Integrative analysis of ferroptosis in the hypoxic microenvironment of gastric cancer unveils the immune landscape and personalized therapeutic strategies by Xiao Xu, Liangling Fa, Xiaoxiao Sun, Fangfang Yang, Yongrui Liu, Jifu Song, Yongli Zhao, Jigang Dong, Jigang Dong

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Update on the therapeutic role of metformin in the management of polycystic ovary syndrome: Effects on pathophysiologic process and fertility outcomes by Kerstin MG Brand, Ulrike Gottwald-Hostalek, Aimee Andag-Silva

“…However, regulatory approvals for this therapeutic indication are still exceptional and exist only in a few countries, including for the originator, Glucophage®. …”
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Altered Immunoregulation in Rheumatoid Arthritis: The Role of Regulatory T Cells and Proinflammatory Th17 Cells and Therapeutic Implications by Alessia Alunno, Mirko Manetti, Sara Caterbi, Lidia Ibba-Manneschi, Onelia Bistoni, Elena Bartoloni, Valentina Valentini, Riccardo Terenzi, Roberto Gerli

“…In addition, the effects of currently employed RA therapeutic strategies on these lymphocyte subpopulations have been extensively investigated. …”
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THE USE OF ARTIFICIAL INTELLIGENCE IN THE THERAPEUTIC MANAGEMENT OF PAPILLARY THYROID MICROCARCINOMA: A RANDOMIZED CONTROLLED TRIAL PROTOCOL by Ramona Elena Teiu, Tudor Florin Ursuleanu, Hlescu Cristian Stefan, Roxana Grigorovici, Andreea Roxana Luca, Maria Paula Comanescu, Alina Ionela Calin, Alexandru Grigorovici

“…Aim of the study The correct establishment of the therapeutic conduct in papillary thyroid cancer through the use of artificial intelligence (AI) models is essential in medical practice in diagnosing and establishing the prognosis of the disease, this aspect implies the most accurate and effective therapeutic approach. …”
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The Interaction of Src Kinase with β3 Integrin Tails: A Potential Therapeutic Target in Thrombosis and Cancer by Stephan Huveneers, Erik H. J. Danen

“…Here, we give an overview of the β3-c-Src interaction and its implications for signaling in platelets and tumor cells, and we mention the possibilities for therapeutic intervention that is aimed at disrupting the β3-c-Src interaction for antithrombotic and anticancer purposes.…”
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The Role of Methylation in Chronic Lymphocytic Leukemia and Its Prognostic and Therapeutic Impacts in the Disease: A Systematic Review by Sevastianos Chatzidavid, Christina-Nefeli Kontandreopoulou, Nefeli Giannakopoulou, Panagiotis T. Diamantopoulos, Christos Stafylidis, Marie-Christine Kyrtsonis, Maria Dimou, Panayiotis Panayiotidis, Nora-Athina Viniou

“…Τhe application of these findings beyond the theoretical understanding can not only lead to the creation of prognostic and predictive models and scores but also to the design of novel therapeutic agents. The following is a review focusing on the present knowledge about single gene/gene promoter methylation or mRNA expression in CLL cases as well as records of older data that have been published in past papers.…”
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Multi-modality Imaging Identifies Key Times for Annexin V Imaging as an Early Predictor of Therapeutic Outcome by Stefanie J. Mandl, Carina Mari, Matthias Edinger, Robert S. Negrin, Jonathan F. Tait, Christopher H. Contag, Francis G. Blankenberg

“…Multimodality imaging revealed the temporal patterns of tumor cell loss and annexin V uptake revealing a better understanding of the timing of radiolabeled annexin V uptake for its development as a marker of therapeutic efficacy.…”
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Mitochondrial quality control: a pathophysiological mechanism and potential therapeutic target for chronic obstructive pulmonary disease by Mengjiao Xu, Peng Feng, Peng Feng, Jun Yan, Lei Li

“…Additionally, we analyze the limitations and challenges of existing therapeutic strategies, aiming to provide new insights and methods for COPD treatment.…”
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A New Antibody–Cytokine Construct Targeting Natural Killer Cells: An Immunotherapeutic Approach to Chronic Lymphocytic Leukemia by Michela Flego, Mauro Andreotti, Francesca Romana Mauro, Maria Beatrice Arasi, Silvia Zamboni, Zuleika Michelini, Sara Pepe, Clementina Maria Galluzzo, Roberta Amici, Diego Moricoli, Chiara Mazzei, Alessandro Ascione, Alessandra Mallano

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Pan-caspase inhibitor protects against noise-induced hearing loss in a rodent model by Maria Fernanda Yepes, Kayla Minesinger, Federica M. Raciti, Maria Camila Salazar, Suhrud M. Rajguru, Suhrud M. Rajguru, Suhrud M. Rajguru

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Metabolites Profiling of Soil Actinomycetes with Antimicrobial and Anticancer Activities by Ram Prabodh Yadav, Bibek Raj Bhattarai, Rabin Budhathoki, Padamlal Budthapa, Monika Rana, Rubin Thapa Magar, Bijaya Bahadur Thapa, Akkal Dev Mishra, Niranjan Parajuli

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Digital mental health treatment implementation playbook: successful practices from implementation experiences in American healthcare organizations by David C. Mohr, David C. Mohr, Alexandra L. Silverman, Alexandra L. Silverman, Soo Jeong Youn, Soo Jeong Youn, Soo Jeong Youn, Patricia Areán, Andrew Bertagnolli, Jenna Carl, Tarolyn Carlton, Neha Chaudhary, David Cooper, Shelly DeVito, Stephanie Eaneff, Megan Flom, Valerie L. Forman-Hoffman, Leanna Fortunato, Karen Franchino, Andrea K. Graham, Heidi Greenberger, Jessica Hauflaire, Benjamin Kaveladze, Rachel Kornfield, Kaylee P. Kruzan, Eric Kuhn, Eric Kuhn, Carolyn MacIver, Frederick Muench, Regina Misch, Adrian Ortega, Lisa Palko, Derek Richards, Derek Richards, Louisa Salhi, Jonathan Schremp, Eva Szigethy, Eva Szigethy, Nathan Tatro, Bethany A. Teachman, Bethany A. Teachman, Trina Histon

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Deciphering genomic complexity: Understanding intratumor heterogeneity, clonal evolution, and therapeutic vulnerabilities in oral squamous cell carcinoma by Vishnu Priya Veeraraghavan, Bharati R. Doni, Arun Kumar Dasari, Chaitra Patil, Krishna A. Rao, Santosh R. Patil

“…Key driver mutations and therapeutic vulnerabilities were identified using next-generation sequencing and functional genomics approaches. …”
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Therapeutical Intervention, Relaxation, Mental Images, and Spirituality (RIME) for Spiritual Pain in Terminal Patients. A Training Program by Ana Catarina de Araújo Elias, Joel Sales Giglio, Cibele Andrucioli de Mattos Pimenta, Linda Gentry El-Dash

“…Therapeutic intervention involving the technique of Relaxation, Mental Images, and Spirituality (RIME) can foster the redefinition of spiritual pain in terminal patients. …”
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The potential therapeutic effects of coenzyme Q10 on the sciatic nerve regeneration following short- and long-term injury by Ahmed Omer Mead, Berrin Zuhal Altunkaynak, Süleyman Kaplan

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ENO1/Hsp70 Interaction Domains: In Silico and In Vitro Insight for a Putative Therapeutic Target in Cancer by Maria Rita Gulotta, Ugo Perricone, Patrizia Rubino, Angela Bonura, Salvatore Feo, Agata Giallongo, Giovanni Perconti

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Lipopolymers as the Basis of Non-Viral Delivery of Therapeutic siRNA Nanoparticles in a Leukemia (MOLM-13) Model by Panadda Yotsomnuk, Amarnath Praphakar Rajendran, Daniel Nisakar Meenakshi Sundaram, Luis Carlos Morales, Cezary Kucharski, Mohammad Nasrullah, Wanwisa Skolpap, Xiaoyan Jiang, Spencer B. Gibson, Joseph Brandwein, Hasan Uludağ

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Pirfenidone: An Encouraging Therapeutic Approach For Enhancing Lateral Spinothalamic Tract Function After Spinal Cord Compression Injury by Noman Ullah Wazir, Ambereen Humayun, Irum Javaid, Asma Amir, Nayyab Khattak, Ayesha Iftikhar

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Novel and potent MICA/B antibody is therapeutically effective in KRAS LKB1 mutant lung cancer models by Shohei Koyama, Yujiro Naito, John D Minna, David E Gerber, Ryan R Kowash, Manoj Sabnani, Laura T Gray, Qing Deng, Nusrat U A Saleh, Luc Girard, Kentaro Masahiro, Zhiqian Lucy Liu, Hemanta Baruah, Esra A Akbay

“…MICA/B are shed across different tumors making this therapeutic strategy universally applicable.…”
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The Therapeutic Potential of Low-Intensity Pulsed Ultrasound in Enhancing Gallbladder Function and Reducing Inflammation in Cholesterol Gallstone Disease by Fang Chen, Run Guo, Tian Chen, Liping Liu, Fan Ding, Gang Zhao, Bo Zhang

“…These findings highlight the potential of LIPUS as a non-invasive therapeutic approach for managing CGS.…”
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