2 Studies with high-level evidence can unmask false therapeutic myths: Using the example ofurolithiasis prophylaxis by B. Roth, K. Stritt, D. Fuster

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Early therapeutic drug monitoring of methotrexate and its association with acute kidney injury: A retrospective cohort study by Nicolás Tentoni, Miriam Hwang, Gabriela Villanueva, Ryan Combs, Jennifer Lowe, Laura B. Ramsey, Zachary L. Taylor, Thais Murciano Carrillo, María Dolores Aumente, Teresa López‐Viñau López, Carmelo Rizzari, Scott C. Howard

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Integrating environmental effects in the benefit-risk assessment of therapeutic products: a proposal and example for sustainable health and healthcare by Emiliano Giovagnoni, Luisa Mattoli, Andrea Cossu, Vitalia Murgia

“…However, current benefit-risk assessments of therapeutic products do not systematically include environmental risk data. …”
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Comparison of three therapeutic interventions for chronic constipation in paediatric patients with cerebral palsy: a randomised clinical trial by Mohammad Hadi Imanieh, Mohammad Reza Golpayegan, Mostafa Sedighi, Kamal Ahmadi, Abbas Aghaie, Seyed Mohsen Dehghani, Gholamreza Yousefi

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Enhanced therapeutic effects of hypoxia-preconditioned mesenchymal stromal cell-derived extracellular vesicles in renal ischemic injury by Fei Yuan, Jie Liu, Liang Zhong, Pengtao Liu, Ting Li, Kexin Yang, Wei Gao, Guangyuan Zhang, Jie Sun, Xiangyu Zou

“…However, the specific effects of hypoxia on MSCs and MSC-EVs, as well as their therapeutic potential in renal IRI, remain unclear. …”
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Severe Short Stature in an Adolescent Male with Prader-Willi Syndrome and Congenital Adrenal Hyperplasia: A Therapeutic Conundrum by Meredith Wasserman, Erin M. Mulvihill, Angela Ganan-Soto, Serife Uysal, Jose Bernardo Quintos

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Synthesis, Antimalarial Activity and Molecular Dynamics Studies of Pipecolisporin: A Novel Cyclic Hexapeptide with Potent Therapeutic Potential by Nety Kurniaty, Taufik Muhammad Fakih, Rani Maharani, Unang Supratman, Ace Tatang Hidayat, Nurhidanatasha Abu Bakar, Xiaoshuang Wei

“…This study explores the synthesis, antimalarial activity, and computational studies of pipecolisporin, aiming to better understand its therapeutic potential. The peptide was successfully synthesized using Fmoc-based solid-phase peptide synthesis (SPPS) followed by cyclization in solution. …”
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Genetic and epigenetic characterization of sarcoma stem cells across subtypes identifies EZH2 as a therapeutic target by Edmond O’Donnell, Maria Muñoz, Ryan Davis, Jessica Bergonio, R. Lor Randall, Clifford Tepper, Janai Carr-Ascher

“…These data confirm the presence of shared genetic programs across distinct subtypes of CSC-STS that can be therapeutically targeted.…”
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Molecular mechanisms and therapeutic strategies of Naegleria fowleri Carter (1970): a review of the fatal brain-eating amoeba by N. Datta

“…However, there are still many unanswered questions regarding the complex interactions between the amoeba and its host, which limit the development of effective diagnostic and therapeutic strategies. PAM is often misdiagnosed as bacterial meningitis, due to its nonspecific clinical presentation and lack of reliable diagnostic tests. …”
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A Quantitative Examination and Comparison of the Ability of Australian Gentamicin Dosing Guidelines to Achieve Target Therapeutic Concentrations in Neonates by Luke E. Grzeskowiak, Sheree Wynne, Michael J. Stark

“…<b>Conclusions:</b> Current Australian gentamicin guidelines demonstrate significant variability in their ability to achieve defined therapeutic targets, necessitating efforts to improve standardisation of dosing recommendations. …”
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Microcystic Elongated and Fragmented Pattern Invasion in Endometrial Cancer: Possible Prognostic Value to Precise and Individualized Therapeutic Strategies by Christos IAVAZZO, Alexandros FOTIOU, Ioannis D GKEGKES, Nikolaos VRACHNIS

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Evaluation of the Costs and Outcomes of COVID-19 Therapeutic Protocols in Critically Ill Patients in Alzahra Hospital, Isfahan, Iran by Majid Davari, Sarah Mousavi, Mohammad Reza Maracy, Elahe Khorasani, Masih Zamani, Mohammadreza Amirsadri

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Connexin-Based Therapeutics and Tissue Engineering Approaches to the Amelioration of Chronic Pancreatitis and Type I Diabetes: Construction and Characterization of a Novel Prevascularized Bioartificial Pancreas by J. Matthew Rhett, Hongjun Wang, Heather Bainbridge, Lili Song, Michael J. Yost

“…Connexin43 (Cx43) channels play a key role in early inflammation and have proven to be viable therapeutic targets. Even if cell death due to early inflammation is avoided, insufficient vascularization is a primary obstacle to maintaining the viability of implanted cells. …”
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Time in therapeutic range of tacrolimus in allogeneic hematopoietic stem cell transplant recipients is associated with acute graft-versus-host disease prophylaxis by Naoki Yoshikawa, Yukina Ehara, Yusei Yamada, Yuki Matsusaki, Kazuya Shimoda, Ryuji Ikeda

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Monitoring M-Protein, Therapeutic Antibodies, and Polyclonal Antibodies in a Multiparametric Mass Spectrometry Assay Provides Insight into Therapy Response Kinetics in Patients with Multiple Myeloma by Charissa Wijnands, Peter G. A. Karel, Jolein Gloerich, Gad Armony, Anastasia Tzasta, Corrie M. de Kat Angelino, Luciano Di Stefano, Vincent Bonifay, Theo M. Luider, Martijn M. VanDuijn, Sandra J. Croockewit, Elizabeth A. de Kort, Daan A. R. Castelijn, Claudia A. M. Stege, Hans J. C. T. Wessels, Alain J. van Gool, Niels W. C. J. van de Donk, Joannes F. M. Jacobs

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Non-Operative Management of Traumatic Gallbladder Bleeding with Cystic Artery Injury: A Case Report by Tae Hoon Kim

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NOS2 as a prognostic biomarker for early-onset colorectal cancer based on public data and clinical validation analysis by Chaoqun Xing, Lipeng Zhao, Weiwei Zou, Xie Peng, Xiao-Liang Xing, Jie Li

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Transcatheter Arterial Embolization for the Control of Neoplastic Hemorrhage in Locally Advanced Breast Cancer: A Case Report by Ji Hwan Kang, Myung Sub Kim, Hyun Pyo Hong, Do Yeon Ahn

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Cours de vie, apprentissage et transformations d’habitudes de vie d’une malade diabétique by Jérôme Guerin, André Zeitler

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Myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment and their targeting in cancer therapy by Shuyan He, Lu Zheng, Chunjian Qi

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