The role of the microbiota and metabolites in the treatment of pulmonary fibrosis with UC-MSCs: Integrating fecal metabolomics and 16S rDNA analysis. by Yukai Luo, Shuang Zhou, Xiaojing Zhang, Yijian Lin, Jun Liu, Wenzhao Cheng, Yiming Zeng

“…The objective of our study was to investigate the potential therapeutic role of umbilical cord-derived MSCs (UC-MSCs) in the management of PF, with a focus on the alterations in the gut microbiota and its metabolites during the use of UC-MSCs for the treatment of pulmonary fibrosis, as well as the possible mechanisms involved.…”
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Evaluation of Knowledge and Practice of Pharmacy Professionals regarding the Risk of Medication Use during Pregnancy in Dessie Town, Northeast Ethiopia: A Cross-Sectional Study by Abdu Tuha, Yilak Gurbie, Haftom Gebregergs Hailu

“…The developing organism is unique in its responsiveness to drugs and predictability of therapeutic effectiveness based on the adult which can lead to grave consequences in the neonate and child. …”
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The Genetic Expression Difference of A2058 Cells Treated by Plasma Direct Exposure and Plasma-Treated Medium and the Appropriate Treatment Strategy by Chao-Yu Chen, Chung-Hsien Chou, Yun-Chien Cheng

“…<b>Conclusions</b>: The anti-cancer efficiency of plasma could be enhanced by pre-treatments and by adjusting the liquid interfaces to avoid the rapid consumption of short-lived RONS in the medium. To achieve better therapeutic effects and selectivity, more evidence is necessary to find optional plasma treatments.…”
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Surgical resection versus thermal ablation after intra-arterial conversion therapy for unresectable hepatocellular carcinoma: a multicenter retrospective one as per the STROBE guid... by Yusen Du, Chao An, Wendao Liu

“…However, the selection of sequential therapeutic modalities is still controversial. This study compared the efficacy and safety of surgical resection (SR) versus thermal ablation (TA) after patients with uHCC received ICT.Methods From May 2008 to November 2021, 3553 consecutive patients were reviewed and 791 patients were downstaged to receive TA or SR. …”
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Prevalence and Reinfection Rates of Schistosoma mansoni and Praziquantel Efficacy against the Parasite among Primary School Children in Sanja Town, Northwest Ethiopia by Eden Woldegerima, Abebe Genetu Bayih, Yalewayker Tegegne, Mulugeta Aemero, Ayalew Jejaw Zeleke

“…The schoolchildren in the three primary schools of Sanja are at moderate risk of the infection caused by S. mansoni. Although the therapeutic potency of PZQ at 40 mg/kg was efficient against S. mansoni, a high rate of reinfection was reported in the study site, suggesting the need for integrated schistosomiasis control measures.…”
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First Report on Microbial-Derived Polydeoxyribonucleotide: A Sustainable and Enhanced Alternative to Salmon-Based Polydeoxyribonucleotide by Doobyeong Chae, Sae-Woong Oh, Yoon-Seo Choi, Dae-Jung Kang, Chun-Woong Park, Jongsung Lee, Won-Sang Seo

“…The novel approach of utilizing microbial-derived PDRN opens new avenues for therapeutic applications in oxidative stress management, tissue regeneration, and immune modulation, paving the way for a paradigm shift in PDRN sourcing and functionality.…”
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Synthesis, Characterization, and Antiproliferative Effect of CuO-TiO2-Chitosan-Amygdalin Nanocomposites in Human Leukemic MOLT4 Cells by Abozer Y. Elderdery, Badr Alzahrani, Siddiqa M. A. Hamza, Gomaa Mostafa-Hedeab, Pooi Ling Mok, Suresh Kumar Subbiah

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Ocular Findings in COVID-19 Patients: A Review of Direct Manifestations and Indirect Effects on the Eye by Federica Bertoli, Daniele Veritti, Carla Danese, Francesco Samassa, Valentina Sarao, Nicolò Rassu, Tommaso Gambato, Paolo Lanzetta

“…While diagnostic and therapeutic efforts have been focused on respiratory complications of the disease, several ocular implications have also emerged. …”
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HACE1 protects against myocardial ischemia–reperfusion injury via inhibition of mitochondrial fission in mice by Bang-Xia Liu, Juan Zheng, Zhan-Wei Tang, Lei Gao, Meng Wang, Ying Sun, Chen Chen, Heng-Chen Yao

“…Therefore, HACE1 could be a promising therapeutic target for the treatment of myocardial I/RI.…”
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RETRACTED ARTICLE: LRPPRC regulates malignant behaviors, protects mitochondrial homeostasis, mitochondrial function in osteosarcoma and derived cancer stem-like cells by Ziyi Zhao, Yingwei Sun, Jing Tang, Yuting Yang, Xiaochao Xu

“…This suggests that LRPPRC might be a promising therapeutic target for osteosarcomas.…”
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Trichinella spiralis excretory/secretory proteins mediated larval invasion via inducing gut epithelial apoptosis and barrier disruption. by Qi Qi Lu, Wen Wen Zheng, Zhao Yu Zhang, Pei Kun Cong, Xin Guo, Yao Zhang, Xin Zhuo Zhang, Shao Rong Long, Ruo Dan Liu, Zhong Quan Wang, Jing Cui

“…These findings provided a basis of further understanding the interaction mechanism between T. spiralis and host gut epithelium, and they were valuable to the development new prevention and therapeutic strategy of early T. spiralis infection.…”
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Genomic Insights into Blood Pressure Regulation: Exploring Ion Channel and Transporter Gene Variations in Jordanian Hypertensive Individuals by Mansour Abdullah Alghamdi, Laith AL-Eitan, Rasheed Ibdah, Islam Bani Khalid, Salma Darabseh, Maryam Alasmar, Asaad Ataa

“…This study provides new insights into the genetic factors contributing to hypertension and highlights the potential of WNK1 as a target for future therapeutic interventions.…”
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Is Weight Loss the Main Driver for A1C Improvement by Glucagon‐Like Peptide 1 (GLP‐1) Receptor Agonists? A 2.5‐Year Analysis in Real‐World Clinical Practice by Marwa Al‐Badri, Shilton Dhaver, Osama Hamdy

“…This highlights the importance of weight reduction as a key therapeutic target for optimizing glycemic outcomes in patients with T2D receiving GLP‐1 RAs.…”
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Experimental paradigm to test the effects of providing social support: study protocol of the PROSPECT trial (Study 2) by Vivien Hajak, Simone Grimm, Ewa Gruszczyńska, Aleksandra Kroemeke, Natalia Józefacka, Lisa Marie Warner

“…Insights into the conditions under which the provision of social support is detrimental or beneficial to the provider can inform the development of preventive and interventional approaches across a range of life domains, motivational and developmental research across the lifespan (e.g. prevention of care-giver burnout), and applied clinical contexts (e.g. therapeutic interventions). Trial registration Pre-registration (2023-11-10): https://doi.org/10.17605/OSF.IO/8SPZW , retrospective registration with more details (2024-10-23): https://www.drks.de/DRKS00034287…”
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A meta-analysis of whole blood transcriptome reveals genes associated with increased neutrophil activity and T cell suppression in sepsis by T. N. Shruthi, Anbazhagan Kolandaswamy, Prabakara Somanna

“…The genes identified through functional analysis could be used as potential diagnostic, prognostic, and therapeutic targets for sepsis conditions.…”
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The Protective Effects of Annexin A1 in Acute Lung Injury Mediated by Nrf2 by Hui Huang, Yuqin Shi, Yuequan Zhou

“…Conclusion Collectively, these findings suggest that AnxA1 alleviates LPS‐induced ALI and might be a promising novel therapeutic agent against LPS‐induced ALI.…”
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Lentinan's effect on gut microbiota and inflammatory cytokines in 5-FU-induced mucositis mice by Xiaoxiao Zhang, Liang Wang, Asif Iqbal Khan, Ata Ur Rehman, Kavish Hasnain Khinsar, Yi Xin

“…Surprisingly, despite the frequency of IM, therapeutic choices remain restricted. In our search for new intestinal mucositis therapies, we wanted to see how Lentinan (LT), derived from Lentinus edodes, would fare in mouse models of intestinal mucositis. …”
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Small Extracellular Vesicles Secreted by iPSC-Derived MSCs Ameliorate Pulmonary Inflammation and Lung Injury Induced by Sepsis through Delivery of miR-125b-5p by Wei Peng, Yun Yang, Jiaquan Chen, Zeyao Xu, Yuanlei Lou, Qi Li, Ning Zhao, Kejian Qian, Fen Liu

“…Small extracellular vesicles, secreted by mesenchymal stem cells (MSCs), derived from human-induced pluripotent stem cells (iMSC-sEV), possess striking advantages when incorporated MSCs and iPSCs, which are considered extremely promising cell-free therapeutic agents. However, no studies have yet been conducted to systemically examine the effects and underlying mechanisms of iMSC-sEV application on attenuated lung injury under sepsis conditions. …”
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Tumor-associated-fibrosis and active collagen-CD44 axis characterize a poor-prognosis subtype of gastric cancer and contribute to tumor immunosuppression by Yingqi Yang, Haohan Sun, Hongkai Yu, Luyao Wang, Chang Gao, Haokun Mei, Xiaomeng Jiang, Minghui Ji

“…The Collagen-CD44 signaling axis has the potential to serve as a novel therapeutic target for gastric cancer by enhancing immune cell-mediated tumor suppression. …”
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Serum cardiac and inflammatory biomarker levels following chemotherapy among female patients with breast cancer attending at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiop... by Muluabay Getie, Biset Asrade Mekonnen, Daniel Seifu, Yonas Mulugeta, Solomon Tebeje, Chernet Tafere, Asmare Amuamuta

“…Abstract Background Chemotherapy is a well-established therapeutic approach for several malignancies, including breast cancer (BCa). …”
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