Biochemical and biophysical cues of the extracellular matrix modulates stem cell fate: Progress and prospect in extracellular matrix mimicking biomaterials by Anuska Mishra, Unnati Modi, Rahul Sharma, Dhiraj Bhatia, Raghu Solanki

“…Stem cell therapies hold immense promise for the treatment of a wide range of diseases; however, the full therapeutic potential remains untaped. This limitation arises primarily from our incomplete understanding of the complex mechanisms of stem cell niches. …”
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Clinical impacts of Artocarpus lakoocha agglutinin-binding glycans for prognosis and treatment of cholangiocarcinoma by Phisit Sintusen, Kulthida Vaeteewoottacharn, Ubon Cha’on, Chawalit Pairojkul, Chaiwat Aphivatanasiri, Sutas Suttiprapa, Panupong Mahalapbutr, Atit Silsirivanit, Sopit Wongkham, Sukanya Luang

“…Overall, these findings may position ALAG as a potential marker for poor prognosis in CCA, while ALA may serve as a novel lectin for both detection and therapeutic applications in CCA.…”
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Small Extracellular Vesicles Promote Axon Outgrowth by Engaging the Wnt-Planar Cell Polarity Pathway by Samar Ahmad, Tania Christova, Melanie Pye, Masahiro Narimatsu, Siyuan Song, Jeffrey L. Wrana, Liliana Attisano

“…Small extracellular vesicles (sEVs), such as exosomes, from diverse sources are known to promote neurite outgrowth and thus may have therapeutic potential. However, the effect of fibroblast-derived exosomes on axon elongation in neurons of the central nervous system under growth-permissive conditions remains unclear. …”
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MFAP5 inhibits the malignant progression of endometrial cancer cells in vitro by Liang Guanying, Qi Zijuan, Du Chun

“…Our findings indicate that MFAP5 overexpression inhibits the malignant behaviors of EC cells, possibly by blocking the AKT/mTOR pathway, suggesting that MFAP5 may be a new therapeutic target for EC.…”
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Social support may buffer, to an extent, the impact of stigma on health-related quality of life among type 2 diabetes mellitus patients by Desmond Uchechukwu Onu, Christy Ngozi Obi-keguna, Osadebe Nnabuike Oguguam, Chukwuedozie K. Ajaero, Elisha John Igwe

“…Therefore, in addition to enhancing social support among T2DM patients, interventions may also do well to incorporate therapeutic approaches aimed at addressing the unique challenges posed by self-stigma in this vulnerable population.…”
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Functional nanocrystal as effective contrast agents for dual-mode imaging: Live-cell sonoluminescence and contrast-enhanced echography by V. Vighetto, E. Pascucci, N.M. Percivalle, A. Troia, K.M. Meiburger, M.R.P. van den Broek, T. Segers, V. Cauda

“…Finally, the stimuli-responsive therapeutic applications of ZnO-Lip against tumors is overviewed, aiming to achieve a fully theranostic approach.…”
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Transcriptome Analysis of Long Noncoding RNAs in Toll-Like Receptor 3-Activated Mesenchymal Stem Cells by Shihua Wang, Xiaoxia Li, Robert Chunhua Zhao

“…Mesenchymal stem cells (MSCs) possess great immunomodulatory capacity which lays the foundation for their therapeutic effects in a variety of diseases. Recently, toll-like receptors (TLR) have been shown to modulate MSC functions; however, the underlying molecular mechanisms are poorly understood. …”
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Zinc deficiency effect on clinical features of Coronavirus Disease 2019 patients: A scoping review by Moch Ikhsan Juliansyah, Lisa Adhia Garina, Mirasari Putri

“… COVID-19 was declared a pandemic in March 2020. Various therapeutic guidelines have been established for treating COVID-19, such as anti-inflammatory, antiviral therapies, and zinc supplementation. …”
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Ectopic expression of the cation-chloride cotransporter KCC2 in blood exosomes as a biomarker for functional rehabilitation by L. Caccialupi Da Prato, A. Rezzag Lebza, A. Consumi, M. Tessier, A. Srinivasan, C. Rivera, C. Rivera, J. Laurin, C. Pellegrino

“…Furthermore, we established a correlation between this decrease in KCC2 expression and the long-term consequences of brain trauma and identified a link between the loss of KCC2 expression and the emergence of depressive-like behavior observed in the mice.ConclusionWe successfully validated our previous findings, supporting the potential therapeutic benefits of bumetanide in mitigating post-traumatic depression (PTD) following TBI. …”
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Electroencephalography Biomarkers of α5-GABA Positive Allosteric Modulators in Rodents by Frank Mazza, Alexandre Guet-McCreight, Thomas D. Prevot, Taufik Valiante, Etienne Sibille, Etay Hay

“…A novel positive allosteric modulator that specifically targets the α5-GABAA receptor subunit (α5-PAM), ligand GL-II-73 shows anxiolytic, antidepressant, and procognitive effects without the common side effects associated with nonspecific modulation by benzodiazepines such as diazepam, thus suggesting novel therapeutic potential. However, it is unknown whether α5-PAM has detectable signatures in clinically relevant brain electroencephalography (EEG). …”
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Expanding the miRNA Transcriptome of Human Kidney and Renal Cell Carcinoma by Adam P. Sage, Brenda C. Minatel, Erin A. Marshall, Victor D. Martinez, Greg L. Stewart, Katey S. S. Enfield, Wan L. Lam

“…Despite advancements in therapeutic strategies, diagnostic and prognostic molecular markers of kidney cancer remain scarce, particularly in patients who do not harbour well-defined driver mutations. …”
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A Biopsychosocial Overview of Speech Disorders: Neuroanatomical, Genetic, and Environmental Insights by Diya Jaishankar, Tanvi Raghuram, Bhuvanesh Kumar Raju, Divyanka Swarna, Shriya Parekh, Narendra Chirmule, Vikramsingh Gujar

“…This comprehensive overview aims to inform future research and therapeutic advancements, particularly in treating fluency disorders like stuttering.…”
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Promoter Polymorphism of RGS2 Gene Is Associated with Change of Blood Pressure in Subjects with Antihypertensive Treatment: The Azelnidipine and Temocapril in Hypertensive Patients... by Ken Sugimoto, Tomohiro Katsuya, Kei Kamide, Tomomi Fujisawa, Izumi Shimaoka, Mitsuru Ohishi, Ryuichi Morishita, Toshio Ogihara, Hiromi Rakugi

“…A-638G polymorphism of the RGS-2 gene could be a predictive factor for therapeutic performance of Ca channel blockers.…”
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Novel classification system and high-risk categories of pediatric acute myeloid leukemia by Masayuki Umeda, Yen-Chun Liu, Seth E. Karol, Jeffery M. Klco

“…We also highlight four high-risk subtypes of pediatric AML, namely CBFA2T3::GLIS2, BCL11B, UBTF-TD, and ETS family fusions, focusing on their disease mechanisms, clinical associations, and possible therapeutic strategies to overcome the dismal clinical outcomes associated with these alterations. …”
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Pleiotrophin deletion prevents high-fat diet-induced cognitive impairment, glial responses, and alterations of the perineuronal nets in the hippocampus by Héctor Cañeque-Rufo, Teresa Fontán-Baselga, Milagros Galán-Llario, Agata Zuccaro, María Gracia Sánchez-Alonso, Esther Gramage, María del Pilar Ramos-Álvarez, Gonzalo Herradón

“…These results show a crucial role of PTN in metabolic responses and brain alterations induced by HFD and suggest the PTN signalling pathway as a promising therapeutic target for brain disorders associated with MetS.…”
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Depression in the Iranian Elderly: A Systematic Review and Meta-Analysis by Hedayat Jafari, Dariush Ghasemi-Semeskandeh, Amir Hossein Goudarzian, Tahereh Heidari, Azar Jafari-Koulaee

“…Depression can lead to increased medical costs, impaired individual and social functioning, nonadherence to therapeutic proceeding, and even suicide and ultimately affect quality of life. …”
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Protective effects of 18β-glycyrrhetinic acid on Pasteurella multocida–induced vascular inflammatory injury in mice by Qirong Lu, Qirong Lu, Luyao Wang, Luyao Wang, Xueping Jiang, Xueping Jiang, Wantong Han, Wantong Han, Pu Guo, Pu Guo, Yu Liu, Yu Liu, Shulin Fu, Shulin Fu, Jianglin Xiong, Jianglin Xiong, Zhongyuan Wu, Zhongyuan Wu, Yinsheng Qiu, Yinsheng Qiu

“…Hence, GA exhibits therapeutic potential in the treatment of vascular injury.…”
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Bioactive sorbicillinoid derivatives from an endophytic fungus Trichoderma citrinoviride by Yan-Ping Xia, Yan Xie, Li Rao, Guo-Ping Yin

“…These findings underscore the therapeutic potential of the new sorbicillinoid derivatives for antioxidant and anti-inflammatory applications.…”
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Biological properties of Moringa oleifera: A systematic review of the last decade [version 1; peer review: 2 approved, 1 approved with reservations] by Andrea Catalina Gómez, Javier Andrés Soto, C. A. Zuniga-Gonzalez, Karen Shirley Molina, Andrea Natalia Barreto, Maryeli Vásquez

“…Therefore, it is critical to search for new therapeutic alternatives. Moringa oleifera is a plant well known for the properties of its phytocomponents and its role has been analyzed in a variety of fields, from medicine to biotechnology. …”
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Intravenous Administration of Bone Marrow-Derived Mesenchymal Stem Cells Induces a Switch from Classical to Atypical Symptoms in Experimental Autoimmune Encephalomyelitis by Mónica Kurte, Javiera Bravo-Alegría, Alexander Torres, Vania Carrasco, Cristina Ibáñez, Ana María Vega-Letter, Catalina Fernández-O’Ryan, Carlos E. Irarrázabal, Fernando E. Figueroa, Rodrigo A. Fuentealba, Claudia Riedel, Flavio Carrión

“…This research examines the therapeutic effect of MSCs administration at different disease stages in experimental autoimmune encephalomyelitis (EAE). …”
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