Therapeutic alliance impact on analgesic outcomes in a real-world clinical setting: An observational study by Barrachina Jordi, Margarit César, Andreu Blanca, Zandonai Thomas, Ballester Pura, Muriel Javier, Cutillas Esperanza, Peiró Ana M.

Subjects: “…therapeutic relationship…”
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PPARG Could Work as a Valid Therapeutic Strategy for the Treatment of Lung Squamous Cell Carcinoma by Shunbin Shi, Guiping Yu, Bin Huang, Yedong Mi, Yan Kang, Julia Pia Simon

“…Previous studies showed that PPAR-gamma (PPARG) ligands might serve as potential therapeutic agents for nonsmall cell lung cancer (NSCLC). …”
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Therapeutic Values of Earthworm Species Extract from Azad Kashmir as Anticoagulant, Antibacterial, and Antioxidant Agents by Rozina Ghulam Mustafa, Andleeb Dr Saiqa, Jorge Domínguez, Madiha Jamil, Saira Manzoor, Samna Wazir, Bushra Shaheen, Asma Parveen, Rida Khan, Shaukat Ali, Nazish Mazhar Ali, Fatima Jalal, Sadaf Azad Raja

“…Current research aimed to explore the therapeutic values of different earthworms as antibacterial, anticoagulant, and antioxidant agents. …”
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Targeting the Interplay Between Autophagy and the Nrf2 Pathway in Parkinson’s Disease with Potential Therapeutic Implications by Mengru Liu, Siqi Liu, Zihan Lin, Xi Chen, Qian Jiao, Xixun Du, Hong Jiang

“…Given the limited efficacy of therapies targeting either autophagy dysfunction or oxidative stress, it is crucial to elucidate the intricate mechanisms governing their interplay in PD to develop more effective therapeutics. This review overviews the role of autophagy and nuclear factor erythroid 2-related factor 2 (Nrf2), a pivotal transcriptional regulator orchestrating cellular defense mechanisms against oxidative stress, and the complex interplay between these processes. …”
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NF-κB signaling and the tumor microenvironment in osteosarcoma: implications for immune evasion and therapeutic resistance by Shaoyan Shi, Xuehai Ou, Chao Liu, Rui Li, Qianjin Zheng, Leiming Hu

“…It also enhances tumor cell resistance to chemotherapy and radiotherapy by activating anti-apoptotic signaling pathways and exacerbating treatment-induced inflammation. Potential therapeutic approaches include using NF-κB inhibitors, possibly in combination with immune checkpoint inhibitors, to overcome tumor cell resistance mechanisms and reshape antitumor immune responses. …”
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Nicotine Has a Therapeutic Window of Effectiveness in a Drosophila melanogaster Model of Parkinson’s Disease by Brady T. Mannett, Braden C. Capt, Krista Pearman, Lori M. Buhlman, John M. VandenBrooks, Gerald B. Call

“…Strong epidemiological evidence and studies in models of Parkinson’s disease (PD) suggest that nicotine may be therapeutically beneficial in PD patients. However, a number of clinical trials utilizing nicotine in PD patients have had mixed results, indicating that either nicotine is not beneficial in PD patients, or an important aspect of nicotine therapy was absent. …”
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Exploring therapeutic strategies for androgen-independent prostate cancer using a magnetic coculture platform by Anjani Chavali, Giles Fitzwilliams, Adam Germain, Sandra Khuon, Young-tae Kim

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The role and therapeutic targeting of the CCL2/CCR2 signaling axis in inflammatory and fibrotic diseases by Shan Guo, Qi Zhang, Yingjie Guo, Xiaoyan Yin, Peng Zhang, Tao Mao, Zibin Tian, Xiaoyu Li

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The critical role of TRIM protein family in intervertebral disc degeneration: mechanistic insights and therapeutic perspectives by Shangze Li, Wenli Jiang, Fei Chen, Jiao Qian, Jun Yang

“…This review explores the multifaceted roles of TRIM proteins in IVDD, highlighting their contributions to pathological pathways and their potential as therapeutic targets. Advancing our understanding of TRIM protein-mediated mechanisms may pave the way for innovative and precise therapeutic strategies to combat IVDD.…”
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Parkinson's Disease: Clinical Signs and Symptoms, Neural Mechanisms, Positron Emission Tomography, and Therapeutic Interventions by K. L. Leenders, W. H. Oertel

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Vimentin-Rab7a Pathway Mediates the Migration of MSCs and Lead to Therapeutic Effects on ARDS by Kai Wang, Boxiang Du, Yan Zhang, Congyou Wu, Xiuli Wang, Xu Zhang, Liwei Wang

“…Rab7a knockout blocked the migration of MSCs and weakened the therapeutic effect of MSCs in ARDS. In conclusion, we have shown that the Vimentin-Rab7a pathway mediates migration of MSCs and leads to therapeutic effects in ARDS.…”
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Improved Therapeutic Effect of Puerarin-Encapsulated PEG-PLGA Nanoparticle on an In Vitro Cerebral Infarction Model by Lei Li, Yan Li, Cheng Miao, Rui Liu

“…This study was to explore the therapeutic effect and mechanism of puerarin (PUE) combined with PEGylated nanoparticles on a rat cerebral infarction cell model. …”
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The Potential Therapeutic Effects of Platelet-Derived Biomaterials on Osteoporosis: A Comprehensive Review of Current Evidence by Mohammad Amin Amiri, Nima Farshidfar, Richard J. Miron, Arkadiusz Dziedzic, Shahram Hamedani, Sajad Daneshi, Lobat Tayebi

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MicroRNA-451a is a candidate biomarker and therapeutic target for major depressive disorder by Yan Chen, Yun Liu, Ming Xiao, Chun Wang, Panpan Hu, Qiuchen Cao, Hu Feng, Jingfan Xu, Weixi Feng, Huaiqing Sun, Huachen Ding, Junying Gao

“…Mechanistically, miR-451a could inhibit CRS-induced corticotropin-releasing factor receptor 1 expression via targeting transcription factor 2, subsequently protecting dendritic spine plasticity.Conclusions Together, these results highlighted miR-451a as a candidate biomarker and therapeutic target for MDD.…”
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Targeting the kynurenine pathway: another therapeutic opportunity in the metabolic crosstalk between cancer and immune cells by Irene Kang, Irene Kang, George Theodoropoulos, Medhi Wangpaichitr, Medhi Wangpaichitr, Medhi Wangpaichitr, Medhi Wangpaichitr

“…We propose that dual inhibition may maximize the therapeutic potential of KP inhibition. Additionally, we delve into the complex cellular interactions in cancer and metabolic dependencies within the tumor microenvironment (TME). …”
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Inhibiting de novo lipogenesis identifies a therapeutic vulnerability in therapy-resistant colorectal cancer by Eeshrita Jog, Ashwin Kumar Jainarayanan, Alessandro La Ferlita, Arnab Chakraborty, Afiya Dalwai, Showket Yahya, Anusha Shivashankar, Bhagya Shree Choudhary, Aakash Chandramouli, Mufaddal Kazi, Darshan Jain, Nileema Khapare, Akshaya B, Bushra K. Khan, Poonam Gera, Prachi Patil, Rahul Thorat, Nandini Verma, Lalit Sehgal, Avanish Saklani, Siddhesh S. Kamat, Sorab N. Dalal, Nazia Chaudhary

“…Targeting the phosphatidic acid (PA) to diacylglycerol (DAG) conversion to prevent lipid droplet formation could be an effective therapeutic approach for therapy-resistant CRC.…”
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Infantile undifferentiated sarcomas: a diagnostic and therapeutic challenge – two case reports and literature review by Aleksandra Stanio, Jakub Czarny, Sandra Rutkowska, Katarzyna Adamczewska-Wawrzynowicz, Łukasz Młynarczyk, Agnieszka Stróżyk, Katarzyna Jończyk-Potoczna, Alicja Bartkowska-Śniatkowska, Jacek Wachowiak, Katarzyna Derwich, Olga Zając-Spychała

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Meta-analysis of Therapeutic Effect in Depression Treatment of Repetitive Transcranial Magnetic Stimulation Combined Paroxetine by Xinyi GUO, Guo YU, Xiaokuo HE

“…Objective:To evaluate the therapeutic effect of repetitive transcranial magnetic stimulation(TMS)combined with paroxetine in the treatment of depression, provide reference for the clinical treatment and related research of depression.Methods:We electronically searched databases, including CNKI Chinese Journal Full-text Database, Wanfang Database, VIP Database, PubMed, the Cochrane Library and EMbase, to collect randomized controlled trials(RCTs)about depression treated by repetitive TMS combined with paroxetine. …”
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Pivotal Cytoprotective Mediators and Promising Therapeutic Strategies for Endothelial Progenitor Cell-Based Cardiovascular Regeneration by Hyunyun Kim, Sujin Kim, Sang Hong Baek, Sang-Mo Kwon

“…In this review, we discuss multiple cytoprotective mediators of EPC-based cardiovascular repair and propose promising therapeutic strategies for the treatment of CVDs.…”
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A Facile Route to Fabricate CS/GO Composite Film for the Application of Therapeutic Contact Lenses by Pin Chen, Xin Wang, Jingyang Kong, Xiaohong Hu

“…Therefore, a transparent film was designed and investigated for the application of therapeutic contact lenses. Chitosan (CS)/graphene oxide (GO) composite film and CS film were fabricated with acceptable transparent and tensile properties by simple casting flow method. …”
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