Regulation of NK cell development, maturation, and antitumor responses by the nuclear receptor NR2F6 by Johannes Woelk, Florian Hornsteiner, Stephanie Aschauer-Wallner, Patrizia Stoitzner, Gottfried Baier, Natascha Hermann-Kleiter

“…Of importance, Nr2f6-deficient mice are protected against MHC-I negative B16-F10 melanoma lung metastasis formation, especially with IL-15 complex treatment, indicating the potential of NR2F6 to affect NKp46-dependent NK cell-mediated tumor surveillance. The therapeutic targeting of NR2F6 may be a promising strategy for boosting NKp46-dependent NK-cell-mediated tumor surveillance and metastasis.…”
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Safety, Tolerability and Pharmacokinetic-Pharmacodynamic Relationship of NX210c Peptide in Healthy Elderly Volunteers: Randomized, Placebo-Controlled, Double-Blind, Multiple Ascend... by Annette Janus, Daniël Dumas, Juliette Le Douce, Sébastien Marie, Giuseppe Pasculli, Pauline Bambury, Sighild Lemarchant, Philip Kremer, Yann Godfrin

“…The effects of NX210c on claudin-5 and biomarkers influencing BBB integrity—and the overarching brain protection it offers—provide a novel therapeutic strategy targeting an underlying driver of neurodegenerative conditions for which disease-modifying treatments are limited or not available.…”
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Curative Effect of Wearable Back Trainer Combined with Massage on Patients of Chronic Nonspecific Low Back Pain by An CAO, Guozhi HUANG, Qing ZENG, Peichen HE, Rihui LI

“…The treatment group (<italic>n</italic>=19) was treated with wearable device treatments based on massage for two weeks, once a day, eight minutes each time, five times a week, while the control group (<italic>n</italic>=19) received massage only for two weeks, once a day, 20 minutes each time, and the blank group (<italic>n</italic>=18) rest only with closely observation. The therapeutic effect of three groups were evaluated by VAS and ODI scores before the treatment, one week after treatment and two weeks after treatment respectively.Results:There was no statistical difference among the three groups in VAS score before treatment (<italic>P</italic>&gt; 0.05). …”
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Primary dysmenorrhea: pathophysiology, improvement of diagnostic and treatment possibilities by T.V. Fartushok, N.V. Fartushok

“…In view of safety and high therapeutic efficiency, the drug based on Vitex agnus castus can be offered for the treatment over the period lasting at least for3 months for girls and young women aged 13 to 45 years with primary dysmenorrhea.…”
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CircHIPK2 recruits SRSF1 to increase TXNIP mRNA stability and promotes autophagy-dependent ferroptosis and apoptosis in myocardial ischemia-reperfusion injury by Zhu Zhang, Jinqi Hao, Qinghong Qiao, Junting Song, Yanqin Yu

“…We further demonstrated that TXNIP upregulation overturned the therapeutic effects of circHIPK2 silencing on H/R model cells. …”
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Association of Body Fat Percentage with Time in Range Generated by Continuous Glucose Monitoring during Continuous Subcutaneous Insulin Infusion Therapy in Type 2 Diabetes by Yuting Ruan, Jiana Zhong, Rongping Chen, Zhen Zhang, Dixing Liu, Jia Sun, Hong Chen

“…Reduction of body fat may be an important therapeutic target to improve glycemic control in high body fat T2DM patients, who may benefit less from intensive insulin treatment.…”
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Achillea millefolium capsule improved liver enzymes and lipid profile compared to placebo in patients with type 2 diabetes: a double-blind randomized clinical trial by Shole Daneshvar-Ghahfarokhi, Hassan Ahmadinia, Tabandeh Sadeghi, Elham Basirat, Vahid Mohammadi-Shahrokhi

“…Abstract Background The therapeutic properties of Achillea Millefolium (AM) in regulating blood lipids and liver enzymes have been proven in studies. …”
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Safety profile of EZH2 inhibitors for cancer: a systematic review and meta-analysis by Zhou Zhao, Xiufeng Chen, Huayang Pang, Yan Shi, Hao Sun

“…Conclusion EZH2 inhibitors demonstrate a manageable safety profile with a low incidence of severe TRAEs, emphasizing their potential as safe therapeutic options in cancer treatment. The low rate of severe TRAEs and the rare occurrences of treatment-related deaths support the continued clinical use and further investigation of EZH2 inhibitors.…”
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Prophylactic Theophyline reduces birth asphyxia related renal injury in term neonates by Salma Aziz, Syeda Maimoona Qudrat, Tanzeela Rani, Qurat-ul-Ain Chughtai, Misbah Aziz, Rai Muhammad Asghar

“…CONCLUSION: Through the findings of this study, the therapeutic efficacy of theophylline is confirmed in terms of maintaining serum creatinine and glomerular filtration rate. …”
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Clinical Value and Potential Mechanism of miRNA-33a-5p in Lung Squamous Cell Carcinoma by Xiang-Ming Wang, Shang-Wei Chen, Gang Chen, Hua-Fu Zhou, Ting-Qing Gan, Jing-Jing Zeng, Zu-Yun Li

“…In summary, our results indicated that miRNA-33a-5p may contribute as a prospective therapeutic target in LUSC.…”
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Potential biomarkers and immune infiltration linking endometriosis with recurrent pregnancy loss based on bioinformatics and machine learning by Jianhui Chen, Qun Li, Xiaofang Liu, Fang Lin, Yaling Jing, Jiayan Yang, Lianfang Zhao

“…These findings may provide new mechanistic insights or therapeutic targets for further research of EMs and RPL.…”
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Revealing Sarcophyton extract's alleviating potential against gentamicin-induced renal and testicular toxicity in rat model by Nada S. Badr, Aml Talaat, Salwa A. El-Saidy, Aml Zaki Ahmed Ghoneim

“…Conclusion Sarcophyton acutum methanol extract demonstrates promising protective effects against gentamicin-induced renal and testicular toxicity in rats, signifying its potential as a therapeutic agent to mitigate antibiotic-induced oxidative damage in vital organs.…”
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Comparative Analysis of Tenogenic Gene Expression in Tenocyte-Derived Induced Pluripotent Stem Cells and Bone Marrow-Derived Mesenchymal Stem Cells in Response to Biochemical and B... by Feikun Yang, Dean W. Richardson

“…Natural healing of injured tendon is poor, and cell-based therapeutic treatment is still a significant clinical challenge. …”
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Comparison of In Vitro Antibacterial Activity of Epaltes divaricata and Vetiveria zizanioides against Methicillin-Resistant Staphylococcus aureus by Hasanga Rathnayake, Manikkuwadura Hasara Nethmini De Zoysa, Ruwani Punyakanthi Hewawasam, Weerasinghe Mudiyanselage Dilip Gaya Bandara Wijayaratne

“…Fractionation, purification, and identification of active compounds will warrant further evaluation of the therapeutic potential of both plant extracts.…”
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Guanxinning Tablet Attenuates Coronary Atherosclerosis via Regulating the Gut Microbiota and Their Metabolites in Tibetan Minipigs Induced by a High-Fat Diet by Qinqin Yang, Yanyun Xu, Liye Shen, Yongming Pan, Junjie Huang, Quanxin Ma, Chen Yu, Jiaojiao Chen, Yu Chen, Minli Chen

“…Thus, the study was aimed at investigating the therapeutic effect of GXNT on CA and further explore the underlying mechanisms from the perspective of gut microbiota. …”
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Clinical characteristics and outcomes in Asian patients with heart failure with mildly reduced ejection fraction by Julian Cheong Kiat Tay, Shaw Yang Chia, Siew Hui Michelle Koh, David Kheng Leng Sim, Ping Chai, Seet Yoong Loh, Fazlur Rehman Jaufeerally, Sheldon Shao Guang Lee, Patrick Zhan Yun Lim, Jonathan Yap

“…HFmrEF represents a distinct HF phenotype with high atherosclerotic burden and clinical outcomes saddled in between those of HFrEF and HFpEF. Further therapeutic studies to guide management of this challenging group of patients are warranted.…”
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High-dose ascorbic acid synergizes with anti-PD1 therapy in non-small cell lung cancer in vitro and in vivo models by Hak Su Kim, Seung-hyun Kwon, Ok Kyung Choi, Taekyu Lim, Taekyu Lim

“…However, there remains a substantial unmet need to identify therapeutic approaches to overcome resistance and provide benefits to these patients. …”
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Exploring the Kidney-Brain Crosstalk: Biomarkers for Early Detection of Kidney Injury-Related Alzheimer&rsquo;s Disease by Cai Y, Huang G, Ren M, Chai Y, Fu Y, Yan T, Zhu L

“…Notably, gefitinib and plumbagin may be therapeutic candidates for intervening in KI-associated AD by targeting EGFR and RELA. …”
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The optimal treatment of invasive ductal and lobular carcinoma occurring at the same time needs to be established by Supriya Peshin, Rafi Iftekher, Rabia Iqbal, Shagun Singh, Moka Nagaishwarya

“…The complexity of this case was further heightened by a significant family history of breast and colon cancers, and comorbid conditions including borderline diabetes, hypertension and coronary artery disease (CAD), which required careful therapeutic consideration to balance efficacy and tolerability. …”
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Potensi Terapi Fitokanabinoid Mayor dalam Pengobatan Cedera Otak Traumatik: sebuah Tinjauan Literatur Farmakologis by Arief Gunawan Darmanto

“…This review aims to explore the therapeutic potential of major phytocannabinoids in TBI treatment by highlighting the pathophysiological mechanisms of TBI and the neuroprotective effects of these compounds. …”
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