The Portosystemic Shunt for the Control of Variceal Bleeding in Cirrhotic Patients: Past and Present by Petre Radu, Virgiliu-Mihail Prunoiu, Victor Strâmbu, Dragos Garofil, Roxana Elena Doncu, Eugen Brătucu, Laurentiu Simion, Maria-Manuela Răvaş, Mircea Nicolae Brătucu

“…PCS remains with very limited indications, in specific situations when the other therapeutic methods have failed or are not recommended.…”
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Human Bone Marrow Mesenchymal Stem Cells Promote Gastric Cancer Growth via Regulating c-Myc by Bin Chen, Jing Yu, Qianqian Wang, Yuanyuan Zhao, Li Sun, Changgen Xu, Xiangdong Zhao, Bo Shen, Mei Wang, Wenrong Xu, Wei Zhu

“…These results indicated that hBM-MSC-CM induced gastric cancer growth via upregulation of c-Myc, which may be a potential risk factor and/or a therapeutic target for clinical applications.…”
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Genes Induced by Panax Notoginseng in a Rodent Model of Ischemia-Reperfusion Injury by Lanqing Meng, Qing Huang, Xuebin Li, Ping Liang, Yueyong Li, Xiaohua Huang, Jingjie Zhao, Qiuping Chen, Rong Qiu, Lan Li, Chongdong Jian, Hongfei Yao, Jianmin Huang, Xionglin Tang, Zechen Wang, Zhongheng Wei, Jun Wu, Liuzhi Wei, Qiuju Wei, Qianli Tang, Lu Huang, Jihua Wei, Dinggui Lu, Qunqiang Luo, Kegong Xie, Yang Ouyang, Jian Chen, Genliang Li, Linxue Luo, Linbo He, Chenyi Zhuo, Anding Xu, Lingzhang Meng

“…In total, 817 DEGs were identified to be related to the therapeutic effect of PN on stroke recovery. Further analysis by Gene Oncology analysis and Kyoto Encyclopedia of Genes and Genomes revealed that most of these genes were involved in the biological function of nerves and blood vessels through the regulation of neuroactive live receptor interactions of PI3K-Akt, Rap1, cAMP, and cGMP-PKG signaling, which included in the 18 pathways identified in our research, of which, 9 were reported firstly that related to PN’s neuroprotective effect. …”
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Laryngeal Cancer in Women: Unveiling Gender-Specific Risk Factors, Treatment Challenges, and Survival Disparities by Barbara Verro, Simona Fiumara, Giuseppe Saraniti, Carmelo Saraniti

“…This review aims to examine gender differences in incidence, risk factors, hormonal mechanisms, survival, and therapeutic approaches for laryngeal cancer in women. …”
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Synthesis and Experimental Validation of New PDI Inhibitors with Antiproliferative Activity by Mariateresa Badolato, Gabriele Carullo, Francesca Aiello, Antonio Garofalo

“…The inhibition of PDI’s activity may have a therapeutic role, in various diseases, including cancer. …”
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Can a mechanical circulatory support comprehensive approach to cardiogenic shock at referral centers reduce 30-day mortality? by Marina Pieri, Marina Pieri, Mario Iannaccone, Francesco Burzotta, Francesco Burzotta, Giulia Botti, Giulia Botti, Cristina Aurigemma, Carlo Trani, Carlo Trani, Silvia Ajello, Savino Altizio, Tommaso Sanna, Tommaso Sanna, Enrico Romagnoli, Lazzaro Paraggio, Luigi Cappannoli, Anna Mara Scandroglio, Alaide Chieffo, Alaide Chieffo

“…Although mortality risk prediction in cardiogenic shock (CS) is possible, assessing the impact of the multitude of therapeutic efforts on outcomes is not straightforward. …”
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Discovery of antimicrobial activity in chemical extracts derived from unexplored algal-bacterial culture systems and isolates by Carolyn L. Fisher, Hailey C. Loehde-Woolard, Pamela D. Lane, Catherine M. Mageeney, Todd W. Lane

“…Identifying novel antimicrobials through innovative methods that are active against human pathogens will create a new, necessary pipeline for chemical discovery and therapeutic development. Our goal was to determine whether algal production systems represent fertile ground for discovery of antibiotics and antifungals. …”
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Lack of Effect of H2-Receptor Antagonists and Antacids on the Gastric and Duodenal Gastrin-, Somatostatin- and Serotonin-Producing Cells in Patients with Acid Peptic Disorders by WR Yacoub, ABR Thomson, P Hooper, LD Jewell

“…Standard therapeutic approaches to acid peptic disorders have dealt with neutralizing or inhibiting aggressive factors and/or bolstering defensive factors. …”
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Effects of Diet Based on IgG Elimination Combined with Probiotics on Migraine Plus Irritable Bowel Syndrome by Yangzhi Xie, Guijuan Zhou, Yan Xu, Bing He, Yilin Wang, Rundong Ma, Yunqian Chang, Duanqun He, Chenlin Xu, Zijian Xiao

“…This study was carried out to investigate therapeutic potential of diet based on IgG elimination combined with probiotics on migraine plus irritable bowel syndrome. …”
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DNA-based hydrogels for bone regeneration: A promising tool for bone organoids by Xiang Wu, Yan Hu, Shihao Sheng, Huijian Yang, Zuhao Li, Qinglin Han, Qin Zhang, Jiacan Su

“…With these advantages and properties, these DNA-based hydrogels can be used to construct bone organoids, providing an innovative tool for disease modeling and therapeutic applications in bone tissue engineering. …”
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Effect of Recombinant Human Growth Hormone Treatment in a Patient with Short Stature Associated with the Ring Chromosome 17 Syndrome by Gustavo Tempone Cardoso Penna, Gabriela de Rezende Lelot, Ana Luiza de Rezende Lelot, Juliana Greghi Hernandez, Carolina Costa Figueiredo, Nara Michelle de Araujo Evangelista, Vania de Fatima Tonetto Fernandes, Guido de Paula Colares Neto

“…Despite no evidence of growth hormone deficiency, rhGH treatment was indicated as a therapeutic test due to his decelerated growth velocity and severe short stature. …”
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Metastatic Urothelial Carcinoma from Transplanted Kidney with Complete Response to an Immune Checkpoint Inhibitor by Ryan S. Chiang, Ashton A. Connor, Brant A. Inman, Wen-Chi Foo, David N. Howell, John F. Madden, Matthew J. Ellis, Aparna S. Rege, Michael R. Harrison

“…Approaches to treatment have largely been individualized based on clinical circumstances given the lack of evidence-based guidelines, with therapeutic options ranging from discontinuation of immunosuppression and transplantectomy to the addition of chemotherapy or radiotherapy. …”
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Microglial NLRP3-gasdermin D activation impairs blood-brain barrier integrity through interleukin-1β-independent neutrophil chemotaxis upon peripheral inflammation in mice by Sung-Hyun Yoon, Chae youn Kim, Eunju Lee, Changjun Lee, Kyung-Seo Lee, Jaeho Lee, Hana Park, Bokeum Choi, Inhwa Hwang, Junhan Kim, Tae-Gyun Kim, Junghyun Son, Young-Min Hyun, Seunghee Hong, Je-Wook Yu

“…Collectively, these findings reveal the important role of NLRP3-driven chemokine production in BBB disintegration, suggesting potential therapeutic targets to mitigate neuroinflammation.…”
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Occupational Radiation Exposure during Endoscopic Retrograde Cholangiopancreatography and Usefulness of Radiation Protective Curtains by Tomoyuki Minami, Tamito Sasaki, Masahiro Serikawa, Michihiro Kamigaki, Masanobu Yukutake, Takashi Ishigaki, Yasutaka Ishii, Teruo Mouri, Satoshi Yoshimi, Akinori Shimizu, Tomofumi Tsuboi, Keisuke Kurihara, Yumiko Tatsukawa, Eisuke Miyaki, Kazuaki Chayama

“…We studied medical staff members who had assisted in 80 consecutive therapeutic endoscopic retrograde cholangiopancreatography (ERCP) procedures. …”
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Current Status of Treatment of Spinal and Bulbar Muscular Atrophy by Fumiaki Tanaka, Masahisa Katsuno, Haruhiko Banno, Keisuke Suzuki, Hiroaki Adachi, Gen Sobue

“…Androgen receptor (AR), a disease-causing protein of SBMA, is a well-characterized ligand-activated transcription factor, and androgen binding induces nuclear translocation, conformational change and recruitment of coregulators for transactivation of AR target genes. Some therapeutic strategies for SBMA are based on these native functions of AR. …”
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Revolution of blood cancer treatment in the oral cavity: Breakthroughs in nanotherapy by Pavithra Bharathy, Elizabeth Rani E, Punniyakoti V. Thanikachalam

“…Nanoparticles (NPs) made from organic and inorganic materials have shown promise in delivering therapeutic substances to cancer cells, enhancing their pharmacological efficacy, and reducing their systemic toxicity. …”
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The Effect of the Thai Herbal Suksaiyad Formula on Platelet Aggregation in Healthy Volunteers: A Quasi-experimental, Single-dose Study by Titchaphorn Palo, Nalinthika Nathananwanit, Pravit Akarasereenont, Suksalin Booranasubkajorn

“…These interactions could result in fluctuations that may enhance or diminish the effectiveness of concurrent antiplatelet therapies, potentially increasing the risk of bleeding or decreasing therapeutic outcomes. …”
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Utility of Computed Tomographic Enteroclysis/Enterography for the Assessment of Mucosal Healing in Crohn's Disease by Shinichi Hashimoto, Kensaku Shimizu, Hiroaki Shibata, Satoko Kanayama, Ryo Tanabe, Hideko Onoda, Naohumi Matsunaga, Isao Sakaida

“…Aim. When determining therapeutic strategy, it is important to diagnose small intestinal lesions in Crohn's disease (CD) precisely and to evaluate mucosal healing as well as clinical remission in CD. …”
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Vaginal Dysbiosis in Infertility: A Comparative Analysis Between Women with Primary and Secondary Infertility by Iliana Alejandra Cortés-Ortíz, Gustavo Acosta-Altamirano, Rafael Nambo-Venegas, Jesús Alejandro Pineda-Migranas, Oscar Giovanni Ríos-Hernández, Eduardo García-Moncada, Alejandra Yareth Bonilla-Cortés, Mónica Sierra-Martínez, Juan Carlos Bravata-Alcántara

“…Conclusion: Our findings suggest that the composition of the vaginal microbiota may play a decisive role in infertility, highlighting the need for personalized therapeutic strategies based on microbial profiles.…”
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CD133+PD-L1+ cancer cells confer resistance to adoptively transferred engineered macrophage-based therapy in melanoma by Jiaojiao Xu, Zhe Li, Qinli Tong, Sihang Zhang, Jianchen Fang, Aihua Wu, Guoguang Wei, Chen Zhang, Sheng Yu, Binbin Zheng, Hongzheng Lin, Xueling Liao, Zeyu Xiao, Wei Lu

“…Abstract Adoptive transfer of genetically or nanoparticle-engineered macrophages represents a promising cell therapy modality for treatment of solid tumor. However, the therapeutic efficacy is suboptimal without achieving a complete tumor regression, and the underlying mechanism remains elusive. …”
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