Therapeutic applications of novel drug delivery systems of liquorice: An updated review on recent advancements by Sanshita, Taneja Ayushi, Sangnim Tanikan, Huanbutta Kampanart, Sindhu Rakesh K., Singh Inderbir

“…In this review, liquorice's historical background, pharmacokinetics, therapeutic applications, different mechanism of actions is discussed with major emphasis on liquorice encapsulated novel formulations (nanoparticles, nanomicelles, liposomes, niosomes, microparticles, microspheres, self-nanoemulsifying system, self-micro-emulsifying system). …”
Get full text

Exploring prognosis and therapeutic strategies for HBV-HCC patients based on disulfidptosis-related genes by Chuankuo Zhang, Xing Zhang, Shengjie Dai, Wenjun Yang

“…This study aims to develop a novel HBV-HCC prognostic signature related to disulfidptosis and explore potential therapeutic approaches through risk stratification based on disulfidptosis.MethodsTranscriptomic data from HBV-HCC patients were analyzed to identify BHDRGs. …”
Get full text

Therapeutic potential of Chromolaena odorata, Vernonia amygdalina, and Cymbopogon citratus against pathogenic Bacteria by Udensi Justina Ugochi, Anyanwu Charles Obinna, Emedoh Andrew Emeka, Anyanwu Emilia Oluchi, Danladi Makeri, Pius Theophilus, Ezera Agwu

“…Those plant species have therefore shown some potential to be used as alternative or complementary therapeutics to antibiotics in addressing antibiotic resistance. …”
Get full text

Therapeutic application and potential mechanism of plant-derived extracellular vesicles in inflammatory bowel disease by Jinling Li, Ting Luo, Dou Wang, Yao Zhao, Yuanxiang Jin, Guiling Yang, Xin Zhang

“…In addition, drug loading enhances the therapeutic potential of PDEVs, particularly regarding improved tissue targeting and stability. …”
Get full text

Enhancing proteasome activity by NMDAR antagonists explains their therapeutic effect in neurodegenerative and mental diseases by Fikret Sahin, Aslihan Gunel, Buse Turegun Atasoy, Ulku Guler, Bekir Salih, Isinsu Kuzu, Mehmet Taspinar, Ozgur Cinar, Selda Kahveci

Get full text

Emerging role of gut microbiota extracellular vesicle in neurodegenerative disorders and insights on their therapeutic management by Adil Hassan, Yin Huang, Mahjabina, Otmilda Hapsari Sudiro, Xiangxiu Wang, Jingqin He, Yan Wei, Xiaoling Liao, Guixue Wang

“…This study also examines the current state and potential therapeutic effects of GMEVs on neurodegenerative illnesses.…”
Get full text

Major Histocompatibility Complex Genes as Therapeutic Opportunity for Immune Cold Molecular Cancer Subtypes by Paweł Karpiński, Łukasz Łaczmański, Maria M. Sąsiadek

Get full text

Exploring FBXO43 as a potential therapeutic target: Implications for oral cancer progression by Dhanraj Ganapathy, Saravanan Sekaran, Pasiyappazham Ramasamy

Get full text

TGF-β1 inhibitor enhances the therapeutic effect of microwave ablation on hepatocellular carcinoma by Shufang Xiang, Juan Li, Mei Zhang

Subjects: Get full text

Gender-related Therapeutical Response to Apremilast: New Insights in a Tailored Management of Psoriasis by Emanuele Trovato, Federico Bardazzi, Vito Di Lernia, Monica Corazza, Claudia Lasagni, Francesca Prignano

Get full text

Leveraging Single-Cell Multi-Omics to Decode Tumor Microenvironment Diversity and Therapeutic Resistance by Hussein Sabit, Borros Arneth, Timothy M. Pawlik, Shaimaa Abdel-Ghany, Aysha Ghazy, Rawan M. Abdelazeem, Amany Alqosaibi, Ibtesam S. Al-Dhuayan, Jawaher Almulhim, Noof A. Alrabiah, Ahmed Hashash

Subjects: Get full text

Depot-specific acetylation profiles of adipose tissues—therapeutic targets for metabolically unhealthy obesity by Haoyue Guo, Zhiyi Zhang, Juntao Yang, Jiangfeng Liu, Hongwei Lin, Ningbei Yin

“…Conclusions This study provided a comprehensive dataset on the proteomic and acetylomic profiles of SA and VA, laying a foundation for investigating the pathogenesis and potential therapeutic approaches for MUO. SA was characterized by pronounced ECM remodeling regulation, while VA exhibited poorer adaptability and more prominent metabolic functional changes. …”
Get full text

Effect of Therapeutic Inhibition of TNF on Circulating Endothelial Progenitor Cells in Patients with Rheumatoid Arthritis by F. R. Spinelli, A. Metere, C. Barbati, M. Pierdominici, C. Iannuccelli, B. Lucchino, F. Ciciarello, L. Agati, G. Valesini, M. Di Franco

“…Short-term treatment with anti-TNF was able to increase circulating EPCs concurrently with a proportional decrease of disease activity suggesting that therapeutic intervention aimed at suppressing the inflammatory process might positively affect the endothelial function.…”
Get full text

Mechanisms and therapeutic implications of gene expression regulation by circRNA-protein interactions in cancer by Nan Zhang, Xinjia Wang, Yu Li, Yiwei Lu, Chengcheng Sheng, Yumeng Sun, Ningye Ma, Yisheng Jiao

“…Additionally, we explore the role of CPIs in tumor drug resistance to gain a deeper understanding of their potential applications in the development of new anti-cancer therapeutic approaches.…”
Get full text

Promising Therapeutic Functions of Bone Marrow Mesenchymal Stem Cells Derived-Exosome in Asthma by Jia-Ying Yuan, Xiang-Yun Wang, Zhi-Ying Tong, Yu-Chao Dong, Jia-Yi Zhao, Yi Zhang, Yan Shang

“…Extracellular vesicles (EVs) enriched in body fluid were characterized as subcomponents of extracellular vesicles and delivered carriers combined with genetic messages in vivo. The therapeutic potential of exosomes has become a research hotspot in many diseases. …”
Get full text

FDA-approved kinase inhibitors: a promising therapeutic avenue for traumatic brain injury by Dezhu Gao, Yu Shi, Zhiliang Wang, Weiming Liu

“…TBI disrupts the normal activity of kinases and molecular signaling pathways, but the effective therapeutic methods for patients remain limited. Nowadays, kinase inhibitors approved by the Food and Drug Administration (FDA) mainly for cancer treatment have shown potential effects in TBI. …”
Get full text

Magnetic precision: Unleashing the therapeutic potential of paclitaxel-loaded nanoparticles in breast cancer treatment by N. Shobhana, N Raghavendra Naveen, Prakash Goudanavar

“…Breast cancer remains a formidable global health challenge, necessitating innovative therapeutic strategies. In this context, our investigation delves into the potential of paclitaxel-loaded magnetic nanoparticles (MNPs) as a targeted and effective therapeutic approach for breast cancer. …”
Get full text

Therapeutic resources used by physiotherapists for the relief of labor pain: a cross-sectional study by Alessandra de Campos Gonçalves, Giovana Garçoni Poli, Clara Maria de Araujo Silva, Ana Carolina Sartorato Beleza, Richard Eloin Liebano

“…Abstract Objective The aim of the study was to identify non-pharmacological therapeutic resources used by physiotherapists for pain relief during labor and childbirth. …”
Get full text

Application of therapeutical nanoparticles with neutrophil membrane camouflaging for inflammatory plaques targeting against atherosclerosis by Ningnannan Zhang, Tianzhu Zhang, Jintang Feng, Jian Shang, Beibei Zhang, Qingyang Dong, Zhang Zhang, Chunyang Sun

“…Precise and effective plaque targeting is a major objective for therapeutic outcomes throughout various stages of atherosclerosis. …”
Get full text

Phytocanabinoids and synthetic cannabinoids: from recreational consumption to potential therapeutic use – a review by Helena M. Teixeira, Helena M. Teixeira

Subjects: Get full text