Crystalline-Like Keratopathy after Intravenous Immunoglobulin Therapy with Incomplete Kawasaki Disease: Case Report and Literature Review by Elif Erdem, Emine Kocabas, Hande Taylan Sekeroglu, Özlem Özgür, Meltem Yagmur, T. Reha Ersoz

Get full text

Oligodendrocyte precursor cell-derived exosomes combined with cell therapy promote clinical recovery by immunomodulation and gliosis attenuation by Sarah Ingrid Pinto Santos, Santiago José Ortiz-Peñuela, Alessandro de Paula Filho, Ana Laura Midori Rossi Tomiyama, Lilian de Oliveira Coser, Juliano Coelho da Silveira, Daniele dos Santos Martins, Adriano Polican Ciena, Alexandre Leite Rodrigues de Oliveira, Carlos Eduardo Ambrósio

“…However, the exclusive application of cell therapy has not proved sufficient to achieve satisfactory therapeutic levels. …”
Get full text

Mechanistic Rationale and Clinical Efficacy of Hyperbaric Oxygen Therapy in Chronic Neuropathic Pain: An Evidence-Based Narrative Review by Simone Schiavo, Julian DeBacker, Carine Djaiani, Anuj Bhatia, Marina Englesakis, Rita Katznelson

“…A growing body of evidence supports the use of hyperbaric oxygen therapy (HBOT) in several chronic neuropathic pain conditions; however, its role and efficacy remain unclear. …”
Get full text

Children with autoimmune hepatitis receiving standard-of-care therapy demonstrate long-term obesity and linear growth delay by Or Steg Saban, Shannon M. Vandriel, Syeda Aiman Fatima, Celine Bourdon, Amrita Mundh, Vicky L. Ng, Simon C. Ling, Robert H.J. Bandsma, Binita M. Kamath

“…Background:. Standard-of-care therapy in children with autoimmune hepatitis (AIH) includes induction with prednisone 1–2 mg/kg daily with gradual weaning of the dose. …”
Get full text

Empiric antibiotic therapy resistance and mortality in emergency department patients with bloodstream infection: a retrospective cohort study by Leonhard M. von Beck, Gabriella Anna Rapszky, Veronika E. Kiss, Szilard Sandor, Szabolcs Gaal-Marschal, Tamas Berenyi, Csaba Varga, Bank G. Fenyves

“…Patients with a positive blood culture receiving emergency department-initiated antibiotic therapy were included. Antibiotic administration, resistance, and survival data were collected. …”
Get full text

Efficient and Fast Differentiation of Human Neural Stem Cells from Human Embryonic Stem Cells for Cell Therapy by Xinxin Han, Liming Yu, Jie Ren, Min Wang, Zhongliang Liu, Xinyu Hu, Daiyu Hu, Yihong Chen, Li Chen, Ying Zhang, Yuehua Liu, Xiaoqing Zhang, Hua He, Zhengliang Gao

“…Stem cell-based therapies have been used for repairing damaged brain tissue and helping functional recovery after brain injury. …”
Get full text

Evaluation of fluorinated phospholipid analogs: A study on ADMET profiles, molecular docking and dynamics simulation in anticancer therapy by Saqib Ishaq, Obaid Habib, Abdul Aziz, Raheel Tahir, Hira Mushtaq, Said Hassan, Sarah Sarwar, Mohammad S. Mubarak, Ajaz Ahmad, Amin Ullah

“…These findings position Edelfosine drug as a promising candidate for targeted cancer therapy appropriated further experimental validation to elucidate its mechanisms of action and therapeutic efficacy.…”
Get full text

The Lipodystrophy Syndrome in HIV-Infected Children under Antiretroviral Therapy: A First Report from the Central Africa by Honoré Kalombayi Tshamala, Loukia Aketi, Pierre Manianga Tshibassu, Mathilde Bothale Ekila, Eric Musalu Mafuta, Patrick Kalambayi Kayembe, Michel Ntetani Aloni, Joseph Diayisu Shiku

“…Despite the high prevalence of the HIV/AIDS, few studies focused on the prevalence of lipodystrophy in pediatric HIV patients on antiretroviral therapy (ARV) in sub-Saharan African countries. The aim of this study was to assess the prevalence and to identify the risk factors of metabolic disorders related to ARV therapy in this population. …”
Get full text

Immunotherapy and Antivascular Targeted Therapy in Patients’ Treatment with Concurrent Malignant Tumors after Organ Transplantation: Opportunity or Challenge by Bairu Shen, Zi Guo, Peng Huang, Minghua Tan, Xiaoshen Zhang, Siyao Lin, Changshan Song, Jiaqing Wang, Minqian Huang

“…To analyze the therapeutic effects and organ rejection of anti-PD-1 immunotherapy or antivascular targeting therapy on patients with combined malignancies after organ transplantation. …”
Get full text

Nanoparticle Therapy Is a Promising Approach in the Management and Prevention of Many Diseases: Does It Help in Curing Alzheimer Disease? by Lamyaa M. Kassem, Nada A. Ibrahim, S. Ayesha Farhana

Get full text

CD19-directed chimeric antigen receptor T-cell therapy: what can we learn from the haematologist? by Marie José Kersten, Maria Theresa Kuipers

“…CD19-directed chimeric antigen receptor (CAR) T-cell therapy, originally developed for haematological malignancies, has recently emerged as a promising therapy for patients with autoimmune diseases. …”
Get full text

Investigating Non-steroidal Anti-Inflammatory Drugs as Potential Cancer Adjuncts: A Novel Approach to Cancer Therapy by Sadaf Alam, Leena Anjum, Muhammad Haneef

“…These drugs reduce inflammation and regulate key biological pathways involved in cancer progression, offering new avenues for prevention and therapy. Methodology: A comprehensive review of clinical, epidemiological, and experimental studies was conducted to assess the roles of NSAIDs including aspirin, meloxicam, celecoxib, sulindac, naproxen, indomethacin, and piroxicam, in cancer treatment. …”
Get full text

Personalized metronomic radiopharmaceutical therapy through injection profile optimization via physiologically based pharmacokinetic (PBPK) modeling by Aryan Golzaryan, M. Soltani, Farshad Moradi Kashkooli, Babak Saboury, Arman Rahmim

Subjects: “…Metronomic radiopharmaceutical therapy…”
Get full text

Efficacy and Safety of the Triple Therapy Containing Ilaprazole, Levofloxacin, and Amoxicillin as First-Line Treatment in Helicobacter pylori Infections by Hyo Jun Ahn, Dong Pil Kim, Myeong Su Chu, Hyeon Jeong Yun, Seok-Hwan Kim, Seung Woo Lee, Dong Soo Lee

“…Conclusions. A 10-day triple therapy containing ilaprazole, levofloxacin, and amoxicillin is a safe alternative first-line eradication treatment for H. pylori.…”
Get full text

Internet-based cognitive behavioural therapy for adults with tinnitus in the UK: study protocol for a randomised controlled trial by Peter M Allen, David M Baguley, Gerhard Andersson, Eldré W Beukes, Vinaya Manchaiah

“…An internet-based cognitive behavioural therapy (iCBT) intervention has been developed in Sweden to improve access to evidence-based tinnitus treatments. …”
Get full text

Inhibition of Steroid Sulfatase Activity in Endometriotic Implants by STX64 (667Coumate): A Potential New Therapy by L. Fusi, A. Purohit, J. Brosens, L. W. L. Woo, B. V. L. Potter, M. J. Reed

Get full text

A Randomized Controlled Trial Comparing Sequential with Triple Therapy for Helicobacter pylori in an Aboriginal Community in the Canadian North by Amy L Morse, Karen J Goodman, Rachel Munday, Hsiu-Ju Chang, John Morse, Monika Keelan, Janis Geary, Sander Veldhuyzen van Zanten, CAN Help Working Group

Get full text

Therapeutic effects of NAC and CoQ10 on aluminium phosphide poisoning as an adjuvant therapy: A Pilot study by Maii Farag Henaidy, Maha Ghanem, Shehata Farag Shehata, Amal M. Shouair, Reda R. Mabrouk

“…This study investigated a new approach for treating acute AlP poisoning by using NAC and Co-Q10 as adjuvant therapy. Subjects and methods: The study design was a retrospective-prospective study. …”
Get full text

Using a mobile application for antiretroviral therapy adherence in people living with HIV: A longitudinal pilot study by Rejane Caetani, Susana L. Wiechmann, Jacques D. Brancher, Vitor H.F Oliveira, Rafael Deminice

Subjects: Get full text

Acceptance, Safety, and Effect Sizes in Online Dialectical Behavior Therapy for Borderline Personality Disorder: Interventional Pilot Study by Ruben Vonderlin, Tali Boritz, Carola Claus, Büsra Senyüz, Saskia Mahalingam, Rachel Tennenhouse, Stefanie Lis, Christian Schmahl, Jürgen Margraf, Tobias Teismann, Nikolaus Kleindienst, Shelley McMain, Martin Bohus

“…ObjectiveThis study aims to provide initial effect size estimates of symptom change from pre- to post treatment, and the acceptance and safety of telehealth dialectical behavior therapy (DBT) for individuals diagnosed with borderline personality disorder (BPD). …”
Get full text