STING agonist-based treatment promotes vascular normalization and tertiary lymphoid structure formation in the therapeutic melanoma microenvironment by Walter J Storkus, Ronald J Fecek, Manoj Chelvanambi, Jennifer L Taylor

“…For T cell repertoireβ-CDR3 analyses, T cell CDR3 was sequenced from gDNA isolated from splenocytes and enzymatically digested tumors.Results We report that activation of STING within the TME leads to slowed melanoma growth in association with increased production of antiangiogenic factors including Tnfsf15 (Vegi) and Cxcl10, and TLS-inducing factors including Ccl19, Ccl21, Lta, Ltb and Light. Therapeutic responses resulting from intratumoral STING activation were characterized by improved VN, enhanced tumor infiltration by CD8+ T cells and CD11c+ DCs and local TLS neogenesis, all of which were dependent on host expression of STING. …”
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Synergistic Therapeutic Effects and Immunoregulatory Mechanism of Maxing Shigan Decoction Combined with Sijunzi Decoction on Viral Pneumonia in Mice by Huimin Huang, Huanhua Yang, Zurong Zhang, Yunlong Song, Li Li, Ke Li, Junjie Zhang, Xiaoyu Qi, Ying Wu

“…Together, SJZD improved the therapeutic effectiveness of MXSGD in treating influenza virus pneumonia than when used alone. …”
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Molecular characterization and potential therapeutic roles of miR125a in HER-2 positive gastric cancer by Afraa Mamoori, Zena Hasan Sahib, Haider Alkafaji

“…Conclusion: miR-125a-3p plays a significant role in the pathogenesis of gastric carcinoma. Therapeutic transfection of miR-125a-3p in HER2 positive gastric cancer cells resulted in reduced cell proliferation and potentiate the effect of 5-FU.…”
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Machine learning prediction of obesity-associated gut microbiota: identifying Bifidobacterium pseudocatenulatum as a potential therapeutic target by Hao Wu, Yuan Li, Yuxuan Jiang, Xinran Li, Shenglan Wang, Changle Zhao, Changle Zhao, Ximiao Yang, Baocheng Chang, Juhong Yang, Juhong Yang, Jianjun Qiao, Jianjun Qiao

“…Furthermore, B. pseudocatenulatum was shown to reduce lipid accumulation in C. elegans and inhibit lipid differentiation in C3H10T1/2 cells.ConclusionBifidobacterium pseudocatenulatum holds potential as a therapeutic agent for managing diet-induced obesity, underscoring its relevance in microbiome-based obesity research and intervention.…”
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Ornamental Exterior versus Therapeutic Interior of Madagascar Periwinkle (Catharanthus roseus): The Two Faces of a Versatile Herb by Naghmeh Nejat, Alireza Valdiani, David Cahill, Yee-How Tan, Mahmood Maziah, Rambod Abiri

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Two Rare Cases of Feline Toxic Epidermal Necrolysis: A Novel Therapeutic Approach With Medical-Grade Honey by Alexandra Peteoacă, Niels A. J. Cremers, Linsey J. F. Peters

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Sensorineural Hearing Loss as a First Presentation of Multiple Myeloma: A Successful Management with Therapeutic Plasma Exchange by Morteza Daraei, Ahmad Khajeh-Mehrizi, Behrooz Amirzargar, Fereshteh Ameli, Fahimeh Zeinalkhan

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Delving into the therapeutic prospects of desmostachya bipinnata (L.) in the context of polycystic ovary syndrome (PCOS): A comprehensive review by Sarthak Mishra, Payal Mittal

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Therapeutic Benefit in Rheumatoid Cachexia Illustrated Using a Novel Primary Human Triple Cell Coculture Model by Tracey Ollewagen, Gareth S. Tarr, Kathryn H. Myburgh, Helmuth Reuter, Carine Smith

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Therapeutic Effect of Human Umbilical Cord Mesenchymal Stem Cells at Various Passages on Acute Liver Failure in Rats by Yongting Zhang, Yuwen Li, Wenting Li, Jie Cai, Ming Yue, Longfeng Jiang, Ruirui Xu, Lili Zhang, Jun Li, Chuanlong Zhu

“…However, data on the therapeutic potential of culture-expanded MSCs are lacking. …”
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Regulation of adipocyte differentiation and lipid metabolism by novel synthetic chromenes exploring anti-obesity and broader therapeutic potential by Kewalin Inthanon, Natthawut Wong-a-nan, Srisulak Dheeranupattana, Andres Garcia Guerra, Neal M. Davies, Chatchai Kesornpun, Sasithorn Sangher, Prasat Kittakoop

“…Abstract Obesity poses a significant global health challenge, necessitating the search for novel therapeutic agents to address this epidemic. Chromenes, known for their diverse bioactivities, hold promise as potential anti-obesity compounds, yet research in this area remains limited. …”
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Targeted co-delivery nanosystem based on methotrexate, curcumin, and PAMAM dendrimer for improvement of the therapeutic efficacy in cervical cancer by Ayuob Aghanejad, Shiva Kheiriabad, Maryam Ghaffari, Simin Namvar Aghdash, Neda Ghafouri, Jafar Ezzati Nazhad Dolatabadi, Hashem Andishmand, Michael R. Hamblin

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Molecular Alterations of PI3K/Akt/mTOR Pathway: A Therapeutic Target in Endometrial Cancer by Athanasia Pavlidou, Nikos F. Vlahos

“…In addition, potential therapeutic targets of this pathway with emphasis on the mTOR inhibitors are also presented.…”
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Multi-omic and machine learning analysis of mitochondrial RNA modification genes in lung adenocarcinoma for prognostic and therapeutic implications by Xiao Zhang, Jiatao Liu, Yaolin Cao, Wei Wang, Haoran Lin, Yue Yu

“…In conclusion, this study establishes MRMS as a robust prognostic biomarker and highlights its dual role in shaping the tumor immune microenvironment and guiding therapeutic strategies. These findings provide novel insights into mitochondrial RNA modifications and their potential applications in personalized treatment for LUAD.…”
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Self‐Boosting Programmable Release of Multiple Therapeutic Agents by Activatable Heterodimeric Prodrug‐Enzyme Assembly for Antitumor Therapy by Shanshan Jiang, Bhaskar Gurram, Junfei Zhu, Shan Lei, Yifan Zhang, Ting He, Oya Tagit, Hui Fang, Peng Huang, Jing Lin

“…Herein, a ROS‐activatable heterodimeric prodrug‐loaded enzyme assembly is developed for self‐boosting programmable release of multiple therapeutic agents. The heterodimeric prodrug NBS‐TK‐PTX (namely NTP) is composed of 5‐(ethylamino)‐9‐diethylaminobenzo[a]phenothiazinium chloride analog (NBS), paclitaxel (PTX) and ROS‐responsive thioketal (TK) linker, which shows a strong binding affinity with glucose oxidase (GOx), thus obtaining NTP@GOx assembly. …”
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Exploring potential therapeutic targets for small cell lung cancer based on transcriptomics combined with Mendelian randomization analysis by Zhicheng Liao, Pengcheng Jia, Yifan Li, Zhihui Zheng, Jizhou Zhang

“…ObjectiveThe main objective of this study was to explore and identify new genetic targets in small-cell lung cancer (SCLC) through transcriptomics analysis and Mendelian randomization (MR) analysis, which will help in the subsequent development of new therapeutic interventions.MethodsIn this study, we extracted the SCLC dataset from the Gene Expression Omnibus (GEO) database, processed the data, and screened out differentially expressed genes (DEGs) using R software. …”
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Therapeutic potential of probiotic Lactobacillus spp. Fermented Talinum triangulare on Helicobacter pylori associated gastrointestinal infectious disorders by En-Su Chang, Cheng-Yi Hsu, Jui-Chen Li, Rajni Dubey, Wei-Chih Kan, Ming-Jen Sheu, Chia-Hui Cheng, Chia-Yu Chang, Chin-Chia Hsu, Jiunn-Jye Chuu

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Endometrial Cancer: Molecular and Cellular Basis of Tumor Development, Novel Biomarkers and Therapeutic Agents, and Innovative Research Approaches by Donghai Dai, Andrew P. Bradford, Eric R. Prossnitz

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Relevance of Angiographic Patterns in Patients with Chronic Kidney Disease and Its Therapeutic Implications in Chronic Limb-threatening Ischemia by Sumanshi Singh, Sapna Vishnurajesh Tiwari, Raghuram Sekhar, Sharad Sheth

“…Endovascular revascularization was effective regardless of vessel involvement or CKD status, thereby negating its therapeutic implications.…”
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Therapeutic Effectiveness of Mirror Therapy Combined with Music Therapy on Upper Limb Motor Function in Hemiplegic Patients with Stroke by SHI Bohan, ZHU Yan, MA Shujie, XU Qian, WANG Ping, CHEN Zhu, ZHU Weijia

“…ObjectiveTo investigate the therapeutic effect of mirror therapy combined with music therapy on the recovery of upper limb function in hemiplegic patients with stroke.MethodsA total of eighty-one stroke patients with upper extremity dysfunction were included and randomly divided into conventional rehabilitation group，mirror therapy group andcombined treatment group，with 27 cases in each group.All patients received routine physical therapy，drug therapy and nursing. …”
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