A 55-Year-Old Man with Stage IV Squamous Cell Carcinoma of the Right Groin after External Beam Radiation for Testicular Cancer by Christine Ibilibor, Jeremy Wells, Sravan Kavuri, Kelvin A. Moses

“…It is unclear whether or not therapeutic radiation in this case promoted the conversion of the patient’s condyloma to a malignant lesion. …”
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Insights from in vivo preclinical cancer studies with histotripsy by Tejaswi Worlikar, Timothy Hall, Man Zhang, Mishal Mendiratta-Lala, Michael Green, Clifford S. Cho, Zhen Xu

“…Research is underway to combine histotripsy with immunotherapy and chemotherapy to improve therapeutic outcomes. In addition to preclinical cancer research, human clinical trials are ongoing for the treatment of liver tumors and renal tumors. …”
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Increasing GLP-1 Circulating Levels by Bariatric Surgery or by GLP-1 Receptor Agonists Therapy: Why Are the Clinical Consequences so Different? by Chloé Amouyal, Fabrizio Andreelli

“…Bariatric surgery is now proposed during the therapeutic management of type 2 diabetes in obese or overweight populations. …”
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Purine-rich element binding protein alpha: a DNA/RNA binding protein with multiple roles in cancers by Shiyi Yu, Chengyang Jiang, Yawen Yang, Fei Cheng, Fangchen Liu, Chang Liu, Xue Gong

“…The present review summarizes the most recently discovered critical roles of PURα in various cancer types, providing an overview of the biomarker and therapeutic target potential of PURα for patients with cancer.…”
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Antibacterial properties of substituted phenethylamine-based β-lactam derivatives in oral infections by Merve Yildirim, Elif Aksakal, Taha Yasin Bayram, Eda Irmak, Harun Gun, Bunyamin Ozgeris, Arzu Gormez

“…These data suggest that β-lactam derivatives could be potent therapeutic agents for oral infections. …”
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Cyclin-Dependent Kinase-Like 5 (CDKL5): Possible Cellular Signalling Targets and Involvement in CDKL5 Deficiency Disorder by Syouichi Katayama, Noriyuki Sueyoshi, Tetsuya Inazu, Isamu Kameshita

“…Consequently, the exploration of CDKL5 substrate characteristics and regulatory mechanisms of its catalytic activity are important for identifying therapeutic target molecules and developing new treatment. …”
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Implications of the Use of Eukaryotic Translation Initiation Factor 5A (eIF5A) for Prognosis and Treatment of Hepatocellular Carcinoma by Felix H. Shek, Sarwat Fatima, Nikki P. Lee

“…In conclusion, eIF5A2 is a potential prognostic marker as well as a therapeutic target for HCC.…”
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The NLRP3 Inflammasome as a Novel Player of the Intercellular Crosstalk in Metabolic Disorders by Elisa Benetti, Fausto Chiazza, Nimesh S. A. Patel, Massimo Collino

“…We will provide here a perspective on the current research on NLRP3 inflammasome, which may represent an innovative therapeutic target to reverse the detrimental metabolic consequences of the metabolic inflammation.…”
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Computational Study of Trisindoline 5 Against Overexpressed EGFR Protein on Breast Cancer Stem Cell by Nurhayati A.P.D., Fatoni M., Santoso M., Wati F.A.

“…This research informed that trisindoline 5 might be potential for developing novel therapeutic drug against BCSCs.…”
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Efficacy of Topical Mesenchymal Stem Cell Therapy in the Treatment of Experimental Dry Eye Syndrome Model by Emrullah Beyazyıldız, Ferda Alpaslan Pınarlı, Özlem Beyazyıldız, Emine Rümeysa Hekimoğlu, Uğur Acar, Muhammed Necati Demir, Aynur Albayrak, Figen Kaymaz, Güngör Sobacı, Tuncay Delibaşı

“…The current study was set out to address the therapeutic efficacy of topically applied mesenchymal stem cells (MSCs) on dry eye syndrome (DES) induced by benzalkonium chloride (BAC) in rats. …”
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Suppression of Th17 Cell Response in the Alleviation of Dextran Sulfate Sodium-Induced Colitis by Ganoderma lucidum Polysaccharides by Bing Wei, Ran Zhang, Jingbo Zhai, Junfeng Zhu, Fangli Yang, Dan Yue, Xiaoyi Liu, Changlong Lu, Xun Sun

“…The aim of this study was to assess the therapeutic potential of GLP to alleviate DSS-induced colitis. …”
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Mandibular posterior bone anchorage technique using steel wire: a retrospective descriptive study on dental movements and clinical tolerance by Grzelczyk Lucie, Ligerot Romain, Filippi Raphaël, Cresseaux Paul, Carlier Adélaïde

“…Conclusion: The Abalakov method appears to complement the therapeutic arsenal available to orthodontists and surgeons for the treatment of patients requiring solid mandibular posterior anchorage.…”
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Adipokines as Drug Targets in Diabetes and Underlying Disturbances by Vinícius Andrade-Oliveira, Niels O.S. Câmara, Pedro M. Moraes-Vieira

“…We describe how adipokines regulate inflammation in these diseases and their therapeutic implications. We also survey current attempts to exploit adipokines for clinical applications, which hold potential as novel approaches to drug development in several immune-mediated diseases.…”
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Mesenchymal Stem Cell-Derived Extracellular Vesicles: Roles in Tumor Growth, Progression, and Drug Resistance by Xiaoyan Zhang, Huaijun Tu, Yazhi Yang, Lijun Fang, Qiong Wu, Jian Li

“…In the present review, we summarize the components of MSC-EVs and discuss the roles of MSC-EVs in different malignant diseases, including the related mechanisms that may account for their therapeutic potential. MSC-EVs open up a promising opportunity in the treatment of cancer with increased efficacy.…”
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Reversal of Early Diabetic Nephropathy by Islet Transplantation under the Kidney Capsule in a Rat Model by Yunqiang He, Ziqiang Xu, Mingshi Zhou, Minmin Wu, Xuehai Chen, Silu Wang, Kaiyan Qiu, Yong Cai, Hongxing Fu, Bicheng Chen, Mengtao Zhou

“…These data suggest that early DN can be reversed after islet transplantation, and they may facilitate the development of a clinical therapeutic strategy for human diabetes mellitus.…”
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Exosomes Play an Important Role in the Progression of Plasma Cell Mastitis via the PI3K-Akt-mTOR Signaling Pathway by Xiaohong Wang, Yong Han, Jian Liu, Yingzhe Zhang, Kai Cheng, Jiwei Guo, Qingqun Guo, Song Liu, Hongguang Sun, Yitong Hua, Guoqiang Zhang, Shujian Xu, Fengli Guo, Zhenlin Yang

“…These results will help to dissect the molecular mechanism of PCM and provide therapeutic targets.…”
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MicroRNAs-Proteomic Networks Characterizing Human Medulloblastoma-SLCs by Giuseppina Catanzaro, Zein Mersini Besharat, Neha Garg, Maurizio Ronci, Luisa Pieroni, Evelina Miele, Angela Mastronuzzi, Andrea Carai, Vincenzo Alfano, Agnese Po, Isabella Screpanti, Franco Locatelli, Andrea Urbani, Elisabetta Ferretti

“…Taken together, our findings highlight microRNAs, genes, and proteins that are significantly modulated in hMB-SLCs with respect to their RA-differentiated counterparts and could open new perspectives for prognostic and therapeutic intervention on MB.…”
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Pycnogenol® Induces Browning of White Adipose Tissue through the PKA Signaling Pathway in Apolipoprotein E-Deficient Mice by Huiying Cong, Wenxia Zhong, Yiying Wang, Shoichiro Ikuyama, Bin Fan, Jianqiu Gu

“…Thus, PYC may be a novel therapeutic target for obesity.…”
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The anti-melanoma roles and mechanisms of tricholoma isoflavone derivative CA028 by Cheng Liang, Jianfu Jiang, Jinkai Li, Xiao Lin, Wenjun Huang, Keng Po Lai, Jian Chen

“…For the first time, our data suggested the possible use of modified isoflavone for therapeutic applications against melanoma.…”
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Treatment journey in rheumatoid arthritis with biosimilars: from better access to good disease control through cost savings and prevention of nocebo effects by Bruno Fautrel, Josef S Smolen, Fabrizio Benedetti, Roberto Caporali, Thomas Doerner, Burkhard Pieper, Minjun Jang

“…Even though many disease-modifying anti-rheumatic drugs (DMARDs) are available for RA treatment, biological DMARDs (bDMARDs) offer expanding therapeutic options and good outcomes in patients with RA who do not have a sufficient response to conventional synthetic DMARDs. …”
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