Balneotherapy for the treatment of post-COVID syndrome: a randomized controlled trial by Diana Ovejero, Anna Ribes, Judit Villar-García, Marta Trenchs-Rodriguez, Daniel Lopez, Xavier Nogués, Robert Güerri-Fernandez, Natalia Garcia-Giralt

“…Conclusion Balneotherapy comprise an effective therapeutic modality that can alleviate several symptoms that characterize PACS, particularly musculoskeletal pain and fatigue. …”
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Synthesis and Antifungal Activity of Fmoc-Protected 1,2,4-Triazolyl-α-Amino Acids and Their Dipeptides Against <i>Aspergillus</i> Species by Tatevik Sargsyan, Lala Stepanyan, Henrik Panosyan, Heghine Hakobyan, Monika Israyelyan, Avetis Tsaturyan, Nelli Hovhannisyan, Caterina Vicidomini, Anna Mkrtchyan, Ashot Saghyan, Giovanni N. Roviello

“…Given the rising concerns about antifungal resistance, these amino acid derivatives, with their unique bioactive structures, could serve as a novel class of therapeutic agents. Further research into their in vivo efficacy and safety profiles is warranted to fully realize their potential as antifungal drugs in clinical and agricultural settings.…”
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Clinical Features at Onset and Genetic Characterization of Pediatric and Adult Patients with TNF-α Receptor—Associated Periodic Syndrome (TRAPS): A Series of 80 Cases from the AIDA... by Carla Gaggiano, Antonio Vitale, Laura Obici, Giampaolo Merlini, Alessandra Soriano, Ombretta Viapiana, Marco Cattalini, Maria Cristina Maggio, Giuseppe Lopalco, Davide Montin, Masen Abdel Jaber, Lorenzo Dagna, Raffaele Manna, Antonella Insalaco, Matteo Piga, Francesco La Torre, Virginia Berlengiero, Viviana Gelardi, Luisa Ciarcia, Giacomo Emmi, Piero Ruscitti, Francesco Caso, Rolando Cimaz, José Hernández-Rodríguez, Paola Parronchi, Ludovico Luca Sicignano, Elena Verrecchia, Florenzo Iannone, Jurgen Sota, Salvatore Grosso, Carlo Salvarani, Bruno Frediani, Roberto Giacomelli, Maria Antonietta Mencarelli, Alessandra Renieri, Donato Rigante, Luca Cantarini

“…This study explores demographic, clinical, and therapeutic features of tumor necrosis factor receptor-associated periodic syndrome (TRAPS) in a cohort of 80 patients recruited from 19 Italian referral Centers. …”
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Sex differences in murine MASH induced by a fructose-palmitate-cholesterol-enriched diet by Lakshmi Arivazhagan, Sofie Delbare, Robin A. Wilson, Michaele B. Manigrasso, Boyan Zhou, Henry H. Ruiz, Kaamashri Mangar, Ryoko Higa, Emily Brown, Huilin Li, Michael J. Garabedian, Ravichandran Ramasamy, Kathryn J. Moore, Edward A. Fisher, Neil D. Theise, Ann Marie Schmidt

“…These results highlight potential mechanistic explanations and therapeutic targets for addressing sex differences and underscore the need to study both sexes in animal models and human MASH.…”
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Navigating Emergency Management of Cancer Patients: A Retrospective Study on First-Time, End-Stage, and Other Established Diagnoses in a High Turnover Emergency County Hospital by Mihaela Corlade-Andrei, Radu-Alexandru Iacobescu, Viorica Popa, Alexandra Hauta, Paul Nedelea, Gabriela Grigorasi, Monica Puticiu, Roxana Elena Ciuntu, Andreea Ivona Sova, Diana Cimpoesu

“…<i>Background and Objectives</i>: The incidence and prevalence of cancers are increasing worldwide, with special emphasis placed on prevention, early detection, and the development of new therapeutic strategies that strongly impact patient outcomes. …”
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Mesenchymal stem cells from perinatal tissues promote diabetic wound healing via PI3K/AKT activation by Jiawei Huang, Qingwen Deng, Lai Ling Tsang, Guozhu Chang, Jinghui Guo, Ye Chun Ruan, Chi Chiu Wang, Gang Li, Hon Fai Chan, Xiaohu Zhang, Xiaohua Jiang

“…This study evaluates and compares the therapeutic potential of MSCs derived from perinatal tissues—human umbilical cord MSCs (hUCMSCs), human chorionic villi MSCs (hCVMSCs), and human decidua basalis MSCs (hDCMSCs)—in a diabetic wound healing model. …”
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Integrating network analysis and experimental validation to reveal the mechanism of Cuscuta chinensis lam. Extract in the treatment of IgA nephropathy by Xianlong Zhang, Mingjie Liang, Ziyang Lin, Minyi Li, Tingting Duan, Yun Han, Lanqing Meng, Mengqiu Li, Guixuan Lin, Tao Xia, Ying Lai, Boen Liang, Bingqiong Li, Minhua Li, Fengxin Kang, Quan Zhu, Zhenghai Li, Junzheng Yang

“…These findings suggest that CCLE has potential as a therapeutic agent for the treatment of IgA nephropathy.…”
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Neoadjuvant immunotherapy for DNA mismatch repair proficient/microsatellite stable non-metastatic rectal cancer: a systematic review and meta-analysis by Huan Zhang, Jing Huang, Huanji Xu, Nanhao Yin, Nanhao Yin, Liyan Zhou, Liyan Zhou, Jianxin Xue, Jianxin Xue, Jianxin Xue, Min Ren

“…BackgroundNeoadjuvant immunotherapy (NIT) has been endorsed by clinical guidelines for the management of DNA mismatch repair deficiency/microsatellite instability-high (dMMR/MSI-H) locally advanced rectal cancer (LARC). Nonetheless, the therapeutic efficacy of NIT in mismatch repair-proficient/microsatellite stable (pMMR/MSS) non-metastatic rectal cancer (RC) remain pending matters. …”
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Macrophage Notch1 signaling modulates regulatory T cells via the TGFB axis in early MASLD by Mengya Zhang, Kun Li, Xiaoxing Huang, Dongqin Xu, Ruobin Zong, Qintong Hu, Xiaoyu Dong, Qinyong Zhang, Chaochen Jiang, Yue Ge, Changyong Li, Jie Ping

“…We identify a previously unrecognized molecular mechanism involving the macrophage Notch1/exosomal miR-142a-3p/TGFBR1 pathway in regulating Treg differentiation, providing a rationale for refined therapeutic strategies for MASLD. Impact and implications:: The immune mechanisms driving MASLD progression, particularly during the early stages of disease, are not fully understood, which limits the development of effective interventions. …”
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Fhl1, a new spatially specific protein, regulates vein graft neointimal hyperplasia by Chaoqun Wang, Jiantao Chen, Zicong Feng, Bohao Jian, Suiqing Huang, Kangni Feng, Haoliang Liu, Zhuoming Zhou, Ziyin Ye, Jing Lu, Mengya Liang, Zhongkai Wu

“…These highlight its potential as a therapeutic target for mitigating vein graft failure associated with cardiovascular procedures. …”
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ELABELA promotes the migration and homing of bone marrow mesenchymal stem cells to myocardial injury sites through the ERK1/2/miR-299a-5p/Exo70 pathway by Jing-Yu Hou, Hao Wu, Shuang-Mei Li, Xiao-Jing Li, Shu-Jun Yang, Xu-Xiang Chen, Chang-Qing Zhou, Hui-Bao Long, Hai-Dong Wu, Jia-Ying Fu, Ya-Jie Guo, Tong Wang

“…ELA also activated ERK1/2 phosphorylation, while inhibition of ERK1/2·with U0126 abrogated F-actin polymerization and migration, increasing miR-299a-5p levels and reducing Exo70.ConclusionELA enhances BMSCs migration and homing to injured cardiomyocytes by activating the APJ receptor, promoting ERK1/2 phosphorylation, downregulating miR-299a-5p, and upregulating Exo70, providing a potential therapeutic strategy for improving stem cell-based cardiac repair.…”
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Efficacy of PD-1 blockade plus chemotherapy in patients with oncogenic-driven non-small-cell lung cancer by Haowei Wang, Lei Cheng, Jian Chen, Peixin Chen, Zhuoran Tang, Qianyi Wang, Ying Ma, Chao Zhao, Xuefei Li, Tao Jiang, Fei Zhou, Xiaoxia Chen, Caicun Zhou

“…Objective response rate (ORR), progression-free survival (PFS), and overall survival (OS) were compared to evaluate the therapeutic outcomes differences among patients with different oncogenic drivers. …”
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Effect of Bian-stone hot ironing-massage and Chinese herbal medicine penetration combined with auricular acupoint sticking and pressing on relief of incomplete intestinal obstructi... by ZHANG Lihua (张丽华), XUE Li (薛丽), HUANG Yanping (黄砚萍), WANG Guifang (王贵芳)

“…Conclusion The Bian-stone hot ironing-massage Chinese herbal medicine penetration combined with auricular acupoint sticking and pressing is potentially effective to relieve the clinical symptoms of incomplete intestinal obstruction and improve the therapeutic effect. (目的 观察砭石熨摩中药透入法联合耳穴贴压缓解不完全性肠梗阻临床症状的效果, 总结相关护理措施。…”
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Impact of Sex on Infection Risk in Patients with Systemic Lupus Erythematosus by R. Borrelli, S. Nicola, F. Corradi, I. Badiu, L. Lo Sardo, N. Rashidy, A. Quinternetto, M. Mazzola, F. Meli, E. Saracco, I. Vitali, S. Negrini, L. Brussino

“…Our findings emphasize the need for tailored clinical management, with increased vigilance for infections in male patients, to improve prevention strategies and targeted therapeutic interventions in this subgroup.…”
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RET inhibition overcomes resistance to combined CDK4/6 inhibitor and endocrine therapy in ER+ breast cancer by Charlotte K. Kindt, Sidse Ehmsen, Sidse Ehmsen, Sidse Ehmsen, Sofie Traynor, Benedetta Policastro, Nikoline Nissen, Mie K. Jakobsen, Monique F. Hundebøl, Lene E. Johansen, Martin Bak, Elsa Arbajian, Johan Staaf, Henrik J. Ditzel, Henrik J. Ditzel, Henrik J. Ditzel, Carla L. Alves

“…We further observed a shorter median survival to combined CDK4/6i and endocrine therapy in patients with RET-positive compared to RET-negative tumors, but this difference did not reach statistical significance.ConclusionsOur findings show that RET is overexpressed in ER+ metastatic breast cancer resistant to combined CDK4/6i and endocrine therapy, rendering RET inhibition a promising therapeutic approach for patients who experience disease progression on combined CDK4/6i and endocrine therapy.…”
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Artificial intelligence-based, non-invasive assessment of the central aortic pressure in adults after operative or interventional treatment of aortic coarctation by Renate Oberhoffer, Peter Ewert, Harald Kaemmerer, Nicole Nagdyman, Oliver Dewald, Frank Klawonn, Michael Huntgeburth, Andreas Eicken, Christian Meierhofer, Sebastian Freilinger, Martin Middeke, Pinar Bambul Heck, Annika Freiberger, Frank Harig, Manuel Lösch, Fritz Mellert, Fabian von Scheidt, Elsa Ury, Nicole Wolfrum, Ann-Sophie Kaemmerer-Suleiman, Mathieu N. Suleiman

“…Conventional blood pressure (BP) measurement methods lack precision for individual diagnoses and therapeutic decisions. This study evaluated the use of artificial intelligence-based pulse wave analysis (AI-PWA) to assess central aortic blood pressure (CABP) and related parameters in post-treatment CoA patients.Methods This exploratory, cross-sectional study enrolled 47 adults with CoA, between June 2023 and May 2024. …”
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Development and interpretation of a pathomics-driven ensemble model for predicting the response to immunotherapy in gastric cancer by Jing Wang, Zhe Li, Wei Wang, Md Tauhidul Islam, Xiaoyan Wang, Zhen Han, Zihan Li, Guoxin Li, Yuming Jiang, Taojun Zhang, Wenjun Xiong, Zepang Sun, Lequan Yu, Zhicheng Zhang, Xianqi Yang, Shengtian Sang, Alyssa A Guo

“…An ensemble model, integrating four classifiers: least absolute shrinkage and selection operator, k-nearest neighbors, decision trees, and random forests, was developed and validated using pathomics features, with the objective of predicting the therapeutic efficacy of immune checkpoint inhibition. …”
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Characterization of Shigella flexneri serotype 6 strains from geographically diverse low- and middle-income countries by Caitlin E. Gabor, Charlotte E. Chong, Jose M. Lemme-Dumit, Tracy H. Hazen, Kate S. Baker, Karen L. Kotloff, Irene N. Kasumba, Sharon M. Tennant, Henry Badji, M. Jahangir Hossain, Richard Omore, Benjamin Ochieng, Alex O. Awuor, Billy Ogwel, Jane Juma, Eileen M. Barry, David A. Rasko

“…Given the genomic diversity of Sf6 compared with other S. flexneri serotypes and Sf6 unique O-antigen core structure, serotype-specific characterization of Sf6 is a critical step to inform Shigella-directed vaccine and alternative therapeutic designs. Herein, we identified conserved genomic content among a large collection of temporally and geographically diverse Sf6 clinical isolates and characterized genotypic and phenotypic properties that separate Sf6 from non-Sf6 S. flexneri serotypes.…”
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Pengaruh Hemodialisis terhadap Urea Reduction Ratio pada Pasien Penyakit Ginjal Kronik Stadium V di RSUP Dr. M. Djamil Padang by Wahyuni Armezya, Ellyza Nasrul, Elizabet Bahar

“…Hemodialysis doses are given to the patient must meet the body’s needs in order to make the therapeutic goals can be achieved well. The objective of this study was to determine the adequacy of hemodialysis measured by URR in hemodialysis patients in the M Djamil hospital Padang. …”
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Comparative efficacy of incretin drugs on glycemic control, body weight, and blood pressure in adults with overweight or obesity and with/without type 2 diabetes: a systematic revi... by Song Liu, Jiaqiang Hu, Chen Zhao, Hang Liu, Chunyang He

“…Safety analysis revealed that Tirzepatide had a favorable safety profile and all agents showed no significant impact on serious adverse events compared to placebo.ConclusionsMulti-receptor drugs demonstrated substantial therapeutic potential in weight management, glycemic control, and blood pressure regulation in adults with overweight or obesity, with or without diabetes, with a generally favorable safety profile.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42024554005.…”
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