Exploring the Therapeutic Potential of Cannabidiol in U87MG Cells: Effects on Autophagy and NRF2 Pathway by Laura Giannotti, Benedetta Di Chiara Stanca, Francesco Spedicato, Daniele Vergara, Eleonora Stanca, Fabrizio Damiano, Luisa Siculella

“…Cannabinoids include both endogenous endocannabinoids and exogenous phytocannabinoids, such as cannabidiol (CBD), and have potential as therapeutic agents in cancer treatment due to their selective anticancer activities. …”
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Decreased nitric oxide production is a novel therapeutic target for salt-induced nocturnal polyuria in aging by Takahiro Imanaka, Kentaro Takezawa, Yuma Kujime, Hiroaki Kitakaze, Go Tsujimura, Sohei Kuribayashi, Yosuke Sekii, Norichika Ueda, Shinichiro Fukuhara, Hiroshi Kiuchi, Hiromitsu Negoro, Norio Nonomura

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The impact of maximum cross-sectional area of lesion on predicting the early therapeutic response of multidrug-resistant tuberculosis by Fuzhen Zhang, Yu Zhang, Zilong Yang, Ruichao Liu, Shanshan Li, Yu Pang, Liang Li

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Research on therapeutic clinical trials including immunotherapy in triple-negative breast cancer: a bibliometric analysis by Qi Xu, Xiaoyu Feng, Siyuan Qin, Yu Hong, Rui Cui, Jia Liang, Zhuya Xiao, Yuan Li

“…Clinical trial is an important tool for optimizing therapeutic strategies in the evaluation of the safety and efficacy for TNBC. …”
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Therapeutic Effect of Cu(II) Complex with Photocatalytic Property on Gastric Cancer by Inhibiting the Proliferation of Tumor Cells by Dan Yu, Shuqin Li

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Molecular characterization of mixed-histology endometrial carcinoma provides prognostic and therapeutic value over morphologic findings by Paulina J. Haight, Ashwini Esnakula, Courtney J. Riedinger, Adrian A. Suarez, Jessica Gillespie, Ashley Patton, Alexis Chassen, David E. Cohn, Casey M. Cosgrove

“…While p53abnl and NSMP tumors have similarly poor outcomes, transcriptome analysis revealed biologic differences that could impact targeted therapeutics in this high-risk group.…”
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Genetic insights into therapeutic targets for gout: evidence from a multi-omics mendelian randomization study by Mingyuan Fan, Zhangjun Yun, Jiushu Yuan, Sai Zhang, Hongyan Xie, Dingyi Lu, Haipo Yuan, Hong Gao

“…Summary data-based Mendelian randomization (SMR) analyses based on transcript and protein levels were further implemented to validate the reliability of the identified potential therapeutic targets for gout. Phenome-wide MR (Phe-MR) analysis was conducted in 1403 diseases to investigate incidental side effects of potential therapeutic targets for gout. …”
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The synergism of occlusal splints along with therapeutic exercise on individuals with temporomandibular joint disorders – A pilot study by Tanuj Bachani, Fathima Banu Raza, Anand Kumar Vaidyanathan

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Therapeutic dose prediction using score-based diffusion model for pretreatment patient-specific quality assurance by Xiuwen Yu, Jiabin Lin, Changfei Gong, Minhui Zhang, Xianyu Luo, Qiegen Liu, Yun Zhang

“…In the context of this work, the limitation of traditional supervised models was broken by proposing a conditional generation method utilizing unsupervised diffusion model.MethodsA conditional generation method base on the score-based diffusion model was proposed, which employed diffusion model for the first time to predict the predict patients’ therapeutic doses (TherapDose). The proposed diffusion model TherapDose prediction method (DMTP) learns the data distribution of dose images. …”
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The Orphan Nuclear Receptor 4A1: A Potential New Therapeutic Target for Metabolic Diseases by Lei Zhang, Qun Wang, Wen Liu, Fangyan Liu, Ailing Ji, Yanzhang Li

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Protocol for a patient-derived preclinical platform to model tumor-immune interactions and evaluate therapeutic efficacy by Wen-Hsin Chang, Andrew I. Chin, Ching-Hsien Chen

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Ultrasound stimulated perfluorobutane microbubbles cavitation enhanced the therapeutic effect of colchicine in rats with acute gouty arthritis by Ji-cheng Zhang, Bo Gou, Tian-rui Wang, Wan-tai Dang, Yan-hui Li, Wen Wen, Jian Liu

“…Objective: This study aimed to explore whether cavitation generated by ultrasound-stimulated microbubbles (USMB) can enhance the therapeutic efficacy of colchicine and diminish its gastrointestinal side effects in rats with acute gouty arthritis (AGA). …”
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Hopf Bifurcation on a Cancer Therapy Model by Oncolytic Virus Involving the Malignancy Effect and Therapeutic Efficacy by F. Adi-Kusumo, L. Aryati, S. Risdayati, S. Norhidayah

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Emetophobia (specific phobia of vomiting): Its Relationship with Anxiety-related Disorders and Cognitive Behavioral Therapeutic Approach by Vahdet Gormez, Yavuz Meral, Abdurrahman Cahid Orengul

“…In this article, a phenomenological, epidemiologic and clinical picture of emetophobia is presented and the cognitive behavioral model is discussed as a therapeutic approach for its treatment [JCBPR 2017; 6(1.000): 39-48]…”
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Robert's Uterus Versus Juvenile Cystic Adenomyoma – Diagnostic and Therapeutic Challenges – Case Report and Review of Literature by Reeta Mahey, Rohitha Cheluvaraju, Supriya Kumari, Garima Kachhawa, Archana Kumari, Monika Rajput, Neerja Bhatla

“…This case report highlights the diagnostic dilemma and therapeutic challenges encountered while managing adolescent girls with progressive dysmenorrhoea and management of Robert's uterus. …”
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Carbapenem-resistant Acinetobacter baumannii and Ventilator-associated Pneumonia; Epidemiology, Risk Factors, and Current Therapeutic Approaches by Malihe Kazemi Najafabadi, Rasool Soltani

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The Diagnostic and Therapeutic Challenges of Posttraumatic Iris Implantation Cysts: Illustrative Case Presentations and a Review of the Literature by Nandini Venkateswaran, Steven S. T. Ching, William Fischer, Frank Lee, Gabrielle Yeaney, Holly B. Hindman

“…Iris implantation cysts can present clinicians with diagnostic and therapeutic challenges given their variable presentations and frequently destructive nature. …”
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Plant protein-derived anti-breast cancer peptides: sources, therapeutic approaches, mechanisms, and nanoparticle design by Deju Zhang, Deju Zhang, Deju Zhang, Ying Yuan, Ying Yuan, Qingdong Zeng, Qingdong Zeng, Juan Xiong, Juan Xiong, Yiming Gan, Kai Jiang, Kai Jiang, Ni Xie

“…Consequently, there is an urgent need for low-cost, low-toxicity and effective therapeutic methods to prevent or mitigate breast cancer progression. …”
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Therapeutic effect of low-dose BMSCs-Loaded 3D microscaffold on early osteonecrosis of the femoral head by Minzheng Guo, Baochuang Qi, Zijie Pei, Haonan Ni, Junxiao Ren, Huan Luo, Hongxin Shi, Chen Meng, Yang Yu, Zhifang Tang, Yongqing Xu, Qingyun Xue, Chuan Li

“…Results showed that the 3D microscaffold with low-dose BMSCs had a therapeutic effect comparable to high-dose free BMSCs. …”
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A Mitochondria‐Related Signature in Diffuse Large B‐Cell Lymphoma: Prognosis, Immune and Therapeutic Features by Zhen‐Zhong Zhou, Jia‐Chen Lu, Song‐Bin Guo, Xiao‐Peng Tian, Hai‐Long Li, Hui Zhou, Wei‐Juan Huang

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