Clinical determinants and prognostic implications of renin and aldosterone in patients with symptomatic heart failure by Masatake Kobayashi, Susan Stienen, Jozine M. terMaaten, Kenneth Dickstein, Nilesh J. Samani, Chim C. Lang, Leong L. Ng, Stefan D. Anker, Macro Metra, Gregoire Preud'homme, Kevin Duarte, Zohra Lamiral, Nicolas Girerd, Patrick Rossignol, Dirk J. vanVeldhuisen, Adriaan A. Voors, Faiez Zannad, João Pedro Ferreira

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Systematic Sex-Based Inequity in the MELD Score-Based Allocation System for Liver Transplantation in Germany by Leke Wiering, Leke Wiering, Annette Aigner, Marieke van Rosmalen, Brigitta Globke, Brigitta Globke, Tomasz Dziodzio, Nathanael Raschzok, Nathanael Raschzok, Münevver Demir, Wenzel Schöning, Frank Tacke, Petra Reinke, Johann Pratschke, Robert Öllinger, Paul V. Ritschl, Paul V. Ritschl

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Survey on first-line therapeutic management of relapsing–remitting multiple sclerosis in clinical practice in Spain by M. Llaneza, G. Fontes, L. Benedito-Palos, E. Moral

“…Introduction: Current therapies for relapsing–remitting multiple sclerosis (RRMS) help reduce morbidity and delay disease progression. …”
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[Translated article] Can 3D-printed patient-specific instruments improve local control and overall survival in pelvic sarcoma? A clinical validation study by T. Fernández-Fernández, L. Mediavilla-Santos, M. Cuervo-Dehesa, E. Gómez-Larrén, R. Pérez-Mañanes, J. Calvo-Haro

“…Demographic and clinical data, including tumor histology, stage, resection technique, associated reconstruction, adjuvant therapies, and complications, were evaluated. Surgical margins (free, marginal, and contaminated) and relapse-free and overall survival curves were analyzed. …”
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Revealing the biological features of the axolotl pancreas as a new research model by Hui Ma, Hui Ma, Hui Ma, Guangcong Peng, Yan Hu, Binbin Lu, Binbin Lu, Yiying Zheng, Yingxian Wu, Weimin Feng, Yu Shi, Xiangyu Pan, Li Song, Ina Stützer, Yanmei Liu, Jifeng Fei, Jifeng Fei, Jifeng Fei

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Case Reports: The core of practice-based evidence by Antonio Villa

“…Furthermore, a case report is often the most important source of information on adverse effects following therapies. According to Greenwalt, case reports can explain a complex reality, because “a carefully documented study of an unusual patient represents an experiment of nature that may be the opportunity to explain a long-recorded but unexplained clinical mystery” [3]. …”
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T Cell-Derived Apoptotic Extracellular Vesicles Ameliorate Bone Loss via CD39 and CD73-Mediated ATP Hydrolysis by Yang X, Zhou Y, Zhou F, Bao L, Wang Z, Li Z, Ding F, Kuang H, Liu H, Tan S, Qiu X, Jing H, Liu S, Ma D

“…Our data underscore the substantive role of T cell-derived ApoEVs to treat osteoporosis, thus providing new ideas for the development of ApoEVs-based therapies in tissue regeneration. Keywords: T cell apoptosis, apoptotic extracellular vesicles, CD39, CD73, adenosine, bone regeneration…”
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Guías impresas en 3D: ¿mejoran el control local y la supervivencia global en el tratamiento de los sarcomas pélvicos? Estudio de validación clínica by T. Fernández-Fernández, L. Mediavilla-Santos, M. Cuervo-Dehesa, E. Gómez-Larrén, R. Pérez-Mañanes, J. Calvo-Haro

“…Demographic and clinical data, including tumor histology, stage, resection technique, associated reconstruction, adjuvant therapies, and complications, were evaluated. Surgical margins (free, marginal, and contaminated) and relapse-free and overall survival curves were analyzed. …”
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Optimizing Prescribing for Individuals With Type 2 Diabetes and Chronic Kidney Disease Through the Development and Validation of Algorithms for Community Pharmacists by Jennifer Morris, Marisa Battistella, Karthik Tennankore, Steven Soroka, Cynthia Kendell, Penelope Poyah, Keigan More, Mathew Grandy, Thomas Ransom, Natalie Kennie-Kaulbach, Daniel Rainkie, Jaclyn Tran, Syed Sibte Raza Abidi, Samina Abidi, Nicole Fulford, Heather Neville, Heather Naylor, Lisa Woodill, Andrea Bishop, Glenn Rodrigues, Diane Harpell, Michelle Stewart, Jo-Anne Wilson

“…Objective: The objective was to develop and validate pharmacist algorithms to confirm T2D and CKD and to prescribe guideline-directed therapies for individuals with an estimated glomerular filtration rate (eGFR) of 30 to 60 mL/min/1.73 m² in community pharmacy primary care clinics in Nova Scotia. …”
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Microbial metabolites and immune modulation by Hassan Ghasemi

“…In cancer immunotherapy, SCFAs enhance the efficacy of immune checkpoint inhibitors like anti-PD-1/PD-L1 therapies by reshaping the tumor microenvironment toward an anti-tumoral state. …”
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EDENT1FI Master Protocol for screening of presymptomatic early-stage type 1 diabetes in children and adolescents by Melanie Gündert, Anette-Gabriele Ziegler, Peter Achenbach, Olga Kordonouri, Agnieszka Szypowska, Ezio Bonifacio, Parth Narendran, Christiane Winkler, R Ribeiro, Sandra Hummel, Przemysława Jarosz-Chobot, Emanuele Bosi, R Lahesmaa, K Casteels, M Peakman, P Jarosz-Chobot, O Kordonouri, Chantal Mathieu, Vito Lampasona, J F Raposo, H Hyöty, F Pociot, João Filipe Raposo, R Berner, R Bergholdt, E Bonifacio, Flemming Pociot, B Petersen, J Van Rampelbergh, L Overbergh, B Van der Schueren, V Lampasona, C Winkler, R Coelho, O Cohen, C Mathieu, E Bosi, Stefanie Arnolds, Lut Overbergh, Zdenek Sumnik, A Koralova, G Sebastiani, Luisa Hoffmann, Mirjam Kohls, Regine Bergholdt, Bianca K Hoefelschweiger, Jurgen Vercauteren, P Gillard, J Vercauteren, A G Ziegler, P Achenbach, F Haupt, S Hummel, T Pieber, J Mader, S Moitzi, S Del Prato, B Torbeyns, Z Sumnik, O Cinek, V Neuman, B Berka, J Antvorskov, J H Klaebel, J E Laiho, F Reschke, T von dem Berge, A Hommel, A Loff, G Gemulla, N Zubizarreta, L Piemonti, F Dotta, A Szypowska, K Karczewski, E Niemoeller, M Baccara-Dinet, K Fogh, M I Buompensiere, C Hurtado del Pozo, E Latres, G Agiostratidou

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Therapeutic plasma exchange accelerates immune cell recovery in severe COVID-19 by Aurelie Guironnet-Paquet, Aurelie Guironnet-Paquet, Hind Hamzeh-Cognasse, Frederic Berard, Fabrice Cognasse, Fabrice Cognasse, Jean Christophe Richard, Hodane Yonis, Mehdi Mezidi, Olivier Desebbe, Bertrand Delannoy, Sophie Demeret, Clemence Marois, Clemence Marois, Clemence Marois, Samir Saheb, Quoc Viet Le, Mathieu Schoeffler, Paul Simon Pugliesi, Sophie Debord, Paul Bastard, Paul Bastard, Paul Bastard, Paul Bastard, Aurélie Cobat, Aurélie Cobat, Aurélie Cobat, Jean Laurent Casanova, Jean Laurent Casanova, Jean Laurent Casanova, Jean Laurent Casanova, Jean Laurent Casanova, Rémi Pescarmona, Sébastien Viel, Jean François Nicolas, Jean François Nicolas, Audrey Nosbaum, Audrey Nosbaum, Marc Vocanson, Olivier Hequet, Olivier Hequet

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Contextual Vulnerability Should Guide Fair Subject Selection in Xenotransplantation Clinical Trials by Gianna Strand

“…This potential subject population includes individuals with broadly reactive antibodies who are unlikely to match to a donor organ and individuals with anatomical contraindications who face prohibitive risks with standard allografts or bridging therapies.[xl] This subject population aligns with the FDA recommendation to enroll subjects for whom safe and effective alternatives are not available.…”
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