Investigation of a Novel Noninvasive Risk Analytics Algorithm With Laboratory Central Venous Oxygen Saturation Measurements in Critically Ill Pediatric Patients by Sarah A. Teele, MD, MSHPEd, Avihu Z. Gazit, MD, Craig Futterman, MD, William G. La Cava, PhD, David S. Cooper, MD, MPH, MBA, Steven M. Schwartz, MD, MS, Joshua W. Salvin, MD, MPH

“…Recognition of patient’s evolving clinical status as well as the impact of therapeutic interventions may be delayed. OBJECTIVE:. …”
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Nanoparticles transfected with plasmid-encoded lncRNA-OIP5-AS1 inhibit renal ischemia-reperfusion injury in mice via the miR-410-3p/Nrf2 axis by Rongjie Zhang, Xin Zhang, Xuhui Zhu, Tao Li, Yansheng Li, Peng Zhang, Yuanhao Chen, Gao Li, Xiuwu Han

“…These findings lay the groundwork for future targeted therapeutic approaches utilizing nanoparticles for RI/R-induced AKI.…”
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Causal relationship of familial hypercholesterolemia with risk of intestinal vascular disorders: A mendelian randomization study by Gang Wei, Cheng Zhang, Feng-Jie Shen, Hua-Qi Guo, Lin Liu

“…Our study may provide evidence for new diagnostic and therapeutic strategies in clinical practices.…”
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Efficacy of Ivermectin, Liquid Paraffin, and Carbaryl against Mange of Farmed Rabbits in Central Kenya by Kennedy O. Ogolla, Joyce Chebet, Robert M. Waruiru, Peter K. Gathumbi, Paul O. Okumu, Gabriel O. Aboge

“…The current study evaluated the efficacy of three commonly used therapeutic agents in Kenya against mange. In a controlled laboratory trial, 20 adult rabbits were recruited for the study (16 of which were infested with mange, while 4 were mange-free). …”
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Transcriptomic and functional characterization of megakaryocytic-derived platelet-like particles: impaired aggregation and prominent anti-tumor effects by Kaitlin Garofano, Vera Mariani, Kameron Rashid, Sumanun Suwunnakorn, Alfateh Sidahmed, Anelia Horvath, Sanjay B. Maggirwar, Travis J. O’Brien, Minoli A. Perera, Michael Whalen, Norman H. Lee

“…These findings indicate that PLPs may have a potential therapeutic role in targeting and disrupting the oncogenic signaling between platelets and cancer cells, offering a new avenue for anti-cancer strategies.…”
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The efficacy and safety of rhGH treatment combined with letrozole/GnRHa in adolescent boys by Ying Zhang, Xin Yuan, Kenneth McCormick, Xiao-Hong Yang, Shi-Jun Chen, Rui-Min Chen

“…Abstract Objective In boys during puberty who were undergoing recombinant human growth hormone (rhGH) treatment, we compared the therapeutic efficacy on growth, and any adverse reactions, of co-therapy with either letrozole or gonadotropin-releasing hormone analog (GnRHa). …”
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Infection of nonclassic monocytes by respiratory syncytial virus induces an imbalance in the CD4+ T-cell subset response by Lianlian Han, Danyang Li, Conghui Wang, Lili Ren, Li Guo, Jianwei Wang

“…These new findings provide potential therapeutic targets for RSV infection.…”
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Banxia Xiexin Decoction Ameliorates t-BHP-Induced Apoptosis in Pancreatic Beta Cells by Activating the PI3K/AKT/FOXO1 Signaling Pathway by Li-juan Du, Bing Pang, Yu-meng Tan, Ya-nan Yang, Mei-zhen Zhang, Qing Pang, Min Sun, Qing Ni

“…BXXD protected MIN6 cells against t-BHP-induced apoptosis and improved insulin secretory function through modulation of the PI3K/AKT pathway and the downstream FOXO1, thus suggesting a novel therapeutic approach for type 2 diabetes mellitus (T2DM).…”
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Effect of electroacupuncture on vascular remodeling in rats with cerebral ischemia by regulating irisin based on VEGF/Akt/eNOS signaling pathway by Lu Cao, Wenchao Ding, Yashuo Feng, Chong Guan, Li Liu, Hongyu Xie, Kewei Yu, Dongyan Xu, Lijuan Zhao, Xuan Sha, Xiaoman Deng, Santian Wu, Yangrui Wang, Yi Wu, Tingting Zhang, Nianhong Wang

“…However, rAAV-shFNDC5 significantly weakened the therapeutic effects of EA. Conclusions: EA upregulated irisin expression, reaching a peak after 7 days of EA and then stabilizing. …”
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Single-cell RNA-seq analysis reveals microenvironmental infiltration of myeloid cells and pancreatic prognostic markers in PDAC by Yanying Fan, Lili Wu, Xinyu Qiu, Han Shi, Longhang Wu, Juan Lin, Jie Lin, Tianhong Teng

“…Abstract Background Pancreatic ductal adenocarcinoma (PDAC) has a heterogeneous make-up of myeloid cells that influences the therapeutic response and prognosis. However, understanding the myeloid cell at both a genetic and cellular level remains a significant challenge. …”
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Activity-based chemical proteomics reveals caffeic acid ameliorates pentylenetetrazol-induced seizures by covalently targeting aconitate decarboxylase 1 by Guanjun Li, Ling Huang, Di Gu, Peili Wang, Letai Yi, Wenhua Kuang, Ying Zhang, Junzhe Zhang, Dandan Liu, Qiaoli Shi, Huan Tang, Jichao Sun, Guohua Zeng, Xin Peng, Jigang Wang

“…Our study provides evidence supporting the utilization of caffeic acid as a promising therapeutic agent for treating epilepsy and neuroinflammation-related disorders.…”
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Relationship Between Perilesional Skin Condition and Survival in Terminally Ill Patients with Pressure Ulcers by María Isabel Pastor-Orduña, Federico Palomar-Llatas, David Palomar-Albert, María Teresa Murillo-Llorente, Ignacio Ventura, Francisco Tomás-Aguirre, Marcelino Pérez-Bermejo

“…These findings support the implementation of therapeutic interventions based on a structured perilesional tissue assessment to improve quality of life and prolong survival in terminally ill patients. …”
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<i>Ex Vivo</i> Regional Gene Therapy Compared to Recombinant BMP-2 for the Treatment of Critical-Size Bone Defects: An In Vivo Single-Cell RNA-Sequencing Study by Arijita Sarkar, Matthew C. Gallo, Jennifer A. Bell, Cory K. Mayfield, Jacob R. Ball, Mina Ayad, Elizabeth Lechtholz-Zey, Stephanie W. Chang, Osamu Sugiyama, Denis Evseenko, Jay R. Lieberman

“…., bone morphogenetic protein-2), seeded onto an osteoconductive scaffold, and then implanted into a bone defect to exert a therapeutic effect. Compared to recombinant human BMP-2 (rhBMP-2), which is approved for clinical use, regional gene therapy may have unique benefits related to the addition of MSCs and the sustained release of BMP-2. …”
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Donkey milk supplementation alleviates renal fibrosis of chronic kidney disease by enhancing anti-inflammatory ability by Cui Huimin, Wang Peng, Chen Man, Lin Hong, Zhao Yuxin, Pu Zhiyu, Yang Jianjun

“…These results indicate that miR-223-3p may be another potential therapeutic target for CKD. Moreover, the contribution of donkey milk to alleviating the inflammatory response and renal fibrosis of CKD is obvious, indicating that donkey milk may be a new functional food for CKD patients to promote health.…”
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Holistic health and social care outreach for people experiencing homelessness with recent non-fatal overdose in Glasgow, Scotland: the Pharmacist and third sector Homeless charity... by Vibhu Paudyal, Nicola Greenlaw, Frances S Mair, Kate Stock, Andrew McPherson, Andrea E Williamson, Richard Lowrie, Donogh Maguire, Steven Ross, James Roy Robertson, Alison Boyle, Clare Duncan, Rebecca Blair, Cian Lombard, Fiona Hughes, Jane Moir, Ailsa Scott, Frank Reilly, Laura Sills, Jennifer Hislop, Stephen Wishart, David Brannan, Rebekah Ramage

“…PHOENIx teams develop therapeutic relationships to address health (physical health, mental health and problem drug use) and social care (housing, welfare benefits and social prescribing) in addition to UC. …”
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Factors associated with failure of humerus nonunion surgery in patients with initial nonoperative management by Alexander Hysong, MD, Noah Harrison, MD, Samuel Posey, MD, Ziqing Yu, MS, Andrew T. Chen, MD, Patrick Pallitto, MD, Joseph R. Hsu, MD, William Obremskey, MD, Evidence-Based Musculoskeletal Injury and Trauma Collaborative (EMIT), Hassan Mir, MD, Roman M. Natoli, MD, PhD, Ishani Sharma, MD, MBA, Jenna Jones, Med, Luke A. Lopas, MD, Hassan Farooq, MD, Robert D. Zura, MD, Alexander Padovano, MD, Nathaniel Koutlas, MD, Steve Hemmerly, BS, Elsa Rodriguez, MD, Daniel E. Pereira, MD, Sharon Babcock, MD, Gabriel James Sowards, BS, Martha Holden, AAS, AA, Anna N. Miller, MD, Marc Schatz, MD, Jessica Rivera, MD, PhD, Katrina Bang, MD, Kamryn King, BS, Zachery Hong, BA, Jarrod Dumpe, MD, Gabriella Lea Stribling, BS, Merritt John Thompson, MD, Tracy Johns, MSN, RN-BC, Rachel Seymour, PhD, Susan Odum, PhD, Stephen Sims, MD, Olivia Rice, MD, Ainsley Bloomer, MD, Katheryn Peterson, BSPH, Amber Stanley, BSPH, Mario Cuadra, MD, Gisele Bailey, MS, Matthew Braswell, MD, Landon Bulloch, MD, William Haynes, MD, Josef Jolissaint, MD, Julia Mastracci, MD, Andrew Wohler, MD, Eddie Komie Afetse, BS, BA, Cara Girardi, Juliette Sweeney, BS, Benjamin Averkamp, MD, Meghan Wally, PhD, Madhav Karunakar, MD, Kevin Phelps, MD, Laurence Kempton, MD, Christine Churchill, MA, CCRP, David Macknet, MD, Hannah Pollock, BS, Rodney Arthur, MS, Samuel Cohen-Tanugi, Isaac Boateng, James Michael Ruth, BS, Joseph Michalski, MD, Anna Hemminger, BS, Kathryn Leighty, Mir Ibrahim Sajid, MD, Thea Lance, BA, William Hunter Waddell, MD, Andres Fidel Moreno Diaz, MD, Joseph Gutbrod, BS, Christopher G. Herbosa, BS

“…Level of Evidence:. Therapeutic level III.…”
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International prevalence of consultation with a naturopathic practitioner: a systematic review and meta-analysis by Amie Steel, Jon Adams, Brenda Leung, Holger Cramer, Matthew J Leach, Jon Wardle, Joshua Goldenberg, Janet Schloss, Rebecca Redmond, Joanna Elizabeth Harnett, Claudine Van de Venter, Andy McLintock, Ryan Bradley, Jason Hawrelak, Kieran Cooley

“…Objectives Naturopathy is a traditional medicine system informed by codified philosophies and principles, and an emphasis on non-pharmacologic therapeutic interventions. While naturopathy is practised by approximately 75 000–100 000 000 naturopathic practitioners in at least 98 countries, little is known about the international prevalence of history of consultation with a naturopathic practitioner. …”
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Effects of perioperative treatment of resectable adenocarcinoma of esophagogastric junction by immunotherapy (Adebrelimab) combined with chemotherapy (XELOX): protocol for a single... by Yingyi Li, Yuqin Cao, Xipeng Wang, Chengqiang Li, Liqin Zhao, Hecheng Li

“…The exploratory outcomes are the biomarkers related to therapeutic efficacy, such as PD-L1 expression, microsatellite instability (MSI), tumor mutational burden(TMB), Epstein-Barr virus(EBV) infection, and circulating tumor DNA(ctDNA). …”
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Raw Cured Poultry Meat Fortified with Bee Pollen: Biomedical Research on Laboratory Animals by Maksim A. Sukhov, Tatiana M. Giro, Sergey V. Kozlov, Irina V. Ziruk

“…As a result, it possesses numerous therapeutic and prophylactic properties. Bee pollen has good prospects as a fortifying agent for jerky meat, i.e., lean and dehydrated trimmed meat cut into strips. …”
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Astaxanthin-loaded brain-permeable liposomes for Parkinson’s disease treatment via antioxidant and anti-inflammatory responses by Thai-Duong Nguyen, Shristi Khanal, Eunhee Lee, Jinsol Choi, Ganesh Bohara, Nikesh Rimal, Dong-Young Choi, Soyeun Park

“…Astaxanthin is an antioxidant and anti-inflammatory agent; however, its high susceptibility to oxidative degradation and low aqueous solubility limit its therapeutic efficacy. This study aimed to improve the pharmaceutical properties and neuroprotective effects of astaxanthin for Parkinson’s disease treatment by using lactoferrin-conjugated astaxanthin-loaded liposomes (Lf-ASX-LPs). …”
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