PEPITEM, its tripeptide pharmacophores and their peptidomimetic analogues regulate the inflammatory response through parenteral and topical dosing in models of peritonitis and psor... by Anella Saviano, Bonita Apta, Samantha Tull, Laleh Pezhman, Areeba Fatima, Mustafa Sevim, Antonio Mete, Myriam Chimen, Anna Schettino, Noemi Marigliano, Helen M. McGettrick, Asif J. Iqbal, Francesco Maione, G. Ed Rainger

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Exploring MAP3K genes in gastric cancer: biomarkers, tumor microenvironment dynamics, and chemotherapy resistance by Senhui Wei, Ying Li, Jing Zhou, Yongming Xia

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Editorial: Methods in respiratory pharmacology 2023 by Nadia Milad, Giulio Cabrini, Maria Cordina

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Metabolomics-Driven Biomarker Discovery for Breast Cancer Prognosis and Diagnosis by Rasanpreet Kaur, Saurabh Gupta, Sunanda Kulshrestha, Vishal Khandelwal, Swadha Pandey, Anil Kumar, Gaurav Sharma, Umesh Kumar, Deepak Parashar, Kaushik Das

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Potentiating intratumoral therapy with immune checkpoint inhibitors: shifting the paradigm of multimodality therapeutics by B.E. Nelson, A. Naing, S. Fu, R.A. Sheth, R. Murthy, S. Piha-Paul

“…Further research is needed to optimize the combination strategies, identify biomarkers of response, and establish the safety and efficacy of these novel therapeutic approaches.…”
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The present and future of digital health, digital medicine, and digital therapeutics for allergic diseases by He Zhang, Yang Cao, Haibo Jiang, Qilin Zhou, Qintai Yang, Lei Cheng

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Manipulating the cGAS-STING Axis: advancing innovative strategies for osteosarcoma therapeutics by BingBing Li, Cheng Zhang, XiaoJuan Xu, QiQin Shen, ShuNan Luo, JunFeng Hu

“…It reviewed the epidemiology and pathological characteristics of OS, highlighting its highly malignant nature and tendency for pulmonary metastasis, underscoring the importance of identifying new therapeutic targets. The cGAS-STING pathway was closely associated with the malignant biological behaviors of OS cells, suggesting that targeting this pathway could be a promising therapeutic strategy. …”
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Shedding new light on atherosclerosis therapeutics: Nanomedicines targeting atherosclerotic immune microenvironment by Zhiyue Wang, Jie Sheng, Guangming Lu, Longjiang Zhang

“…Furthermore, we highlight the possible future directions of AS therapeutics, with a focus on AIME-targeted nanomedicines.…”
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The history and potential future of monoclonal antibody therapeutics development and manufacturing in four eras by Brian Kelley

“…Therapeutic monoclonal antibody (mAb) development and the processes for manufacturing drug substance have evolved since the first approval of the mAb in 1986. …”
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Editorial: Respiratory dysfunction in neurological disease and injury: novel mechanisms and potential therapeutics by Savannah Lusk, Robert M. Wadolowski, Mai K. ElMallah, Carlos B. Mantilla, Carlos B. Mantilla, Teresa Pitts, Irene C. Solomon

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T and B cell epitope analysis for the immunogenicity evaluation and mitigation of antibody-based therapeutics by Ruoxuan Sun, Mark G. Qian, Xiaobin Zhang

“…The surge in the clinical use of therapeutic antibodies has reshaped the landscape of pharmaceutical therapy for many diseases, including rare and challenging conditions. …”
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Therapeutics of bitter plants from Northeast region of India and their pharmacological and phytochemical perspectives by Bhaskar Das, Bharat Gopalrao Somkuwar, Sushil Kumar Chaudhary, Evanylla Kharlyngdoh, Careen Liza Pakyntein, Kishor Basor, Jitendra Kumar Shukla, Pardeep Kumar Bhardwaj, Pulok Kumar Mukherjee

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Extracellular Cold-Inducible RNA-Binding Protein and Hemorrhagic Shock: Mechanisms and Therapeutics by Naureen Rashid, Zhijian Hu, Asha Jacob, Ping Wang

“…Finally, we suggest that future preclinical studies are required to develop the listed therapeutics for hemorrhagic shock and related conditions. …”
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Opportunities and barriers for reimbursement of digital therapeutics in Austria: Findings From expert interviews by Mahdi Sareban, Gunnar Treff, Jan David Smeddinck, Rada Hussein, Josef Niebauer

“…Background Digital therapeutics (DTx) are software-based interventions that aim to prevent or treat especially non-communicable diseases. …”
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Treatment strategies for combining immunostimulatory oncolytic virus therapeutics with dendritic cell injections by Joanna R. Wares, Joseph J. Crivelli, Chae-Ok Yun, Il-Kyu Choi, Jana L. Gevertz, Peter S. Kim

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Human-based complex in vitro models: their promise and potential for rare disease therapeutics by Surat Parvatam, Francesca Pistollato, Lindsay J. Marshall, Fabia Furtmann, Devashree Jahagirdar, Mohua Chakraborty Choudhury, Sujata Mohanty, Harshita Mittal, Saveetha Meganathan, Rakesh Mishra

“…Finally, we propose recommendations on how human relevant CIVMs could be leveraged to increase translatability of basic, applied and nonclinical research outcomes in the field of rare disease therapeutics in developed as well as middle-and low-income countries.…”
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Current strategies in diagnostics and therapeutics against novel coronavirus disease (COVID-19) by ALOTAIBI FAISAL

“…Several advances have been made in understanding the novel coronavirus’s pathophysiology and in the development of newer diagnostics with pinpoint accuracy. Several newer therapeutic methods have either been accepted or are awaiting acceptance. …”
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Comparison of health technology assessments for digital therapeutics in Germany, the United Kingdom and France by Emanuele Arcà, Dorothea Heldt, Martina Smith

“…Objective Digital therapeutics (DTx) are promising technologies. However, current assessment and access frameworks, when they exist, are heterogeneous and fragmented. …”
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Systematic analysis of the pharmacogenomics landscape towards clinical implementation of precision therapeutics in Greece by George P. Patrinos, Kariofyllis Karamperis, Margarita-Ioanna Koufaki, Maria Skokou, Zoe Kordou, Eirini Sparaki, Margarita Skaraki, Christina Mitropoulou

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Aptamers as new promising entities for therapeutics: our experience from the neurological diseases by Macarena Hernández-Jiménez, Fernando de Castro

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