Comparison of oxidative stress status in the kidney tissue of male rats treated with paraquat and nanoparaquat by Fatemeh Bahramibanan, Mohammad Vahabi Rad, Akram Ranjbar, Ashkan Karbasi, Anahita Abbasifard

“…Further studies are warranted to elucidate the underlying mechanisms and potential therapeutic implications of nanoparaquat in oxidative stress-related kidney disorders.…”
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The Role of Cardiac Resynchronization Therapy in Heart Failure: A Narrative Review by Olivier Uwishema, Ece Karabulut, Dalal Sheikhah, Burhan Kantawala, Misgana Gallo, Fatima Soufan, Magda Wojtara

“…All trials have noted the supremacy of CRT compared to pharmaceutical treatment or other therapeutic methods. Majority of the trial participants had an LVEF of ≤ 35%, a QRS duration of ≤ 150 ms, and were categorized as NYHA class II–IV before initiation of CRT and, posttreatment, LVEF was improved significantly. …”
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Identification of prognostic biomarker of non-small cell lung cancer based on mitochondrial permeability transition-driven necrosis-related genes and determination of anti-tumor ef... by Zhifei Ma, Wen Chen, Aiping Zhang, Xiaokang Shen, Lin Zheng

“…Recent evidence suggests that activation of MPTND can effectively induce cancer cell death and may represent a novel therapeutic strategy for cancer. Yet, the role of MPTDN-related genes in non-small cell lung cancer (NSCLC) remains unrevealed. …”
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Usefulness of a TDM-Guided Approach for Optimizing Teicoplanin Exposure in the Treatment of Secondary Bloodstream Infections Caused by Glycopeptide-Susceptible <i>Enterococcus faec... by Milo Gatti, Matteo Rinaldi, Maddalena Giannella, Pierluigi Viale, Federico Pea

“…To assess the clinical usefulness of teicoplanin optimized by means of a therapeutic drug monitoring (TDM)-guided approach for treating secondary bloodstream infections (BSIs) caused by <i>Enterococcus faecium</i>. …”
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Regional insights on the prevalence and antimicrobial susceptibility pattern of carbapenem and colistin-resistant gram-negative bacteria: an observational cross-sectional study fro... by Nazia Khursheed, Fareeha Adnan, Moiz Ahmed Khan, Ramlla Hatif

“…Conclusion Our study highlights a concerning prevalence of colistin resistance (1.7%) among carbapenem-resistant gram-negative bacteria, particularly Klebsiella species, predominantly affecting male in-patients aged 31–49 and ≥ 50 years. This significant therapeutic challenge is underscored by the limited efficacy of available antibiotics, with only tigecycline showing high susceptibility (96%) and others like fosfomycin (53%) and minocycline (50%) offering moderate alternatives.…”
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Apolipoproteins A and B and PCSK9: Nontraditional Cardiovascular Risk Factors in Chronic Kidney Disease and in End-Stage Renal Disease by Cristiana-Elena Vlad, Liliana Foia, Roxana Popescu, Iuliu Ivanov, Mihaela Catalina Luca, Carmen Delianu, Vasilica Toma, Cristian Statescu, Ciprian Rezus, Laura Florea

“…This review is aimed at establishing the biomarker (ApoA, ApoB, and PCSK9) level variations in uremic patients, to identify the studies showing the association between these biomarkers and the development of cardiovascular events and to depict the therapeutic options to reduce cardiovascular risk in CKD and ESRD patients. …”
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Downregulation of LPAR1 Promotes Invasive Behavior in Papillary Thyroid Carcinoma Cells by Zahra Bokaii Hosseini, Fatemeh Rajabi, Reza Morovatshoar, Mahshad Ashrafpour, Panteha Behboodi, Dorsa Zareie, Mohammad Natami

“…This suggests its potential as a biomarker for diagnosis and prognosis and as a therapeutic target for EMT.…”
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Meta-analysis of nifedipine and enalapril combination therapy for hypertensive patients with coronary heart disease: A systematic review and meta-analysis by Kun Wang, Wenchao Ma, Leina Sun, Fangcheng Su

“…Background: Numerous clinical studies have demonstrated that the therapeutic efficacy of combining nifedipine and enalapril in treating hypertension with coronary heart disease surpasses that of nifedipine as a stand-alone treatment. …”
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Genetic coupling of enhancer activity and connectivity in gene expression control by Helen Ray-Jones, Chak Kei Sung, Lai Ting Chan, Alexander Haglund, Pavel Artemov, Monica Della Rosa, Luminita Ruje, Frances Burden, Roman Kreuzhuber, Anna Litovskikh, Eline Weyenbergh, Zoï Brusselaers, Vanessa Xue Hui Tan, Mattia Frontini, Chris Wallace, Valeriya Malysheva, Leonardo Bottolo, Elena Vigorito, Mikhail Spivakov

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The latest diagnostic methods for esophageal and gastric examinations. High-resolution manometry is now available in Ukraine by Yu.M. Stepanov, N.V. Prolom, S.O. Tarabarov

“…This significantly improves patients’ quality of life, as it helps doctors choose the most effective therapeutic strategies based on accurate data about esophageal function.…”
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Physical, chemical and biological properties of MTA Angelus and novel AGM MTA: an in vitro analysis by Sara Nashibi, Parisa Amdjadi, SeyedehSana Ahmadi, Sara Hekmatian, Maryam Torshabi

“…Abstract Introduction Mineral trioxide aggregate (MTA) is a calcium silicate-based cement that has changed conventional dental therapeutic approaches. This study aimed to evaluate physical, chemical and biological properties of novel AGM MTA, in comparison with MTA Angelus. …”
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Mechanism of SET8 Activates the Nrf2-KEAP1-ARE Signaling Pathway to Promote the Recovery of Motor Function after Spinal Cord Injury by Xin Li, Yan Qian, Wanling Shen, Shiying Zhang, Hui Han, Yu Zhang, Shuangmei Liu, Shaokun Lv, Xiuying Zhang

“…Thus, the SET8/H4K20me1 regulatory function may be a promising cellular therapeutic intervention point after SCI.…”
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Miniaturization and characterization of patient derived hepatocellular carcinoma tumor organoid cultures for cancer drug discovery applications by David A. Close, Paul A. Johnston

“…The ability to efficiently generate, expand, and biobank PDTOs has the potential to make the clinical diversity of cancer accessible for personalized medicine assay guided therapeutic drug selection and drug discovery. We describe the miniaturization and growth in 96- and 384-well formats of a single non-tumor liver and two Hepatocellular carcinoma (HCC) organoids derived from cryopreserved PDTO cells and the application of high content imaging (HCI) to characterize the models and enhance drug sensitivity testing. …”
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Mining Potential Drug Targets and Constructing Diagnostic Models for Heart Failure Based on miRNA-mRNA Networks by Xiangming Fang, Rensheng Song, Jiaxing Wei, Qin Liao, Zhenhong Zeng

“…The proximity of drugs to treat HF was also calculated and predicted for potential target therapeutic drug. In addition, further drug identification was performed by molecular docking. …”
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Mapping integral cell-type-specific interferon-induced gene regulatory networks (GRNs) involved in systemic lupus erythematosus using systems and computational analysis by Blessy Kiruba, Akshayata Naidu, Vino Sundararajan, Sajitha Lulu S

“…These findings indicate that IRF3, IRF7, STAT1, MYB, and FOXO1 are promising targets for therapeutic interventions for SLE.…”
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CLINICAL PROFILE AND MANAGEMENT OF HYPERTROPHIC SCARS AT DR. SOETOMO GENERAL ACADEMIC HOSPITAL SURABAYA, INDONESIA by Arda Rahmanisa Perdanakusuma, Iswinarno Doso Saputro, Evy Evrianti

“…The data were collected and processed according to key variables, including age, gender, occupation, etiology, anatomical location of the hypertrophic scars, scar size, and therapeutic interventions. Results:The number of patients with hypertrophic scars at Dr. …”
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Apoptosis antagonizing transcription factor expression and its validation as a potential diagnostic and prognostic biomarker in oral squamous cell carcinoma by Ainiwaerjiang Abudourousuli, Zumulaiti Aierken, Hasiyati Mamuti, Tuxunayi Yimamu, Chengli Da

“…These findings support AATF as a valuable prognostic biomarker and a potential therapeutic target in OSCC, warranting further investigation.…”
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Activity of ceftolozane/tazobactam and comparators against gram-negative bacilli: Results from the Study for Monitoring Antimicrobial Resistance Trends (SMART – Brazil), 2018‒2021... by Amanda Azevedo Bittencourt, Vinicius Lima Faustino, Paula de Mendonça Batista, Lays Paulino Leonel, Marina Della Negra de Paula, Thales José Polis

“…Ceftolozane/tazobactam documented remarkable in vitro activity against E. coli and P. aeruginosa isolates in Brazil, both pre- and post-pandemic periods and could constitute an effective therapeutic option for the treatment of urinary tract infections, intra-abdominal infections, and respiratory tract infections.…”
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Androgen receptor overexpression by immunohistochemistry in malignant salivary gland tumors in Tanzania by Subira Matiku, Gad Murenzi, Eulade Rugengamanzi, Edwin Liwa, Idd Shaban, Aron Orgenes, Erick P. Magorosa, Amos Mwakigonja, Edda Vuhahula

“…However, large-scale studies that will include comprehensive molecular investigations and efficacy exploration of ADT are recommended to clarify our current findings and inform therapeutic options for patient with high grade and recurrent tumors.…”
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The role of gestures in predicting treatment outcomes in children with autism spectrum disorder by YE Qianying, LIU Linru, XU Yanting, ZHU Huilin, DENG Hongzhu

“…Multiple linear regression analysis was applied to predict the therapeutic effect by gestures in children with ASD. …”
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