An Experimental Study: Benefits of Digoxin on Hepatotoxicity Induced by Methotrexate Treatment by Banu Taskin, Mümin Alper Erdoğan, Gürkan Yiğittürk, Sibel Alper, Oytun Erbaş

“…The aim of the study is to examine the possible therapeutic effects of a known cardiac glycoside, digoxin, on a rat model of MTX-induced hepatotoxicity. …”
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In vitro characterization of beta-cyclodextrin liposomal formulation of cisplatin nanomedicine by Panijapatr Wasubhadtanasaka

“…The potential of these nanomedicines, especially BCDCPLP, is in reducing the required dosage while maintaining therapeutic efficacy offers promising advances in cancer therapy.…”
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Prevalence and Associated Factors of Dental Caries in Primary Schoolchildren: An Iranian Setting by Mohammad Ali Youssefi, Solaiman Afroughi

“…Providing and implementing preventive, therapeutic, and informative programs for controlling dental caries at individual, family, and school levels are necessary for local health policymakers.…”
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Anti-inflammatory activity of Alpinia officinarum hance on rat colon inflammation and tissue damage in DSS induced acute and chronic colitis models by Vijayabharathi Rajendiran, Vidhya Natarajan, Sivasithamparam Niranjali Devaraj

“…Taken together, these results suggest that HEAO is a promising anti-oxidant and anti-inflammatory agent that support its possible therapeutic role in the treatment of colitis. Keywords: Alpinia officinarum, Antioxidants, Inflammation, Dextran sulfate sodium (DSS), Inflammatory bowel diseases (IBD)…”
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Do PPAR-Gamma Agonists Have a Future in Parkinson's Disease Therapy? by Anna R. Carta, Augusta Pisanu, Ezio Carboni

“…Specific targeting of immune functions contributing to neuroinflammation either directly (central) or indirectly (peripheral) may represent a novel therapeutic approach for disease modifying therapies in PD.…”
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Bioinformatics exploration of identified garlic-derived antimicrobial peptides: a food-based approach to quorum sensing inhibition in foodborne pathogens by Mahmoud Dahab, Mohammed Aladhadh

“…Even though VS-9 showed more anti QS activity than F3-3-c, more research is needed to fully understand their mechanisms of action and maximize their therapeutic potential. …”
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Matched serum- and urine-derived biomarkers of interstitial cystitis/bladder pain syndrome. by Tadeja Kuret, Igor Sterle, Rok Romih, Peter Veranič

“…Systemic levels of MMP9 can therefore mirror the local pathology within the bladders of IC/BPS patients, and MMP9 may prove to be a useful target for the development of novel therapeutic interventions. Utilizing a comprehensive panel of both urine and serum biomarkers, identified here, holds promise for disease detection in IC/BPS patients.…”
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miRNA-328-3p regulates ZO-1 expression and inhibits PEDV proliferation via the PLC-β1-PKC pathway. by Han Zhao, Jiayu Zhang, Dengliang Li, Zhanding Cui, Jiuyuan Liu, Di Bao, Yiming Wei, Xinyue Zhang, Zhimin Wu, Tianqi Zhang, Kai Wang, Shushuai Yi, Wei Lian, Guixue Hu

“…These findings suggest that PLC-β1 modulates ZO-1 expression through the PKC pathway, providing new insights into the molecular mechanisms of PEDV infection and potential therapeutic targets.…”
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Sex differences in psychiatric comorbidities of attention-deficit/hyperactivity disorder among children, adolescents, and adults: A nationwide population-based cohort study. by Pei-Hsin Kao, Chung-Han Ho, Charles Lung-Cheng Huang

“…These findings underscore the need for age- and sex-specific therapeutic approaches in ADHD management. The cultural context of the study necessitates further research in diverse populations for broader applicability of the findings.…”
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Liposome-Encapsulated Bioactive Guttiferone E Exhibits Anti-Inflammatory Effect in Lipopolysaccharide-Stimulated MH-S Macrophages and Cytotoxicity against Human Cancer Cells by Jean Paul Dzoyem, Shashank Reddy Pinnapireddy, Hugues Fouotsa, Jana Brüßler, Frank Runkel, Udo Bakowsky

“…Guttiferone E is a naturally occurring polyisoprenylated benzophenone exhibiting a wide range of remarkable biological activities. But its therapeutic application is still limited due to its poor water solubility. …”
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EGFR-Mutant Non-small Cell Lung Cancer: State-of-the-Art and Future Perspectives by Antonio Rossi, Ettore Mari

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Dynamic multiday seizure cycles and evolving rhythms in a tetanus toxin rat model of epilepsy by Parvin Zarei Eskikand, Mark J. Cook, Anthony N. Burkitt, David B. Grayden

“…These findings offer promising avenues for improving seizure forecasting and designing personalized, timing-based therapeutic interventions in epilepsy. Future research should explore the underlying neural mechanisms and clinical applications of multiday seizure cycles.…”
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Inferior-Medial Dry Needling at the Thoracolumbar Junction: A Cadaveric Study by Christi L. Williams, Sue E. Curfman, Stacey R. Lindsley, Christian R. Falyar, Ryan C. McConnell

“…# Background Dry needling (DN) has emerged as a popular therapeutic intervention for managing musculoskeletal pain. …”
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Caroli's Disease: Current Knowledge of Its Biliary Pathogenesis Obtained from an Orthologous Rat Model by Yasunori Sato, Xiang Shan Ren, Yasuni Nakanuma

“…The development of the polycystic kidney (PCK) rat, an orthologous rodent model of Caroli's disease with CHF as well as ARPKD, has allowed the molecular pathogenesis of the disease and the therapeutic options for its treatment to be examined. …”
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Machine Learning with Tunicate Swarm Optimization for Improved Disc Herniation Prediction by Theofilos Gofas, Argyros Maris

“…This study highlights the need for accurate prognosis and therapeutic efficacy, and it promotes machine learning (ML) as an essential diagnostic tool. …”
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Exploring the causal impact of body mass index on metabolic biomarkers and cholelithiasis risk: a Mendelian randomization analysis by Feng Zhao, Yanjiang Yang, Wenwen Yang

“…Future research should explore the specific metabolic pathways involved to identify potential therapeutic targets.…”
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An Unexpected Presentation of Serotonin Syndrome in a Patient Receiving ECT by Shahzaib Khan, Breanna Wennberg, Malgorzata Witkowska, Jacob Rattin, Raunak Khisty

“…The mechanism by which ECT confers therapeutic benefit for patients with neuropsychiatric conditions is not entirely understood. …”
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Carpal Tunnel Syndrome and Calcium Deposit in the Surgically Transacted Transverse Carpal Ligament by Ali Abbas Hashim Al-Musawi, Nadia Mahmoud Tawfiq Jebril, Amer Abbas. H. AL-Auhaimid, Zaid Hadi. K. Hammoodi

“…These results indicate that TCL mineralisation by Ca does not characterise CTS, which has important concerns in improving patients’ therapeutic strategies, and Cd and Pb concentrations varied due to different factors.…”
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Cyclosporine and Herbal Supplement Interactions by D. Colombo, L. Lunardon, G. Bellia

“…Cyclosporine (CyA) is a well-known immunosuppressant with a narrow therapeutic window. Its bioavailability is affected by many other traditional drugs and herbal extracts. …”
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Drug Delivery System Targeting Cancer-Associated Fibroblast for Improving Immunotherapy by Zhang Z, Wang R, Chen L

“…As for the cancer treatment, nanomaterials could enhance the therapeutic effect in many ways. Therefore, in this review, we first summarized the current understanding of the complex interactions between CAFs and TME, immune cells, and tumor cells. …”
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