Proceedings of the Fourth International Course on Therapeutic Endoscopy by Norman E Marcon, Gregory Haber, Paul Kortan, Gabor Kandel

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Imitation and dyspraxia in autism: Clinical and therapeutic implications by Leonardo Massoni

“…Meanwhile, by employing intense interaction, imitation, or “expressive art” therapies, which respond intimately to motor activities, some improvements could be made for these symptoms of ASD.Starting from these premises, the aim of this short communication is to discuss some works on the clinical basis and therapeutic perspectives of imitation defects and dyspraxia in autism spectrum disorder.…”
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Human Fungal Infections: Diagnostic and Therapeutic Challenges by Timoleon-Achilleas Vyzantiadis, Eleni Gavriilaki, Athanasios Tragiannidis

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Therapeutic Challenges for Elderly Patients with Primary Hyperparathyroidism by Kenneth Sluis, Hyon Kim, Yuling He, Beatrice Wong, Xiangbing Wang

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Exosomes in Oral Diseases: Mechanisms and Therapeutic Applications by Miao Q, Li S, Lyu W, Zhang J, Han Y

“…Exosomes have a positive effect on the inflammatory environment of the oral cavity, remodeling and regeneration of oral tissues, and offer promising therapeutic options for bone and periodontal tissue restoration. …”
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Psychobiotics, Novel Therapeutic Agents for the Psychiatric Disorders by Praveen Reddy P., K. Sandhya, Aparna Srikantam

“…Hence, alternative therapeutic strategies/agents are much needed. Clinical researchers suggest that certain microorganisms (beneficial microorganisms/probiotics) could be substituted for conventional therapies and/ or can be used in combination with current drugs. …”
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Hepatocellular carcinoma: signaling pathways and therapeutic advances by Jiaojiao Zheng, Siying Wang, Lei Xia, Zhen Sun, Kui Ming Chan, René Bernards, Wenxin Qin, Jinhong Chen, Qiang Xia, Haojie Jin

“…Beyond the frequently altered and therapeutically targeted receptor tyrosine kinase (RTK) pathways in HCC, pathways involved in cell differentiation, telomere regulation, epigenetic modification and stress response also provide therapeutic potential. …”
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Nucleic Acid Aptamers for Human Norovirus GII.4 and GII.17 Virus-Like Particles (VLPs) Exhibit Specific Binding and Inhibit VLPs from Entering Cells by Cheng C, Sun M, Li J, Xue Y, Cai X, Liu J, Wang X, Xu S, Xie Y, Zhang J

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Silymarin: a promising modulator of apoptosis and survival signaling in cancer by Ujjawal Sharma, Praveen Kumar Sahni, Bunty Sharma, Madhu Gupta, Damandeep Kaur, Darin Mansor Mathkor, Shafiul Haque, Sabiha Khatoon, Hardeep Singh Tuli, Astha Mishra, Faraz Ahmad

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Design of therapeutic siRNAs for potential application to infection with chikungunya virus by Ahmed Ahsan Adib, Muhammad Manjurul Karim

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PEPITEM, its tripeptide pharmacophores and their peptidomimetic analogues regulate the inflammatory response through parenteral and topical dosing in models of peritonitis and psor... by Anella Saviano, Bonita Apta, Samantha Tull, Laleh Pezhman, Areeba Fatima, Mustafa Sevim, Antonio Mete, Myriam Chimen, Anna Schettino, Noemi Marigliano, Helen M. McGettrick, Asif J. Iqbal, Francesco Maione, G. Ed Rainger

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Exploring MAP3K genes in gastric cancer: biomarkers, tumor microenvironment dynamics, and chemotherapy resistance by Senhui Wei, Ying Li, Jing Zhou, Yongming Xia

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Potentiating intratumoral therapy with immune checkpoint inhibitors: shifting the paradigm of multimodality therapeutics by B.E. Nelson, A. Naing, S. Fu, R.A. Sheth, R. Murthy, S. Piha-Paul

“…Further research is needed to optimize the combination strategies, identify biomarkers of response, and establish the safety and efficacy of these novel therapeutic approaches.…”
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The present and future of digital health, digital medicine, and digital therapeutics for allergic diseases by He Zhang, Yang Cao, Haibo Jiang, Qilin Zhou, Qintai Yang, Lei Cheng

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Manipulating the cGAS-STING Axis: advancing innovative strategies for osteosarcoma therapeutics by BingBing Li, Cheng Zhang, XiaoJuan Xu, QiQin Shen, ShuNan Luo, JunFeng Hu

“…It reviewed the epidemiology and pathological characteristics of OS, highlighting its highly malignant nature and tendency for pulmonary metastasis, underscoring the importance of identifying new therapeutic targets. The cGAS-STING pathway was closely associated with the malignant biological behaviors of OS cells, suggesting that targeting this pathway could be a promising therapeutic strategy. …”
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The history and potential future of monoclonal antibody therapeutics development and manufacturing in four eras by Brian Kelley

“…Therapeutic monoclonal antibody (mAb) development and the processes for manufacturing drug substance have evolved since the first approval of the mAb in 1986. …”
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Editorial: Respiratory dysfunction in neurological disease and injury: novel mechanisms and potential therapeutics by Savannah Lusk, Robert M. Wadolowski, Mai K. ElMallah, Carlos B. Mantilla, Carlos B. Mantilla, Teresa Pitts, Irene C. Solomon

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T and B cell epitope analysis for the immunogenicity evaluation and mitigation of antibody-based therapeutics by Ruoxuan Sun, Mark G. Qian, Xiaobin Zhang

“…The surge in the clinical use of therapeutic antibodies has reshaped the landscape of pharmaceutical therapy for many diseases, including rare and challenging conditions. …”
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Therapeutics of bitter plants from Northeast region of India and their pharmacological and phytochemical perspectives by Bhaskar Das, Bharat Gopalrao Somkuwar, Sushil Kumar Chaudhary, Evanylla Kharlyngdoh, Careen Liza Pakyntein, Kishor Basor, Jitendra Kumar Shukla, Pardeep Kumar Bhardwaj, Pulok Kumar Mukherjee

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Extracellular Cold-Inducible RNA-Binding Protein and Hemorrhagic Shock: Mechanisms and Therapeutics by Naureen Rashid, Zhijian Hu, Asha Jacob, Ping Wang

“…Finally, we suggest that future preclinical studies are required to develop the listed therapeutics for hemorrhagic shock and related conditions. …”
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