Determinants of Undernutrition among Adult Tuberculosis Patients Receiving Treatment in Public Health Institutions in Shashemane Town, Southern Ethiopia by Adane Tesfaye Anbese, Gudina Egeta, Frehiwot Mesfin, Abinet Arega Sadore

“…Thus, relevant actors should give attention to fast nutritional intervention together with standard therapeutic regimen in the management of pulmonary tuberculosis patients to curb their nutritional derangement.…”
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Identification of a New m6A Regulator-Related Methylation Signature for Predicting the Prognosis and Immune Microenvironment of Patients with Pancreatic Cancer by Tianle Zou, Dan Shi, Weiwei Wang, Guoyong Chen, Xianbin Zhang, Yu Tian, Peng Gong

“…The findings might prove useful for therapeutic customization and the process of making medical decisions.…”
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siRNA-mediated inhibition of hTERT enhances the effects of curcumin in promoting cell death in precursor-B acute lymphoblastic leukemia cells: an in silico and in vitro study by Muhammad Hossein Ashoub, Ali Afgar, Alireza Farsinejad, Razieh Razavi, Samira Anvari, Ahmad Fatemi

“…The cell-type-specific responses suggest promising therapeutic strategies through combined hTERT suppression and ferroptosis induction.…”
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Synthesis of Novel Benzothiazole–Profen Hybrid Amides as Potential NSAID Candidates by Iliyan Ivanov, Stanimir Manolov, Dimitar Bojilov, Yordan Stremski, Gabriel Marc, Stela Statkova-Abeghe, Smaranda Oniga, Ovidiu Oniga, Paraskev Nedialkov

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Genetic insight into dissecting the immunophenotypes and inflammatory profiles in the pathogenesis of Sjogren syndrome by Jingyi Xu, Shucheng Si, Yijun Han, Lin Zeng, Jinxia Zhao

“…Conclusions By providing a novel genetic insight into unveiling the roles of autoimmunity and inflammation in Sjogren syndrome, our findings may potentially lead to identifying new clinical biomarkers for disease monitoring and therapeutic targets that offer more effective alternatives for treating this condition. …”
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Application of Short Peptide Enteral Nutrition in Mechanically Ventilated Critically Ill Children with Severe Pneumonia and Its Impact on Patient Recovery by Xu Z, Ding Y, Deng XM, Mao XX, Xia PF, Li DR, Lu YP

“…Moreover, there was no statistically significant difference in disease outcomes between the two groups (P > 0.05).Conclusion: Short peptide enteral nutrition formulation contributes to improving the treatment outcomes of mechanically ventilated pneumonia patients, providing a therapeutic approach for the nutritional support of critically ill children requiring mechanical ventilation.Keywords: short peptide enteral nutrition formulation, mechanical ventilation, pediatric patients with severe pneumonia, nutritional status…”
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PDE4B promotes ferroptosis in nucleus pulposus cells and is involved in intervertebral disc degeneration by Weixing Xu, Rana Dhar, Danyang Zheng, Qi Peng, Yue Li, Sheng Mei, Huifang Tang

“…So PDE4B inhibition may be a potential therapeutic strategy for IDD.…”
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Exploring the influence of age on the causes of death in advanced nasopharyngeal carcinoma patients undergoing chemoradiotherapy using machine learning methods by Mengni Zhang, Shipeng Zhang, Xudong Ao, Lisha Liu, Shunlin Peng

“…Additionally, seven different machine learning models were employed as predictive tools to identify key variables and assess the therapeutic outcomes in NPC patients receiving CRT. …”
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In Vitro Biological and GC-MS Analysis of Whole Plant Calotropis procera by Qahir Shah, Jahangir Khan Achakzai, Muhammad Anwar Panezai, Basira Akhtar, Abdul Manan Kakar, Ali Akbar, Shahabuddin Kakar, Nisar Ahmed Shahwani, Javed Khan, Nazima Yousaf Khan, Ghulam Mustafa Khan, Nizam Baloch, Bakht Zareen Rahim, Noor Hassan

“…Calotropis procera is a medicinal, traditional, and therapeutic plant in Pakistan. In this research study, the biological activities, for instance, anticancer, antileishmanial, antibacterial, antifungal, anti-inflammatory, and brine shrimp lethality assay and GC-MS are studied. …”
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Imaging Bone–Cartilage Interactions in Osteoarthritis Using [F]-NaF PET-MRI by Dragana Savic MSc, Valentina Pedoia PhD, Youngho Seo PhD, Jaewon Yang PhD, Matt Bucknor MD, Benjamin L. Franc MD, Sharmila Majumdar PhD

“…These observations highlight the complex biomechanical and biochemical interactions in the whole knee joint in OA, which potentially could help assess therapeutic targets in treating OA.…”
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“It’s a delicate balance”: clinicians’ experiences of providing heroin-assisted treatment by Rune Ellefsen, Silvana De Pirro, Vegard Haukland, Linda Elise Couëssurel Wüsthoff, Espen Ajo Arnevik

“…Because a positive patient–clinician relationship is crucial to patient satisfaction and treatment outcomes in HAT, the provision of training for clinicians on navigating the inherent tensions of HAT provision, nurturing therapeutic alliances with patients, and managing their role as gatekeepers to medical heroin and valuable services, seem particularly important for ensuring that care is patient-centered and staff are adequately supported.…”
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Proliferin-1 Ameliorates Cardiotoxin-Related Skeletal Muscle Repair in Mice by Hiroki Goto, Aiko Inoue, Limei Piao, Lina Hu, Zhe Huang, Xiangkun Meng, Yusuke Suzuki, Hiroyuki Umegaki, Masafumi Kuzuya, Xian Wu Cheng

“…These findings demonstrated that PLF-1 can improve skeletal muscle repair in response to injury, possibly via the modulation of inflammation and proliferation and regeneration, suggesting a novel therapeutic strategy for the management of skeletal muscle diseases.…”
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Pyrvinium Pamoate Synergizes with Azoles in vitro and in vivo to Exert Antifungal Efficacy Against Candida auris and Other Candida Species by Zhang J, Li G, Hu J, Tan J, Zhang H, Zhou Y

“…The inclusion of PP in combination with itraconazole, voriconazole, or posaconazole resulted in varying degrees of improvement in the survival rates of these larvae.Conclusion: Combining PP with azoles represents a promising approach to effectively disrupting the growth of azole-resistant C. auris and other Candida spp. such that it may be a promising anti-Candida therapeutic option.Keywords: Candida auris, pyrvinium pamoate, synergy azoles, Galleria mellonella…”
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Antibiotic Resistance of Enterobacteriaceae in Microbiomes Associated with Poultry Farming by Anna S. Krivonogova, Irina M. Donnik, Albina G. Isaeva, Egor A. Loginov, Maxim V. Petropavlovskiy, Elisey N. Bespamyatnykh

“…Antibiotics have long been overused for non-therapeutic purposes. As a result, Escherichia, Enterobacter, Klebsiella, and Proteus in avian microbiomes have become reservoirs for genetic determinants of resistance, thus spreading resistance to antibiotics and contaminating raw materials and finished products. …”
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Efficacy of ceftazidime-avibactam with or without polymyxin for carbapenem-resistant Klebsiella pneumoniae infections after initial treatment with polymyxin by Jingli Lu, Yani Ma, Zhe Cao, Baoling Zhu, Luna Fan, Haiyang Meng

“…The rate of in-hospital crude mortality was 25.5% (27/106), with the highest rate observed in patients treated with regimens containing polymyxin B (41.2%; 14/34). Therapeutic response was observed in 81 (76.4%) patients, with microbiological eradication achieved in 77.1% (74/96) of cases. …”
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Elucidating the causal relationship between gut microbiota, metabolites, and diabetic nephropathy in European patients: Revelations from genome-wide bidirectional mendelian randomi... by Siyuan Song, Li Ning, Jiangyi Yu

“…Such approaches could transform the treatment and management of diabetic nephropathy and its associated risk factors, paving the way for more effective therapeutic strategies to combat this debilitating condition.…”
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Preparation and In Vitro Evaluation of Alginate Microparticles Containing Amphotericin B for the Treatment of Candida Infections by Merlis P. Alvarez-Berrios, Lisa M. Aponte-Reyes, Lourdes Diaz-Figueroa, Juan Vivero-Escoto, Alexis Johnston, David Sanchez-Rodriguez

“…In the last decades, alginate has gained significant interest in drug delivery applications as a cost-effective strategy to improve the safety and therapeutic effect of toxic drugs. In this work, the clinically relevant drug AmB was encapsulated into alginate microparticles using the emulsification/external gelation method. …”
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miR-21 and cathepsin B in familial Mediterranean fever: novel findings regarding their impact on disease severity by Emrah Yucesan, Mehmet Yildiz, Ramila Hajiyeva

“…Our findings suggest that miR-21-5p and IL-1β play key roles in subclinical inflammation, and these molecules might be a potential therapeutic target.…”
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Blood Cells Parameters in Second Trimester of Pregnancy and Gestational Diabetes Mellitus: A Systematic Review and Meta‐Analysis by Vida Ghasemi, Mojdeh Banaei, Zahra Kiani, Fahimeh Ramezani Tehrani, Marzieh Saei Ghare Naz

“…Future studies should investigate the potential role of these haematological markers as predictive tools for adverse pregnancy outcomes and evaluate therapeutic interventions targeting these parameters to enhance maternal and fetal health.…”
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Perceptions in 3.6 Million Web-Based Posts of Online Communities on the Use of Cancer Immunotherapy: Data Mining Using BERTopic by Xingyue Wu, Chun Sing Lam, Ka Ho Hui, Herbert Ho-fung Loong, Keary Rui Zhou, Chun-Kit Ngan, Yin Ting Cheung

“…ConclusionsThis study provides an overview of the multifaceted considerations essential for the application of immunotherapy as a therapeutic intervention. The topics and themes identified can serve as supporting information to facilitate physician-patient communication and the decision-making process. …”
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