Proteomic analysis of whole blood to investigate the therapeutic effects of nervonic acid on cerebral ischemia-reperfusion injury in rats by Qingqing Li, Fengrong Zhang, Xianyu Li, Qing Wang

“…Nervonic acid (NA), a vital long-chain monounsaturated fatty acid found in mammalian nervous tissue, shows promising therapeutic potential in neurological disorders. This study aimed to develop a reliable methodology for whole blood proteomics to identify early warning biomarkers and evaluate drug treatment efficacy.MethodsAfter modeling via the classic thread embolization method, whole blood samples were collected from the rats. …”
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Radiofrequency Ablation in the Management of Advanced Stage Thymomas: A Case Report on a Novel Multidisciplinary Therapeutic Approach by Panagiotis Paliogiannis, Carlo Pala, Renato Versace, Claudio Pusceddu

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“Subtype-precise” therapy leads diagnostic and therapeutic innovations: a new pattern for precision treatment of breast cancer by ZHANG Siwei, MA Ding, JIANG Yizhou, SHAO Zhimin

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Therapeutic efficacy of a potent anti-Venezuelan equine encephalitis virus antibody is contingent on Fc effector function by Jennifer L. Schwedler, Maxwell A. Stefan, Christine E. Thatcher, Peter R. McIlroy, Anupama Sinha, Ashlee M. Phillips, Christopher A. Sumner, Colleen M. Courtney, Christina Y. Kim, Dina R. Weilhammer, Brooke Harmon

“…However, when hF5-WT and hF5-LALA were administered + 48 h post infection, there was a significant decrease in the therapeutic efficacy of hF5-LALA. Together these results demonstrate that optimal therapeutic Ab treatment of VEEV, and possibly other encephalitic alphaviruses, requires neutralization paired with engagement of immune effectors via the Fc region.…”
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Therapeutic Effect of Repetitive Transcranial Magnetic Stimulation Combined with Local Vibration Therapy on Children with Hemiplegic Cerebral Palsy by LI Mingdi, LIANG Guanjun, ZHANG Dali, ZHANG Hewei, WANG Wei, GU Qin

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Synergistic therapeutic approach for hemorrhoids: integrating mesenchymal stem cells with diosmin-hesperidin to target tissue edema and inflammation by M. Hidayat Budi Kusumo, Adi Prayitno, Soetrisno ., Abdurahman Laqif

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Therapeutic Effect of Mirror Therapy Combined with Conventional Speech Training on Subcortical Aphasia after Acute Cerebral Infarction by Qingmei CHEN, Xiuying CAI, Jun KE, Dan SHEN, Keke FAN, Weixin YANG, Li LI, Qi FANG

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Preclinical pharmaco-toxicological screening of biomimetic melanin-like nanoparticles as a potential therapeutic strategy for cutaneous melanoma by Iasmina Marcovici, Iasmina Marcovici, Raul Chioibas, Raul Chioibas, Istvan Zupko, Iulia Pinzaru, Iulia Pinzaru, Alina Moaca, Alina Moaca, Adriana Ledeti, Adriana Ledeti, Lucian Barbu-Tudoran, Lucian Barbu-Tudoran, Andreea Geamantan, Andreea Geamantan, Iasmina Predescu, Iasmina Predescu, Cristina Adriana Dehelean, Cristina Adriana Dehelean

“…IntroductionDespite its rarity, cutaneous melanoma (CM) represents the deadliest skin cancer with a high mortality rate, an incidence on the rise, and limited therapeutic options at present. Melanin is a polymeric pigment naturally produced within melanocytes and CM cells that gained a noteworthy attention due to its pharmacological properties, and potential for the design of nanoplatforms with biomedical applications. …”
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SARS-CoV-2: Molecular Structure, Pathogenesis, Potential Therapeutic Targets, and Immune Response of the Infected Subject by R. Wumba, M. Mandina, Y. Nlandu, J. R. Makulo, A. Tshimpi, P. Mbala, A. Mbangama, P. Kabututu, J. M. Kayembe

“…Papers of interest were those addressing virological and molecular data on SARS-CoV-2, therapeutic aspects of COVID-19, and immunity of the infected subject. …”
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Targeting Epac2 and GluA3-containing AMPARs: a novel therapeutic strategy for Alzheimer’s disease by Tong Zhang, Martina Schmidt

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Clinico- Therapeutic Study of Stevens Johnson Syndrome-Toxic Epidermal Necrolysis and Prognostic Significance of SCORTEN in Indian Patients by Neha Chetan Jangid, Ankita Nirmal Choudhary, Bela Jashwantlal Shah, Shikha Rupalkumar Shah, Harshita R Vyas, Deval Mistry

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Toll-Like Receptors Expression and Signaling in Glia Cells in Neuro-Amyloidogenic Diseases: Towards Future Therapeutic Application by Dorit Trudler, Dorit Farfara, Dan Frenkel

“…Understanding the pattern of TLR signaling in the glial cells may lead to the identification of new targets for therapeutic application.…”
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Increasing the neoantigen expression by nonsense mediated mRNA decay inhibitors: An effective therapeutic approach in oral cancer? by Saravanan Sekaran

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Utilizing bioinformatics and machine learning to identify CXCR4 gene-related therapeutic targets in diabetic foot ulcers by Hengyan Zhang, Ye Zhou, Heguo Yan, Changxing Huang, Licong Yang, Yangwen Liu

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Single-cell and bulk RNA sequencing analysis reveals CENPA as a potential biomarker and therapeutic target in cancers by Hengrui Liu, Miray Karsidag, Kunwer Chhatwal, Panpan Wang, Tao Tang

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Angiotensin‐converting enzyme 2 modulation of pyroptosis pathway in traumatic brain injury: A potential therapeutic target by Jinxiu Guo, Shiyuan Zhao, Xue Chu, Changshui Wang, Junjun Meng, Shanshan Wei, Jianhua Wang, Yujin Guo, Weihua Kong, Wenxue Sun, Tao Zhang, Ruili Dang, Mengqi Yang, Jing Chen, Pei Jiang

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The Role of Vitamin D in the Pathomechanism of Inflammatory Bowel Disease (IBD) and its Therapeutic Implications - a literature review by Wiktoria Maria Tomaszewska, Paweł Siudziński, Mateusz Łyko, Alicja Skoczylas, Jakub Kurasz, Wojciech Maj, Wiktoria Podlasiewicz, Katarzyna Pala, Piotr Dudziak, Anna Nowak, Maria Golińska

“…Aim: The purpose of this study was to analyze the mechanisms of action of vitamin D in the context of the pathogenesis of inflammatory bowel disease (IBD) and its potential therapeutic applications, with particular emphasis on clinical studies evaluating vitamin D supplementation. …”
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A study on the levels and withdrawal times of chloramphenicol from milk of mastitic cows medicated with chloramphenicol at therapeutic dose by Ahmet Acet, Ömer Demet, D. Ali Dinç, Bünyamin Traş, A. Levent Baş

“…This study was conducted to determine chloramphenicol level and its clearance time from milk cow with mastitis, which were medicated with chloramphenicol at therapeutic doses.<p> In this experimental study, three groups that each has two Browns Swiss cows were used. …”
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Therapeutic efficacy of LysGH15 against necrotising pneumonia caused by Staphylococcus aureus in a rabbit model by Bowei Zhang, Liran Song, Yongran Wang, Meimei Zhang, Chong Chen, Hui Ning, Li Wang, Cao Qiu, Xinwu Wang, Changjiang Sun, Xin Feng, Wenyu Han, Wenyu Han, Bin Wang, Yalu Ji, Jingmin Gu, Jingmin Gu

“…IntroductionStaphylococcus aureus (S. aureus) is one of the most important zoonotic pathogens and can be transmitted to humans through the meat diet routes, causing necrotising pneumonia.MethodsThis study investigated the therapeutic effect of bacteriophage lysin LysGH15 on necrotising pneumonia in rabbit model caused by S. aureus.ResultsIn the in vitro experiments, 50 μg/mL LysGH15 not only significantly reduced the viable count (approximately 3.24 × 106 CFU/g) of chicken meat stored at 4°C for 48 h but also effectively reduced the viable count of chicken meat thawed at 4°C and 30°C, with reductions of approximately 1.42 × 106 CFU/g and 2.78 × 106 CFU/g, respectively. …”
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Employing a Carbon-Based Nanocomposite as a Diffusive Solid-Phase Extraction Adsorbent for Methamphetamine for Therapeutic Purposes by K. Lakshmi Kala, G. Anbuchezhiyan, Kavitha Pingili, Pradeep Kumar Singh, V. M. Vel, Kareem Yusuf, Ahmed Muteb Aljuwayid, Md Ataul Islam, David Christopher

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