Tumor biomarkers contribute to the diagnosis and clinical management of the O-RADS MRI risk stratification system for epithelial ovarian tumors by Shengjie Xu, Weijian Gong, Xiyi Chen, Jiatong Wang, Yuan Zhu, Tao Zhang, Yun Gu, Jinxia Zheng, Juan Xu

“…For EOTs with a ROMA index less than 20.14% (premenopausal) or 29.9% (postmenopausal), minimally invasive surgery is recommended for diagnostic and therapeutic purposes. Comprehensive staging or cytoreductive surgery is recommended for the remaining patients, especially when fertility preservation is not a priority. …”
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A stratified two-stage tumor molecular profiling algorithm to identify clinically actionable molecular alterations in pancreatic cancer☆ by S. Hussung, D. Akhoundova, C. Pistoni, D. Lenggenhager, A. Töpfer, C. Pauli, B. Pestalozzi, C. Britschgi, M. Zoche, M. Rechsteiner, H. Moch, A. Weber, R. Fritsch

“…Conclusions: Stratified two-stage TMP reliably identifies actionable alterations in PC patients, with potential therapeutic benefit. The proposed TMP algorithm might be as effective, yet more feasible and economic compared with comprehensive upfront testing.…”
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Establishment and validation of a nomogram for coronary artery lesions in children with Kawasaki disease by Chong Hu, Chong Hu, Xiao Yan, Henglian Song, Qin Dong, Qin Dong, Changying Yi, Changying Yi, Jianzhi Li, Jianzhi Li, Xin Lv, Xin Lv

“…This model had a high predictive accuracy and reliability for identifying high-risk children in the very early stage of disease with remarkable precision, laying the foundation for personalized treatment strategies and targeted treatment and providing a strong scientific basis for precise therapeutic intervention.…”
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The Role of Indoxyl Sulfate in Exacerbating Colorectal Cancer During Chronic Kidney Disease Progression: Insights into the Akt/β-Catenin/c-Myc and AhR/c-Myc Pathways in HCT-116 Col... by Yu Ichisaka, Chihiro Takei, Kazuma Naito, Manami Higa, Shozo Yano, Toshimitsu Niwa, Hidehisa Shimizu

“…Therefore, indoxyl sulfate could potentially serve as a therapeutic target for CRC aggravation in patients with CKD.…”
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Cx43 Inhibition Attenuates Sepsis-Induced Intestinal Injury via Downregulating ROS Transfer and the Activation of the JNK1/Sirt1/FoxO3a Signaling Pathway by Zhaowei Zou, Bin Liu, Lisi Zeng, Xianzi Yang, Renli Huang, Cheng Wu, Huijuan Zhu, Yi Gao, Dongdong Yuan, Jinlong Yu

“…Thus, we explored the effects of connexin43 (Cx43) on sepsis-induced intestinal injury in order to provide potential therapeutic strategies. Rat cecal ligation and puncture (CLP) models in vivo and cell models (IEC-6 cells) pretreated with LPS in vitro were used in the current study. …”
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Exploring the role of curcumin in mitigating oxidative stress to alleviate lipid metabolism disorders by Maojun Cheng, Maojun Cheng, Fang Ding, Fang Ding, Liyang Li, Liyang Li, Changmao Dai, Changmao Dai, Xiaolan Sun, Xiaolan Sun, Jia Xu, Jia Xu, Feier Chen, Feier Chen, Mingxiu Li, Xueping Li

“…Notably, the article reviews the role of curcumin in mitigating oxidative stress and in preventing and treating diseases associated with lipid metabolism disorders, including hyperlipidemia, non-alcoholic fatty liver disease (NAFLD), atherosclerosis, obesity, and diabetes, thereby highlighting the therapeutic potential of curcumin in lipid metabolism-related diseases.…”
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A novel USP4 inhibitor that suppresses colorectal cancer stemness by promoting β-catenin and Twist1 degradation by Fengtian Li, Yi Zhou, Xinyue Lin, Yaxin Zhang, Qingyong Hu, Enen Zhao, Huali Li, Xingyan Pan, Feng Shu, Kun Zhang, Chengmei Huang, Na Tang, Wenting Liao

“…Conclusions This study identifies U4-I05 as a USP4 inhibitor with significant therapeutic efficacy against CRC, offering a promising avenue for the development of new treatments targeting cancer stemness and chemotherapy resistance. …”
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Uvaol attenuates TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells by modulating expression and membrane localization of β-catenin by Liliane Patrícia Gonçalves Tenório, Liliane Patrícia Gonçalves Tenório, Liliane Patrícia Gonçalves Tenório, Liliane Patrícia Gonçalves Tenório, Liliane Patrícia Gonçalves Tenório, Felipe Henrique da Cunha Xavier, Felipe Henrique da Cunha Xavier, Felipe Henrique da Cunha Xavier, Felipe Henrique da Cunha Xavier, Mônica Silveira Wagner, Kayo Moreira Bagri, Erick Gabriel Alves Ferreira, Romulo Galvani, Romulo Galvani, Romulo Galvani, Romulo Galvani, Claudia Mermelstein, Adriana Cesar Bonomo, Adriana Cesar Bonomo, Adriana Cesar Bonomo, Adriana Cesar Bonomo, Wilson Savino, Wilson Savino, Wilson Savino, Wilson Savino, Emiliano Barreto, Emiliano Barreto

“…Classical inducers associated with the maintenance of EMT, such as TGF-β1, have become targets of several anti-EMT therapeutic strategies. Natural products from the pentacyclic triterpene class have emerged as promising elements in inhibiting EMT. …”
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Immune microenvironment features underlying the superior efficacy of neoadjuvant immunochemotherapy over chemotherapy in local advanced gastric cancer by Ning Zhang, Chunyu Li, Zehua Zhao, Biying Jiang, Wentao Wang, Fujing Sun, Yong Zhang, Yanmei Zhu

“…BackgroundThe therapeutic efficacy of neoadjuvant immunotherapy combined with chemotherapy (Io+Chemo) is superior than chemotherapy alone (Chemo). …”
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Electrophysiological and Structural Changes in Chinese Patients with LHON by Min Wang, Hong Guo, Shiying Li, Gang Wang, Yanling Long, Xiaohong Meng, Bo Liu, Yong Liu, Anthony G. Robson, Zheng Qin Yin

“…The study highlights the importance of comprehensive electrophysiological and structural assessments of the retina in LHON and is pertinent to studies that aim to monitor disease progression or the effects of future therapeutic interventions.…”
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PPARα suppresses growth of hepatocellular carcinoma in a high-fat diet context by reducing neutrophil extracellular trap release by Banglun Pan, Zhu Zhang, Dongjie Ye, Xiaoxia Zhang, Yuxin Yao, Yue Luo, Haijie Hong, Xinran Cai, Yanling Chen, Nanhong Tang

“…Impact and implications:: We have identified PPARα and its agonists as therapeutic targets for controlling the neutrophil extracellular traps associated with high lipid metabolism. …”
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Electroacupuncture may protect pulmonary dysplasia in offspring with perinatal nicotine exposure by altering maternal gut microbiota and metabolites by Yana Xie, Yang Fang, Yitian Liu, Bo Ji, Reiko Sakurai, Yifei Wang, Hewen Li, Ling Zhang, Le Wu, Tingting Guo, Ye Quan, Virender K. Rehan

“…However, the beneficial effects of EA on offspring pulmonary function (FVC, PEF, PIF, and Cdyn) and lung morphology (alveolar number and MLI) were lost after maternal gut microbiota depletion.ConclusionThese findings suggest that EA may exert its therapeutic effects on PNE-induced lung phenotype by altering maternal gut microbiota. …”
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Unsupervised machine learning model for phenogroup-based stratification in acute type A aortic dissection to identify postoperative acute gastrointestinal injury by Yuhu Ma, Xiaofang Yang, Chenxiang Weng, Xiaoqing Wang, Baoping Zhang, Ying Liu, Rui Wang, Zhenxing Bao, Peining Yang, Hong Zhang, Yatao Liu

“…The areas under the curve (AUCs) for diagnosing postoperative AGI of phenogroup A, B, and C were 0.943 (0.854–0.992), 0.990 (0.966–1.000), and 0.964 (0.899–0.997) using the RF model, respectively.ConclusionPhenogroup stratification based on unsupervised learning can accurately identify high-risk populations for postoperative AGI in ATAAD, providing a new approach for implementing individualized preventive and therapeutic measures in clinical practice.…”
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Characteristics, Mortality, and Clinical Outcomes of Hospitalized Patients with COVID-19 and Diabetes: A Reference Single-Center Cohort Study from Poland by Michał Kania, Konrad Mazur, Michał Terlecki, Bartłomiej Matejko, Jerzy Hohendorff, Zlata Chaykivska, Mateusz Fiema, Marianna Kopka, Małgorzata Kostrzycka, Magdalena Wilk, Tomasz Klupa, Przemysław Witek, Barbara Katra, Marek Klocek, Marek Rajzer, Maciej T. Malecki

“…We identified a number of clinical, laboratory, and therapeutic variables associated with the risk of hospital death in DPs.…”
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Development of a stable eukaryotic strain producing fully human monoclonal antibody on the basis of the human antibody against ectromelia virus by A. L. Matveev, Ya. A. Khlusevich, I. K. Baykov, I. V.  Babkin, E. P. Goncharova, V. V. Morozova, N. V. Tikunova

“…Fully­human antibodies have a great therapeutic importance; however, the development of stable strains providing a high level of production of full­size antibodies is a challenging task, as antibody molecules contain two types of polypeptide chains. …”
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Evaluation of the antidiabetic and antinephritic effects of Pueraria tuberosa and Pterocarpus santalinus extracts co-encapsulated in nanostructured lipid carriers in streptozotocin... by Gyamcho Tshering Bhutia, Asit Kumar De, Manas Bhowmik, Pavia Bera, Tanmoy Bera

“…Study design: The in vivo study evaluated the therapeutic potential of NLCs loaded with hydroalcoholic extracts of P. tuberosa tubers (PTE) and P. santalinus heartwood (PSE) in managing DN over eight weeks in streptozotocin (STZ)-induced diabetic mice. …”
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Childhood contact with social services, self-harm and suicidal or self-harm ideation in young adulthood: a population-wide record-linkage study by S. McKenna, D. O’Reilly, E. Ross, A. Maguire

“…Conclusions Understanding the magnitude of childhood adversity amongst adults that present to EDs with self-harm or ideation may inform clinicians’ understanding and therapeutic decision-making. Whilst EDs provide an important setting in which to administer brief interventions, a multi-agency approach is required to reduce self-harm/ideation in young adults that had contact with social services in childhood. …”
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The Association of Cell-Free LncH19 and miR-29b Expression with the PI3K/AKT/HIF-1/VEGF Pathway in Patients with Diabetic Nephropathy: In Silico Prediction and Clinical Validation by Noha M. Abd El-Fadeal, Basma Osman Sultan, Asmaa K. K. AbdelMaogood, Essam Al Ageeli, Fatma Tohamy Mekhamer, Sherihan Rohayem, Ahmed Shahidy, Nora Hosny, Manal S. Fawzy, Mohammed M. Ismail, Hidi A. A. Abdellatif

“…A growing body of evidence suggests that long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in DN signaling pathways might serve as novel biomarkers or therapeutic targets, although this remains to be fully explored. …”
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Preoperative prediction of multiple biological characteristics in colorectal cancer using MRI and machine learning by Qiao-yi Huang, Hui-da Zheng, Bin Xiong, Qi-ming Huang, Kai Ye, Shu Lin, Jian-hua Xu

“…Colorectal cancer (CRC) is the second most prevalent cause of oncological mortality, and its diagnostic and therapeutic decision-making processes is complex. Alteration in molecular characteristic expression is closely related to tumor invasiveness and can serve a novel biomarker for predicting cancer prognosis. …”
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Aspergillus fumigatus extract modulates human eosinophils via NOD2 and oxidative stress by Hisashi Sasaki, Jun Miyata, Yusuke Kawashima, Ryo Konno, Masaki Ishikawa, Yoshinori Hasegawa, Ryuta Onozato, Yo Otsu, Emiko Matsuyama, Keeya Sunata, Katsunori Masaki, Hiroki Kabata, Yoshifumi Kimizuka, Tomoe Abe, Shigeharu Ueki, Koichiro Asano, Akihiko Kawana, Koichi Fukunaga

“…NOD2 inhibitors and antioxidants can have therapeutic potential against A. fumigatus-related allergic disorders.…”
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