Jamal Siddiqi, Muhammad Shahzeb Khan, Muhammad Arbaz Arshad Khan, Safi U. Khan, Intekhab Askari Syed, Mustafa Rahim, Srihari S. Naidu, Rami Doukky, Mohamad Alkhouli

“…To compare percutaneous mitral valve repair (PMVR) with optimal medical therapy (OMT) in patients with heart failure (HF) and severe functional mitral regurgitation (FMR). …”
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Steroid Pulse Therapy for Severe Central Nervous System Involvement in Shiga Toxin-Producing Escherichia coli-Related Hemolytic Uremic Syndrome by Chiara Rosazza, Alberto M Cappellari, Cristiano Gandini, Elisa Scola, Gianluigi Ardissino

“…Therefore, neurologic manifestations were thought to be related to reperfusion damage to the CNS and high-dose IV steroid pulse therapy was empirically administered. Following this therapeutic scheme, neurologic involvement resolved with no sequelae. …”
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SARS-CoV-2 infections in pediatric and young adult recipients of chimeric antigen receptor T-cell therapy: an international registry report by Hongyan Liu, Colleen Callahan, Shannon L Maude, Kevin Owen McNerney, Rebecca M Richards, Paibel Aguayo-Hiraldo, Friso G Calkoen, Julie-An Talano, Amy Moskop, Adriana Balduzzi, Jennifer Krajewski, Hema Dave, Anant Vatsayan, Yimei Li, Kara Lynn Davis

“…Journal for ImmunoTherapy of Cancer…”
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Components of cognitive–behavioural therapy for mitigating core symptoms in attention-deficit hyperactivity disorder: a systematic review and network meta-analysis by Sayo Hamatani, Kazuki Matsumoto, Yoshihiko Kunisato, Yoshifumi Mizuno

“…Question Cognitive–behavioural therapy (CBT) is frequently implemented for individuals with attention-deficit hyperactivity disorder (ADHD). …”
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Effects of low-level diode laser therapy as an adjunct to modified Widman flap in subjects with Stage III periodontitis: A clinical study by Shailesh Varshney, Rajkumar Kelvin, M. Siddharth

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Catheter-Directed Therapies for Deep Vein Thrombosis and Pulmonary Embolism: Nationwide Trends in Medicare Part B Patients from 2015 to 2021 by Alex G. Thomas, Osman S. Ahmed, Qian Yu, Divya Kumari, Mikin V. Patel

Subjects: “…catheter-directed therapy…”
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Combination Therapy of an Intestine-Specific Inhibitor of Microsomal Triglyceride Transfer Protein and Peroxisome Proliferator-Activated Receptor γ Agonist in Diabetic Rat by Shohei Sakata, Yasuko Mera, Yukiharu Kuroki, Reiko Nashida, Makoto Kakutani, Takeshi Ohta

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Enhancing antibacterial photodynamic therapy with NIR‐activated gold nanoclusters: Atomic‐precision size effect on reducing bacterial biofilm formation and virulence by Chengyu Liu, Tenghui Tian, Yujia Shi, Meiqi Li, Le Hong, Jing Zhou, Jia Liu, Yuan Zhong, Xue Wang, Zhenyu Wang, Xue Bai, Lin Wang, Chunyan Li, Zhennan Wu

Subjects: “…antibacterial photodynamic therapy…”
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Pembrolizumab with external radiation therapy effectively controlled TMB-high unresectable recurrent parathyroid cancer: a case report with review of literature by Hiroshi Katoh, Tomoya Mitsuma, Riku Okamoto, Kanako Naito, Takaaki Tokito, Mariko Kikuchi, Takafumi Sangai

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Early antiretroviral therapy in SIV-infected rhesus macaques reveals a multiphasic, saturable dynamic accumulation of the rebound competent viral reservoir. by Brandon F Keele, Afam A Okoye, Christine M Fennessey, Benjamin Varco-Merth, Taina T Immonen, Emek Kose, Andrew Conchas, Mykola Pinkevych, Leslie Lipkey, Laura Newman, Agatha Macairan, Marjorie Bosche, William J Bosche, Brian Berkemeier, Randy Fast, Mike Hull, Kelli Oswald, Rebecca Shoemaker, Lorna Silipino, Robert J Gorelick, Derick Duell, Alejandra Marenco, William Brantley, Jeremy Smedley, Michael Axthelm, Miles P Davenport, Jeffrey D Lifson, Louis J Picker

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