Peroxisome Proliferator-Activated Receptor δ: A Target with a Broad Therapeutic Potential for Drug Discovery by Francine M. Gregoire

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Untargeted metabolomic and proteomic analysis implicates SIRT2 as a novel therapeutic target for diabetic nephropathy by Ruijing Zhang, Runze Chang, Heng Wang, Jinshan Chen, Chuanlong Lu, Keyi Fan, Yuhang Zhang, Lizheng Li, Sheng Yan, Honglin Dong

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Augmentation of Tonic GABAA Inhibition in Absence Epilepsy: Therapeutic Value of Inverse Agonists at Extrasynaptic GABAA Receptors by Adam C. Errington, David W. Cope, Vincenzo Crunelli

“…Moreover, they explain why pharmacological agents that enhance GABA receptor function can initiate or exacerbate absence seizures and suggest a potential therapeutic role for inverse agonists at eGABAARs in absence epilepsy.…”
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Oxidative Stress, Glutathione Insufficiency, and Inflammatory Pathways in Type 2 Diabetes Mellitus: Implications for Therapeutic Interventions by John Dawi, Yura Misakyan, Stephen Affa, Samuel Kades, Ananya Narasimhan, Fouad Hajjar, Max Besser, Kevin Tumanyan, Vishwanath Venketaraman

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The therapeutic potential of targeting Oncostatin M and the interleukin-6 family in retinal diseases: A comprehensive review by Mori Tommaso, Nagaraj Nareshkumar Ragavachetty, Surico Pier Luigi, Zhou Wenjing, Parmar Uday Pratap Singh, D’Esposito Fabiana, Gagliano Caterina, Musa Mutali, Zeppieri Marco

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Erratum to “Development of Delivery Systems Enhances the Potency of Cell-Based HIV-1 Therapeutic Vaccine Candidates” by Amin Hadi, Abbas Rastgoo, Maryam Eskandarian, Nooshin Haghighipour, Azam Bolhassani

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Recurrent Hydatidiform Moles: A Clinical Challenge—A Case Report and an Update on Management and Therapeutical Strategies by S. Riccio, F. Galanti, M. Scudo, L. Di Troia, M. G. Ferrillo, F. Manzara, P. Ianiri, F. A. Battaglia

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Use of art as therapeutic intervention for enhancement of hand function in patients with rheumatoid arthritis: A pilot study by Sayali Khedekar, Apurv P Shimpi, Ashok Shyam, Parag Sancheti

“…The current study aimed to evaluate the efficacy of art as a creative therapeutic procedure for enhancement of hand functions, self-perception, and quality of life in patients with rheumatoid arthritis (RA). …”
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Safety and efficacy of therapeutic plasma exchange in neuromyelitis optica: A retrospective study from South India by Dibyajyoti Sahoo, Pragya Silwal, Abhishekh Basavarajegowda

“…The effectiveness of therapeutic plasma exchange (TPE) has been shown by many studies across the globe but are only a few from India. …”
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Evaluation of Diagnostic and Therapeutic Measures in Patients with Persistent Idiopathic Facial Pain before a Definitive Diagnosis by Leila Farhad Mollashahi, Narges Farhad Mollashahi, Fahimeh Afzaljavan, Amir Hossein Saati

“…In addition to demographic information, the average time between the onset of symptoms and the final diagnosis, the number of consultations before diagnosis and the history of undergone diagnostic and therapeutic measures for pain relief; were recorded. …”
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Stimulation of DC-CIK with PADI4 Protein Can Significantly Elevate the Therapeutic Efficiency in Esophageal Cancer by Chunyan Liu, Yingying Zheng, Junyi Tang, Dawei Wang, Zhenshen Ma, Shutong Li, Xiaotian Chang

“…PADI4 may be a potential tumor marker that could be used to improve the therapeutic efficiency of DC-CIK cells.…”
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Genetic and Plasma Proteomic Approaches to Identify Therapeutic Targets for Graves’ Disease and Graves’ Ophthalmopathy by Ke C, Yu Y, Li J, Yu Y, Sun Y, Wang Y, Wang B, Lu Y, Tang M, Wang N, Chen Y

“…BTN1A1 and FCRL1 were prioritized as the causal proteins for GO onset and were not associated with GD.Conclusion: By synthesizing proteomic and genetic data, we identified several protein biomarkers for GD, with one linked to both GD and GO and two other protein biomarkers specific to GO onset, which provides valuable insights into the etiology and potential therapeutic targets for the two diseases.Keywords: plasma proteomics, Graves’ disease, Olink, Mendelian randomization…”
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Retracted: Risk Factors of Benign Stricture of Anastomotic Stoma after Esophagectomy and Therapeutic Effect of Stent Implantation by Emergency Medicine International

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Comment on “Unlocking the therapeutic potential of microalgal astaxanthin a super antioxidant in oral cancer and associated ailments” by Antonyraj Matharasi Perianaika Anahas, Dhanraj Ganapathy

“…In order to enhance the therapeutic uses of C-PC in oral cancer, further studies may investigate genetically modified microalgae. …”
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Bioassay-guided isolation and identification of antimutagenic compounds from Morina coulteriana and evaluation of its therapeutic potential by Jasbir Kour, Bashir Ahmad Lone, Amit Kumar, Bashir A. Ganai, Govind Yadav, Prasoon Gupta, Md.Niamat Ali, Seema Akbar

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Keratosis Lichenoides Chronica Successfully Treated With Doxycycline: A Therapeutic Option for a Rare Dermatologic Condition by Paula Dall’Oglio Furlan, Martín Vásquez Zuloaga, Cristhian Muñoz, Danielle Quintella, Tullia Cuzzi, Marcus Trovo

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HLA I immunopeptidome of synthetic long peptide pulsed human dendritic cells for therapeutic vaccine design by Amy L. Kessler, Roel F. A. Pieterman, Wouter A. S. Doff, Karel Bezstarosti, Rachid Bouzid, Kim Klarenaar, Diahann T. S. L. Jansen, Robbie J. Luijten, Jeroen A. A. Demmers, Sonja I. Buschow

“…Our work puts forward DC immunopeptidomics as a valuable tool for therapeutic vaccine design.…”
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Pentavalent Antimonials Combined with Other Therapeutic Alternatives for the Treatment of Cutaneous and Mucocutaneous Leishmaniasis: A Systematic Review by Taisa Rocha Navasconi Berbert, Tatiane França Perles de Mello, Priscila Wolf Nassif, Camila Alves Mota, Aline Verzignassi Silveira, Giovana Chiqueto Duarte, Izabel Galhardo Demarchi, Sandra Mara Alessi Aristides, Maria Valdrinez Campana Lonardoni, Jorge Juarez Vieira Teixeira, Thaís Gomes Verziganassi Silveira

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Meta-analysis and Trial Sequential Analysis for Therapeutic Eefficacy and Safety of Acupotomy and Acupuncture for Cervical Spondylotic Radiculopathy by Renpan ZHANG, Zhongbiao XIU, Jing LIU, Bin CHEN, Hong LIU, Hongjia ZHAO

“…Objective:To compare the therapeutic efficacy and safety between acupotomy and acupuncture for cervical spondylotic radiculopathy patients, to provide evidence for clinical practice.Methods:To search in the database, such as PubMed, Cochrane, China Biomedical Literature Database(CBM), China Knowledge Network Database(CNKI), Chinese Scientific Journal Database(VIP)and Wanfang Database. …”
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Advances in the understanding and therapeutic manipulation of cancer immune responsiveness: a Society for Immunotherapy of Cancer (SITC) review by Francesco M Marincola, Alessandra Cesano, Yana G Najjar, Davide Bedognetti, Marco Ruella, Sarah Warren, Christine Spencer, Elad Ziv, Tomas Kirchhoff, Jennifer McQuade, Tullia C Bruno, Jakob Nikolas Kather, Allison Betof Warner, Christian Hammer, Alberto Carturan, Ryan Augustin, Rhine Shen, Winson S Ho, Rongze O Lu, Luigi Barrea, Violena Pietrobon, Laura Soldati

“…Though CIR is multifactorial, fundamental concepts are emerging that should be considered for the design of novel therapeutic strategies and related clinical studies. …”
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