Rational design, synthesis, in vitro, and in-silico studies of pyrazole‑phthalazine hybrids as new α‑glucosidase inhibitors by Mehrdad Roshan, Roghieh Mirzazadeh, Azadeh Tajmir-Riahi, Mohammad Sadegh Asgari

“…The rationale for this study stems from the need for new, more effective inhibitors of α-glucosidase with improved efficacy and safety profiles compared to currently available therapies like Acarbose. The synthesized compounds were tested against the yeast α-glucosidase enzyme and showed significantly higher activity than the standard drug Acarbose. …”
Get full text

Platelet Responses in Cardiovascular Disease: Sex-Related Differences in Nutritional and Pharmacological Interventions by Valeria Gasperi, M. Valeria Catani, Isabella Savini

“…Here, we examined the state of the art concerning sex differences in platelet biology and their relationship with specific cardiovascular events and responses to common antiplatelet therapies. Moreover, as healthy nutrition is widely recognized to play a key role in CVD, we also focused our attention on specific dietary components (especially polyunsaturated fatty acids and flavonoids) and patterns (such as Mediterranean diet), which also emerged to impact platelet functions in a sex-dependent manner. …”
Get full text

Emerging antifungal resistance in Trichophyton mentagrophytes: insights from susceptibility profiling and genetic mutation analysis by Yakun Shao, Jin Shao, Sybren de Hoog, Paul Verweij, Lin Bai, Riina Richardson, Malcolm Richardson, Zhe Wan, Ruoyu Li, Jin Yu, Yinggai Song

“…Together, these findings highlight a growing prevalence of antibiotic resistance among Trichophyton and identify potential target genes for new therapies, underscoring the need for ongoing monitoring and offering directions for novel therapeutics.…”
Get full text

Slipping Rib Syndrome in a Female Adult with Longstanding Intractable Upper Abdominal Pain by Noman Ahmed Jang Khan, Saba Waseem, Saad Ullah, Hassan Mehmood

“…She underwent frequent physical therapies, treated with multiple muscle relaxants and analgesics with minimal improvement. …”
Get full text

Theoretical and Practical Issues That Are Relevant When Scaling Up hMSC Microcarrier Production Processes by Valentin Jossen, Cedric Schirmer, Dolman Mostafa Sindi, Regine Eibl, Matthias Kraume, Ralf Pörtner, Dieter Eibl

“…The potential of human mesenchymal stem cells (hMSCs) for allogeneic cell therapies has created a large amount of interest. However, this presupposes the availability of efficient scale-up procedures. …”
Get full text

Effects of radiation and manganese oxide nanoparticles on human glioblastoma cell line U-87 MG glycolysis by N. B. Illarionova, D. V. Petrovski, I. A. Razumov, E. L. Zavyalov

“…This study may be useful for the development of new therapies and diagnosis of gliomas.…”
Get full text

Pan-cancer analysis of the immunological and oncogenic roles of ATAD2 with verification in papillary thyroid carcinoma by Zhecheng Li, Yaxin Zhao, Peng Huang, Zhaoyi Wu, Dengjie Ouyang, Adolphus Osei Nyarko, Lei Ai, Zhejia Zhang, Shi Chang

“…Collectively, ATAD2 holds promise as a biomarker for pan-cancer diagnosis and prognosis, as well as a predictor of immunotherapeutic responsiveness and a therapeutic target to enhance the efficacy of existing anti-tumor immune therapies.…”
Get full text

Versatile High-Throughput Platform for Focused Ultrasound In Vitro Application by Steffen H. Tretbar, Marc Fournelle, Christian Degel, Franz-Josef Becker, Peter Weber, Sarah Therre-Mohr, Wolfgang Bost, Lisa Landgraf, Andreas Melzer

“…For the more efficient application of ultrasound in future therapies, fundamental research is needed on the mode of action of ultrasound on biological systems using therapeutic frequencies. …”
Get full text

Bile cast nephropathy (cholemic nephropathy) associated with hepatitis A-induced acute liver failure and haemolysis in a patient with glucose-6-phosphate dehydrogenase deficiency by Ali Hamdan, Johny Salem, Karam Karam, Maria Ziadeh, Pierre Hani

“…In this case, plasmapheresis effectively reduced bilirubin and inflammatory mediators, while haemodialysis addressed renal dysfunction. Together, these therapies were crucial in stabilising renal function. …”
Get full text

Impacts of home-based physical exercises on the health of people with spinal cord injury: a systematic review by José Igor Vasconcelos de Oliveira, Lúcia Inês Guedes Leite de Oliveira, Manoel da Cunha Costa, Raphael José Perrier-Melo, Mário Antônio de Moura Simim, Saulo Fernandes Melo de Oliveira

“…In view of the countless therapies targeted at this public, it is necessary to highlight the benefits of exercises performed at home. …”
Get full text

Semiautomatic Landmark-Based Two-Dimensional—Three-Dimensional Image Fusion in Living Mice: Correlation of Near-Infrared Fluorescence Imaging of Cy5.5-Labeled Antibodies with Flat-... by Christian Dullin, Marta Zientkowska, Joanna Napp, Jeannine Missbach-Guentner, Hans-Willi Krell, Friedemann Muller, Eckhardt Grabbe, Lutz-F. Tietze, Frauke Alves

“…The combination of fpVCT with NIRF imaging will now allow targeted and effective monitoring of preclinical tumor therapies.…”
Get full text

The multifaceted anti-atherosclerotic properties of herbal flavonoids: A comprehensive review by Meiwen Huang, Xuena Xie, Rong Yuan, Qiqi Xin, Shudong Ma, Hongai Guo, Yu Miao, Chunyu Hu, Yizhun Zhu, Weihong Cong

“…This comprehensive review endeavors to synthesize and analyse the most recent findings on herbal flavonoids, shedding light on their anti-atherosclerotic potential and the underlying protective mechanisms and related-targets, which might pave the way for the development of novel drug candidates or the optimization of flavonoid-based therapies.…”
Get full text

A novel 4-(1,3,4-thiadiazole-2-ylthio)pyrimidine derivative inhibits cell proliferation by suppressing the MEK/ERK signaling pathway in colorectal cancer by Li Weiwei, Yang Zhifu, Ding Likun, Wang Ying, Zhao Xian, Chu Jian Jie, Ji Qing, Yao Minna, Wang Jingwen

“…Although molecularly targeted therapies have significantly improved treatment outcomes, most of these target inhibitors are resistant. …”
Get full text

Gamified Shoulder Rehabilitation for Mild Stroke Patients Using Virtual Reality by Roy Francis Navea, Vincent Mao Talde, Francisco Luis Armintia, Sarrah Mae Dela Cruz, Gabriel Medina, Alvin Decena

“…The feedback and evaluation results from participants showed that, on average, 75% agreed with the metrics used, underscoring the significance of participant feedback and involvement in effective rehabilitation therapies, while perceptions of effectiveness, which influenced motivation and adherence, highlighted the importance of enhancing user experience in VR rehabilitation for better recovery outcomes which is supported by 69% of participant’s agreement. …”
Get full text

Development of Automated Image Processing for High-Throughput Screening of Potential Anti-Chikungunya Virus Compounds by Pathaphon Wiriwithya, Siwaporn Boonyasuppayakorn, Pattadon Sawetpiyakul, Duangpron Peypala, Gridsada Phanomchoeng

“…Chikungunya virus, a member of the Alphavirus genus, continues to present a global health challenge due to its widespread occurrence and the absence of specific antiviral therapies. Accurate detection of viral infections, such as chikungunya, is critical for antiviral research, yet traditional methods are time-consuming and prone to error. …”
Get full text

Age-Related Changes in Nucleus Pulposus Mesenchymal Stem Cells: An In Vitro Study in Rats by Yachao Zhao, Zhiwei Jia, Shanshan Huang, Yaohong Wu, Longgang Liu, Linghan Lin, Deli Wang, Qing He, Dike Ruan

“…The functions of mesenchymal stem cells (MSCs) appear to decline with age due to cellular senescence, which could reduce the efficacy of MSCs-based therapies. Recently, MSCs have been identified in the nucleus pulposus, which offers great potential for intervertebral disc (IVD) repair. …”
Get full text

Management of Oro-Antral Communication: A Systemic Review of Diagnostic and Therapeutic Strategies by Gianna Dipalma, Angelo Michele Inchingolo, Irma Trilli, Laura Ferrante, Angela Di Noia, Elisabetta de Ruvo, Francesco Inchingolo, Antonio Mancini, Stefan Cocis, Andrea Palermo, Alessio Danilo Inchingolo

“…Multidisciplinary collaboration, along with timely surgical intervention and adherence to medical therapies, is essential for successful management. …”
Get full text

Distribution, Phytochemical Insights, and Cytotoxic Potential of the <i>Sesbania</i> Genus: A Comprehensive Review of <i>Sesbania grandiflora</i>, <i>Sesbania sesban</i>, and <i>Se... by Fatma Alzahraa Mokhtar, Mariam Ahmed, Aishah Saeed Al Dhanhani, Serag Eldin I. Elbehairi, Mohammad Y. Alfaifi, Ali A. Shati, Amal M. Fakhry

“…While further research is warranted, the <i>Sesbania</i> genus offers a promising basis for the development of innovative anticancer therapies.…”
Get full text

Comparative analysis of Proximate and Anti-fungal Activities on Palm Oil Treated Ash Extracts of Musa sapientum and Musa paradisiaca Peels collected from Local Market in Akwa Ibom... by I. D. Uffia, O. E. Udofia, M. E. Bassey, R. O. Esen, E. J. Egong, O. D. Akan

“… Extracts from banana and plantain parts (flowers, bracts, ripe, unripe fruits, leaves, and stems) have bioactive constituents used as therapies for different human ailments. Although similar in growing on large herbs, elongated leaves, and producing edible fruits, they differ in taste and need for processing. …”
Get full text

Identification of blood plasma protein ratios for distinguishing Alzheimer's disease from healthy controls using machine learning by Ali Safi, Elisa Giunti, Omar Melikechi, Weiming Xia, Noureddine Melikechi

“…Early detection of Alzheimer's disease is essential for effective treatment and the development of therapies that modify disease progression. Developing sensitive and specific noninvasive diagnostic tools is crucial for improving clinical outcomes and advancing our understanding of this condition. …”
Get full text