Hipofosfatemia tras la administración de hierro intravenoso by Nicolás Alcalá-Rivera, Anxela Crestelo Vieitez, María del Mar García Andreu, Fabiola Diez Massó, Martín Gericó Aseguinolaza, Raúl Martínez Murgui, Paula Aragonés Pequerul, Isabel Fiteni Mera, Santiago Rubio Félix, Jesús Díez-Manglano

“…Introduction: Intravenous iron administration is a frequent procedure in wards and day-hospitals due to the existence of new pharmacological preparations and more therapeutic indications. Hypophosphatemia has been observed as an adverse effect. …”
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A Multicenter, Prospective Study of a New Fully Covered Expandable Metal Biliary Stent for the Palliative Treatment of Malignant Bile Duct Obstruction by Bret T. Petersen, Michel Kahaleh, Richard A. Kozarek, David Loren, Kapil Gupta, Thomas Kowalski, Martin Freeman, Yang K. Chen, Malcolm S. Branch, Steven Edmundowicz, Michael Gluck, Kenneth Binmoeller, Todd H. Baron, Raj J. Shah, Timothy Kinney, William Ross, Paul Jowell, David Carr-Locke

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Correlation of HER2 expression and clinicopathological characteristics in patients with urothelial carcinoma in China by WANG Shanshan, YE Dingwei, YANG Li, CHENG Fan, YANG Tiejun, ZHANG Xiaoping, YU Zhixian, ZHANG Qingyun, YANG Yong

“…HER2 is a significant biomarker and therapeutic target in various tumors. In recent years, anti-HER2 antibody-drug conjugates have shown significant clinical efficacy in UC patients with HER2 overexpression. …”
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Safety and tolerability of the M2 muscarinic acetylcholine receptor modulator BAY 2413555 in heart failure with reduced ejection fraction in the REMOTE-HF study by Marat Fudim, Muhammad Shahzeb Khan, Dominik Linz, JoAnn Lindenfeld, Calum MacRae, Nina Kimmeskamp-Kirschbaum, Michaela Meyer, Thomas Mondritzki, Hanna Tinel, Wilfried Dinh, Robert J. Mentz

“…This study tested the safety, tolerability and pharmacokinetics of this novel therapeutic option. REMOTE-HF was a multicenter, double-blind, randomized, placebo-controlled, phase Ib dose-titration study with two active arms. …”
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Caesalpinia sappan L. ethyl acetate extract regulated angiogenesis in atherosclerosis by modulating the miR-126/VEGF signalling pathway by Yue He, Chao Huang, Jingjing Chen, Weizeng Shen

“…Conclusion: This study emphasises CSEAE as a natural medicinal extract for the treatment of AS that can improve the migratory viability and reduce the apoptosis of HUVECs to maintain the health of the arterial endothelial microenvironment, while CSEAE also inhibits angiogenesis and delays plaque formation in ApoE−/− mice, suggesting that the therapeutic effect of CSEAE for AS may be related to its inhibition of neovascularisation and that its molecular mechanism may be related to the miR-126/VEGF signalling pathway.…”
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Role of 18F-PSMA-1007 PET/CT-derived quantitative volumetric tumor parameters in cytoreductive radical prostatectomy selection for patients with low-volume metastatic hormone-sensi... by Junjie Fan, Ke Xu, Zhangdong Jiang, Chaosheng Gan, Hao Song, Guoqiang Gao, Guojing Wang, Qiyuan Kang, Liang Luo, Zhuonan Wang, Dalin He, XiaoYi Duan, Kaijie Wu

“…Abstract Background Cytoreductive radical prostatectomy (cRP) has emerged as a promising therapeutic approach for low-volume metastatic hormone-sensitive prostate cancer (mHSPC), but the best candidates for cRP are still unknown. …”
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Ginsenoside Rd protects against acute liver injury by regulating the autophagy NLRP3 inflammasome pathway by Xiaomei Zhong, Yibin Sun, Yanxiang Lin, Shan Deng, Huan Wang, Xian Zhou, Jinjian Lu, Yanfang Zheng, Ruoyin Luo, Mingqing Huang, Jianyuan Song

“…Finally, the inhibitory effects of Rd on autophagy and inflammation in HSC-T6 cells were partially blocked by rapamycin and GSK621. Rd is a promising therapeutic agent to protect liver against TAA-induced acute liver injury by regulating the autophagy-NLRP3 inflammasome pathway.…”
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Development of Solid Self-Nanoemulsifying Drug Delivery System of Rhein to Improve Biopharmaceutical Performance: Physiochemical Characterization, and Pharmacokinetic Evaluation by More SM, Rashid MA, Kharwade RS, Taha M, Alhamhoom Y, Elhassan GO, Gangane P, Asar TO, Pise A, Kaleem M, Mujtaba MA

“…We also examined the Cmax and AUC0-t of RS-SNEDDS in the brain and it was found to be 2.90 ± 0.171 μg/mL and 18.18 ± 1.68 μg/mL*hr respectively.Conclusion: This study concludes that the RS-SNEDDS improves brain tissue concentration and oral bioavailability, both of which increase therapeutic potential. Keywords: rhein, bioavailability, solubility, nanoemulsion, drug release, pharmacokinetic…”
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An artificial intelligence application to predict prolonged dependence on mechanical ventilation among patients with critical orthopaedic trauma: an establishment and validation st... by Weigang Jiang, Tao Liu, Baisheng Sun, Lixia Zhong, Zhencan Han, Minhua Lu, Mingxing Lei

“…Based on the risk of prolonged dependence on mechanical ventilation, patients were stratified into the high-risk or the low-risk groups, and corresponding therapeutic interventions were recommended, accordingly. …”
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Small RNA CjNC110 regulates the activated methyl cycle to enable optimal chicken colonization by Campylobacter jejuni by Brandon Ruddell, Alan Hassall, Orhan Sahin, Paul J. Plummer, Qijing Zhang, Amanda J. Kreuder

“…As a growing body of evidence suggests that maintenance of L-met homeostasis appears to be critical for C. jejuni colonization, interventions targeting the AMC could provide a critical control point for therapeutic drug options to combat this zoonotic pathogen. …”
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Olutasidenib in combination with azacitidine induces durable complete remissions in patients with relapsed or refractory mIDH1 acute myeloid leukemia: a multicohort open-label phas... by Jorge E. Cortes, Gail J. Roboz, Maria R. Baer, Brian A. Jonas, Gary J. Schiller, Karen Yee, P. Brent Ferrell, Jay Yang, Eunice S. Wang, William G. Blum, Alice Mims, Hua Tian, Aaron Sheppard, Stéphane de Botton, Pau Montesinos, Antonio Curti, Justin M. Watts, the Olutasidenib Combination Therapy Study Group

“…The results represent another therapeutic option for patients with mIDH1 AML who may benefit from a targeted therapy. …”
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Ginger-Derived Exosome-Like Nanoparticles Loaded With Indocyanine Green Enhances Phototherapy Efficacy for Breast Cancer by Guo Z, Li G, Shen L, Pan J, Dou D, Gong Y, Shi W, Sun Y, Zhang Y, Ma K, Cui C, Li W, Liu Q, Zhu X

“…Moreover, by detecting the expression of CD31, N-cadherin, IL-6, IFN-γ, CD8, p16, p21, and p53 in tumor tissues, we found that GDNPs@ICG substantially reduced angiogenesis, inhibited metastasis, activated the anti-tumor immune response, and promoted cell senescence in breast tumor.Conclusion: Our study demonstrated that the novel bio-nanoplatform GDNPs@ICG enhanced the photo-mediated therapeutic effect in breast tumor. GDNPs@ICG could be an alternative for precise and efficient anti-tumor phototherapy.Keywords: ginger-derived exosome-like nanoparticles, phototherapy, indocyanine green, lipid peroxidation, ER stress…”
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Reliability of non-invasive imaging methods in the evaluation of pancreatic parenchyma changes in tumors of the pancreaticoduodenal zone by M.M. Veligotskyy, S.E. Arutyunov, I.I. Yakovtsova, I.V. Ivakhno, O.M. Veligotskyi

“…Assessment of changes in the pancreatic parenchyma at the preoperative stage will allow appropriate therapeutic and preventive measures to be taken to reduce the frequency of pancreatic fistula. …”
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Mechanism of Qingjie Fuzheng Granules on alleviating 5-FU chemotherapy-induced intestinal mucositis in a mouse model of Colorectal Cancer by regulating Cathepsin B/NLRP3 pathway by Yuan Yingfei, Lin Jiumao, Lin Minghe, Zhao Jinyan, Chen Xuzheng, Liu Jinhong, Zhu Xiaoqin

“…ObjectiveTo investigate the therapeutic effect and mechanism of Qingjie Fuzheng Granules on 5-FU chemotherapy-induced intestinal mucositis in a mouse model of Colorectal Cancer based on Cathepsin B/NLRP3 pathway.MethodsTwenty-four male BALB/c mice were inoculated with CT26 cells subcutaneously in the axillary of the right forelimb to construct a mouse model of colorectal cancer subcutaneous xenograft. …”
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NDM-1-Positive K. pneumoniae at a Teaching Hospital in Southwestern China: Clinical Characteristics, Antimicrobial Resistance, Molecular Characterization, Biofilm Assay, and Virule... by Kai Yang, Shumin Liu, Huanqin Li, Na Du, Jing Yao, Qiuyue He, Yan Du

“…The emergence of the NDM-1-positive Klebsiella pneumoniae (K. pneumoniae) strains has led to limited therapeutic options for clinical treatment. Understanding the clinical characteristics, antimicrobial resistance, biofilm assay, and the virulence genes of these isolated strains is of great significance. …”
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Preservative-free therapy for glaucoma after corneal refractive surgery by A.A. Antonov, I.V. Kozlova, T.S. Mitichkina, I.I. Vedmedenko

“…Preservative-free prostaglandin analogue, tafluprost, is a novel IOP-l owering therapeutic agent to prescribe after corneal refractive surgery.…”
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Acid-Unlocked Two-Layer Ca-Loaded Nanoplatform to Interfere With Mitochondria for Synergistic Tumor Therapy by Zheng Y, Williams GR, Hu R, Tong S, Xu J, Wang T, Zhang Y, Wu J, Li F, Cai Y, Zhu LM

“…Oxidative damage-triggered immunogenic cell death (ICD) in turn leads to the polarization of macrophages to the M1 phenotype, inducing immunogenic cell death and inhibiting tumor cell proliferation and metastasis.Discussion: The acid two-step unlocking nanoplatform is a therapeutic modality that combines calcium storm and oxidative damage. …”
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Warm and humid environment induces gut microbiota dysbiosis and bacterial translocation leading to inflammatory state and promotes proliferation and biofilm formation of certain ba... by Yinrui Guo, Jianlang He, Shaojie Li, Shiqi Zou, Haiting Zhang, Xin Yang, Jian Wang

“…Conclusions These findings provided new insights into the biological mechanisms of ‘Dampness Syndrome’ and support the therapeutic role of Huoxiang Zhengqi Water in treating symptoms associated with microbial dysbiosis and inflammation. …”
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Clozapine for Treatment-Resistant Disruptive Behaviors in Youths With Autism Spectrum Disorder Aged 10-17 Years: Protocol for an Open-Label Trial by André Luiz Schuh Teixeira da Rosa, Marina Ribeiro Barreto da Costa, Gabriela Bezerra Sorato, Felipe de Moura Manjabosco, Érica Bonganhi de Bem, Lucas Dellazari, Arthur Bezerra Falcão, Lucas de Oliveira Cia, Olivia Sorato Bezerra, Rogério Boff Borges, Luis Augusto Rohde, Ana Soledade Graeff-Martins

“…The atypical antipsychotics risperidone and aripiprazole, currently the only Food and Drug Administration–approved treatments for severe DB in patients with ASD, often encounter therapeutic failure or intolerance. Given this, exploring pharmacological alternatives for more effective management of DB associated with ASD is essential. …”
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Lutetium-177 labeled iPD-L1 as a novel immunomodulator for cancer-targeted radiotherapy by Myrna Luna-Gutiérrez, Erika Azorín-Vega, Rigoberto Oros-Pantoja, Blanca Ocampo-García, Pedro Cruz-Nova, Nallely Jiménez-Mancilla, Gerardo Bravo-Villegas, Clara Santos-Cuevas, Laura Meléndez-Alafort, Guillermina Ferro-Flores

“…Conclusions Therefore, this study warrants further dosimetric and clinical studies to determine the immunomodulatory effect and therapeutic efficacy of 177Lu-iPD-L1 in treating PD-L1-positive tumors in combination with anti-PD-1/PD-L1 immunotherapy protocols.…”
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