Inebilizumab treatment in a patient with co-occurring AQP4-IgG positive neuromyelitis optica spectrum disorder and myasthenia gravis: a case report and literature review by Xiaoqian Song, Xiaoqian Song, Jingjiao Chen, Chenyang Jin, Yilong Peng, Yuewen Sun, Xueping Zheng

“…ObjectiveThis study aims to delineate the clinical features underlying the concurrent disease of neuromyelitis optica spectrum disorder (NMOSD) and myasthenia gravis (MG), and to identify efficacious therapeutic strategies.BackgroundNMOSD and MG are uncommon autoimmune diseases that infrequently co-exist. …”
Get full text

A temporary cholesterol-rich diet and bacterial extracellular matrix factors favor Salmonella spp. biofilm formation in the cecum by Alonso Cruz-Cruz, Megan E. Schreeg, John S. Gunn

“…A greater understanding of these mechanisms will allow the formulation of new therapeutic strategies specifically targeted at preventing typhoid fever dissemination from chronic carriers.…”
Get full text

Effects of Compressive and Tensile Strain on Macrophages during Simulated Orthodontic Tooth Movement by Agnes Schröder, Paul Käppler, Ute Nazet, Jonathan Jantsch, Peter Proff, Fabian Cieplik, James Deschner, Christian Kirschneck

“…During orthodontic tooth movement (OTM) to therapeutically correct the position of misaligned teeth, thus improving oral health and quality of life, fibroblasts, macrophages, and other immune cells within the periodontal ligament (PDL), which connects a tooth to its surrounding bone, are exposed to compressive and tensile strain. …”
Get full text

Development and In Vitro Evaluation of Oral Capsules from Antiaris: A Convenient Substitute for Peripheral Neuropathy by Mary-Ann Archer, Doris Kumadoh, Samuel Nii-Bortier Gaizer, Adelaide Mensah, Jonathan Jato, Micheal Odoi Kyene, Susana Oteng Mintah, Genevieve Naana Yeboah, Paul kwesi Sodzi, Ofosua Adi-Dako

“…These challenges have resulted in a decrease in therapeutic outcome. This study sought to transform Antiaris into oral capsules to mask its bitter taste and reduce bulkiness of the product to improve patients’ convenience. …”
Get full text

Reconstruction of built-up urban areas taking into account accessibility to limited mobility population groups: the case of Krasnodar by E. P. Shnurnikova, S. P. Gorzova, V. V. Kononenko

“…Uncomfortable housing conditions can hinder therapeutic and preventive care aimed at health improvement, and physical barriers in housing and yard spaces can hamper the socialization of disabled residents. …”
Get full text

Lactate Ameliorates Kainic Acid-Induced Neuroinflammation and Cognitive Impairment via the Chemokine Signaling Pathway in Mice by Chu X, Ge Y, Geng C, Cao P, Wei P, Fu B, Deng Z, Li Y, Zhao G

“…In mice with acute epilepsy, lactate treatment mitigated neuronal damage, microglial activation, and inflammatory responses in the hippocampus and ameliorated anxiety-like behavior and cognitive impairment.Conclusion: Lactate exerts therapeutic effects on epilepsy through the chemokine signaling pathway. …”
Get full text

Application of a novel sliding ⁃ traction head holder in craniovertebral junction abnormalities surgery by WU Kun, ZHANG Fan, FAN Tao

“…Demonstrating significant therapeutic effects in the surgical treatment of patients with congenital basilar invagination.…”
Get full text

(<i>aS</i>)-Glucosciadopitysin, a New Biflavonoid Glycoside from the Leaves of <i>Ginkgo biloba</i> and Osteogenic Activity of Bioflavonoids by Se Yun Jeong, Kwang Ho Lee, Seon Hee Kim, Min Hye Yang, Gakyung Lee, Ki Hyun Kim

“…Ginkgetin (<b>2</b>) shows potential as a therapeutic agent for osteopenia by promoting osteogenesis in MSCs, suggesting its promising role in treating osteoporosis.…”
Get full text

Unpacking Performance Factors of Innovation Systems and Studying Germany’s Attempt to Foster the Role of the Patient Through a Market Access Pathway for Digital Health Applications... by Sara Gehder, Moritz Goeldner

“…The findings highlight the need for future research on patient empowerment and the development of methodologies beyond traditional therapeutic outcomes.…”
Get full text

A rare case of adult-onset vanishing white matter leukoencephalopathy with movement disorder, expressing homozygous EIF2B3 and PRKN pathogenic variants by Bashar Kamal Ali Douden, Yazan Mohammad Abdullah Abufara, Mahmood Fayez Ali Aldrabeeh, Naela Ramadan Mohammad Tell, Ismail Abudaya

“…These findings underscore the importance of enhancing the region’s diagnostic and therapeutic capabilities.…”
Get full text

Identification of lethality-related m7G methylation modification patterns and the regulatory features of immune microenvironment in sepsis by Dan Wang, Rujie Huo, Lu Ye

“…Conclusion: The constructed survival status diagnostic model based on the five lethality-related m7G signature genes may help predict the survival status of patients, and the 10 hub genes obtained may be potential therapeutic targets for sepsis.…”
Get full text

Silencing of STEAP3 suppresses cervical cancer cell proliferation and migration via JAK/STAT3 signaling pathway by Zouyu Zhao, Panpan Yu, Yan Wang, Hong Li, Hui Qiao, Chongfeng Sun, Lina Zhu, Ping Yang

“…Conclusion STEAP3 was significantly associated with CC progression mediated via the JAK/STAT3 signaling pathway and may serve as an effective therapeutic target.…”
Get full text

Anti-Tumor Necrosis Factor-α Use in Pediatric Inflammatory Bowel Disease—Reports from a Romanian Center by Roxana Matran, Andra-Mihaela Diaconu, Andreea Maria Iordache, Irina Dijmărescu, Alexandra Coroleucă, Daniela Păcurar, Cristina Becheanu

“…<b>Background/Objectives:</b> The introduction of anti-tumor necrosis factor-α (anti-TNF-α) agents, particularly infliximab (IFX) and adalimumab (ADA), has significantly expanded the therapeutic arsenal for inflammatory bowel disease (IBD). …”
Get full text

Integrating bioinformatics and machine learning to identify AhR-related gene signatures for prognosis and tumor microenvironment modulation in melanoma by Qianru Li, Qianru Li, Heli Li

“…In the mouse melanoma model, Map2k1 and Prkacb mRNA levels exhibited a progressive increase with tumor progression, supporting their role in melanoma advancement.ConclusionsThis study presents a comprehensive analysis of AhR-related genes in melanoma, highlighting MAP2K1, PRKACB, KLF5, and PIK3R2 as key prognostic markers and potential therapeutic targets. The integration of bioinformatics and machine learning provides a robust framework for enhancing prognostic evaluation in melanoma patients and offers new avenues for the development of treatments, particularly for those resistant to current immunotherapies.…”
Get full text

Decrease of NAD+ Inhibits the Apoptosis of OLP T Cells via Inducing Mitochondrial Fission by Zhang ZY, Wang F, Zhou G

“…NAD+ supplementation mitigated these effects, suggesting a potential therapeutic strategy for restoring T cell homeostasis in OLP.Keywords: mitochondria, nicotinamide adenine dinucleotide, T cells, oral lichen planus…”
Get full text

Deciphering In Vitro and In Vivo Pharmacological Properties of Seed and Fruit Extracts of Flacourtia jangomas (Lour.) Raeusch by Farhana Alam Ripa, Fowzia Alam, Fahmida Haque Riya, Yesmin Begum, Sharmin Akter Eti, Nusratun Nahar, Zebunnesa Ahmed, Sabrina Sharmin

“…Our phytochemical analysis of the examined extracts confirmed the presence of various therapeutically active phytoconstituents, including flavonoids, tannins, glycosides, and alkaloids. …”
Get full text

Poldip2/Nox4 Mediates Lipopolysaccharide-Induced Oxidative Stress and Inflammation in Human Lung Epithelial Cells by Yueguo Wang, Zhenxing Ding, Youhui Tu, Xu Wu, Wenying Zhang, Shuang Ji, Jilong Shen, Li Zhang, Huimei Wu, Guanghe Fei

“…Targeting Poldip2 could be a beneficial therapeutic strategy for the treatment of ALI.…”
Get full text

Aberrant SNHG expression predicts poor prognosis in esophageal cancer using meta-analysis and bioinformatics analysis by Ke Shi, Li-De Huang, Dan Li, Wei-Min Luo, Hua-Song Liu, Dong-Xiao Ding, Qiang Guo, Yue-Feng Liu

“…These findings suggest that SNHG may serve as a prognostic marker and therapeutic target for EC.…”
Get full text

Combined Graphene Oxide with 2-Methoxyestradiol for Effective Anticancer Therapy in-vitro Model by Uzdrowska K, Knap N, Konieczna L, Kamm A, Kuban-Jankowska A, Gierałtowska J, Belka M, Baran M, Chlanda A, Kowiorski KM, Żołnierski A, Gulczynski J, Lipińska L, Bączek T, Izycka-Swieszewska E, Górska-Ponikowska M

“…This is a very important result, considering the fact that 2-ME itself has no inhibitory properties against this phosphatase.Discussion: Graphene oxide flakes embroidered with 2-methoxyestradiol molecules may be a promising solution, bringing a new and important effect in the form of improving the bioavailability of the therapeutic substance, ie 2-ME. An appropriate dosage of GO-2-ME/rGO-2-ME, in which GO/rGO is a carrier of 2-methoxyestradiol (2-ME), can ensure effective penetration of the active substance through biological boundaries/membranes and controlled modification of cell signalling, ultimately leading to the selective elimination of malignant cells.Keywords: new graphene-based anticancer drugs, graphene-based oncological therapy, new anticancer treatment, biomedical innovations, drugs delivery systems…”
Get full text

Evaluation of anti-Mullerian hormone as parameter of ovarian function in patients with systemic lupus erythematosus: A systematic review and meta-analysis by Mukhammad Nooryanto, Wulandari Wulandari

“…For individuals with systemic lupus erythematosus, particularly women in their reproductive years, assessing serum AMH levels can serve as a pivotal tool to inform therapeutic decisions and preserve ovarian health. Our study contributes to enhanced clinical understanding and patient care within the realm of SLE and reproductive health.…”
Get full text