The Impacts of SLC22A1 rs594709 and SLC47A1 rs2289669 Polymorphisms on Metformin Therapeutic Efficacy in Chinese Type 2 Diabetes Patients by Di Xiao, Yu Guo, Xi Li, Ji-Ye Yin, Wei Zheng, Xin-Wen Qiu, Ling Xiao, Rang-Ru Liu, Sai-Ying Wang, Wei-Jing Gong, Hong-Hao Zhou, Zhao-Qian Liu

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Combining single-cell analysis and molecular docking techniques to construct a prognostic model for colon adenocarcinoma and uncovering inhibin subunit βb as a novel therapeutic target by Qinqing Wu, Qinqing Wu, Lu Ye, Yuwei Wu, Mengyu Zhao, Mengyu Zhao, Jiaxin Lu, Yanping Yu, Yanping Yu, Yixiao Niu, Yixiao Niu, Luxiao Zhang, Peijun Zuo, Peijun Zuo

“…Additionally, we employed molecular docking techniques to evaluate the potential of inhibin subunit beta B (INHBB) as therapeutic targets and to assess the binding affinity of candidate drugs. …”
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Large-scale data mining of four billion human antibody variable regions reveals convergence between therapeutic and natural antibodies that constrains search space for biologics drug discovery by Pawel Dudzic, Dawid Chomicz, Jarosław Kończak, Tadeusz Satława, Bartosz Janusz, Sonia Wrobel, Tomasz Gawłowski, Igor Jaszczyszyn, Weronika Bielska, Samuel Demharter, Roberto Spreafico, Lukas Schulte, Kyle Martin, Stephen R. Comeau, Konrad Krawczyk

“…Identifying subsets of this prohibitively large space where therapeutically relevant antibodies may be found is useful for development of these agents. …”
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TNF-α Enhances the Therapeutic Effects of MenSC-Derived Small Extracellular Vesicles on Inflammatory Bowel Disease through Macrophage Polarization by miR-24-3p by Huikang Xu, Jiamin Fu, Lijun Chen, Sining Zhou, Yangxin Fang, Qi Zhang, Xin Chen, Li Yuan, Yifei Li, Zhenyu Xu, Charlie Xiang

“…At present, the existing therapeutic methods are ineffective for many patients and have obvious side effects. …”
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Core Outcome Set development for LEPtospirosis trials (COS-LEP): a study protocol to develop a core outcome set for the evaluation of clinical therapeutic interventions for human leptospirosis by Nathaniel Lee, Chris Smith, Robin Bailey, Koya Ariyoshi, Sarah Smith, Nick Black, Tansy Edwards

“…This includes (1) a systematic review of available quantitative and qualitative literature reporting therapeutic response and safety outcomes and measures; (2) focused interviews with healthcare professional and people treated for leptospirosis exploring outcomes of interests using qualitative methodology; (3) narrowing the choice of outcomes by international consensus using a Delphi survey process; and (4) undertaking a hybrid consensus meeting with key stakeholders to build the final COS. …”
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Association between terminal pleural elastance and radiographic lung re-expansion after therapeutic thoracentesis in patients with symptomatic pleural effusion: a post-hoc analysis of a randomised trial by Fabien Maldonado, Michael Lester, Otis B Rickman, Lance J Roller, Sameer K Avasarala, James M Katsis, Robert J Lentz

“…We investigated the association between lung re-expansion on post-pleural drainage chest imaging and pleural physiology, with particular attention to pleural elastance over the final 200 mL aspirated.Design Post-hoc analysis of a recent randomised trial.Setting and participants Post-results analysis of 61 subjects at least 18 years old with symptomatic pleural effusions estimated to be at least of 0.5 L in volume allocated to manometry-guided therapeutic thoracentesis in a recent randomised trial conducted at two major university hospitals in the USA.Primary outcome measures The primary outcome was concordance of radiographic with normal terminal pleural elastance over the final 200 mL aspirated. …”
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Deciphering the therapeutic effects of Xiyanping injection: insights into pulmonary and gut microbiome modulation, SerpinB2/PAI-2 targeting, and alleviation of influenza a virus-induced lung injury by Tengwen Liu, Shuping Li, Xuerui Wang, Mingjiang Liu, Yuchen Wang, Jie Ying, Shuwen Zhang, Yan Lin, Ning Wang, Yungjing Bai, Lan Xie, Tengfei Chen, Quansheng Feng, Xiaolong Xu

“…Overall, our study provides valuable insights into the therapeutic potential of XYP injection in treating influenza, highlighting its multifaceted effects on host microbiota and immune responses, and pinpointing SerpinB2/PAI-2 as the target for XYP injection in exerting anti-inflammatory and antiviral therapeutic mechanisms.…”
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Therapeutic Potential of Ginger Ethanolic Extract, Ginger-Loaded Chitosan ‎Nanoparticles, and Chitosan Nanoparticles in Induced Type 2 Diabetes Mellitus in Dogss in Induced Type 2 Diabetes Mellitus in Dogs by Rasema M Hameed, Alaa K Mahmood

“…This study assessed the therapeutic potential of ginger ethanolic extract (GEE), GEE-loaded chitosan nanoparticles (GEE-CNPs), and chitosan nanoparticles (CNPs) against T2DM in dogs. …”
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Proceedings of the 1st All-Russian Congress of the Russian Association of Therapeutic Radiation Oncologists (RATRO) "New technologies in radiotherapy and nuclear medicine.... by Editorial Article

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Gene Therapy with HSV1-sr39TK/GCV Exhibits a Stronger Therapeutic Efficacy Than HSV1-TK/GCV in Rat C6 Glioma Cells by Lei-qing Li, Fang Shen, Xiao-yan Xu, Hong Zhang, Xiao-feng Yang, Wei-guo Liu

“…Therefore, In order to reduce the GCV dose required, we aim to compare the therapeutic efficacy of HSV1-sr39TK, an HSV1-TK mutant with increased GCV prodrug catalytic activity, with wildtype TK in C6 glioma cells. …”
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Therapeutic role of miR-26a on cardiorenal injury in a mice model of angiotensin-II induced chronic kidney disease through inhibition of LIMS1/ILK pathway by Weijie Ni, Yajie Zhao, Jinxin Shen, Qing Yin, Yao Wang, Zuolin Li, Taotao Tang, Yi Wen, Yilin Zhang, Wei Jiang, Liangyunzi Jiang, Jinxuan Wei, Weihua Gan, Aiqing Zhang, Xiaoyu Zhou, Bin Wang, Bi-Cheng Liu, Yuanyuan Ji

“…Our findings suggest that miR-26a could be a promising therapeutic target for the treatment of cardiorenal injury in CKD. …”
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Liquid chromatography-tandem mass spectrometry for the quantification of ripretinib and its metabolites DP-5439 in human plasma by Jiahui Lin, Jiahui Lin, Aiting Jiang, Juntao Zheng, Jingjing Wu, Hao Li, Hao Li, Shirong Cai, Yulong He, Xiao Chen, Guoping Zhong, Ke-Jing Tang, Ke-Jing Tang, Xinhua Zhang, Yanzhe Xia

Subjects: “…therapeutic drug monitoring (TDM)…”
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Psychotherapists’ readiness to treat PTSD: the influence of refugees’ country of origin by Pia Maria Schwegler, Katharina Gossmann, Theresa Neumann, Anne Moser, Theresa Speth, Rita Rosner

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Sepsis subphenotypes: bridging the gaps in sepsis treatment strategies by Xue Zhang, Wei Zhang, Huan Zhang, Xuelian Liao, Xuelian Liao

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La folie de l’arc-en-ciel ou la longue errance de Bwila by Claudie Haxaire

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Systematic analysis of Fc mutations designed to enhance binding to Fc-gamma receptors by Geoff Hale, Alastair Douglas Davy, Ian Wilkinson

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Controversial Roles of Regenerating Family Proteins in Tissue Repair and Tumor Development by Luting Yu, Qingyun Wu, Shenglong Jiang, Jia Liu, Junli Liu, Guoguang Chen

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New insights into N6-methyladenosine in hepatocellular carcinoma immunotherapy by Mengran Li, Mengran Li, Hu Tian, Yanshuang Zhuang, Zili Zhang, Zili Zhang

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Unlocking the Potential of Receptor-Based Approaches in Diabetes Treatment by Mohsina Patwekar, Faheem Patwekar, J. Pavan Kumar, P. Dharani Prasad, Nazia Malik, A. Venkata Badarinath, Prashanth Parupathi, Konatham Teja Kumar Reddy, Selvaraja Elumalai, Zainul Abedeen Ab Samad

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Strategies for Optimizing Acute Burn Wound Therapy: A Comprehensive Review by Andrei Cretu, Andreea Grosu-Bularda, Eliza-Maria Bordeanu-Diaconescu, Florin-Vlad Hodea, Vladut-Alin Ratoiu, Catalina-Stefania Dumitru, Mihaela-Cristina Andrei, Tiberiu-Paul Neagu, Ioan Lascar, Cristian-Sorin Hariga

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